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Patent # Description
2018/0148473 PROCESS FOR PREPARATION OF NITROGEN MUSTARD DERIVATIVES
The present invention provides a process for the production of compound (III) or a deprotected product thereof: comprising reacting compound (II) with...
2018/0148472 AFFINITY-ASSISTED PROTEIN MODIFICATION AND RECYCLING
Methods for preparing a protein conjugate having a defined number of conjugate groups are provided. The method includes: forming a mixture containing a...
2018/0148471 METHODS FOR ONAPRISTONE SYNTHESIS DEHYDRATION AND DEPROTECTION
Methods and systems for making onapristone (ONA) using acidic hydrolysis and dehydration with sulfuric acid in an alcoholic solution are provided.
2018/0148470 CHOLIC ACID DERIVATIVE, AND PREPARATION METHOD AND MEDICAL USE THEREOF
The present invention relates to a cholic acid derivative, and a preparation method and a medical use thereof. In particular, the present invention relates to...
2018/0148469 PROCESS FOR PREPARATION OF SULFONYLUREA BILE ACID DERIVATIVES
The present invention relates to processes for preparing a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt or solvate thereof. These...
2018/0148468 USE OF UAP INHIBITORS TO INHIBIT FLUX THROUGH THE HEXOSAMINE BIOSYNTHETIC PATHWAY
Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.
2018/0148467 A METHOD AND AN APPARATUS FOR WASHING A CRUDE LIGNIN, A SOLUBLE CARBOHYDRATE CONTAINING FRACTION, A SOLID...
The invention relates to a method and an apparatus for washing a crude lignin slurry (5) formed from plant based raw material, wherein the method comprises...
2018/0148466 Precursors For Deposition Of Metal, Metal Nitride And Metal Oxide Based Films Of Transition Metals
Metal coordination complexes comprising a metal atom coordinated to at least one aza-allyl ligand having the structure represented by: ##STR00001## where each...
2018/0148465 PROCESS
The present invention relates to improved processes for the preparation of ruthenium or osmium complexes comprising acetate ligands, in particular, ruthenium...
2018/0148464 TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES
Tetradentate and octahedral metal complexes suitable for use as phosphorescent or delayed fluorescent and phosphorescent emitters in display and lighting...
2018/0148463 Novel Prodrugs And Methods Of Use Thereof
The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are...
2018/0148462 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME
A polycyclic compound and an organic electroluminescence device, the polycyclic compound being represented by Formula 1: ##STR00001##
2018/0148461 NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (Ia): ##STR00001## or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all...
2018/0148460 TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus...
2018/0148459 4-((2-ACRYLAMIDOPHENYL)AMINO)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS
The present invention relates to a novel 4-((2-acrylamidophenyl)amino)thieno[3,2-d]pyrimidine-7-carboxamide compound, an anticancer agent containing the...
2018/0148458 TETRAHYDROISOQUINOLINE DERIVATIVES
Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in...
2018/0148457 FUSED HETEROCYCLIC COMPOUNDS AS CAM KINASE INHIBITORS
The present disclosure relates to compounds that are CaM Kinase inhibitors and to their use in the treatment of various disease states, including atrial...
2018/0148456 NOTCH PATHWAY SIGNALING INHIBITOR COMPOUNDS
The present invention provides the following compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing said compounds...
2018/0148455 NOVEL TLR2 ANTAGONISTS
The present disclosure relates to a novel small molecule TLR2 antagonist, and particularly, to 19 novel TLR2 antagonists, a pharmaceutical composition,...
2018/0148454 USE OF PTERIDINONE DERIVATIVE SERVING AS EGFR INHIBITOR
The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a...
2018/0148453 DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS
The present invention is directed to dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central...
2018/0148452 TOLL-LIKE RECEPTOR-7 AGONIST
Disclosed are a novel pyrrolopyrimidine ring compound as a TLR7 agonist or a pharmaceutically acceptable salt thereof, used for preventing or treating allergic...
2018/0148451 HYDROXYL PURINE COMPOUNDS AND USE THEREOF
Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNF.alpha. inhibitors, in particular, the compounds as shown in formula (I),...
2018/0148450 TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS
The present invention relates to compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, wherein L and R.sup.1 to R.sup.5 are as...
2018/0148449 Substituted-Quinoxaline-Type Bridged-Piperidine Compounds and the Uses Thereof
The invention relates to Substituted-Quinoxaline-Type Bridged-Piperidine Compounds, compositions comprising an effective amount of a ...
2018/0148448 -LACTAMASE INHIBITORS AND USES THEREOF
The present invention relates to a compound of Formula (I)-(IV) useful as .beta.-lactamase inhibitor, a pharmaceutically acceptable salt, ester, solvate or...
2018/0148447 PYRAZOLO[1,5-A]PYRIDINE DERIVATIVES AND METHODS OF THEIR USE
The invention is directed to pyrazolo[1,5-a]pyridine derivatives and their use as AXL and c-MET kinase inhibitors.
2018/0148446 PYRROLO [2,3-c] PYRIDINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE
Provision of a compound having a superior proton pump action, which shows an antiulcer activity and the like after conversion to an in vivo proton pump...
2018/0148445 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
Provided herein are compounds of the Formula I: ##STR00001## or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X.sup.1, X.sup.2, X.sup.3,...
2018/0148444 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-B]PYRIDINE AND THERAPEUTIC USES THEREOF
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
2018/0148443 CRYSTALS OF AZABICYCLIC COMPOUND
Provided are crystals of 3-ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-- 1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide which are stable...
2018/0148442 Polycyclic Indoline and Indolenine Compounds
The present invention relates to indoline and indolenine alkaloid compounds. In particular, indoline and indolenine alkaloid compounds of the invention have...
2018/0148441 Cycloalkyl-Linked Diheterocycle Derivatives
The present invention relates to compounds of formula (I) ##STR00001## or pharmaceutically acceptable salts thereof, wherein A, L, D, R.sup.1-R.sup.15, w, x,...
2018/0148440 SUBSTITUTED 2-(CHROMAN-6-YLOXYL)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, ##STR00001## in which Ar, R2, R3 and R4 are as defined in the...
2018/0148439 DEUTERATED O-SULFATED BETA LACTAM HYDROXAMIC ACIDS AND DEUTERATED N-SULFATED BETA LACTAMS
Provided herein are deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams, pharmaceutical compositions thereof and methods...
2018/0148438 CYTOCHROME P450 INHIBITORS AND USES THEREOF
The present invention provides compounds having the general structural formula (I) ##STR00001## and pharmaceutically acceptable derivatives thereof, as...
2018/0148437 Novel Ezrin Inhibitors and Methods of Making and Using
The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or...
2018/0148436 PYRIDONE DERIVATIVES HAVING TETRAHYDROPYRANYLMETHYL GROUPS
The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment...
2018/0148435 4-AMINOQUINAZOLIN COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS
Aminoquinazolinyl compounds of formula (I) are described, ##STR00001## which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in...
2018/0148434 Novel 16-member triamilide derivatives and uses thereof
The invention discloses 20,23-modified novel derivatives of 16-membered demycarosyltylonolide antibiotics, which are useful against bacterial and mycoplasmic...
2018/0148433 New Pyrazolyl-substituted Heteroaryls and their use as Medicaments
The invention relates to new substituted heteroaryls of formula 1 ##STR00001## or of formula 1' ##STR00002## wherein A is either N or CH, wherein R.sup.2 is...
2018/0148432 HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS
The present invention provides compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof wherein the variables R.sup.1, R.sup.2,...
2018/0148431 2-H-INDAZOLE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBOTORS AND THERAPEUTIC USES THEREOF
Indazole compounds of formula (I) as cyclin-dependent kinase (CDK) and cell-proliferation inhibitors, and therapeutic uses and methods of preparation thereof,...
2018/0148430 METHOD FOR PREPARING NILOTINIB
A method for preparing nilotinib includes the following steps: performing an aminocarbonylation reaction on a compound A and ...
2018/0148429 SUBSTITUTED QUINOXALINE DERIVATIVES
The present invention relates to substituted quinoxaline derivatives. These compounds are useful for the prevention and/or treatment of several medical...
2018/0148428 ORGANIC LIGHT EMITTING DEVICE WITH THERMALLY ACTIVATED DELAYED FLUORESCENT LIGHT EMITTING MATERIAL
The present disclosure is directed to organic electroluminescent devices comprising thermally activated emission material(s) in an emission layer. The present...
2018/0148427 PHENOL DERIVATIVES TO TREAT CANCER
The present invention relates to compounds of general formula (I) ##STR00001## wherein R.sup.1-R.sup.8 take various meanings, pharmaceutical compositions...
2018/0148426 EPOXIDATION USING PEROXYGENASE
The invention relates to enzymatic methods for epoxidation of a non-cyclic aliphatic alkene, or a terpene.
2018/0148425 N-ARALKYLCARBONYL-PIPERAZINE AND -HOMOPIPERAZINE COMPOUNDS AND PERSONAL CARE COMPOSITIONS COMPRISING THE SAME
A personal care composition comprising N-aralkylcarbonyl-piperazine and/or -homopiperazines. When such compounds are used in personal care compositions, they...
2018/0148424 METHOD FOR PRODUCING DICARBOXYLIC ACID COMPOUND
It is an object of the present invention to provide an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as...
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