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Patent # Description
2018/0155350 CELL IMPERMEABLE COELENTERAZINE ANALOGUES
Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection...
2018/0155349 TYK2 INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated...
2018/0155348 INHIBITORS OF KRAS G12C MUTANT PROTEINS
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): ##STR00001## or a...
2018/0155347 PHARMACEUTICAL COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVES
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated...
2018/0155346 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions...
2018/0155345 sGC STIMULATORS
The present patent application discloses at least the compounds according to Formula I' shown below, or pharmaceutically acceptable salts thereof, ##STR00001## ...
2018/0155344 TRICYCLIC PIPERIDINE COMPOUNDS
The present invention relates to compounds of the formula (I) ##STR00001## wherein R.sup.1a, R.sup.1b, R.sup.2, R.sup.3, (R.sup.4).sub.n and ring (A) are as...
2018/0155343 SPIRO-ISOQUINOLINE-3,4'-PIPERIDINE COMPOUNDS HAVING ACTIVITY AGAINST PAIN
The present invention relates to compounds having pharmacological activity towards the sigma (.sigma.) receptor, and more particularly to ...
2018/0155342 INHIBITORS OF INFLUENZA VIRUSES REPLICATION
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological...
2018/0155341 Antibacterial Compounds
The present invention relates to the following compounds ##STR00001## wherein the integers are as defined in the description, and where the compounds may be...
2018/0155340 QUINOLONE DERIVATIVES AS FGFR INHIBITORS
Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are...
2018/0155339 METHOD FOR THE PRODUCTION OF PRAZIQUANTEL
The present invention relates to a method for the racemization of enantiomerically pure or enantiomerically enriched Praziquantel under basic conditions and a...
2018/0155338 ORGANIC THIN FILM TRANSISTOR, METHOD OF MANUFACTURING ORGANIC THIN FILM TRANSISTOR, ORGANIC THIN FILM...
An object of the present invention is to provide an organic thin film transistor that has an organic semiconductor film manufactured by using a compound having...
2018/0155337 CRYSTALLINE FORMS OF (3-AMINO-OXETAN-3-YLMETHYL)-[2-(5,5-DIOXO-5,6,7,9-TETRAHYDRO-5LAMBDA*6*-T- ...
The present invention relates to novel crystalline forms of compound (I), ##STR00001## (3-Amino-oxetan-3-ylmethyl)-[2-(5,5-dioxo-5,6,7,9-tetrahydro-5lambda*6*-t- ...
2018/0155336 PROCESS FOR THE PREPARATION OF 2-{4-[2-({[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]METHYL}SULFANYL)-3,5-DICYA- ...
The present application relates to a novel and improved process for preparing the compound ...
2018/0155335 SALT AND CRYSTAL FORMS OF PLK-4 INHIBITOR
A fumarate salt and a maleate salt of compound (I) represented by the following structural formula, as well as their corresponding pharmaceutical compositions,...
2018/0155334 NOVEL PROCESSES
The present invention provides novel processes for preparing compounds of formula (IV) and salts thereof ##STR00001## novel intermediates, and a novel salt and...
2018/0155333 Heterocyclic Compound
The present invention provide a compound having an orexin receptor antagonistic activity, which is expected to be useful as medicaments such as agents for the...
2018/0155332 SMALL MOLECULE BASED ANTIBODY-RECRUITING COMPOUNDS FOR CANCER TREATMENT
The present invention relates to chimeric (including bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a...
2018/0155331 DIARYL ISOXAZOLINE COMPOUND
The present invention concerns compounds of formula (I) or an N-oxide or salt thereof and their use for controlling parasites in and on warm-blooded animals or...
2018/0155330 N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS
A compound of formula (I), or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound. The compound is an inhibitor...
2018/0155329 ANHYDROUS CRYSTALLINE FORM OF (1S)-1,5-ANHYDRO-1-[3-[[5-(4-FLUOROPHENYL)-2-THIENYL]METHYL]-4-METHYLPHEN- ...
The present invention is directed to an anhydrous crystalline for of (1S)-1,5-anhydro-1-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphen- yl]-D-glucitol,...
2018/0155328 MONOMERS AND POLYMERS FOR FUNCTIONAL POLYCARBONATES AND POLY(ESTER-CARBONATES) AND PEG-CO-POLYCARBONATE HYDROGELS
The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with...
2018/0155327 PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS
The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for...
2018/0155326 METHOD FOR PREPARING TRITYL CANDESARTAN
The present invention uses a candesartan cyclic compound as a starting material and performs thereon a three-step reaction of forming tetrazole, hydrolysis and...
2018/0155325 COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE, COMPOSITION FOR ORGANIC OPTOELECTRONIC DEVICE AND ORGANIC...
Disclosed are a compound for an organic optoelectronic device represented by Chemical Formula 1, a composition for an organic optoelectronic device, an organic...
2018/0155324 2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-1-(5-SUBSTITUTED-PYRIDIN-2-YL)-3-(1H-T- ETRAZOL-1-YL)PROPAN-2-OLS AND...
Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-- tetrazol-1-yl)propan-2-ols and ...
2018/0155323 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an...
2018/0155322 TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS
The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present...
2018/0155321 VIOLOGEN COMPOUND, AND ELECTROLYTE, LIGHT-TRANSMITTANCE-VARIABLE PANEL AND DISPLAY DEVICE INCLUDING THE...
A display device comprises a light-transmittance-variable panel including a first substrate and a second substrate facing each other; a first transparent...
2018/0155320 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1
The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) and new 2-oxo-1,2-dihydropyridine-3-carboxamide compounds of...
2018/0155319 DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions. ##STR00001##
2018/0155318 METHODS OF USE OF CYCLIC AMIDE DERIVATIVES TO TREAT SCHIZOPHRENIA
Disclosed herein are compositions and methods for treating schizophrenia and symptoms of schizophrenia, including negative symptoms of schizophrenia.
2018/0155317 NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
The present invention relates to compounds of formula I: ##STR00001## and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the...
2018/0155316 4'-O-SUBSTITUTED ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
Provided are 4'-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods...
2018/0155315 MUSCARINIC AGONISTS
This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor and/or M.sub.4 receptor and which are useful in the treatment of...
2018/0155314 PIPERDINYL NOCICEPTIN RECEPTOR COMPOUNDS
The present invention provides novel piperidinyl-containing nociceptin receptor ligand compounds and pharmaceutical compositions useful in the treatment of...
2018/0155313 METHOD AND DEVICE FOR MANUFACTURING LACTIDE
A method and a device for manufacturing lactide, whereby crude lactide, being prepared by means of depolymerization of lactic acid oligomers, is purified by...
2018/0155312 COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME
Provided are a novel compound and an organic electronic device using the same. The novel corn pound is represented by the following Formula (I): ##STR00001## ...
2018/0155311 SEPARATION OF CHIRAL ISOMERS BY SFC
The present invention relates to the field of separating chiral isomers from each other. Particularly, it relates to the field of separating of chiral isomers...
2018/0155310 INHIBITORS OF PSEUDOMONAS AERUGINOSA LECB
The present invention relates to compounds derived from deoxy fucose. These compounds are useful as lectin inhibitors, especially as inhibitors of LecB. The...
2018/0155309 PROCESS FOR THE PREPARATION OF A PURIFIED ACID COMPOSITION
A purified acid composition including 2,5-furandicarboxylic acid is prepared by a process including a) providing an acid composition solution of a crude acid...
2018/0155308 PROCESS FOR THE PREPARATION OF A PURIFIED ACID COMPOSITION
A purified acid composition including 2,5-furandicarboxylic acid is prepared in a process, including oxidizing a feedstock containing 5-alkoxymethylfurfural to...
2018/0155307 REACTIVE DISTILLATION PROCESS FOR THE ESTERIFICATION OF FURANDICARBOXYLIC ACID
A process for efficiently esterifying furan dicarboxylic acid, especially 2,5-furan dicarboxylic acid in the presence of an alcohol and, optionally, a catalyst...
2018/0155306 PROCESS FOR PURIFYING A CRUDE COMPOSITION OF DIALKYL ESTER OF 2,5-FURANDICARBOXYLIC ACID
An ester composition including at least 90% wt of the dialkyi ester of 2,5-furandicarboxylic acid as starting dialkyi ester concentration and up to 5% wt of...
2018/0155305 CATALYTIC HYDROLYSIS AND DEHYDRATION OF SACCHARIDES
In one aspect, methods of HMF production are described herein. A method of HMF production, in some embodiments, comprises providing a saccharide feedstock...
2018/0155304 CATIONIC LIPID
The present invention aims to provide a cationic lipid that can be used as a nucleic acid delivery carrier, a lipid membrane structure using a cationic lipid,...
2018/0155303 RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2...
2018/0155302 MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric...
2018/0155301 ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS
This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using...
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