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Patent # Description
2018/0148726 RNAi Inhibition of Alpha-ENaC Expression
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC...
2018/0148725 UNA OLIGOMERS AND COMPOSITIONS FOR TREATING AMYLOIDOSIS
This invention encompasses compounds and compositions useful in methods for medical therapy, in general, for inhibiting expression of a TTR gene in a subject....
2018/0148724 SMN2 Element 1 Antisense Compositions and Methods and Uses Thereof
The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions...
2018/0148723 CHEMICAL MODIFICATION OF SHORT SMALL HAIRPIN RNAS FOR INHIBITION OF GENE EXPRESSION
Aspects of the present invention include the production and use of chemically modified RNAi agents (e.g., shRNAs) in gene silencing applications. The...
2018/0148722 Dual Targeting siRNA Agents
The invention relates to dual targeting siRNA agents targeting a PCSK9 gene and a second gene, and methods of using dual targeting siRNA agents to inhibit...
2018/0148721 Natural Antisense and Non-Coding RNA Transcripts as Drug Targets
Small interfering RNA (siRNA) knock down antisense transcripts, and regulate the expression of their sense partners. This regulation can either be discordant...
2018/0148720 INHIBITION OF LNCRNA HOTAIR AND RELATED MATERIALS AND METHODS
Embodiments disclosed herein concern compositions and methods for treating a condition characterized by overexpression of long non-coding RNA HOTAIR. In...
2018/0148719 DELIVERING CRISPR THERAPEUTICS WITH LIPID NANOPARTICLES
The present invention provides lipid particles comprising therapeutic nucleic acids such as gRNA that target gene expression.
2018/0148718 COMPOUNDS AND METHODS FOR INCREASING ANTISENSE ACTIVITY
In certain embodiments, the present disclosure provides compounds and methods for increasing the antisense activity of an antisense compound in a cell. In...
2018/0148717 Methods for Generating Circular DNA from Circular RNA
Provided herein are methods of amplifying nucleic acids. In particular, methods are provided for amplifying circular RNA molecules. In certain embodiments,...
2018/0148716 EFFICIENCY IMPROVING LIGATION METHODS
The present invention provides new methods and kits to improve the efficiency of ligation reactions, in particular in molecular biology applications, such as...
2018/0148715 High-Throughput Single Cell Barcoding
Methods and compositions for high-throughput, single cell analyses are provided. The methods and compositions can be used for analysis of genomes and...
2018/0148714 HIGH THROUGHPUT OPTIMIZATION OF CONTENT-LOADED NANOPARTICLES
The present invention relates to tagged particles and the identification and characterization of particles based on their tag. In particular, the present...
2018/0148713 DEPARAFFINIZATION OF FFPE TISSUE SAMPLES
A method for deparaffinizing an FFPE tissue sample comprises mixing the FFPE tissue sample with an organic solvent to form a first mixture (10). A surfactant...
2018/0148712 Method and Test Kit For Rapid Isolation of Nucleic Acids Using Rough Surfaces
The invention relates to a method for isolation of nucleic acids from aqueous samples containing nucleic acids in free form or liberated by lysis. Before or...
2018/0148711 GENOME EDITING VECTORS
The present invention generally provides HSV-based genome editing vectors, cell-based compositions, and methods of using the same.
2018/0148710 Electrophoresis assisted method for purifying a target nucleic acid using a delayed elution approach
Provided is inter alia to an electrophoresis assisted method for purifying a target nucleic acid from a nucleic acid containing sample, comprising (a)...
2018/0148709 COMPOSITES MATERIAL WITH SUSPENDED PARTICLES AND METHOD OF USING THE SAME
An intermediate composite capable of transferring a biological or chemical material to be patterned on a surface. The intermediate composite includes a...
2018/0148708 COMPOSITES MATERIAL WITH SUSPENDED PARTICLES AND METHOD OF USING THE SAME
An intermediate composite capable of transferring a biological or chemical material to be patterned on a surface. The intermediate composite includes a...
2018/0148707 TECHNIQUE FOR AGGREGATING MACROMOLECULES TOGETHER WITH CELLS
The present invention provides a technique for efficiently aggregating a polymer such as ECM together with cells. A method for preparing a polymer-loaded cell or...
2018/0148706 METHYL BUTENOL SYNTHASE
The present invention provides novels genes encoding methyl butenol (MBO) synthase, methyl butenol synthases and their use in methyl butenol production.
2018/0148705 METHOD FOR PRODUCING BLOOD COAGULATION FACTOR VII, AND BLOOD COAGULATION FACTOR VII
A process for producing blood coagulation factor VII in 3 human cell lines (HepG2, Sk-Hep, HKB-11) and to select the best recombinant protein producer. The...
2018/0148704 POLYPEPTIDES HAVING BETA-MANNANASE ACTIVITY AND METHODS OF USE
The present compositions and methods relate to a beta-mannanase from Bacillus hemicellulosilyticus, polynucleotides encoding the beta-mannanase, and methods of...
2018/0148703 STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF
Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed...
2018/0148702 Polypeptides Having Endoglucanase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also...
2018/0148701 High Fidelity Restriction Endonucleases
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a...
2018/0148700 Bifunctional Lipase Mutant and Methods of Using Same
The present invention provides a novel dual-function lipase variant and its application in processing of flour products. The amino acid sequence of the lipase...
2018/0148699 Bifunctional Lipase Mutant and Methods of Using Same
The present invention provides a novel dual-function lipase variant and its application in processing of flour products. The amino acid sequence of the lipase...
2018/0148698 ENGINEERED BIOCATALYSTS AND METHODS FOR SYNTHESIZING CHIRAL AMINES
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host...
2018/0148697 MICROBIAL PRODUCTION OF TERPENOIDS
The present invention provides genetically engineered host organisms capable of producing terpenoids. The present invention also relates terpenoids obtained...
2018/0148695 MUTANT ENZYMES
This invention relates to mutant enzymes with enhanced properties and processes for oxidation of organic compound substrates using such enzymes.
2018/0148694 ONCOLYTIC VIRUS THERAPY FOR RESISTANT TUMORS
Disclosed herein is a recombinant oncolytic virus comprising a nucleic acid sequence encoding tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)....
2018/0148693 CELL CULTURE METHOD USING BONE MARROW-LIKE STRUCTURE, AND POLYIMIDE POROUS MEMBRANE FOR TREATING BONE DAMAGE SITE
The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured....
2018/0148692 Methods for Accelerated and Enhanced Cardiac Differentiation of IPS Cells by Electrical Stimulation
Methods of generating cardiomyocytes from induced pluripotent stem cells (IPSCs) are provided. More specifically, the present disclosure relates to methods of...
2018/0148691 METHODS FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS
The present invention provides methods for isolating human cardiac ventricular progenitor cells (HVPs), wherein cultures of day 5-7 cardiac progenitor cells...
2018/0148690 METHODS OF ISOLATING T CELLS AND T CELL RECEPTORS HAVING ANTIGENIC SPECIFICITY FOR A CANCER-SPECIFIC MUTATION...
Disclosed are methods of isolating T cells and TCRs having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Also...
2018/0148689 Generation of Inner Ear Cells
Methods for generating cells of the inner ear, e.g., hair cells and supporting cells, from stem cells, e.g., mesenchymal stem cells, are provided, as well as...
2018/0148688 CHEMICAL REPROGRAMMING OF HUMAN GLIAL CELLS INTO NEURONS WITH SMALL MOLECULE COCKTAIL
Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to...
2018/0148687 GENERATING INDUCED NEURAL PROGENITOR CELLS FROM BLOOD
The present disclosure provides a method of generating induced neural progenitor cells from CD34+/CD45+ blood cells using a POU domain containing gene or...
2018/0148686 INTERVENTION FOR TENDINOPATHY
Methods for treating tendinopathy and tendonitis and for preventing tendinopathy are disclosed.
2018/0148685 CORNEAL EPITHELIOID CELLS DERIVED FROM SURFACE ECTODERMAL CELLS
The present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell from a surface ectoderm-derived cell. More specifically,...
2018/0148684 MICROCARRIER PERFUSION CULTURING METHODS AND USES THEREOF
Provided herein are methods of perfusion culturing an adherent mammalian cell using a shake flask and a plurality of microcarriers, and various methods that...
2018/0148683 INDUCTION OF GENE EXPRESSION USING A HIGH CONCENTRATION SUGAR MIXTURE
Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for...
2018/0148682 Molding System for Fungal Structures
A molding system for forming an inoculated lignocellulose based medium into a fungal molded shape, the molding system comprising a vessel within which...
2018/0148681 COMPOSITION CAPABLE OF PROMOTING THE GROWTH OF DENITRIFYING MICROORGANISMS AND USES THEREOF
The present invention relates to the field of biotechnology, and discloses a composition capable of promoting the growth of denitrifying microorganisms and...
2018/0148680 CONCENTRATING DEVICE AND METHOD FOR CONCENTRATING CELL SUSPENSION
A means capable of simply and efficiently concentrating a cell suspension. A concentrator has a culture vessel having a first port and a second port, a server...
2018/0148679 Liquefaction of cellulose-containing feedstocks
A method for producing a pumpable slurry from a cellulose-containing feedstock is presented herein.
2018/0148678 MICROBIAL EXPERIMENT COOLING AND TEMPERATURE-SENSING MULTIPURPOSE RACK
A multi-function cooling and thermo-sensitive rack includes horizontal bars, a base, positioning holes, connectors, a lateral frame, connecting holes, a...
2018/0148677 Alternating Tangential Flow Rapid Harvesting
Methods and systems of harvesting a cell product from a cell culture by culturing cells in a fluid medium until the cells have produced a cell product at a...
2018/0148676 CONTAINER APPARATUS
The invention relates to a container device (1), comprising: a container receiving portion (4) for receiving a container; at least one valve (6) for...
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