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Patent # Description
2018/0162924 Fusion Polypeptides Capable Of Activating Receptors
A fusion polypeptide comprising (A).sub.x-M-(A').sub.y, wherein A and A' are each polypeptides capable of binding a target receptor. The fusion polypeptides of...
2018/0162923 B1SP FUSION PROTEIN THERAPEUTICS, METHODS, AND USES
Provided are methods, uses and pharmaceutical compositions for treatment of cancer with a B1SP fusion protein in a biologically effective amount sufficient to...
2018/0162922 T CELL RECEPTORS WITH IMPROVED PAIRING
The present invention relates to modified T cell receptor (TCR) .alpha. or .beta. chains, or heterodimers comprising the same, wherein in the variable domain...
2018/0162921 HIGH AFFINITY T CELL RECEPTOR AND USE THEREOF
The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding same,...
2018/0162920 PROTEASE-RESISTANT LIPIDATED GLP-1 ANALOGS
The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and...
2018/0162919 MULTIVALENT REGULATORY T CELL MODULATORS
This disclosure provides compounds that contain an IL-2 receptor-binding moiety and an ST2-binding moiety. The methods described in the present disclosure...
2018/0162918 IL-37 VARIANTS
This invention relates to polypeptides, including variants of interleukin-37 (IL-37), and related therapeutics and compositions. The invention also relates to...
2018/0162917 RECOMBINANT PROTEINS AND THEIR THERAPEUTIC USES
A recombinant protein expressing one or more human growth factors, tumor antigens, and/or receptors or epitopes thereof on or within an immunogenic expression...
2018/0162916 METHOD FOR PRODUCTION OF MOTH PHEROMONES IN YEAST
The present disclosure relates to methods for production of (Z)-11-hexadecen-1-ol in a yeast cell using desaturases and fatty acyl-CoA reductase. Also...
2018/0162915 METHODS AND COMPOSITIONS FOR MODIFYING PLANT ARCHITECTURE AND DEVELOPMENT
Methods and compositions useful for modifying plant architecture and development are provided herein. Plants with altered levels of MATE-efflux polypeptides...
2018/0162914 METHODS OF OPTIMIZING NUCLEOTIDE SEQUENCES ENCODING ENGINEERED INFLUENZA PROTEINS
The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized...
2018/0162913 METHODS FOR POTENTIATING AN IMMUNE RESPONSE USING DEPOT-FORMING AND NON-DEPOT-FORMING VACCINES
The present disclosure provides methods, vaccines and kits for potentiating an immune response to an antigen in a subject. The methods comprise administering...
2018/0162912 CYTOKINE
A novel cytokine, U83A, is described, as are variant forms of the cytokine, having a wide range of agonistic and antagonistic activity against chemokine...
2018/0162911 POLYPEPTIDES FOR THE DIAGNOSIS AND THE TREATMENT OF C3 NEF ASSOCIATED C3 GLOMERULOPATHY
The present invention relates to polypeptides for the diagnosis and treatment of C3 NeF associated C3 Glomerulopathy. In particular, the present invention is...
2018/0162910 DE NOVO STRUCTURAL PROTEIN DESIGN FOR MANUFACTURING HIGH STRENGTH MATERIALS
Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming...
2018/0162909 CONOTOXIN PEPTIDE K-CPTX-BTL03, PREPARATION METHOD THEREFOR, AND USES THEREOF
Provided are a conotoxin peptide .kappa.-CPTx-bt103 and a derivative polypeptide. The amino acid sequence of the conotoxin peptide is indicated by SEQ ID NO:...
2018/0162908 CONOTOXIN PEPTIDE K-CPTX-BTL02, PREPARATION METHOD THEREFOR, AND USES THEREOF
Provided is a new conotoxin peptide .kappa.-CPTx-btl02. The conotoxin peptide .kappa.-CPTx-btl02 has derivative polypeptide that has an amino acid sequence...
2018/0162907 STABILIZED MINIMAL COILED-COIL MIMETICS
This invention relates to a macrostructure that includes an antiparallel coiled-coil structure shown below or a parallel coiled-coil structure shown below and...
2018/0162906 CAHUITAMYCINS AND METHODS OF MAKING AND USING THE SAME
Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm...
2018/0162905 MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS
The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit serine...
2018/0162904 IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions...
2018/0162903 METHOD FOR THE REDUCTION OF VIRAL TITER IN PHARMACEUTICALS
Disclosed are methods and devices for the optimization of virus removal from solutions. A method of filtering a process fluid comprising a product includes...
2018/0162902 POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS
The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies...
2018/0162901 Method For Facilitating Extraction Of A Fraction From A Biological Sample
A method is provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a...
2018/0162900 POLYMORPHIC FORMS OF AN OXYSTEROL AND METHODS OF MAKING THEM
Compositions and methods for preparing OXY133 polymorphs Form C to Form I are provided. The methods include subjecting a slurry of OXY133 to conditions...
2018/0162899 CYCLIC DINUCLEOTIDES AS STING AGONISTS
Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of...
2018/0162897 TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
The present invention provides fluorine substituted tricyclic nucleosides of formula (I) wherein: the substituents are as defined in the claims. The present...
2018/0162896 Synthesis of Phosphoramidates
A process for preparing a nucleoside phosphoramidate, in particular to a process for preparing sofosbuvir, wherein a phosphoramidate derivative is used as...
2018/0162895 METHOD FOR PREPARING NICOTINAMIDE MONONUCLEOTIDE (NMN)
The present invention provides a method for preparing nicotinamide mononucleotide (NMN) by biocatalysis. The method includes a step of catalytically reacting a...
2018/0162894 PROCESSES FOR THE PREPARATION OF GALNAC ACID DERIVATIVES
The invention comprises a new process for the preparation of GalNAc derivatives of the formula I ##STR00001## wherein n is an integer between 0 and 10 and its...
2018/0162893 UTILITY OF NEMATODE SMALL MOLECULES
The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present...
2018/0162892 CHLORINATION OF SUCROSE-6-ESTERS
There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acylate, wherein said...
2018/0162891 METHOD AND AN APPARATUS FOR FORMING A LIGNIN FRACTION, A LIGNIN COMPOSITION AND ITS USE
The invention relates to a method and an apparatus for forming a lignin fraction from crude lignin which has been processed by means of a treatment step...
2018/0162890 Phosphepine Matrix Compound for a Semiconducting Material
The present invention is directed to a compound comprising at least one phosphepine ring and having the phosphorous atom of the phosphepine ring substituted...
2018/0162889 PHOSPHINE OXIDE ALKYL AMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS MODULATORS OF IL-12, IL-23, AND/OR IFN ALPHA...
Compounds having the following formula I: ##STR00001## or a stereoisomer or pharmaceutically-acceptable salt thereof, where all substituents are as defined...
2018/0162888 FURAN-CONTAINING FLAME RETARDANT MOLECULES
A furan-containing flame retardant molecule includes a furan moiety bonded to a phosphorus moiety via a phosphoryl linkage or via a phosphinyl linkage.
2018/0162887 METATITANIC ACID PARTICLE, COMPOSITION FOR FORMING PHOTOCATALYST, AND PHOTOCATALYST
A metatitanic acid particle including bonded thereon a metal-containing compound which has a hydrocarbon group, wherein the metatitanic acid particle has an...
2018/0162886 COORDINATIVELY UNSATURATED TITANIUM CATECHOLATE COMPLEXES AND PROCESSES ASSOCIATED THEREWITH
Coordinatively saturated titanium (IV) coordination compounds containing catecholate ligands can be desirable active materials for flow batteries and other...
2018/0162885 COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts...
2018/0162884 POLYENE COMPOUND, PREPARATION METHOD AND USE THEREOF
Disclosed are a polyene compound, preparation method and use thereof. Provided in the present invention is the preparation method of a polyene compound I,...
2018/0162883 AMINE SUBSTITUTED TRISILYLAMINE AND TRIDISILYLAMINE COMPOUNDS AND SYNTHESIS METHODS THEREOF
Halogen free amine substituted trisilylamine and tridisilylamine compounds and a method of their preparation via dehydrogenative coupling between the...
2018/0162882 GROUP 4 METAL ELEMENT-CONTAINING COMPOUND, METHOD OF PREPARING THE SAME, PRECURSOR COMPOSITION INCLUDING THE...
The present disclosure provides a Group 4 metal element-containing novel compound, a method of preparing the Group 4 metal element-containing compound, a...
2018/0162881 HIGHLY REACTIVE METAL HYDRIDES, PROCESS FOR THEIR PREPARATION AND USE
The invention relates to powdery, highly reactive alkali and alkaline earth hydride compounds, and to mixtures with elements of the third main group of the...
2018/0162880 METHOD FOR PRODUCING METAL ORGANYLS
The invention relates to a method for producing organometallic compounds RMn (M=alkali or alkaline earth element, R=alkyl residue) where n=valence of the metal...
2018/0162879 JANUS KINASE INHIBITOR
Disclosed are a series of Janus kinase inhibitors, and particularly disclosed are a compound or pharmaceutically acceptable salts thereof of Formula (I) and...
2018/0162878 ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE
Disclosed is a substituted nitroimidazole derivative, which is mainly used for treating related diseases caused by mycobacterial infections, such as...
2018/0162877 PYRAZOLOPYRIDINAMINES AS MKNK1 AND MKNK2 INHIBITORS
The present invention relates to substituted pyrazolopyridinamine compounds of general formula (I) as described and defined herein, to methods of preparing...
2018/0162876 NITROGEN-CONTAINING TRICYCLIC DERIVATIVES HAVING HIV REPLICATION INHIBITORY ACTIVITY
The present invention provides a novel compound having antiviral activity, especially HIV replication inhibitory activity and a medicament containing the same....
2018/0162875 HETEROCYCLIC COMPOUND AND USE THEREOF
Provided is a compound represented by the formula (I): ##STR00001## wherein each symbol is as defined in the specification, or a salt thereof, which has an AMPA ...
2018/0162874 SUBSTITUTED PYRAZOLO/IMIDAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS
The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous...
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