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Patent # Description
2018/0171013 JAM-C ANTIBODIES AND METHODS FOR TREATMENT OF CANCER
A novel method to reduce B-cell lymphoma cell migration to and engraftment of the spleen in patients with JAM-C positive B-cell lymphomas is described. In...
2018/0171012 Anti-Human Transferrin Receptor Antibody Permeating Blood-Brain Barrier
Disclosed are a means to convert compounds having physiological or pharmacological activity and unable to pass through the blood-brain barrier into a form that...
2018/0171011 ANTIBODIES THAT RECOGNIZE IAPP
The invention provides monoclonal antibody 6B8 and related antibodies. The 6B8 antibody binds to an epitope within residues 3-12 of IAPP. The antibodies of the...
2018/0171010 COMPOSITION, KIT AND METHOD FOR INHIBITION OF IL-21 MEDIATED ACTIVATION OF HUMAN CELLS
A synergistic composition, kit and method for inhibition and/or neutralization of IL-21 mediated activation of human cells including (i) a first agent being an...
2018/0171009 M-CSF Specific Monoclonal Antibody and Uses Thereof
M-CSF-specific RX1-based or RX-1 derived antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a...
2018/0171008 ANTIBODY
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which...
2018/0171007 ANTI-CCL17 ANTIBODIES
The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using...
2018/0171006 COMPOSITIONS AND METHODS FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFICALLY ANTAGONIZING GDF8 AND...
The present invention provides compositions and methods which involve specifically antagonizing GDF8 and Activin A. In certain embodiments, compositions are...
2018/0171005 COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING BMP6
The present invention relates to antibodies and antigen-binding fragments thereof to human BMP6 and compositions and methods of use thereof.
2018/0171004 ANTIBODY FORMULATION
The invention provides a stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, optionally, not subjected to...
2018/0171003 Chimeric and Humanized Anti-Histone Antibodies
The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein....
2018/0171002 FILAMIN A BINDING PROTEINS AND USES THEREOF
The present invention encompasses filamin A (FLNA) binding proteins. Specifically, the invention relates to antibodies to FLNA. An antibody of the invention...
2018/0171001 Broadly Neutralizing Anti-HIV Antibodies and Epitope Therefor
The present invention relates to broadly neutralizing anti-HIV-1 antibodies and isolated antigens. Also disclosed are related methods and compositions.
2018/0171000 RECOMBINANT LIPOPROTEIN MODIFIED BY MONOSIALOTETRAHEXOSYL GANGLIOSIDE AND APPLICATION THEREOF
The present invention discloses a reconstituted lipoprotein modified by monosialoteterahexosyl ganglioside, an application in preparing a drug carrier thereof,...
2018/0170999 BTLA FUSION PROTEIN AGONISTS AND USES THEREOF
The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention...
2018/0170998 AML ANTIGENS AND USES THEREOF
The present invention provides novel compounds comprising an antigen of AML cells, and uses thereof.
2018/0170997 NOVEL EPITOPE FOR SWITCHING TO TH17 CELL AND USE THEREOF
The present invention relates to a novel epitope to convert T cell to type 17 helper T (T.sub.H17) cell. Specifically, the present invention relates to an...
2018/0170996 METHOD OF DIAGNOSIS OR TREATMENT OF NEUROLOGICAL DISORDERS WITH P75ECD AND/OR P75
A method of treating and/or preventing neurological conditions, comprising administering to a subject in need thereof a therapeutically effective amount of a...
2018/0170995 P75NTR -FC FUSION PROTEIN
The present invention relates to a new p75NTR neurotrophin binding protein (NBP)-Fc fusion protein comprising a p75NTR (NBP) portion and an immunoglobulin...
2018/0170994 Bi-targeted Mutain MuR5S4TR of TRAIL and Preparation Method and Application Thereof
The present invention belongs to the field of genetic engineering drugs, and provides a mutein MuR5S4TR of TRAIL, and a preparation method and use thereof. The...
2018/0170993 Bi-targeted Mutain MuR6S4TR of TRAIL and Preparation Method and Application Thereof
The present invention belongs to the field of genetic engineering drugs, and provides a mutein MuR6S4TR of TRAIL, and a preparation method and use thereof. The...
2018/0170992 CAR T CELLS RECOGNIZING CANCER-SPECIFIC IL 13Ra2
Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13R.alpha.2, a receptor polypeptide preferentially found on the...
2018/0170991 LONG-ACTING ADRENOMEDULLIN DERIVATIVES
There is provided a novel adrenomedullin derivative capable of sustainably acting for a longer period than natural adrenomedullin. The invention relates to a...
2018/0170990 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA...
2018/0170989 Targeted Modified TNF Family Members
The present invention relates to a modified cytokine of the TNF superfamily, with reduced activity to its receptor, wherein said modified cytokine is...
2018/0170988 BMP-7 PEPTIDES AND METHODS OF USE
The invention relates to truncated BMP-7 growth factors and variants thereof. The invention also relate to methods of making and using the truncated BMP-7...
2018/0170987 CRYPTIC POLYPEPTIDES AND USES THEREOF
The disclosure features, among other things, polypeptides comprising a Cryptic polypeptide, a functional fragment thereof, or variants of any of the foregoing....
2018/0170986 CANCER ANTIGEN HELPER PEPTIDE
The present invention relates to a WT1 peptide which has an amino acid sequence consisting of contiguous amino acids derived from a WT1 protein and induces...
2018/0170985 CRISPR-BASED METHODS AND PRODUCTS FOR INCREASING FRATAXIN LEVELS AND USES THEREOF
Methods and products (e.g., gRNAs, recombinant fusion proteins, frataxin targeting systems, compositions and kits) are described for increasing frataxin...
2018/0170984 SITE-SPECIFIC DNA BASE EDITING USING MODIFIED APOBEC ENZYMES
Materials and methods for using modified Cas9-APOBEC fusion polypeptides for targeted modification of specific DNA sequences are provided herein.
2018/0170983 New Use of Cell-Permeable Peptide Inhibitors of the JNK Signal Transduction Pathway for the Treatment of Mild...
The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun N-terminal...
2018/0170982 METHODS OF MODIFYING TRANSCRIPTIONAL REGULATORY NETWORKS IN STEM CELLS
The vast differentiation potential of human embryonic and induced pluripotent stem cells, including their potential to cascade through all of the somatic cell...
2018/0170981 RECOMBINANT POLYPEPTIDE FOR ENHANCING CELL TRANSDUCTION EFFICIENCY OF A TARGET AGENT
The invention provides a recombinant polypeptide X--Y for enhancing cell transduction efficiency of a target agent, wherein X is a cell penetrating peptide...
2018/0170980 NOVEL POLYPEPTIDE CAPABLE OF BINDING TO VASCULAR ENDOTHELIAL GROWTH FACTOR, AND USE THEREOF
The present disclosure relates to a novel polypeptide capable of binding specifically to vascular endothelial growth factor, a polynucleotide encoding the...
2018/0170979 FUSION PROTEINS FOR INHIBITING ANGIOGENESIS
The present invention relates to a biologic that inhibits angiogenesis. In particular, the present invention relates to fusion proteins that inhibit the...
2018/0170978 MODULAR ANTIGEN TRANSPORTATION MOLECULES AND USES THEROF
The present invention relates to (isolated) recombinant proteins, also referred to as improved MAT (iMAT) molecules, comprising at least one translocation...
2018/0170977 CYCLIC RGD CELL-BINDING MOTIF AND USES THEREOF
A recombinant fusion protein is comprising a spider silk fragment and a cyclic RGD cell-binding motif with selectivity for integrins, such as for ...
2018/0170976 PLANT TRANSCRIPTIONAL REGULATORS
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of...
2018/0170975 IMMUNOGENIC COMPOSITIONS COMPRISING MYCOBACTERIUM TUBERCULOSIS POLYPEPTIDES AND FUSIONS THEREOF
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and polynucleotides encoding such...
2018/0170974 VACCINE AGAINST S. SUIS INFECTION
The present disclosure relates to immunogenic polypeptides, immunogenic compositions and vaccine compositions and use thereof for immunization of mammals...
2018/0170973 IMMUNOGLOBULIN-BINDING MODIFIED PROTEIN
A protein includes two or more amino acid sequences, wherein each amino acid sequence is derived from a sequence selected from the group consisting of SEQ ID...
2018/0170972 Adenovirus Polynucleotides and Polypeptides
There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a...
2018/0170971 IMMUNOGENS FOR HIV VACCINATION
The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment...
2018/0170970 VIRAL CHIMERIC PARTICLE OF POTATO VIRUS X AND USE THEREOF FOR IN VITRO DIAGNOSIS OF SJOGREN SYNDROME
The present invention relates to a chimeric virus particle of potato virus X, said particle having, as a capsid protein, a fusion protein containing a capsid...
2018/0170969 COMPOSITIONS AND METHODS FOR TREATING DISEASES BY INHIBITING EXOSOME RELEASE
A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion...
2018/0170968 Poultry Farm Practices
The present invention relates to methods of improving the environment within a poultry farming facility including reducing ammonia production in a poultry...
2018/0170967 STAPLED PEPTIDES AND USES THEREOF
Cyclized peptides derived from the hyaluronan binding region of RHAMM are provided. Pharmaceutical compositions and methods for using the peptides and...
2018/0170966 PEPTIDE FOR SUPPRESSING OSTEOCLAST DIFFERENTIATION AND USE THEREOF
The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin...
2018/0170965 PEPTIDE HAVING ANTIMICROBIAL ACTIVITY AGAINST PATHOGENS AND ANTIMICROBIAL PEPTIDE COMPOSITION COMPRISING THE SAME
An antimicrobial peptide and an antimicrobial peptide composition comprising the same are provided. The antimicrobial peptide and the antimicrobial peptide...
2018/0170964 Novel Peptides and Analogs for Use in the Treatment of Oral Mucositis
Preclinical data obtained in models of chemotherapy-induced mucositis, radiation-induced mucositis, neutropenic infection and colitis indicate oral mucositis...
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