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Patent # Description
2018/0171365 Enzymatic Hydroxylation of Aliphatic Hydrocarbon
The invention relates to enzymatic methods for hydroxylation in position 2 or 3 of substituted or unsubstituted, linear or branched aliphatic hydrocarbons.
2018/0171364 PRODUCTION METHOD FOR POLYISOPRENOID, VECTOR, TRANSGENIC PLANT, PRODUCTION METHOD FOR PNEUMATIC TIRE, AND...
The present invention provides a method for producing a polyisoprenoid with which it is possible to enhance the rubber synthesis activity of rubber particles...
2018/0171363 PRODUCTION OF BETA-PHELLANDRENE USING GENETICALLY ENGINEERED PHOTOSYNTHETIC MICROORGANISMS
The present invention provides methods and compositions for producing .beta.-phellandrene hydrocarbons from a photosynthetic microorganism such as cyanobacteria.
2018/0171362 ASSAYS FOR EVALUATING CELL CULTURE REAGENTS
Some aspects of the present disclosure provide methods, compositions and kits for identifying one or more reagents, such as a culture medium, that are...
2018/0171361 Multiplexed Genome Editing
A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that...
2018/0171360 METHODS FOR INCREASING CAS9-MEDIATED ENGINEERING EFFICIENCY
Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease...
2018/0171359 METHODS OF MODIFYING A TARGET NUCLEIC ACID WITH AN ARGONAUTE
This disclosure provides for compositions and methods for the use of designed nucleic acid-targeting nucleic acids, Argonautes, and complexes thereof.
2018/0171358 PROCESSES FOR PACKAGING OLIGONUCLEOTIDES INTO VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES
The invention provides processes for the producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle...
2018/0171357 SELF-LIMITING VIRAL VECTORS ENCODING NUCLEASES
Disclosed herein are viral vectors for use in recombinant molecular biology techniques. In particular, the present disclosure relates to self-limiting viral...
2018/0171356 DESIGN METHOD FOR SYNTHETIC GENES
The present invention provides a method of designing an optimized gene which comprises altering a nucleotide sequence of a target protein gene, so that only...
2018/0171355 METHODS OF CELL RENEWAL
The present invention encompasses compositions and methods to rejuvenate cells by, expanding the replicative life span of the cells for, e.g., use in...
2018/0171354 VECTORS
We disclose dumbbell-shaped vectors adapted for efficient expression in mammalian cells. We also disclose a novel method allowing the efficient synthesis of...
2018/0171353 PEPPER PLANTS WITH IMPROVED DISEASE RESISTANCE
The present disclosure provides pepper plants exhibiting resistance to Phytophthora capsici. Such plants may comprise novel introgressed chromosomal regions...
2018/0171352 PEPPER HYBRID SVPB6988 AND PARENTS THEREOF
The invention provides seed and plants of pepper hybrid SVPB6988 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue...
2018/0171351 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USING SAME FOR INCREASING PLANT YIELD, BIOMASS, GROWTH...
Provided are isolated polynucleotides comprising a nucleic acid sequence encoding a polypeptide at least 80% identical to SEQ ID NO: 422, 362-421, 423-601,...
2018/0171350 TRANSGENIC SOYBEAN PLANTS AND CHROMOSOMES
Described herein are transgenic soybean chromosomes containing a recombinant DNA that transcribes to an RNA molecule that hybridizes to and forms a...
2018/0171349 HIGH FRUCTAN CEREAL PLANTS
The invention provides cereal plants having a high level of fructan useful for the production of a range of food, beverage, nutraceutical and pharmaceutical...
2018/0171348 PLANT REGULATORY ELEMENTS AND METHODS OF USE THEREOF
The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a...
2018/0171347 CITRUS DERIVED TRANSCRIPTION AND TRANSLATION REGULATORY ELEMENTS FOR TISSUE SPECIFIC EXPRESSION
Expression vectors and expression cassettes containing a tissue specific 5' transcription regulatory element, optionally linked to a translation regulatory...
2018/0171346 METHODS AND COMPOSITIONS FOR TARGETED POLYNUCLEOTIDE MODIFICATION
A variety of methods and compositions are provided, including methods and compositions for targeted modification of a specific target site in a cell or...
2018/0171345 NOVEL MAIZE UBIQUITIN PROMOTERS
The Zea mays c.v. B73 Ubiquitin-1 (Z. mays c.v. B73 Ubi-1) promoter drives high levels of constitutive transgene expression in plants. Repeated use of the same...
2018/0171344 METHOD OF GENE EXPRESSION REGULATION
The invention discloses a promoter which can be induced to express in acidic conditions, and relates to the field of bioengineering technology. The promoters...
2018/0171343 Recombinant Bacillus subtilis for Producing Acetylglucosamine and Construction Method thereof
The present invention provides a recombinant Bacillus subtilis for producing acetylglucosamine and construction method thereof. The recombinant Bacillus...
2018/0171342 FUSION CONSTRUCTS AS PROTEIN OVER-EXPRESSION VECTORS
This invention provides compositions and methods for providing high product yield of transgenes expressed in cyanobacteria and microalgae.
2018/0171341 MALTOSE DEPENDENT DEGRONS, MALTOSE-RESPONSIVE PROMOTERS, STABILIZATION CONSTRUCTS, AND THEIR USE IN PRODUCTION...
The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational...
2018/0171340 COMPOSITIONS AND METHODS FOR ENHANCING GENE EXPRESSION
The present disclosure generally relates to nucleic acid molecules for use in regulating gene expression. Disclosed herein include nucleic acid molecules...
2018/0171339 AGENT FOR THE PROPHYLAXIS AND THERAPY OF VIRAL INFECTION
The present invention relates to the preparation of a medicinal agent comprising DNAzymes according to Seq. ID 2-62 for the prophylaxis and treatment of virus...
2018/0171338 COMPOSITIONS AND METHODS FOR OLIGONUCLEOTIDE FORMULATIONS
The present invention relates generally to immunostimulatory nucleic acids, compositions thereof and methods of using the immunostimulatory nucleic acids. In...
2018/0171337 THERAPEUTIC OLIGONUCLEOTIDES
Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived...
2018/0171336 SELECTIVE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED TRI-NUCLEOTIDE REPEAT CONTAINING GENES
Aspects of the invention include methods of selectively reducing the deleterious activity of mutant extended trinucleotide repeat containing genes in a cell,...
2018/0171335 ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF CANCER STEM CELLS
The invention provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and...
2018/0171334 TARGETING MICRORNAS FOR METABOLIC DISORDERS
Described herein are compounds comprising modified oligonucleotides that are complementary to miR-103 and/or miR-107 and methods of treating diseases and...
2018/0171333 ANTISENSE MOLECULES AND METHODS FOR TREATING PATHOLOGIES
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59.
2018/0171332 siRNA Therapy for Transthyretin (TTR) Related Ocular Amyloidosis
The invention relates to a method of treating ocular amyloidosis by reducing TTR expression in a subject by administering a double-stranded ribonucleic acid...
2018/0171331 METHODS AND DEVICES FOR MICRO-ISOLATION, EXTRACTION, AND/OR ANALYSIS OF MICROSCALE COMPONENTS IN AN ARRAY
Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation device described can comprise a photomask...
2018/0171330 METHODS AND DEVICES FOR MICRO-ISOLATION, EXTRACTION, AND/OR ANALYSIS OF MICROSCALE COMPONENTS IN AN ARRAY
Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation device described can comprise a photomask...
2018/0171329 REAGENTS, KITS AND METHODS FOR MOLECULAR BARCODING
Multimeric barcoding reagents for labelling a target nucleic acid comprise: first and second barcode molecules linked together, wherein each of the barcode...
2018/0171328 High Fidelity Restriction Endonucleases
Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits...
2018/0171327 System and Apparatus for Genetic Regulation by Electromagnetic Stimulation Fields
The present invention provides a system for delivering a time-varying stimulation field to a subject. In the system, a power source, a control component and a...
2018/0171326 GALVANOTAXIS ASSAY FOR QUANTITATIVE ASSESSMENT OF THE METASTATIC POTENTIAL OF CANCER CELLS
An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that...
2018/0171325 Nanoparticle-attached enzyme cascades for accelerated multistep biocatalysis
A nanoparticle (for example, quantum dot) serves as a substrate for immobilizing enzymes involved in consecutive reactions as a cascade. This results in a...
2018/0171324 CELL STRUCTURE, NON-HUMAN MODEL ANIMAL, METHOD FOR PRODUCING NON-HUMAN MODEL ANIMAL, AND METHOD FOR EVALUATING...
An object of the present invention is to provide a non-human model animal rich in stromal tissue, a cell structure useful for producing the above-described...
2018/0171323 ACETOLACTATE DECARBOXYLASE
The present disclosure provides methods, compositions, apparatuses and kits comprising ALDC enzymes having a better stability and/or activity, and, optionally,...
2018/0171322 IMPROVED CELL-PERMEABLE (ICP) PARKIN RECOMBINANT PROTEIN AND USE THEREOF
Disclosed are improved cell-permeable Parkin recombinant proteins (iCP-Parkin) which have been developed as a protein-based anti-neurodegenerative agent for...
2018/0171321 PLATFORM FOR A NON-NATURAL AMINO ACID INCORPORATION INTO PROTEINS
A complement to tRNAs and a protein translation system are provided that enable the incorporation of non-natural moieties such as non-natural amino acids...
2018/0171320 SERINE PROTEASES
The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics...
2018/0171319 Protease Variants and Polynucleotides Encoding Same
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding...
2018/0171318 Polypeptides Having Protease Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention further relates...
2018/0171317 SUBTILASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to subtilase variants suitable for use in, e.g., cleaning or detergent compositions, such as laundry detergent compositions and...
2018/0171316 POLYPEPTIDES HAVING MANNANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to polypeptides having mannanase activity, catalytic domains, and carbohydrate binding modules, and polynucleotides encoding the...
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