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Patent # Description
2018/0179566 HIGH-PURITY GALACTOOLIGOSACCHARIDE COMPOSITIONS, PREPARATIONS, AND APPLICATIONS THEREOF
Provided is a method of preparing a high-purity galactooligosaccharide composition by fermentation of a low-purity galactooligosaccharide mixture with a yeast...
2018/0179565 LOV-D ACYLTRANSFERASE MEDIATED ACYLATION
Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii)...
2018/0179564 APPARATUS AND METHODS FOR BIOSYNTHETIC PRODUCTION OF CANNABINOIDS
The present invention provides an apparatus and methods for producing tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA) and cannabichromenic...
2018/0179563 METHOD FOR PRODUCING SPHINGOID BASE OR SPHINGOLIPID
A method for producing an objective substance such as sphingoid bases and sphingolipids using yeast is provided. An objective substance is produced by...
2018/0179562 METHOD FOR PRODUCING PHYTOSPHINGOSINE OR SPHINGANINE
A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by...
2018/0179561 Methods and Compositions For Making Ephedrine and Related Alkaloid Compounds
Methods for making alkaloid compounds, including ephedrine and derivatives thereof. The methods involve the performance of an N-methyltransferase catalyzed...
2018/0179560 METHODS FOR PRODUCING BIOMASS RICH IN DHA, PALMITIC ACID AND PROTEIN USING A EUKARYOTIC MICROORGANISM
Provided herein are eukaryotic microorganisms having a simple lipid profile comprising long chain fatty acids (LCFAs). Also provided are compositions and...
2018/0179559 Biological and Chemical Process Utilizing Chemoautotrophic Microorganisms for the Chemosynthetic Fixation of...
The invention described herein presents compositions and methods for a multistep biological and chemical process for the capture and conversion of carbon...
2018/0179558 MICROORGANISMS AND METHODS FOR THE CO-PRODUCTION OF ETHYLENE GLYCOL AND THREE CARBON COMPOUNDS
The present application relates to recombinant microorganisms useful in the biosynthesis of monoethylene glycol (MEG) and one or more three-carbon compounds...
2018/0179557 YEAST ORGANISM PRODUCING ISOBUTANOL AT A HIGH YIELD
The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant...
2018/0179556 BUTANOL EXPRESSION CASSETTE, RECOMBINANT PLASMID AND BUTANOL PRODUCTION RELATED GENE EXPRESSION METHOD
A butanol expression cassette includes a butanol production related genes and a fermentation regulatory element. The fermentation regulatory element controls...
2018/0179555 TARGETED GENE DELIVERY FOR DENDRITIC CELL VACCINATION
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus...
2018/0179554 HUMAN TYPE 55 REPLICATION DEFECTIVE ADENOVIRUS VECTOR, METHOD FOR PREPARING SAME AND USES THEREOF
Provided are a human type 55 replication defective adenovirus vector, a method for preparing the same and uses thereof. The human type 55 replication defective...
2018/0179553 COMPOSITIONS AND METHODS FOR NUCLEIC ACID AND/OR PROTEIN PAYLOAD DELIVERY
Provided are methods and compositions for nanoparticle delivery of payloads (e.g., nucleic acid and/or protein payloads) to cells. In some embodiments, a...
2018/0179552 Methods for Inducing Apomixis in Plants
The present invention relates to methods for inducing apomixis in a plant, methods for the production of apomictic plants and the plants and plant seeds...
2018/0179551 TRANSGENIC PLANT COMPRISING A POLYNUCLEOTIDE ENCODING A VARIABLE DOMAIN OF HEAVY-CHAIN ANTIBODY
This disclosure relates to a transgenic plant or plant tissue. In particular this disclosure relates to a transgenic plant or plant tissue or plant cell...
2018/0179550 PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES
The present invention provides a plant or plant part comprising a polynucleotide encoding a wildtype or mutant TriA polypeptide, the expression of said...
2018/0179549 METHODS AND MEANS FOR OBTAINING MODIFIED PHENOTYPES
Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably...
2018/0179548 MOLECULAR BIOLOGY TOOLS FOR ALGAL ENGINEERING
The present invention provides compositions and methods for the genetic manipulation of Algal cells. The compositions and methods allow enhanced transfer of...
2018/0179547 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and...
2018/0179546 OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for...
2018/0179545 REDUCTION OF LIPASE ACTIVITY IN PRODUCT FORMULATIONS
The invention relates a method for producing a stable recombinant protein, comprising growing a non-naturally occurring host cell in a culture medium to...
2018/0179544 MEDICINE FOR TREATING CANCER AND METHOD FOR TREATING CANCER
An object of the present invention is to reveal a role of a stem cell control factor including Matrin-3 in cancer exhibiting neural differentiation including...
2018/0179543 DEVICE AND METHOD TO TREAT ESOPHAGEAL DISORDERS
Described are devices for treating disease in subjects wherein the devices include a sponge comprising a hydrogel, extracellular vesicles (EVs), and an agent....
2018/0179542 OLIGONUCLEOTIDE TARGETING STRATEGY FOR cccDNA
The present disclosure provides oligonucleotide compositions that target the covalently closed circular (ccc) DNA of hepatitis B virus (HBV). Also disclosed...
2018/0179541 Modified L-Nucleic Acid
A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in...
2018/0179540 FUNCTIONAL LIGANDS TO OPIOIDS AND OPIOID METABOLITES
The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for...
2018/0179539 RNA HYDROGELS
Disclosed herein are RNA molecules with particular nucleotide sequences that, through Watson-Crick base pairing, enable the RNAs to form a hydrogel.
2018/0179538 ANTISENSE NUCLEIC ACIDS
Provided is a drug that allows highly-efficient skipping of exon 51 in the human dystrophin gene. The present invention provides an antisense oligomer which...
2018/0179537 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179536 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179535 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179534 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179533 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179532 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179531 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179530 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179529 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179528 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0179527 MODULATION OF BCL11A FOR TREATMENT OF HEMOGLOBINOPATHIES
The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A...
2018/0179526 Method and Medicament For Inhibiting The Expression of A Given Gene
The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA...
2018/0179525 METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION
The present disclosure provides compositions with a modulating gene expression and methods for modulating transcription.
2018/0179524 COMPOSITIONS AND METHODS FOR INHIBITING CELL PROLIFERATION
The present disclosure provides, among other things, compounds that inhibit the expression or activity of gene products having a synthetic lethal interaction...
2018/0179523 CRISPR-BASED COMPOSITIONS AND METHODS OF USE
This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified...
2018/0179522 TUNABLE ENDOGENOUS PROTEIN DEGRADATION
The present invention provides a means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knock-out...
2018/0179521 MODIFIED CRISPR RNA AND MODIFIED SINGLE CRISPR RNA AND USES THEREOF
The present disclosure provides compounds comprising modified oligonucleotides for use in CRISPR. In certain embodiments, such modified oligonucleotides...
2018/0179520 SCAFFOLDED NUCLEIC ACID POLYMER PARTICLES AND METHODS OF MAKING AND USING
The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow...
2018/0179519 PEPTIDE LIBRARY CONSTRUCTING METHOD AND RELATED VECTORS
An improved peptide library preparation method is described for constructing complete peptide libraries such as a complete tripeptide library, tetrapeptide...
2018/0179518 IDENTIFYING GENES INVOLVED IN ANTIBIOTIC RESISTANCE AND SENSITIVITY IN BACTERIA USING MICROCULTURES
Described is a method for identifying a gene which mediates antibiotic sensitivity or resistance in a target bacterium, the method comprising the steps of: (a)...
2018/0179517 Monoliths with Attached Recognition Compounds, Arrays Thereof and Uses Thereof
Provided herein are monoliths with attached recognition compounds which selectively bind ligands, methods of preparing such monoliths, arrays thereof and uses...
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