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Patent # Description
2018/0170913 MALEATE SALTS OF A QUINAZOLINE DERIVATIVE USEFUL AS AN ANTIANGIOGENIC AGENT
The present invention relates to AZD2171 maleate salt, to particular crystalline forms of AZD2171 maleate salt, to processes for their preparation, to...
2018/0170912 SALICYLATE INHIBITORS OF MELK AND METHODS OF USE
Provided herein are small molecule inhibitors of maternal embryonic leucine zipper kinase (MELK) having the structure of formula (I), ##STR00001## wherein X and...
2018/0170911 PYRROLCARBOXAMIDE DERIVATIVES FOR THE INHIBITION OF ERK5
The invention provides compounds of formula (I) ##STR00001## or a tautomer, stereoisomer, N-oxide, pharmaceutically acceptable salt or solvate thereof. The...
2018/0170910 ALPHA-HELIX MIMETICS AS MODULATORS OF ABETA SELF-ASSEMBLY
The invention relates to compounds and pharmaceutical compositions capable of treating amyloid diseases and other diseases characterized by oligomerization...
2018/0170909 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS
Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1....
2018/0170908 GLP-1 Agonists and Uses Thereof
Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said...
2018/0170907 SALTS OF A PIM KINASE INHIBITOR
The present invention relates to salt forms of the Pim kinase inhibitor N-{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy- ...
2018/0170906 THERAPEUTIC INHIBITORY COMPOUNDS
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma...
2018/0170905 Method for Producing Sulfonyl Chloride Compound
An object of the present invention is to provide a production method of an intermediate used in the production method of a sulfonylpyrrole compound useful as a...
2018/0170904 PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the...
2018/0170903 PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the...
2018/0170902 COMPOUND AND ORGANIC ELECTRONIC DEVICE COMPRISING SAME
The present specification relates to a compound and an organic electronic device including the same.
2018/0170901 LIGHT EMITTING MATERIAL, MANUFACTURE METHOD THEREOF AND ORGANIC LIGHT EMITTING DIODE USING THE LIGHT EMITTING...
The present invention provides a light emitting material, a manufacture method thereof and an organic light emitting diode using the light emitting material....
2018/0170900 LIGHT EMITTING MATERIAL, MANUFACTURE METHOD THEREOF AND ORGANIC LIGHT EMITTING DIODE USING THE LIGHT EMITTING...
The present invention provides a light emitting material, a manufacture method thereof and an organic light emitting diode using the light emitting material....
2018/0170899 LIGHT EMITTING MATERIAL, MANUFACTURE METHOD THEREOF AND ORGANIC LIGHT EMITTING DIODE USING THE LIGHT EMITTING...
The present invention provides a light emitting material, a manufacture method thereof and an organic light emitting diode using the light emitting material....
2018/0170898 BETA- AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS
Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that...
2018/0170897 HUMAN GLUT5 SPECIFIC INHIBITORS AND METHODS OF TREATMENT
The present invention relates to compounds which have been discovered to be potent ligands (inhibitors) of human GLUT5 (glucose transporter type 5), a...
2018/0170896 METHODS OF PREPARING OXA-BICYCLOALKENE
Disclosed is a method of preparing an oxa-bicycloalkene via the reaction of a cycloalkanone and an allyl alcohol compound in the presence of an organic acid, a...
2018/0170895 Mitochondria-Targeted Lapachone Compounds and Uses Therefor
Compounds, compositions and methods useful for treating cancer and neiirodegeneration are provided. The compounds comprise a mitochondria-targeting moiety...
2018/0170894 LIGHT EMITTING MATERIAL, MANUFACTURE METHOD THEREOF AND ORGANIC LIGHT EMITTING DIODE USING THE LIGHT EMITTING...
The present invention provides a light emitting material, a manufacture method thereof and an organic light emitting diode using the light emitting material....
2018/0170893 LIGHT EMITTING MATERIAL, MANUFACTURE METHOD THEREOF AND ORGANIC LIGHT EMITTING DIODE USING THE LIGHT EMITTING...
The present invention provides a light emitting material, a manufacture method thereof and an organic light emitting diode using the light emitting material....
2018/0170892 COMPOUND FOR THE PROPHYLAXIS OR TREATMENT OF ORGAN DAGAMAGE
The present invention relates to compounds for prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen...
2018/0170891 4H-Pyran Compounds as Insulin-Regulated Aminopeptidase (IRAP) Inhibitors
The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to...
2018/0170890 PROCESS FOR THE PREPARATION OF A FURFURAL DERIVATIVE
A furfural derivative having the chemical formula (1) ##STR00001## wherein R represents hydrogen, an alkyl group or an acyl group, is prepared in a process,...
2018/0170889 Simplified Structural Mimetics of AIPS as Quorum Sensing Inhibitors
Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas...
2018/0170888 BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND/OR INFECTIOUS DISEASES
The present invention relates to bicyclic tetrahydrothiazepine of formula (I), wherein R.sup.1 to R.sup.3, X.sup.1, X.sup.2 and R.sup.18 have the meaning as...
2018/0170887 NOVEL HETEROARYL BUTANOIC ACID DERIVATIVES
The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase...
2018/0170886 PROCESS FOR THE PREPARATION OF TRIAZINES
The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I) wherein R.sup.1 is a C.sub.1C.sub.18alkyl group or...
2018/0170885 NOVEL PROCESS FOR THE ETHERIFICATION OF BIS-RESORCINYOL TRIAZINES
The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I), wherein R.sup.1 is hydrogen, a ...
2018/0170884 ANTI-HCMV COMPOSITIONS AND METHODS
This document relates to compounds useful as agents for preventing or treating human cytomegalovirus (HCMV) infections.
2018/0170883 HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME
The present invention, among other things, provides compounds and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present...
2018/0170882 N-METHYLBENZIMIDAZOLES AS MIDH1 INHIBITORS
The present invention relates to benzimidazol-2-amines of general formula (I), in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and...
2018/0170881 NOVEL BENZIMIDAZOLE COMPOUND AND MEDICAL USE THEREOF
The present invention provides a medicament for treating a disease involving Nav 1.7 such as neuropathic pain, nociceptive pain, inflammatory pain, small-fiber...
2018/0170880 METHOD FOR PRODUCING 1-(ACYLOXY)ALKYL CARBAMATE DERIVATIVE
A method for producing a 1-(acyloxy)alkyl carbamate derivative (III), using a fluorous alkyl carbonate derivative (I), and a fluorous alkyl carbonate...
2018/0170879 PYRAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
[Problem] The present invention is to provide a novel pyrazole derivative, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition...
2018/0170878 PHOTOCROSSLINKING REAGENTS AND METHODS OF USE THEREOF
Provided herein are photocrosslinking reagents, crosslinkable proteins displaying photocrosslinking groups, crosslinked protein-protein complexes, and methods...
2018/0170877 ROR GAMMA (RORY) MODULATORS
Compounds according to Formula I: ##STR00001## or a pharmaceutically acceptable salt wherein: A.sub.1 is NR.sub.1 or CR.sub.1, with R.sub.1 herein; the...
2018/0170876 NOVEL HISTONE DEACETYLASE INHIBITORS
The present invention is a compound of the formula or a pharmaceutically acceptable salt thereof. The compounds are useful as HDAC inhibitors. ##STR00001##
2018/0170875 COMPOSITION AND METHODS FOR MODULATING A KINASE CASCADE
The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention also relates to substantially pure...
2018/0170874 HETEROCYCLIC COMPOUND
The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital...
2018/0170873 RESIN COMPOSITIONS
The present disclosure is directed to resins and to polymers, copolymers, and blends formed therefrom.
2018/0170872 NOVEL-ALKYNYL-SUBSTITUTED 3-PHENYLPYRROLIDINE-2,4-DIONES AND USE THEREOF AS HERBICIDES
Novel alkynyl-substituted 3-phenylpyrrolidine-2,4-diones and use thereof as herbicides The present invention relates to novel effective alkynyl-substituted ...
2018/0170871 CRYSTALLINE FORMS
This invention relates to crystalline forms of (R)-1-(1-(methylsulfonyl)propan-2-yl)-4-(trifluoromethyl)indoline-5-carbo- nitrile, a modulator of the androgen...
2018/0170870 5-BROMO-INDIRUBINS
Disclosed herein are compositions and methods for treating cancer, FLT3-AML, and CML.
2018/0170869 BENZENESULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T))
Benzenesulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of...
2018/0170868 PSYCHOTROPIC AGENTS AND USES THEREOF
Novel amisulpride derivatives and pharmaceutical compositions thereof are disclosed. The amisulpride derivative disclosed herein or a pharmaceutical...
2018/0170867 STEREOSELECTIVE SYNTHESIS OF 9-CIS.13,14-DIHYDRORETINOIC ACID AND ITS ETHYL ESTERS
The retinoid X receptors (RXRs) are ligand-activated transcription factors heterodimerize with a number of nuclear hormone receptors, thereby controlling a...
2018/0170866 IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
What is described is a compound of formula I ##STR00001## consisting of a compound in which R.sub.1 is a branched chain alkyl consisting of 10 to 31 carbons;...
2018/0170865 IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
What is described is a compound of formula I ##STR00001## wherein R.sub.1 is a linear alkyl, alkenyl, or alkynyl of 2 to 12 carbons, or a branched alkyl with...
2018/0170864 PROCESS FOR OXIDIZING ONE OR MORE THIOL COMPOUNDS AND SUBSEQUENT SEPARATION IN A SINGLE VESSEL
One exemplary embodiment can be a process for oxidizing one or more thiol compounds from an alkaline stream. The process may include passing a mixed stream...
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