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Patent # Description
2018/0153884 COMBINATION COMPOSITIONS FOR IMMUNOTHERAPY
The present invention relates to therapeutic combinations comprising WNT inhibitors and methods for treating cancers using combination therapy.
2018/0153883 METHODS AND COMPOSITIONS FOR TREATING DIABETES, METABOLIC SYNDROME AND OTHER CONDITIONS
Pharmaceuticals compositions comprising the 2S, 4R, ketoconazole enantiomer or its pharmaceutically acceptable salts, hydrates, and solvates, that are...
2018/0153882 AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases
The present invention provides a compound of Formula I or Formula II: ##STR00001## enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically...
2018/0153881 Dosing Regimens for Fast Onset of Antidepressant Effect
A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition...
2018/0153880 COMPOSITIONS FOR THE MOBILIZATION, HOMING, EXPANSION AND DIFFERENTIATION OF STEM CELLS AND METHODS OF USING THE...
The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for...
2018/0153879 Solid Dispersion Comprising .mu.-Opioid Antagonists
The present invention relates to a solid dispersion comprising, preferably consisting of, naloxegol salts in amorphous form and at least one pharmaceutically...
2018/0153878 ORAL SOLID FORMULATION CONTAINING IRINOTECAN AND METHOD OF PREPARING THE SAME
An oral solid formulation includes irinotecan or a pharmaceutically acceptable salt thereof as an active ingredient, and an acidifying agent.
2018/0153877 THERAPEUTIC TARGETING OF MYELOPOLIFERATIVE NEOPLASMAS BY DUSP1 INHIBITION
Methods and compositions disclosed herein generally relate to methods, compounds, and compositions for treating myeloproliferative neoplasms (MPNs) or a...
2018/0153876 CGRP Receptor Antagonists
The disclosures herein relate to novel compounds of formula ##STR00001## wherein Ar.sup.1 and R.sup.1 are as defined herein, and their use in treating,...
2018/0153875 AQUEOUS DRUG
An aqueous drug in which the chemical decomposition of the compound represented by formula (1) or of a salt thereof is inhibited, and a method for producing...
2018/0153874 PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF
The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II...
2018/0153873 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
2018/0153872 HETEROARYL CARBONITRILES FOR THE TREATMENT OF DISEASE
The invention relates to pharmaceutical compositions and dosage forms having a piperidine carbonitrile as an active ingredient for the treatment of various...
2018/0153871 COMPOSITIONS AND METHODS FOR TREATING SCHIZOPHRENIA
The disclosure provides a novel polymorph of Compound (I): ##STR00001## 2-((1-(2-(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-o- ne...
2018/0153870 BIPERIDEN FOR TREATING CANCER
The present invention relates to the use of the compound biperiden as a MALT1 inhibitor in the treatment of a cancerous disease. The invention in particular...
2018/0153869 SUSTAINED RELEASE AMINOPYRIDINE COMPOSITION
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a...
2018/0153868 TREATMENT OF BREAST CANCER BY CONCOMITANT ADMINISTRATION OF A BROMODOMAIN INHIBITOR AND A SECOND AGENT
Methods for treating breast cancer comprising administering to a subject in need thereof a bromodomain inhibitor concomitantly with a second agent. The second...
2018/0153867 TREATMENT OF PROSTATE CANCER BY CONCOMITANT ADMINISTRATION OF A BROMODOMAIN INHIBITOR AND A SECOND AGENT
Methods for treating prostate cancer comprising administering to a subject in need thereof a bromodomain inhibitor concomitantly with a second agent. The...
2018/0153866 TREATMENT OF SUNBURN USING ANALGESICS AND ANTIHISTAMINES
Combination compositions and kits comprising an analgesic and an antihistamine are provided as well as methods of use in treating sunburn.
2018/0153865 NEW USE OF INHIBITOR OF CYSTINE-GLUTAMATE TRANSPORTER
The invention surprisingly found that agents that inhibit system x.sub.c.sup.- provide the therapeutic intervention in substance-related and addictive...
2018/0153864 COMPOSITION COMPRISING COMBINATION OF RAPAMYCIN AND AN ACTIVATOR OF AMP KINASE AND USE THEREOF FOR TREATING...
A formulation, especially one that is topically administered, comprising a combination of rapamycin and metformin in a molar ratio of about 20:1, 10:1, 5:1,...
2018/0153863 METHODS OF TREATING SOLID TUMORS USING NANOPARTICLE MTOR INHIBITOR COMBINATION THERAPY
The present invention relates to methods and compositions for the treatment of a solid tumor by administering compositions comprising nanoparticles that...
2018/0153862 SUBLINGUAL ADMINISTRATION OF RILUZOLE
Disclosed is sublingual administration of riluzole. In particular, a method for treating a neuropsychiatric disorder or symptom by administering a sublingual...
2018/0153861 METHOD OF TREATING ATHEROSCLEROSIS IN HIGH TRIGLYCERIDE SUBJECTS
The present invention provides a compound of Formula I for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP...
2018/0153860 METHODS OF DOSE ADMINISTRATION FOR TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES
The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders.
2018/0153859 METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE
The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the...
2018/0153858 METHODS FOR IDENTIFYING AND USING INHIBITORS OF CASEIN KINASE 1 EPSILON ISOFORM FOR INHIBITING THE GROWTH...
In one aspect, the invention provides a method for inhibiting the growth and/or proliferation of a myc-driven tumor cell comprising the step of contacting the...
2018/0153857 N-PHENYL-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
Inhibitors of HBV replication of Formula (I) ##STR00001## including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R.sup.1,...
2018/0153856 USE OF STATINS FOR PERIODONTAL DISEASE AND BONE REGENERATION
The present invention discloses topical compositions comprising at least one statin as the main active compound for primary prevention or treatment of...
2018/0153855 SIGMA RECEPTOR-BINDING AGENT
A sigma receptor-binding agent, which comprises an alkyl ether derivative represented by formula [1] or a salt thereof is provided. ##STR00001## wherein R.sup.1...
2018/0153854 NON-AROMATIC DIFLUORO ANALOGUES OF RESORCYLIC ACID LACTONES
This disclosure is directed to non-aromatic difluoro analogues of resorcylic acid lactones, pharmaceutical compositions comprising non-aromatic difluoro...
2018/0153853 INHIBITION OF CANCER CELL MOTILITY
Provided herein are compositions and methods for inhibiting cancer cell motility and/or metastasis. In particular embodiments, KBU2046 (or an analog thereof)...
2018/0153852 COMPOSITION FOR PREVENTING AND TREATING MUSCLE DISEASES OR IMPROVING MUSCULAR FUNCTION, CONTAINING MORUSIN,...
The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing, as an active ingredient,...
2018/0153851 MONOTERPENES FOR TREATING RESPIRATORY DISEASES, IN PARTICULAR BRONCHOPULMONARY DISEASES
The invention relates to the combined use of at least one monoterpene which can be applied systemically, in particular perorally, and at least one respiratory...
2018/0153850 COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER
Methods and compositions are provided for treatment of cancer, including prostate cancer. In one aspect, the present invention provides a composition...
2018/0153849 MULTI-DRUG COMBINATIONS THAT ACT AS POTENT RADIOSENSITIZERS
Provided is a method of treatment including administering to lung, brain or esophageal cancer cells an effective amount of radiation in conjunction with a...
2018/0153848 CABAZITAXEL FAT EMULSION, AND PREPARATION METHOD AND USE THEREOF
Provided in the present invention is a cabazitaxel fat emulsion injection, wherein the cabazitaxel fat emulsion injection contains cabazitaxel, a medium chain...
2018/0153847 TREPROSTINIL PRODRUGS
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
2018/0153846 METHODS OF REDUCING THE RISK OF A CARDIOVASCULAR EVENT IN A SUBJECT ON STATIN THERAPY
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in...
2018/0153844 CREATINE ESTER ANTI-INFLAMMATORY COMPOUNDS AND FORMULATIONS
The present invention provides a creatine ester anti-inflammatory compound which may be received by animals and then metabolized into a biologically active...
2018/0153843 ANTI-INFLAMMATORY OMEGA-3 SYNERGISTIC COMBINATIONS
This invention is directed to compositions having synergistic combinations of omega-3 fatty acid such as OMEGA-3 with a tomato extract lycopene, and optionally...
2018/0153842 AMINO ACID SUPPLEMENTATION FOR A HEALTHY MICROBIOTA ECOSYSTEM
A nutritional composition is used to reconstitute an optimal healthy microbiota ecosystem in humans or animals. In particular, an ingestible carrier contains...
2018/0153841 COMPOSITIONS AND METHODS FOR INDUCTION OF REMISSION OF INFLAMMATORY BOWEL DISEASES
The present invention discloses compositions which comprises steviol glycoside, citric acid monohydrate, monosodium glutamate and/or glycine. Furthermore, the...
2018/0153840 THE COMPOSITIONS OF GLYCEROL AND /OR NON-TOXIC AMINO ACIDS FOR INHIBITING AND DESTROYING BIOFILM, INCLUDING...
The invention relates to compositions that include non-toxic, non-bonded amino acids, individually or in combination, with or without glycerol and other...
2018/0153839 COMPOSITIONS AND METHODS TO REDUCE PHARMACEUTICAL-INDUCED TOXICITY
Provided herein are compositions and methods to reduce toxicity resulting from pharmaceutical treatment, that can lead to increased risk of developing...
2018/0153838 LEVOTHYROXINE LIQUID FORMULATIONS
The present invention is directed to a liquid formulation comprising levothyroxine or a pharmaceutically acceptable salt thereof. The formulation of the...
2018/0153837 METHODS OF IMPROVING PHYSIOLOGICAL RESPONSES RELATED TO POST-TRAUMATIC STRESS DISORDER THROUGH DIETARY...
The present invention provides methods of improving physiological responses related to post-traumatic stress disorder, wherein the free amino acid...
2018/0153836 DERMAL THERAPEUTIC SYSTEM WITH HIGH ADHESIVITY
The present invention relates to a high adhesion dermal therapeutic system comprising an adhesive polymeric matrix with a salt of Diclofenac.
2018/0153835 COMPOSITIONS OF DICLOFENAC ACID
The present invention provides solid oral pharmaceutical compositions comprising wet milled Diclofenac acid and one or more pharmaceutically acceptable...
2018/0153834 TREATMENT OF CONDITIONS RELATED TO SHOCK
Techniques are disclosed for prevention or treatment of physiological shock by administering a specific therapeutic agent, which is able to use smaller volumes...
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