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Patent # Description
2018/0163227 RECOMBINANT ADENO-ASSOCIATED VECTORS FOR TARGETED TREATMENT
Novel adeno-associated virus (AAV) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain...
2018/0163226 CHIMERIC NUCLEIC ACID MOLECULES WITH NON-AUG TRANSLATION INITIATION SEQUENCES AND USES THEREOF
The present disclosure relates to nucleic acid vaccine compositions and methods for preventing or treating pathological conditions, such as cancer or...
2018/0163225 EXPRESSION CASSETTE
The present invention relates to an expression cassette useful for the expression of a polynucleotide sequence encoding a polypeptide.
2018/0163224 CRY1D FOR CONTROLLING CORN EARWORM
The subject invention relates in part to the surprising discovery that Cry1Da is active against corn earworm (CEW), Helicoverpa zea (Boddie). Methods for using...
2018/0163223 Pesticidal Genes and Methods of Use
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal...
2018/0163222 DROUGHT RESISTANCE IN PLANTS: PECTINESTERASE
The present invention relates to a new method for increasing drought resistance of a plant. The method encompasses the impairment of the expression of a gene...
2018/0163221 TRANSGENIC PLANTS EXPRESSING TYPE 2C PROTEIN PHOSPHATASE ABSCISIC ACID (PP2CABA) PROTEINS AND USES THEREOF
The present disclosure relates to transgenic plants that over-express PP2CABA and methods of using such for enhancing osmotic stress tolerance.
2018/0163220 SYNTHETIC PATHWAY FOR BIOLOGICAL CARBON DIOXIDE SEQUESTRATION
This invention relates to methods for increasing carbon fixation and/or increasing biomass production in a plant, comprising: introducing into a plant, plant...
2018/0163219 METHODS AND COMPOSITIONS FOR INTRODUCING NUCLEIC ACIDS INTO PLANTS
The present disclosure provides compositions and methods for introducing nucleic acids into plants. More specifically, disclosed herein are methods and...
2018/0163218 RECONSTRUCTION OF SITE SPECIFIC NUCLEASE BINDING SITES
Disclosed herein are methods and compositions for the repair of site specific nuclease binding sites by targeted integration and/or targeted excision of one or...
2018/0163217 FAD3 PERFORMANCE LOCI AND CORRESPONDING TARGET SITE SPECIFIC BINDING PROTEINS CAPABLE OF INDUCING TARGETED BREAKS
A method of gene editing or gene stacking within a FAD3 loci by cleaving, in a site directed manner, a location in a FAD3 gene in a cell, to generate a break...
2018/0163216 GENE EXPRESSION IN BACTEROIDES
Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides...
2018/0163215 IRRE PROTEIN FUNCTIONAL DOMAIN FOR IMPROVING ANTI-OXIDATION CAPABILITY OF CELL AND APPLICATION THEREOF
Provided is an amino acid optimization of a functional motif on an IrrE protein of a Deinococcus geothermalis strain and homologous proteins thereof obtained...
2018/0163214 SLIT2D2-HSA FUSION PROTEIN AND USE THEREOF AGAINST TUMOURS
Provided in the present invention are a Slit2D2-HAS fusion protein and the use thereof against tumours. The fusion protein can significantly inhibit the...
2018/0163213 CAS9 MRNAS
In certain aspects, the disclosure relates to compositions comprising modified Cas9 polyribonucleotides and methods of use, as well as Cas9 polynucleotides and...
2018/0163212 BENZYLISOQUINOLINE ALKALOID (BIA) PRECURSOR PRODUCING MICROBES, AND METHODS OF MAKING AND USING THE SAME
Methods and engineered yeast cells for generating a benzylisoquinoline alkaloid product are provided herein. A method comprises providing engineered yeast...
2018/0163211 SORTILIN 1 IS A NOVEL INDUCER OF VASCULAR CALCIFICATION
The invention relates to methods for decreasing, inhibiting, preventing, or reducing calcification by inhibiting sortilin 1.
2018/0163210 COMPOSITIONS AND METHODS FOR CONTROLLING VASCULATURE
The invention relates to compositions and methods for reducing excessive vascular development and treat related disorders. In one aspect, the invention...
2018/0163209 MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION
Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods,...
2018/0163208 ANTITUMOR AGENT
This invention provides a composition and a method for treating or preventing a subject having a tumor that more highly expresses a TUG1 gene than in normal...
2018/0163207 SDF-1 Binding Nucleic Acids
The present invention is related to an L nucleic acid that binds to an SDF-1.
2018/0163206 IN VIVO PRODUCTION OF SMALL INTERFERING RNAS THAT MEDIATE GENE SILENCING
The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs)...
2018/0163205 ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
2018/0163204 MICRO-RNA FAMILY THAT MODULATES FIBROSIS AND USES THEREOF
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The...
2018/0163203 COMPOSITIONS AND METHODS FOR DELIVERY OF A POLYNUCLEOTIDE INTO A PLANT
The present disclosure provides compositions and methods for delivering a polynucleotide from the exterior surface of a plant or plant part into the interior...
2018/0163202 Compositions and Methods for Degradation of Misfolded Proteins
The present invention relates to compositions and methods for promoting the degradation of misfolded proteins and protein aggregates. The compositions and...
2018/0163201 METHODS FOR TAGGING AND AMPLIFYING RNA TEMPLATE MOLECULES FOR PREPARING SEQUENCING LIBRARIES
Aspects of the invention include methods for preparing sequencing libraries comprising a plurality of RNA molecules. In some embodiments, the subject methods...
2018/0163200 METHODS AND DEVICES FOR HIGH FIDELITY POLYNUCLEOTIDE SYNTHESIS
Disclosed are methods for synthesizing and/or assembling at least one polynucleotide product having a predefined sequence from a plurality of different...
2018/0163199 TEMPLATE DIRECTED SPLIT AND MIX SYNTHESIS OF SMALL MOLECULE LIBRARIES
The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a)...
2018/0163198 METHODS AND SYSTEMS FOR SCREENING USING MICROCAPILLARY ARRAYS
High-throughput methods for screening large populations of variant proteins are provided. The methods utilize large-scale arrays of microcapillaries, where...
2018/0163197 ASSAYS TO IDENTIFY GENETIC ELEMENTS AFFECTING PHENOTYPE
The present invention comprises generally applicable methods for identifying endogenous physiologically relevant genetic elements that affects a intracellular...
2018/0163196 CRISPR/CAS9 BASED ENGINEERING OF ACTINOMYCETAL GENOMES
The present invention relates to CRISPR/Cas-based methods for generating random-sized deletions around at least one target nucleic acid sequence, or for...
2018/0163195 INDUCIBLE DIMERIZATION OF RECOMBINASES
The technology described herein relates to controlled chemically- or light-induced rejoinder of split-recombinases. In some embodiments, compositions, methods,...
2018/0163194 INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements...
2018/0163193 MEDIUM COMPOSITION FOR PREPARING BOTULINUM TOXIN
The present invention relates to a medium composition for production of botulinum toxin and, more particularly, to a medium composition for culture of...
2018/0163192 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2018/0163191 Alpha-Amylase Combinatorial Variants
Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and...
2018/0163190 ANTI-TUMOR MEDICAMENT BASED ON ADENOVIRUS
The invention provides manipulated adenovirus, i.e. a viral particle based on a manipulated adenovirus, for use as a medicament, especially for use in the...
2018/0163189 Polypeptide Variants
The present invention relates to polypeptide variants and methods for obtaining variants. The present invention also relates to polynucleotides encoding the...
2018/0163188 Engineering of a minimal SaCas9 CRISPR/Cas system for gene editing and transcriptional regulation optimized by...
The presently claimed invention offers programmable and precise regulation of Cas9 functions by utilizing a set of compact Cas9 derivatives created by deleting...
2018/0163187 ALK4:ACTRIIB HETEROMULTIMERS AND USES THEREOF
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK4 receptor and an...
2018/0163186 MICROORGANISM HAVING QUINOLINIC ACID PRODUCTION ABILITY, AND METHOD FOR PRODUCING QUINOLINIC ACID BY USING SAME
The present disclosure relates to a microorganism having producing ability of quinolinic acid and a method for producing quinolinic acid using the microorganism.
2018/0163185 MUTATED SIALIDASES
The invention provides engineered enzymes of transsialidase and/or sialyl transferase activity that have increased regioselectivity and/or increased...
2018/0163184 RECOMBINANT PROTEIN, AND PREPARATION METHOD AND APPLICATION THEREOF
The fructosyl amino acid oxidase (FPOX-CE) of other species, wild-type fructosyl amino acid oxidase (PnFPOX), and the recombinant proteins (PnFPOX-SS,...
2018/0163183 RECOMBINANT ADENO-ASSOCIATED VIRUS PARTICLE PURIFICATION WITH MULTIPLE-STEP ANION EXCHANGE CHROMATOGRAPHY
The invention describes a method for obtaining purified recombinant Adeno-Associated Virus particles (rAAV), comprising the steps of: a) performing a depth...
2018/0163182 PROCESSES FOR PRODUCTION AND PURIFICATION OF NUCLEIC ACID-CONTAINING COMPOSITIONS
Described are improved processes for production and purification of nucleic acid-containing compositions, such as non-naturally occurring viruses, for example,...
2018/0163180 METHOD OF ENHANCING SOMATIC CELL REPROGRAMMING WITH THE ACETYLLYSINE READER BRD3R
A method of generating an induced pluripotent stem cell (iPSC) comprises introducing to an animal somatic cell at least one nuclear reprogramming inducing...
2018/0163179 METHOD FOR IMPROVEMENT OF DRUG METABOLISM OF HUMAN STEM CELL-DERIVED HEPATOCYTES
The present invention relates to a method for improving drug metabolism function of human stem cell-derived hepatocytes. More precisely, the human stem...
2018/0163178 AUF1 ENCODING COMPOSITIONS FOR MUSCLE CELL UPTAKE, SATELLITE CELL POPULATIONS, AND SATELLITE CELL MEDIATED...
The present invention relates to compositions (e.g., AUF1 encoding compositions) for muscle cell uptake, satellite cell populations and compositions containing...
2018/0163177 SERUM-FREE CULTURE MEDIUM AND METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS
A serum-free culture medium for hematopoietic stem cell (HSC) expansion is provided. The serum-free culture medium includes a serum-free base medium,...
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