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Patent # Description
2018/0169142 METHODS, MEANS AND COMPOSITIONS FOR IMPROVING OUTCOMES OF SURGICAL INTERVENTIONS AND INFLAMMATORY SEQUEL
Disclosed are methods, means and compositions of matter useful for improving outcomes after surgical interventions, said improvements including reduction of...
2018/0169141 INJECTABLE HYDROGELS THAT PROMOTE MINERALIZATION AND AFFORD SUSTAINED RELEASE OF BIOACTIVE IONS
The present invention provides a hybrid hydrogel stabilized by multivalent cross-linking domains. The hydrogel combines inorganic nanoparticles along with an...
2018/0169140 ANTIBIOTIC COMPOSITIONS AND METHODS OF USE
The present disclosure describes compositions comprising .beta.-lactam antibiotics and branched poly-ethylenimines (BPEI), having efficacy against various...
2018/0169139 COMPOSITION AND METHODS FOR TREATMENT OF LOSS OF FLUIDS LEADING TO HYPOTENSION AND/OR HYPOVOLEMIA
The present invention is directed to a composition containing at least one salt, at least one natural or synthetic saccharide, and at least one natural or...
2018/0169138 Use Of Gastrointestinally Administered Porous Enteron Sorbent Polymers To Prevent Or Treat Radiation Induced...
Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal...
2018/0169137 COMPOSITIONS AND METHODS COMPRISING GROWTH FACTORS, CHONDROITIN AND GLUCOSAMINE FOR DEGENERATIVE DISC REGENERATION
There is disclosed herein compositions, methods, uses and systems for reducing pain in a patient that emanates from a body area, preferably spine or joint....
2018/0169136 USE OF PHARMACEUTICAL COMPOSITION IN PREPARATION OF DRUG FOR PROMOTING CHONDROCYTE GENERATION
The present invention relates to a use of a pharmaceutical composition in the preparation of a drug for promoting chondrogenesis, wherein the pharmaceutical...
2018/0169135 METHOD FOR PREVENTING TRANSPLANT FAILURE IN A HOST
This invention is in the field of medical treatment, in particular the invention provides a method for the prevention, amelioration or reduction of transplant...
2018/0169134 CHITOSAN MATERIALS FROM CARBONIC ACID SOLUTION
The present invention comprises chitosan materials and methods of using carbonic acid for aqueous solubilization of neutralized or pre-treated chitosan gels...
2018/0169133 Pet Food Compositions
Described herein are pet food compositions comprising a blood glucose management component comprising soy isoflavone and yeast beta-glucan (.beta.-glucan);...
2018/0169132 COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using...
2018/0169131 ALLELE SPECIFIC MODULATORS OF P23H RHODOPSIN
The present embodiments provide methods, compounds, and compositions for treating, preventing, ameliorating, or slowing progression of retinitis pigmentosa...
2018/0169130 COMBINED THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY
The present invention relates to the combined use of antisense oligonucleotides and viral vectors for the treatment of Duchenne muscular dystrophy.
2018/0169129 POLYNUCLEOTIDE AGENTS TARGETING ANGIOTENSINOGEN (AGT) AND METHODS OF USE THEREOF
The invention relates to polynucleotide agents, e.g., antisense polynucleotide agents, targeting an angiotensinogen (AGT) gene, and methods of using such...
2018/0169128 IMMUNOASSAY OF S-ADENOSYLMETHIONINE USING ANALOGS THEREOF AND PERSONALIZED THERAPEUTICS
A method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine...
2018/0169127 COMPOSITIONS AND METHODS THAT MODULATE WHITE BLOOD CELLS OR NEUTROPHILS IN A COMPANION ANIMAL
White blood cells and/or neutrophils in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which...
2018/0169126 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF
The present invention relates to certain SGLT-2 inhibitors for treating, preventing, protecting against and/or delaying the progression of chronic kidney...
2018/0169125 COMPOSITIONS OF MULTICATIONIC DRUGS FOR REDUCING INTERACTIONS WITH POLYANIONIC BIOMOLECULES AND METHODS OF USE...
The present invention relates, in part, to a composition comprising a multicationic drug and an organic multianion. In some embodiments, the multicationic drug...
2018/0169124 SUSTAINED RELEASE OF ANTIINFECTIVES
Provided, among other things, is a method of treating or ameliorating pulmonary infection in a cystic fibrosis patient comprising pulmonary administration of...
2018/0169123 COMBINATION THERAPY WITH A FLAVAGLINE AND 2-DEOXYGLUCOSE
The present invention relates to a combined preparation comprising 2-deoxyglucose and a flavagline and to the use of said combined preparation as a medicament...
2018/0169122 SYNTHETIC COMPOSITION AND METHOD FOR TREATING IRRITABLE BOWEL SYNDROME
The application relates to a method for treating a patient with irritable bowel syndrome (IBS), the method comprising administering to the patient a mixture...
2018/0169121 NUTRITIONAL FORMULATIONS INCLUDING HUMAN MILK OLIGOSACCHARIDES AND ANTIOXIDANTS AND USES THEREOF
Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that...
2018/0169120 COMBINATION THERAPY INCLUDING SAPC-DOPS FOR THE TREATMENT OF PANCREATIC CANCER
Disclosed herein, according to the present invention, are methods of treating pancreatic cancer comprising administering a first pharmaceutical composition...
2018/0169119 COMPOSITIONS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING LOW BACK PAIN
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid form or a salt form, such as a disodium salt form, can be used to treat or...
2018/0169118 NOVEL PRODRUG SALTS
Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel...
2018/0169117 PHARMACEUTICAL FORMULATION COMPRISING A SUBSTITUTED PHENYL - (1,3-DIHYDRO-ISOINDOL-2-YL) - METHANONE
Provided herein are formulations of (2,4-dihydroxy-5-isopropyl-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3- -dihydro-isoindol-2-yl]-methanone of formula...
2018/0169116 TREATMENT OF OTITIS MEDIA WITH RETROAURICULAR INJECTION OF AN ANTI-INFLAMMATORY DRUG
The present invention relates to the treatment of otitis media, in particularly secretory otitis media, with an anti-inflammatory drug such as a steroid or a...
2018/0169115 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION
The present invention relates to methods and pharmaceutical compositions for the treatment of hepatitis B virus infection. In particular, the present invention...
2018/0169114 METHODS FOR REDUCING CELLULAR PROLIFERATION AND TREATING CERTAIN DISEASES
Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and...
2018/0169113 HIGH CONCENTRATION FORMULATION
The present disclosure provides high concentration formulations of cortexolone-17.alpha.-propionate suitable for treating alopecia.
2018/0169112 PHARMACEUTICAL USE
The invention relates to the use of a pharmaceutical medication comprising an aromatase inhibitor, preferably a steroidal aromatase inactivator and an...
2018/0169111 METHODS AND COMPOSITIONS FOR TOPICAL DELIVERY OF PROSTAGLANDINS TO SUBCUTANEOUS FAT
Described herein are compositions comprising a prostaglandin FP receptor agonist (PFPRA) compound and a fatty acid, e.g., oleic acid, that, when topically...
2018/0169110 Nrf2 REGULATORS
The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
2018/0169109 TARGETED PROTEIN DEGRADATION TO ATTENUATE ADOPTIVE T-CELL THERAPY ASSOCIATED ADVERSE INFLAMMATORY RESPONSES
This invention is in the area of compositions and methods for regulating chimeric antigen receptor immune effector cell, for example T-cell (CAR-T), therapy to...
2018/0169108 Drug Combinations For the Treatment of HIV
Provided herein are effective latency-reversing agent (LRA) combinations of drugs for the reversal of HIV-1 latency. Such methods utilize, for example, the...
2018/0169107 METHODS FOR TREATING HYPERSOMNIA
Provided herein are methods, formulations and dosing regimens for treating hypersomnia in a subject. For instance, methods provided herein comprise...
2018/0169106 CEFTOLOZANE-TAZOBACTAM PHARMACEUTICAL COMPOSITIONS
Pharmaceutical compositions are provided in unit dosage forms comprising ceftolozane and tazobactam in separate unit dosage form containers, ceftolozane...
2018/0169105 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS
The present invention relates to interferon-gamma (IFN-.gamma.) inhibitors, and their utility in treating or controlling diseases that can be treated or...
2018/0169104 FUSED, SPIROCYCLIC HETEROAROMATIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
Disclosed are methods for treating various bacterial infections with (2R,4S,4aS)-11-fluoro-2,4-dimethyl-8-[(4S)-4-methyl-2-oxo-1,3-oxazolidin-- ...
2018/0169103 METHODS OF IMPROVING MYOCARDIAL PERFORMANCE IN FONTAN PATIENTS USING UDENAFIL COMPOSITIONS
The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan...
2018/0169102 Composition for Inducing Differentiation and Protection of Neural Stem Cells and Method for Inducing...
The present invention relates to a method of inducing neuro-regeneration comprising administering a MEK 1/2 inhibitor to a patient in need thereof. In the...
2018/0169101 METHODS FOR TREATING CANCER
Disclosed herein are methods of inhibiting tumor growth or producing tumor regression in a subject by administering to the subject a therapeutically effective...
2018/0169100 Cancer Stem Cell Targeting Compounds
The present invention provides compounds of formula (I), compositions, uses thereof and methods for inhibiting proliferation or obliterating cancer stem cells...
2018/0169099 HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof,...
2018/0169098 SMALL MOLECULES TARGETING HIV-1 NEF
A method of treating HIV in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound having a general...
2018/0169097 COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
The present disclosure provides combination therapy of a transcription inhibitor and a kinase inhibitor. The combination of the transcription inhibitor and the...
2018/0169096 HETEROCYCLIC COMPOUNDS FOR TREATING PSORIASIS
Disclosed herein is a method of treating psoriasis involving the use of compound of formula I and/or a pharmaceutically acceptable salt thereof ##STR00001##
2018/0169095 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF...
Use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and healing of Digital Ulcers which are concomitant to...
2018/0169094 PYRIMIDINE PYRAZOLYL DERIVATIVES AND THEIR USE AS IRAK INHIBITORS
The present invention provides compounds of Formula (II) for the treatment of cancer, rheumatoid arthritis and other diseases. ##STR00001##
2018/0169093 USE OF A STATIN COMPOUND AS LOCAL DRUG FOR TREATING OBESITY, DIABETES, HYPERTENSION AND HYPERLIPEMIA
The invention discloses a use of a statin compound in the preparation of local drugs for improving lipid metabolism and treating obesity, hypertension,...
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