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Patent # Description
2018/0148524 TACKIFIER COMPOUNDS AND METHODS OF USING THE SAME
The present invention relates to tackifier compounds and methods of using the same. In various embodiments, the present invention provides a tackifier compound...
2018/0148523 Synthesis of Functionalized Polyisobutylenes
Disclosed is a simplified process for formation of polyisobutylene functionalized with at least one terminal primary or secondary alcohol. The process...
2018/0148522 CATALYST COMPRISING A METALLOCENE COMPLEX AND A CO-CATALYST
The invention relates to a metallocene complex according to formula I ##STR00001## wherein M is a metal selected from lanthanides or transition metals from...
2018/0148521 METHOD OF PRODUCING AQUEOUS SOLUTION OF VINYLAMINE UNIT-CONTAINING POLYMER
A method comprising producing N-vinylformamide, polymerizing a monomer ingredient comprising the N-vinylformamide to produce a polymer comprising...
2018/0148520 PROCESS AND CATALYST COMPOSITION FOR PRODUCING SELECTIVELY HYDROGENATED CONJUGATED DIENE POLYMER
A catalyst composition for selectively hydrogenating a conjugated diene polymer in a homogeneous system is provided, wherein the conjugated diene polymer...
2018/0148519 PHOTOPOLYMERIZATION INITIATOR COMPOSITION, ACTIVE ENERGY RAY-CURABLE COMPOSITION, AND CURED PRODUCT
An object of the present invention is to provide a photopolymerization initiator composition, which exhibits excellent storage stability at a low temperature...
2018/0148518 Bulk Polymerization of Silicone-Containing Copolymers
Methods for preparing silicone-containing polymers by essentially adiabatic polymerization methods are disclosed. The polymerization system includes free...
2018/0148517 Bulk Polymerization of Silicone-Containing Copolymers
Methods for preparing silicone-containing polymers by essentially adiabatic polymerization methods are disclosed. The polymerization system includes free...
2018/0148516 Cellulosic Arabinoxylan fiber (CAF) and Methods of Preparing
Processes for the preparation of cellulosic arabinoxylan fiber. Cellulosic arabinoxylan fiber prepared by the processes. Edible formulations, containing the...
2018/0148515 METHOD FOR PREPARING A CELLULOSE SPONGE
A method for preparing a cellulose sponge, comprising: (A) providing a solution of hydroxypropyl cellulose having a self-crosslinkable substituent; and (B)...
2018/0148514 MULTIVALENT MEDITOPES, MEDITOPE-BINDING ANTIBODIES AND USES THEREOF
Provided are methods for altering the distribution of a cell surface antigen. Also provided are compositions for use in the methods, including multivalent...
2018/0148513 ANTI-PD-1 ANTIBODIES AND THEIR USES
The present disclosure provides novel anti-PD-1 antibodies, compositions including the new antibodies, nucleic acids encoding the antibodies, and methods of...
2018/0148512 FUSION PROTEINS THAT FACILITATE CANCER CELL DESTRUCTION
Provided is a fusion protein comprising a polypeptide component that blocks binding of CD47 to SIRP alpha and a polypeptide that binds to and triggers a TRAIL...
2018/0148511 OPTIMIZED ANTIBODIES THAT TARGET CD19
The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein...
2018/0148510 PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of...
2018/0148509 COMPOSITION FOR TREATING IL-6-RELATED DISEASES
The present invention provides a pharmaceutical composition for treating IL-6-related diseases containing an IL-6 inhibitor as an active ingredient, wherein...
2018/0148508 MASKING CHIMERIC ANTIGEN RECEPTOR T CELLS FOR TUMOR-SPECIFIC ACTIVATION
The invention is directed to a masked chimeric antigen receptor, comprising: (a) a masking peptide; (b) one or more antigen-specific targeting domains; (c) an...
2018/0148507 METHODS OF USING BISPECIFIC CD33 AND CD3 BINDING PROTEINS
Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human...
2018/0148506 BLOCKADE OF CD7 EXPRESSION AND CHIMERIC ANTIGEN RECEPTORS FOR IMMUNOTHERAPY OF T-CELL MALIGNANCIES
The present invention provides compositions comprising an anti-CD7 chimeric activating receptor (CAR) and an anti-CD7 protein expression blocker, and methods...
2018/0148505 LINGO-1 ANTAGONISTS AND USES FOR TREATMENT OF DEMYELINATING DISORDERS
Methods, compositions and kits comprising an anti-LINGO antibody molecule are described herein useful for detecting and/or treating a CNS demyelinating disease.
2018/0148504 Anti-Folate Receptor Alpha Antibodies And Uses Thereof
Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression...
2018/0148503 T CELL RECEPTOR-LIKE ANTIBODIES SPECIFIC FOR A PRAME PEPTIDE
The presently disclosed subject matter provides antigen-binding proteins that specifically bind to Preferentially expressed antigen of melanoma (PRAME),...
2018/0148502 Antibodies against phosphorylcholine in combination therapy with biologic agents
Antibodies against PC, PC conjugate or bioactive components and/or fragments thereof for use in combination therapy with one or more biologic agents and/or...
2018/0148501 TGF-BETA 3 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF
Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 3 (TGF-.beta.3) are provided,...
2018/0148500 METHODS OF SHIFTING AN ISOELECTRIC PROFILE OF A PROTEIN PRODUCT AND USES THEREOF
Provided herein are methods shifting the isoelectric profile of a recombinant protein product and the use of such methods in the manufacture of recombinant...
2018/0148499 Antibody Therapy for Amyloid Beta Disease
The present disclosure relates generally to a protocol to treat or prevent diseases or conditions associated with pathological forms of amyloid beta (A.beta.),...
2018/0148498 FUNGAL DETECTION USING MANNAN EPITOPE
Non-invasive methods are provided herein for diagnosing samples as including a fungus, including fungal infection or contamination, with specific monoclonal...
2018/0148497 BISPECIFIC MOLECULES COMPRISING AN HIV-1 ENVELOPE TARGETING ARM
The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising...
2018/0148495 VARIANT FACTOR VIII POLYPEPTIDES AND METHODS OF THEIR PRODUCTION AND USE
This disclosure relates to variant Factor VIII polypeptides comprising an amino acid substitution at one or more positions within one or both of the thrombin...
2018/0148494 SOLUBLE FGFR3 DECOYS FOR TREATING SKELETAL GROWTH DISORDERS
The invention features soluble FGF decoy polypeptides and fusion polypeptides comprising an FGF decoy polypeptide linked to a heterologous polypeptide, such as...
2018/0148493 HIV VPR-SPECIFIC T-CELL RECEPTORS
The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQQL).
2018/0148492 CDH26 BASED THERAPEUTIC AGENTS AND THEIR USE
The invention provides (CDH26)-based therapeutic agent, compositions comprising same, and methods of treating inflammatory conditions using same.
2018/0148491 Novel Hybrid ActRIIB Ligand Trap Proteins For Treating Muscle Wasting Diseases
The present disclosure describes novel hybrid soluble ActRIIB-ECD polypeptides which fully retain binding affinity for myostatin and activin A but demonstrate...
2018/0148490 MONOMERIC CXCL121 PEPTIDE AND USE THEREOF
The present invention provides a CXCL12.sub.1 peptide engineered to resist peptide-induced dimerization by maintaining steric repulsion of the chemokine helix,...
2018/0148489 IDR PEPTIDE COMPOSITIONS AND USE THEREOF FOR TREATMENT OF TH2-DYSREGULATED INFLAMMATORY CONDITIONS
A composition for treating or preventing a Th2-dysregulated inflammatory condition wherein the composition comprises a therapeutically effective amount of one...
2018/0148488 NOVEL MICRO-DYSTROPHINS AND RELATED METHODS OF USE
Nucleotide sequences including a micro-dystrophin gene are provided. The micro-dystrophin genes may be operatively linked to a regulatory cassette. Methods of...
2018/0148487 NOVEL TLR4 ANTAGONIST
The present disclosure relates to a peptide for inhibiting a TLR4 signaling pathway, a TLR4 antagonist including the peptide, and a composition for preventing...
2018/0148486 HUMAN CELL LINES MUTANT FOR ZIC2
Human cell lines mutant for ZIC2 with altered cellular phenotype are disclosed, including HEK 293T, LN prostate cancer, and PC-3 cell lines. Method of making...
2018/0148485 ANTI-CANCER FUSION POLYPEPTIDE
The disclosure provides a fusion polypeptide specific for both CD137 and GPC3, which fusion polypeptide can be useful for directing CD137 clustering and...
2018/0148484 NOVEL PROTEINS SPECIFIC FOR CD137
The present disclosure provides human lipocalin muteins that bind CD137 and can be used in pharmaceutical applications, for example, as anti-cancer agents...
2018/0148483 Mu-Conotoxin Peptides And Use Thereof As A Local Anesthetic
The present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and/or variants thereof. The...
2018/0148482 Toxoid Peptides Derived From Phenol Soluble Modulin, Delta Toxin, Superantigens, and Fusions Thereof
The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the disclosure...
2018/0148481 MUTANT CSGG PORES
The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
2018/0148480 SYNTHETIC ENHANCEMENT OF THE T-CELL ARMAMENTARIUM AS AN ANTI-CANCER THERAPY
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for using synthetically...
2018/0148479 MULTITARGET-DIRECTED BIO-INORGANIC HYBRID STRUCTURE
Provided herein is a multitarget-directed bio-inorganic hybrid structure. The hybrid structure is based on carbon nanotubes, and includes: carbon nanotubes;...
2018/0148478 Melanocortin Receptor-Specific Peptide with C-Terminal Naphthylalanine
Melanocortin receptor-specific peptides with a C-terminal naphthylalanine of the formula: ##STR00001## where R.sub.4, R.sub.7, R.sub.9, R.sub.11, R.sub.18,...
2018/0148477 NOVEL a4B7 PEPTIDE MONOMER AND DIMER ANTAGONISTS
The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of .alpha.4.beta.7 to the mucosal addressin cell...
2018/0148476 Compositions for Colon Cleansing and the Treatment of Gastrointestinal Disorders
The present invention provides peptides and compositions that are useful for the treatment of gastrointestinal disorders or for colon cleansing. The present...
2018/0148475 Cardiovascular Therapeutics
Compounds and compositions comprising a B-type natriuretic signal peptide fragment agent, and methods of use thereof, are provided for the treatment or...
2018/0148474 PEPTIDE DERIVATIVE FOR REGULATING THYMIC STROMAL LYMPHOID PROTEIN-MEDIATED SIGNALING AND PHARMACEUTICAL...
The present invention relates to a peptide derivative for regulating the thymic stromal lymphoid protein-mediated signaling and a pharmaceutical composition...
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