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Patent # Description
2018/0155451 HETERODIMERIZED POLYPEPTIDE
The present inventors produced a heterodimerized polypeptide having an Fc region formed from two polypeptides with different amino acid sequences (a first...
2018/0155450 Dual Variable Region Antibody-Like Binding Proteins Having Cross-Over Binding Region Orientation
The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of...
2018/0155449 COVALENT DISULFIDE-LINKED DIABODIES AND USES THEREOF
The present invention provides recombinant antibody fragments which include a variable domain which has been modified by the addition of a tail sequence to its...
2018/0155448 ANTI-ADAM28 ANTIBODY FOR TREATING CANCER
The present invention provides an antibody that specifically binds to human ADAM28, inhibits enzyme activity of human ADAM28, and has an activity to suppress...
2018/0155447 METHODS FOR TREATING CARDIOVASCULAR DISEASES
Provided herein are methods that relate to a novel therapeutic strategy for treatment of heart and/or cardiovascular diseases. The method includes...
2018/0155446 Anti-Human Receptor-Type Protein Tyrosine Phosphatase Sigma Antibody
A monoclonal antibody that binds to an extracellular domain of human receptor-type protein tyrosine phosphatase .sigma. (human PTPRS), or a fragment including...
2018/0155445 ANTI-VASA ANTIBODIES, AND METHODS OF PRODUCTION AND USE THEREOF
Anti-VASA antibodies (mAbs), particularly humanized mAbs that specifically bind to VASA with high affinity, are disclosed. The amino acid sequences of the CDRs...
2018/0155444 Antibodies to Plasminogen Activator Inhibitor-1 (PAI-1) and Uses Thereof
The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1). The invention also provides pharmaceutical...
2018/0155443 METHODS OF TREATING TTP WITH IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS AND USES THEREOF
The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to...
2018/0155442 METHODS OF TREATING TTP WITH IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS AND USES THEREOF
The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to...
2018/0155441 METHODS OF TREATING TTP WITH IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS AND USES THEREOF
The present invention is based on the finding that administration of polypeptides comprising at least one immunoglobulin single variable domains against vWF to...
2018/0155440 METHODS OF TREATING TTP WITH IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS AND USES THEREOF
The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to...
2018/0155439 Compositions and Conjugates Comprising an Interleukin and Polypeptides That Specifically Bind TGF-beta
This disclosure relates to compositions and conjugates comprising an interleukin, e.g., IL-15 and a polypeptide that specifically binds TGF-beta. Typically the...
2018/0155438 DIAGNOSIS AND TREATMENT OF CANCER USING ANTI-ITM2A ANTIBODY
Disclosed is a monoclonal antibody binding to an ITM2A protein. This antibody is useful in the diagnosis, prevention, and treatment of cancer such as Ewing's...
2018/0155437 ANTIBODIES AGAINST HUMAN AND CANINE IL-13RA2
Provided herein are monoclonal antibodies that specifically bind IL-13RA2 with cross-reactivity in humans and canines. Also provided are methods of use of the...
2018/0155436 Methods of Treating Inflammatory Conditions
The present invention provides methods for treating inflammatory diseases, or conditions associated with, or resulting in part from, elevated levels of IL-33...
2018/0155435 REGULATING IL-4 AND IL-13 LEVELS BY BLOCKING HIGH AFFINITY BINDING BY IL-3, IL-5 AND GM-CSF TO THEIR COMMON...
A method of reducing IL-4 and/or IL-13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an...
2018/0155434 THERAPEUTIC AGENT AND THERAPEUTIC METHOD FOR PULMONARY HYPERTENSION
The present invention relates to a therapeutic agent for pulmonary hypertension comprising an interleukin-5 receptor (hereinafter, abbreviated to...
2018/0155433 ANTI-HUMAN-HER3 ANTIBODIES AND USES THEREOF
The present disclosure relates to a neuregulin non competitive allosteric anti-human-HER3 antibody having a human constant region; and less than 65% of the...
2018/0155432 INHIBITORS OF PROTOTYPIC GALECTIN DIMERIZATION AND USES THEREOF
Agents that inhibit the dimerization of a prototypic galectin such as galectin-7 are described. These agents, for example antibodies and peptides, bind to a...
2018/0155431 COMBINATION THERAPY OF ANTIBODY BINDING TO ANGIOPOIETIN 2 WITH ANTIBODY BINDING TO PROGRAMMED DEATH LIGAND 1
The present invention relates to a combination therapy of an antibody specifically binding to Angiopoietin 2 (ANG-2), and an antibody specifically binding to...
2018/0155430 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent...
2018/0155429 TREATMENT OF PD-L1 POSITIVE LUNG CANCER USING AN ANTI-PD-1 ANTIBODY
This disclosure provides a method for treating a subject afflicted with a PD-L1 positive non-squamous non-small cell lung cancer (NSCLC). The method comprises...
2018/0155428 BTLA Antibodies and Uses Thereof
The invention relates to BTLA antibodies that block BTLA-HVEM interaction and uses thereof.
2018/0155427 ANTIBODY MOLECULES TO PD-1 AND USES THEREOF
Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or...
2018/0155426 MODULATION OF IMMUNE RESPONSE USING BTLA AGONIST ANTIBODIES
The present invention relates to the seminal discovery that BTLA agonist antibodies modulate the immune system. Specifically, the present invention provides...
2018/0155425 BISPECIFIC ANTIBODY, PRODUCTION METHOD THEREFOR AND USE THEREOF
Described is a bispecific antibody, and a method for producing the bispecific antibody. The bispecific antibody can be used in the preparation of a drug for...
2018/0155424 Compositions and Methods to Enhance the Immune System
The invention relates to the field of molecular medicine. In particular, it relates to compositions and methods to enhance the clearance of aberrant cells,...
2018/0155423 Bispecific Molecules That Are Immunoreactive With Immune Effector Cells That Express An Activating Receptor And...
The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally...
2018/0155422 ANTIGEN BINDING MOLECULES TO TIGIT
Provided herein are antigen binding molecules that bind to TIGIT, include antibodies and antigen binding fragments thereof.
2018/0155421 CANCER TARGETS AND USES THEREOF
Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets ("CAT"). Methods and...
2018/0155420 CARDIOVASCULAR RELATED USES OF IL-1BETA ANTIBODIES AND BINDING FRAGMENTS THEREOF
Disclosed are methods for the reduction, prevention or treatment of cardiovascular events and/or cardiovascular diseases, including acute cardiovascular...
2018/0155419 ANTI-MIF ANTIBODIES IN THE TREATMENT OF CANCERS CONTAINING MUTANT TP53 AND/OR MUTANT RAS
The present invention pertains to anti-MIF antibodies, preferably in combination with cancer therapeutics, i.e. chemotherapeutic agents, in the treatment of...
2018/0155418 IL-31 ANTIBODY COMPOSITIONS
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The...
2018/0155417 MULTIMERIC CONSTRUCTS
Multimeric fusion proteins of an Ig-like domain of Flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host...
2018/0155416 ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
The present invention provides antibodies that bind to Activin A and methods of using the same. According to certain embodiments of the invention, the...
2018/0155415 MOLECULES THAT ARE ABLE TO INHIBIT THE BINDING BETWEEN NGF AND THE TRKA RECEPTOR AS ANALGESICS WITH PROLONGED...
Use of an anti-NGF antibody capable of inhibiting the binding between NGF and TrkA, capable of blocking the biological activity of TrkA for the preparation of...
2018/0155414 Targeting Apolipoprotein E (APOE) in Neurologic Disease
Methods for treating neurologic diseases, e.g., amyotrophic lateral sclerosis (ALS) and multiple sclerosis, by modulating the APOE-TGFbeta pathway. The methods...
2018/0155413 NEUTRALIZING ANTI-INFLUENZA BINDING MOLECULES AND USES THEREOF
Binding molecules, including bispecific antibodies that include at least two anti-influenza binding domains are disclosed, including binding molecules having a...
2018/0155412 AAV-MEDIATED EXPRESSION OF ANTI-INFLUENZA ANTIBODIES AND METHODS OF USE THEREOF
AAV vectors expressing anti-influenza antibodies are provided. Also described are pharmaceutical compositions useful in delivery same for prophylactic or...
2018/0155411 HETEROTYPIC ANTIBODIES SPECIFIC FOR HUMAN ROTAVIRUS
Compositions and methods are provided relating to rotavirus serotypes and antibodies that bind to human rotavirus and modifications thereto which enhance the...
2018/0155410 THERAPY FOR ENTERIC INFECTIONS
A method and composition for treating enteric pathogen infections in animals suffering from such infections or displaying diseases or conditions consistent...
2018/0155409 NOVEL PHAGE DISPLAY LIBRARY, MEMBERS THEREOF AND USES OF THE SAME
The present invention relates to a library (in particular a phage display library) from which an improved human antibody having greater specificity and potency...
2018/0155408 VEGF ANTAGONIST FORMULATIONS SUITABLE FOR INTRAVITREAL ADMINISTRATION
Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration...
2018/0155407 COMPOUNDS AS PEPTIDIC GLP1/GLUCAGON/GIP RECEPTOR AGONISTS
The present invention relates to trigonal GLP-1/glucagon/GIP receptor agonists and their medical use, for example in the treatment of disorders of the...
2018/0155406 COMPOUNDS AS PEPTIDIC TRIGONAL GLP1/GLUCAGON/GIP RECEPTOR AGONISTS
The present invention relates to trigonal GLP-1/glucagon/GIP receptor agonists and their medical use, for example in the treatment of disorders of the...
2018/0155405 SIRP POLYPEPTIDE COMPOSITIONS AND METHODS OF USE
Provided herein are SIRP-gamma, SIRP-beta or SIRP-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy,...
2018/0155404 Fusokines Involving Cytokines with Strongly Reduced Receptor Binding Affinities
The present invention relates to a fusion protein comprising at least two cytokines, of which at least one is a modified cytokine with a strongly reduced...
2018/0155403 HISTONE ANTI-CANCER VACCINES
The present invention pertains to novel immunogenic peptide sequences that can be used as vaccines in the treatment of cancer diseases such as brain cancers...
2018/0155402 RECOMBINANT BINDING PROTEINS TARGETING HER2 AND SERUM ALBUMIN, AND THEIR USES
New recombinant binding proteins, comprising designed ankyrin repeat domain(s) with binding specificity for HER2, and comprising designed ankyrin repeat...
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