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Patent # Description
2018/0170963 CONOTOXIN PEPTIDE K-CPTX-BTL04, PREPARATION METHOD THEREFOR, AND USES THEREOF
Provided are a conotoxin peptide .kappa.-CPTx-btl04 and a derivative polypeptide. The amino acid sequence of the conotoxin peptide is indicated by SEQ ID NO:...
2018/0170962 COMPOUNDS FOR PROTEASOME ENZYME INHIBITION
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile...
2018/0170961 PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE COMPRISING THE PEPTIDE...
The present invention relates to a peptide separated from the fraction of oyster enzyme hydrate displaying the ability of suppressing angiotensin converting...
2018/0170960 Active-Form Mutant Enzyme Production Method, New Active-Form Mutant Enzyme, and Solubilized Mutant Protein...
A method for expressing, as a soluble protein or an active-form mutant enzyme, an enzyme that cannot be expressed as a soluble protein or an active-form enzyme...
2018/0170959 METHOD FOR PRODUCING ALPHA-FORM CRYSTAL OF REDUCED GLUTATHIONE, AND METHOD FOR STORING SAID CRYSTAL
The invention provides a method of efficiently and stably producing .alpha.-form crystal of reduced glutathione, and a preservation method thereof. According...
2018/0170958 CRYSTALLINE FORM A OF OBETICHOLIC ACID AND PREPARATION METHOD THEREOF
The present invention relates to crystalline Form A of obeticholic acid and the preparation method thereof. The present invention provides Form A having...
2018/0170957 HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS
Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.
2018/0170956 NOVEL PROCESS FOR PREPARING POLYOL GLYCOSIDES
A process for preparing a composition (C.sub.1) represented by the formula (I): HO--CH.sub.2--(CHOH).sub.n--CH.sub.2--O-(G).sub.x-H, in which G represents the...
2018/0170955 HEXOSE DERIVATIVES, PREPARATION AND USES THEREOF
A compound of formula I: ##STR00001## or a salt thereof, wherein: R.sup.1 is --OC(H)(X)(CH.sub.2).sub.nC(.dbd.O)OH; R.sup.2 is --OH, --N.sub.3, or ...
2018/0170954 Process
The present invention relates to improved processes for the preparation of ruthenium or osmium complexes comprising P and N donor ligands, in particular,...
2018/0170953 PROTOTYPE SYSTEMS OF THERANOSTIC BIOMARKERS FOR IN VIVO MOLECULAR MANAGEMENT OF CANCER
The present invention relates to a theranostic system comprising a beacon and a compound selected from the group consisting of a quinazoline-based tyrosine...
2018/0170952 PREPARATION OF RHODIUM(III)-2-ETHYLHEXANOATE
The present invention provides a method for preparing rhodium (III) 2-ethylhexanoate solutions which supplies the reaction product with higher space yield, as...
2018/0170951 AMIDE-LINKED EP4 AGONIST-BISPHOSPHONATE COMPOUNDS AND USES THEREOF
The present invention relates to conjugate compounds and methods of making and using same.
2018/0170950 PROCESS FOR SEPARATING ALUMINUM CHLORIDE FROM SILANES
Aluminum chloride is separated from a silane mixture containing aluminum chloride by reacting the aluminum chloride with a compound reactive therewith which...
2018/0170949 SYNTHESIS OF CEPHALOSPORIN COMPOUNDS
Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.
2018/0170948 COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1.alpha., GSPT1, aiolos, and/or...
2018/0170947 HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Compounds of formula (I): ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.13, R.sub.a, R.sub.b, A and n are as defined...
2018/0170946 INHIBITORS OF PTP4A3 FOR THE TREATMENT OF CANCER
The invention provides protein tyrosine phosphatase inhibitor compounds, Their pharmaceutical compositions, uses, and methods of use, such as in the treatment...
2018/0170945 CRYSTALLINE FORMS OF DARUNAVIR
The present invention relates to novel crystalline forms of darunavir, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral...
2018/0170944 USE OF THE FL-ONE HUNDRED EIGHTEEN CORE CHEMICAL STRUCTURE PLATFORM TO GENERATE FL-ONE HUNDRED EIGHTEEN...
Described herein, are FL118 core structure platform compounds, matter of compositions, formulation, methods and uses for treating cancer or other human...
2018/0170943 PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
The present invention relates to a piperidine derivative and the preparation method and a pharmaceutical use thereof. In particular, the present invention...
2018/0170942 POLYCYCLIC DERIVATIVES TARGETING RAL GTPASES AND THEIR THERAPEUTICAL APPLICATIONS
Contemplated compounds, compositions and methods are directed to Ral GTPase inhibitors with improved activity.
2018/0170941 BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT
This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods...
2018/0170940 CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
2018/0170939 BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO- KINASE INHIBITORS
Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be useful in the treatment of many disorders...
2018/0170938 BICYCLIC HETEROARYL DERIVATIVES AS CFTR POTENTIATORS
The present invention relates to 1,3-disubstituted-1H-pyrazolo[3,4-d]pyrimidin-4-amine derivatives, 5,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazin-4-amine...
2018/0170937 NEW SOLID FORMS OF SITAGLIPTIN
New amorphous solid phases of sitagliptin with derivatives of hydroxybenzoic acids, dihydroxybenzoic acids and trihydroxybenzoic acids as coformers; the...
2018/0170936 PROCESS FOR THE PREPARATION OF BENZIMIDAZO[1,2-A] BENZIMIDAZOLES
The present invention relates to process for the preparation of a compound of formula (I), comprising heating a compound of formula (II) in the presence of a...
2018/0170935 3,3-DIFLUOROPIPERIDINE CARBAMATE HETEROCYCLIC COMPOUNDS AS NR2B NMDA RECEPTOR ANTAGONISTS
Disclosed are chemical entities of Formula (I), wherein R.sup.1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are...
2018/0170934 FOLATE DERIVATIVES, USEFUL IN PARTICULAR IN THE CONTEXT OF THE FOLATE ASSAY
Use of a folate derivative to assay in vitro the folate in a sample such as a biological sample.
2018/0170933 PURINONE DERIVATIVE
Compounds represented by general formula (I) (all of the symbols in the formula conform to the definitions in the Description) are compounds that, in addition...
2018/0170932 PURINE DIONES AS WNT PATHWAY MODULATORS
The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R.sup.1,...
2018/0170931 Small Molecule Inhibitors of the JAK Family of Kinases
2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)ace- tonitrile compounds, pharmaceutical compositions containing them, methods of making...
2018/0170930 1,6- DIAZABICYCLO [3,2,1] OCTAN-7-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed. ##STR00001##
2018/0170929 PYRIMIDINE-2,4-DIAMINE DERIVATIVES FOR TREATMENT OF CANCER
A compound of formula I, ##STR00001## or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may...
2018/0170928 Methyl- and Trifluoromethyl-Substituted Pyrrolopyridine Modulators of RORC2 and Methods of Use Thereof
The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR.gamma....
2018/0170927 INHIBITORS OF RIP1 KINASE AND METHODS OF USE THEREOF
The invention provides novel compounds having RIP1 kinase inhibitory activity, pharmaceutical compositions including the compounds and methods of using the...
2018/0170926 CRYSTAL OF 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE
A crystal of a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof has an excellent LCAT-activating effect and is...
2018/0170925 NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF HBV INFECTION
The disclosure includes compounds of Formula (I) ##STR00001## wherein Z.sub.1, Z.sub.2, Z.sub.3, X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and...
2018/0170924 PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY
Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity...
2018/0170923 COMPOUNDS FOR THE TREATMENT OF CANCER
The present invention relates to a FoxM1 gene splicing modifier selected from a compound of formula (I) or of formula (VI) ##STR00001## wherein A and B are as...
2018/0170922 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable...
2018/0170921 3-(6-ALKOXY-5-CHLOROBENZO[D]ISOXAZOL-3-YL)PROPANOIC ACID USEFUL AS KYNURENINE MONOOXYGENASE INHIBITORS
The present invention relates to a compound of formula (I) ##STR00001## or pharmaceutically acceptable salts thereof, which are Kynurenine monooxygenase (KMO)...
2018/0170920 3-(6-CHLORO-3-OXO-3,4-DIHYDRO-(2H)-1,4-BENZOXAZIN-4-YL) PROPANOIC ACID DERIVATIVES AND THEIR USE AS KMO INHIBITORS
Compounds of formula (I) ##STR00001## wherein: R.sup.1 is heteroaryl optionally substituted by methyl, ethyl, halo or .dbd.O; and R.sup.2 is H, methyl or...
2018/0170919 CRYSTALINE FORMS OF N-[6-(CIS-2,6-DIMETHYLMORPHOLINE -4-YL)PYRIDINE-3-YL]-2-METHYL-4'-(TRIFLUOROMETHOXY) ...
The present disclosure relates to novel crystalline forms of N-[6-(cis-2,6-dimethylmorpholine-4-yl)pyridine-3-yl]-2-methyl-4'-(trifluo- romethoxy)...
2018/0170918 METHODS OF SYNTHESIZING A DIFLUOROLACTAM ANALOG
The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R.sup.1, R.sup.4, R.sup.5, R.sup.6, and L.sup.1...
2018/0170917 COMPOUNDS AND COMPOSITIONS AS RAF KINASE INHIBITORS
The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment...
2018/0170916 INHIBITORS OF CXCR2
Compounds are provided as inhibitors of CXCR2, having the structure: ##STR00001##
2018/0170915 5-BROMO-INDIRUBINS
Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.
2018/0170914 II(PI)-CONJUGATED COMPOUND, ORGANIC ELECTROLUMINESCENCE ELEMENT MATERIAL, LIGHT-EMITTING MATERIAL,...
In order to provide a novel .pi.-conjugated compound capable of increasing the light-emission efficiency of an organic electroluminescence element, for...
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