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Patent # Description
2018/0153934 ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS
The present invention relates to the treatment of Pin1-associated disorders (e.g., disorders characterized by elevated Pin1 activity) with arsenic trioxide,...
2018/0153933 Method of Manufacturing a Zinc Compound Lozenge
The invention described herein is a method for manufacturing a zinc compound lozenge, comprising the steps of adding at least one form of glycine and at least...
2018/0153932 METHOD FOR MAINTAINING INCREASED INTRACELLULAR p53 LEVEL, INDUCED BY PLATINUM-BASED ANTICANCER DRUG, AND...
The present invention relates to a method for maintaining the increased intracellular p53 level, induced by a platinum-based anticancer drug, and an...
2018/0153931 ANTITUMORAL COMBINATION COMPRISING CABAZITAXEL AND CISPLATIN
The present invention relates to a combination comprising cabazitaxel and cisplatin. The present invention relates also to a pharmaceutical composition...
2018/0153930 COMPOSITIONS OF AMORPHOUS CALCIUM CARBONATE FOR INHALATION, SUBLINGUAL OR BUCCAL ADMINISTRATION
The present invention provides compositions comprising amorphous calcium carbonate (ACC), suitable to being administered by inhalation, and methods for their...
2018/0153929 METHOD OF PRODUCING PHYSIOLOGICAL AND THERAPEUTIC LEVELS OF NITRIC OXIDE THROUGH AN ORAL DELIVERY SYSTEM
A composition and method of providing nitric oxide and nitrite therapy to patients whereby a therapeutic amount is bioavailable within approximately 30 minutes...
2018/0153928 NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME
Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic...
2018/0153927 Application of maltotriose-coated 4th generation poly(propyleneimine) dendrimer PPI-G4-OS-Mal-III
The subject matter of the invention relates to the method of administering the polypropyleneimine dendrimer of the fourth generation, coated with maltotriose,...
2018/0153926 POLYMER LUNG SURFACTANTS
Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer...
2018/0153925 METHODS FOR TREATING OVERWEIGHT OR OBESITY
The present invention relates to methods of managing weight, and treating overweight or obesity and treating or preventing diabetes in a subject in need...
2018/0153924 COMPOSITIONS AND METHODS FOR AQUACULTURE
Methods and compositions for increasing the growth rate of a prey fish are described. A method includes contacting the prey fish with a water-soluble growth...
2018/0153923 SYNERGISM OF GOS AND POLYFRUCTOSE
The present invention relates to the field of prebiotics. Provided are uses for compositions comprising synergistically effective amounts of polyfructose and...
2018/0153922 INHIBITION OF EXPANSION AND FUNCTION OF PATHOGENIC AGE-ASSOCIATED B CELLS AND USE FOR THE PREVENTION AND...
This current invention provides methods and agents for preventing and treating autoimmune and lymphoproliferative disease by targeting pathogenic...
2018/0153921 TAU MODULATORS AND METHODS AND COMPOSITIONS FOR DELIVERY THEREOF
The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.
2018/0153920 UNIT STRUCTURE-TYPE PHARMACEUTICAL COMPOSITION FOR NUCLEIC ACID DELIVERY
A unit structure consists of a single nucleic acid having a length of 10 to 30 bases, and a single block copolymer having a cationic polyamino acid segment and...
2018/0153919 ORGANIC COMPOSITIONS TO TREAT KRAS-RELATED DISEASES
The present disclosure relates to RNAi agents useful in methods of treating KRAS-related diseases such as a proliferative disease, including without limitation...
2018/0153918 LIPID-BASED COMPOSITIONS OF ANTIINFECTIVES FOR TREATING PULMONARY INFECTIONS AND METHODS OF USE THEREOF
A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of...
2018/0153917 COMPOSITIONS AND METHODS FOR REDUCING OXIDATIVE DAMAGE
Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the...
2018/0153916 ISOTOPOLOGUES OF 5-AZACYTIDINE
The present disclosure provides pharmaceutical compositions comprising cytidine analogs for oral administration, wherein the compositions release the cytidine...
2018/0153915 USE OF OLIGOSACCHARIDE COMPOSITIONS TO ENHANCE WEIGHT GAIN
Provided herein are compositions and methods related to use of oligosaccharides, such as 2'-fucosyllactose, for increasing weight gain in a subject. In some...
2018/0153914 TREATMENT OF PAIN WITH ORAL DOSAGE FORMS COMPRISING ZOLEDRONIC ACID AND AN ENHANCER
Disclosed herein are methods of treating or preventing pain. Typically, a pharmaceutical composition having a therapeutically effective amount of the...
2018/0153913 STABILIZED LIQUID FOSAPREPITANT FORMULATIONS
The present invention relates to stable pharmaceutical compositions of fosaprepitant or a salt thereof in the form of ready-to-use or ready-to-dilute...
2018/0153912 Prodrugs of 2,4-Pyrimidinediamine Compounds and Their Uses
The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, salts and hydrates of the prodrugs, compositions comprising...
2018/0153911 TREATMENT OF GRAFT VERSUS HOST DISEASE IN TRANSPLANT PATIENTS
The present invention relates to a method of treating patients who undergo hematopoietic stem cell transplantation (HSCT) with peripheral blood mobilized stem...
2018/0153910 PROSTATE CANCER TREATMENT VIA SYNERGISTIC INHIBITION OF ARYL HYDROCARBON RECEPTOR (AHR) AND SRC
Simultaneous inhibition of the aryl hydrocarbon receptor (AhR) and SRC abolishing androgen receptor (AR) signaling in prostate cancer cells is disclosed herein...
2018/0153909 COMBINATION THERAPY FOR SKIN DISORDERS
The present invention provides a novel therapeutic combination comprising one or more anti-androgen agents and one or more antibiotic/anti-inflammatory agents...
2018/0153908 9-Aminomethyl Minocycline Compounds And Use Thereof In Treating Community-Acquired Bacterial Pneumonia (CABP)
The invention disclosed herein provides a method for treating Community-Acquired Bacterial Pneumonia (CABP) using 9-[(2,2-dimethyl-propyl...
2018/0153907 Ciclesonide for the Treatment of Airway Disease in Horses
Methods of treating airway diseases in equines include administering to an equine an effective amount of ciclesonide or a pharmaceutically acceptable salt...
2018/0153906 MITIGATION OF EPILEPTIC SEIZURES BY COMBINATION THERAPY USING BENZODIAZEPINES AND NEUROSTEROIDS
Provided are compositions comprising a benzodiazepine and a neurosteroid, containing one or both of the benzodiazepine and the neurosteroid in a subtherapeutic...
2018/0153905 ORAL TESTOSTERONE TRIDECANOATE THERAPY
The present disclosure provides methods and compositions for testosterone replacement therapy. The methods and compositions employ a fixed dose dosing regimen...
2018/0153904 HIGH-STRENGTH TESTOSTERONE UNDECANOATE COMPOSITIONS
The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The...
2018/0153903 OIL-IN-WATER METHOD FOR MAKING POLYMERIC IMPLANTS CONTAINING A HYPOTENSIVE LIPID
Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the...
2018/0153902 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION
The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for...
2018/0153901 REVERSAL OF LATENCY OF RETROVIRUSES WITH A GALECTIN PROTEIN
The present invention relates to the seminal discovery of methods of using recombinant galectin proteins to reverse HIV latency. Specifically, the present...
2018/0153900 MUSCARINIC M1 RECEPTOR AGONISTS
This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated...
2018/0153899 PHARMACEUTICAL COMPOSITIONS
Pharmaceutical compositions comprising the drug substance (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benz- ...
2018/0153898 COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION
Several compounds have been discovered that modulate signal transduction through the PD-1 receptor. In certain embodiments, the compounds promote or induce an...
2018/0153897 RIBOFLAVIN FOR THE TREATMENT OF ISCHEMIC STROKE AND/OR OTHER GLUTAMATE EXCITOTOXICITY-ASSOCIATED DISEASES
The present invention relates to a combination therapy comprising the use of riboflavin and oxaloacetate. Specifically, it is directed to new compositions,...
2018/0153896 METHODS OF TREATING FIBROSIS
Disclosed are methods of treating fibrosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of an ACK...
2018/0153895 Crystalline Forms of Ibrutinib
The present invention provides crystalline forms of Ibrutinib. Specific crystalline forms provided by the present invention include Ibrutinib Form APO-I, an...
2018/0153894 FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers,...
2018/0153893 Therapeutic Compositions Containing Dipyridamole, Treatment Packs and Kits Including Such Compositions and...
A method comprising: (a) identifying a subject in need of treatment for cataract and/or nevus and/or tumor lesion; and (b) topically administering to the eye...
2018/0153892 COMBINATION OF AN ANTI-CD19 ANTIBODY AND A BRUTON'S TYROSINE KINASE INHIBITOR AND USES THEREOF
The present disclosure describes a pharmaceutical combination of an anti-CD19 antibody and a Bruton's tyrosine kinase (BTK) inhibitor for the treatment of...
2018/0153891 ANTIEPILEPTIC DRUGS
The present invention describes novel pharmaceutical compositions and methods for treatment of diseases, disorders, or conditions characterized by recurrent...
2018/0153890 PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
The present disclosure provides pharmaceutical compositions comprising micronized Compound A and use thereof. ##STR00001##
2018/0153889 MODULATION OF CELL FATES AND ACTIVITIES BY PHTHALAZINEDIONES
Phthalazinediones that function as intracellular redox modulators in the redox therapy of certain stressed cells are provided. By buffering aberrant redox...
2018/0153888 COMBINATION THERAPY WITH AXL INHIBITOR AND IMMUNE CHECKPOINT MODULATOR OR ONCOLYTIC VIRUS
An Axl inhibitor and one or more immune checkpoint (activity) modulators and/or one or more oncolytic viruses, for use in the prevention, treatment or...
2018/0153887 POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## ...
2018/0153886 USE OF TRIMETHAZINE IN PREPARATION OF DRUGS FOR PREVENTING AND TREATING LIVER DISEASES
Disclosed is a use of trimethazine in the preparation of drugs for preventing and treating liver diseases. Trimethazine is capable of inhibiting activation of...
2018/0153885 PRESERVATIVE FREE OCULAR COMPOSITIONS AND METHODS FOR USING THE SAME FOR TREATING DRY EYE DISEASE AND OTHER EYE...
The present invention provides a preservative free ophthalmic formulation. In particular, the ophthalmic formulations of the invention are aqueous formulations...
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