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Patent # Description
2018/0161454 COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the...
2018/0161453 COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the...
2018/0161452 COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the...
2018/0161451 COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR IMMUNOSTIMULATION
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the...
2018/0161450 SDR5-FC FUSION PROTEIN MUTANT AND USE THEREOF
The present disclosure discloses a human sDR5-Fc fusion protein in the preparation of adjuvant therapy for myocardial ischemia-reperfusion injury. The sDR5-Fc...
2018/0161449 FORMATION OF CYCLOSPORIN A/CYCLODEXTRIN NANOPARTICLES
Methods of forming cyclosporin/cyclodextrin complex nanoparticles and microparticles, and administration of the nano- and microsuspension formed to an eye of a...
2018/0161448 LONG-ACTING INSULIN OR INSULIN ANALOGUE CONJUGATE
The present invention relates to insulin and/or an insulin analogue conjugate, and a use thereof, wherein the insulin and/or insulin analogue have improved in...
2018/0161447 METHODS AND COMPOSITIONS FOR NUCLEIC ACID AND PROTEIN PAYLOAD DELIVERY
Provided are methods and compositions for delivering a nucleic acid, protein, and/or ribonucleoprotein payload to a cell. Also provided are delivery molecules...
2018/0161446 ANTIBODY DRUG CONJUGATE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF
Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo...
2018/0161445 METHODS FOR IMPROVING THE ADSORPTION OF POLYSACCHARIDE-PROTEIN CONJUGATES AND MULTIVALENT VACCINE FORMULATION...
The present invention provides methods for preparation of stable multivalent pneumococcal polysaccharide-protein conjugate vaccine formulations. Instant stable...
2018/0161444 COMPOSITIONS AND METHODS FOR TRANSPORT ACROSS THE BLOOD BRAIN BARRIER
Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx protein which can be...
2018/0161443 GROWTH HORMONE POLYPEPTIDES AND METHODS OF MAKING AND USING SAME
The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the...
2018/0161442 METHODS FOR THE TREATMENT OF LEPTOMENINGEAL CARCINOMATOSIS
The present invention features a method of treating leptomeningeal carcinomatosis in a subject using a peptide-therapeutic conjugate as exemplified by the...
2018/0161441 STAPLED ACID-SENSITIVE ENDOSOME DISRUPTING ALGINATES
An agent comprising: an algin crosslinked with acetal linkages; and at least one cation coupled to the crosslinked algin.
2018/0161440 ANTIBODY-SN-38 IMMUNOCONJUGATES WITH A CL2A LINKER
The present invention concerns improved methods and compositions for preparing SN-38 conjugates of proteins or peptides, preferably immunoconjugates of...
2018/0161439 Acid-Labile Lipophilic Prodrugs of Cancer Chemotherapeutic Agents
The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially...
2018/0161438 Aqueous Ophthalmic Composition
The present invention relates to an aqueous ophthalmic composition that contains (A) vaseline and (B) at least one selected from the group consisting of a...
2018/0161437 Foamed Medical devices with Additives
A medical device including an implantable medical prosthesis that can be reshaped into a scaffold to support the bodily tissues and bones. Additionally, the...
2018/0161436 NERVE GROWTH FACTOR COMPOSITION AND POWDER INJECTION
The present invention discloses nerve growth factor composition and an injection powder comprising the following components: 10 .mu.g/mL-100 .mu.g/mL of a...
2018/0161435 Low Toxicity Topical Active Agent Delivery System
An active agent delivery composition is provided that allows topical delivery of active agents including vitamin A and its derivatives. A polyhalogenic vehicle...
2018/0161434 USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO TREAT DIARRHEA IN SUBJECTS WITH DISEASES OR TREATMENTS...
The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically...
2018/0161433 SIZE TUNABLE MICROBIAL MIMETICS FOR IMMUNOTHERAPY OF THYROID CARCINOMAS AND SOLID TUMORS
This invention describes novel immunogenic complexes, which are designed to trigger a robust host immune response against cancer cells by co-opting the immune...
2018/0161432 FKBP52-TAU INTERACTION AS A NOVEL THERAPEUTICAL TARGET FOR TREATING THE NEUROLOGICAL DISORDERS INVOLVING TAU...
The invention relates generally to neuroprotection and repair in neurological disorders involving Tau dysfunction (including Alzheimer's disease). The...
2018/0161431 PROTON INDUCED BORON CAPTURE THERAPY
The present disclosure provides methods of treating a biological tissue using a proton beam. A method includes the steps of: irradiating a proton beam to a...
2018/0161430 COMBINATIONS OF A PHOTOSENSITIZER WITH A HYDROGEN SULFIDE DONOR, THIOREDOXIN INHIBITOR OR NITROXIDE FOR USE IN...
The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen...
2018/0161429 CANCER THERAPY TARGETING TETRASPANIN 33 (TSPAN33) IN MYELOID DERIVED SUPPRESSOR CELLS
Methods for treating cancer, e.g., in conjunction with anti-cancer therapy, like immunotherapy, and for identifying candidate therapeutic agents, by targeting...
2018/0161428 Prostate Specific Membrane Antigen Binding Protein
Disclosed herein are PSMA binding proteins with improved binding affinities, and robust aggregation profiles. Also described are multispecific binding proteins...
2018/0161427 COMBINATION OF AN ANTI-IL-10 ANTIBODY AND A CPG-C TYPE OLIGONUCLEOTIDE FOR TREATING CANCER
The present disclosure describes combination therapies comprising an anti-IL-10 antibody or antigen-binding fragment thereof and a CpG-C type oligonucleotide,...
2018/0161426 IN VITRO CELL CULTURE METHODS FOR BETA-THALASSEMIA USING ACTIVIN TYPE II RECEPTOR LIGAND TRAPS
Provided herein are methods of treating beta-thalassemia in a subject comprising administering to the subject an activin type II receptor (ActRII) signaling...
2018/0161425 NOVEL PROTEIN STRUCTURE USED FOR EFFICIENT ANTIBODY PRODUCTION IN IMMUNIZATION
A method of enhancing immune response is provided, including covalent linking an amphipathic peptide to an antigen to form an antigen-complex composition; and...
2018/0161424 VACCINE COMPOSITION AND PREPARATION METHOD AND USE THEREOF
The present disclosure relates to a vaccine composition, wherein the vaccine composition comprises an immune amount of fowl adenovirus Fiber-2 protein or an...
2018/0161423 LIPOSOME-PEPTIDE CONJUGATE AND METHOD OF USING SAME TO INDUCE PRODUCTION OF ANTI-HIV ANTIBODIES
The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV...
2018/0161422 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL...
The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a...
2018/0161421 RECOMBINANT VACCINIA VIRUS HAVING HEMAGGLUTININ PROTEIN GENES DERIVED FROM NOVEL INFLUENZA VIRUSES
Provided are a highly-safe recombinant vaccinia virus that is effective in preventing the onset of symptoms due to infection by novel influenza viruses, and a...
2018/0161420 Modified H7 Hemagglutinin Glycoprotein of the Influenza A/Shanghai/2/2013 H7 Sequence
The present invention is directed to a sequence modification of the H7 hemagglutinin glycoprotein of the Influenza A/Shanghai/2/2013 H7 sequence together with...
2018/0161419 METHODS FOR IMPROVING THE EFFICACY OF VACCINE ANTIGENS
The present technology is directed to a sequence modification of the H7 hemagglutinin glycoprotein of the Influenza A/Shanghai/2/2013 H7 sequence together with...
2018/0161418 Modified H7 Hemagluttinin Glycoprotein of the Influenza A/Shanghai/2/2013 H7 Sequence
The present invention is directed to a sequence modification of the H7 hemagglutinin glycoprotein of the Influenza A/Shanghai/2/2013 H7 sequence together with...
2018/0161417 Immortalized Porcine Alveolar Macrophage
The present invention relates to immortalized porcine alveolar macrophages (PAMs), to cell cultures comprising such PAMs, to methods for the immortalization of...
2018/0161416 EXOSOMES AND THEIR USE AS VACCINE
The present invention provides exosomes isolated from an animal, wherein the animal (a) has overcome a disease caused by a pathogen, and (b) it is free from...
2018/0161415 Stable, Spray Dryed, Immunogenic, Viral Compositions
Viruses, and particularly genetically engineered, replication deficient viruses such as adenoviruses, poxviruses, MVA viruses, and baculoviruses which encode...
2018/0161414 VACCINE COMPRISING LACTOBACILLUS STRAINS FOR TREATING PROSTATE INFLAMMATION AND BENIGN PROSTATE HYPERPLASIAS
The invention relates to vaccines for treating prostate inflammation and benign prostate hyperplasias (stages I and II) comprising Lactobacillus strains in an...
2018/0161413 INFECTIOUS PLASMODIUM SPOROZOITES GROWN IN VITRO
The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is...
2018/0161412 EXTENDED PROTECTION PROTEIN VACCINES AGAINST INFECTIOUS AGENTS
Protein-based vaccines against infectious agents, including malaria and Zika virus, are described. The protein-based vaccines include an antigen domain and an...
2018/0161411 ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF CANCERS
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides...
2018/0161410 Methods to Treat Diseases with Protein, Peptide, Antigen Modification and Hemopurification
The current invention discloses methods to modify protein and peptide and antigen to treat disease such as pathogen infection, autoimmune diseases and cancer....
2018/0161409 Method of Treating Proteinuria in Pregnancy
A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and a method for preparing the therapeutic agent are disclosed. The therapeutic...
2018/0161408 SITE-SPECIFIC POLYETHYLENE GLYCOLYLATED (PEGYLATED) ASPARAGINASE, PREPARATION METHOD THEREFOR AND USE THEREOF
The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal...
2018/0161407 Novel Method of Treating Macular Degeneration using Botulinum Toxin-Based Pharmaceuticals
Formulations and methods of treatment are disclosed for prevention and/or treatment of visual loss from age-related macular degeneration. The disclosed...
2018/0161406 Botulinum Neurotoxin Compositions
Present invention provides a stable pharmaceutical composition comprising botulinum neurotoxin, anesthetic in a buffer. Present invention also provides a...
2018/0161405 IMPROVED METHODS FOR TREATING OCULAR DISEASES BY GENE THERAPY
The invention relates to a pharmaceutical composition comprising a recombinant adeno-associated virus (r AAV) vector carrying a nucleic acid sequence encoding...
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