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Patent # Description
2018/0179263 ENDOSTATIN FRAGMENTS AND VARIANTS FOR USE IN TREATING FIBROSIS
Materials and methods for using polypeptides containing fragments and variants of endostatin to treat fibrosis are described herein.
2018/0179262 Compounds Suitable for Treatment of Haemophilia
The present invention relates to VWF compounds as well as compositions suitable for treatment of blood clotting diseases.
2018/0179261 TGF-BETA RECEPTOR TYPE II VARIANTS AND USES THEREOF
In certain aspects, the present disclosure relates to polypeptides comprising a truncated, ligand-binding portion of the extracellular domain of T.beta.RII...
2018/0179260 REDIRECTED CELLS WITH MHC CHIMERIC RECEPTORS AND METHODS OF USE IN IMMUNOTHERAPY
Chimeric receptors featuring major histocompatibility molecules grafted onto T cell receptor molecules and surrogate co-receptors featuring cell surface...
2018/0179259 Methods for the Treatment and Diagnosis of Alzheimer's Disease and Traumatic Brain Injuries
The invention relates to the use of HNRNPC-expressing vectors for preventing and/or treating a tauopathy, such as Alzheimer's disease. The invention relates to...
2018/0179258 FCRN ANTAGONISTS AND METHODS OF USE
Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH...
2018/0179257 HPV VACCINES
Provided herein are genetically modified arenaviruses suitable as vaccines against neoplastic diseases or cancer. The invention also relates to pharmaceutical...
2018/0179256 Modified H7 Hemagglutinin Glycoprotein of the Influenza A/Shanghai/2/2013 H7 Sequence
The present invention is directed to a sequence modification of the H7 hemagglutinin glycoprotein of the Influenza A/Shanghai/2/2013 H7 sequence together with...
2018/0179255 HEPARIN-BINDING CATIONIC PEPTIDE SELF-ASSEMBLING PEPTIDE AMPHIPHILES USEFUL AGAINST DRUG-RESISTANT BACTERIA
Disclosed are peptides comprising an amphiphilic backbone and a cationic heparin-binding motif peptide. The peptides can be used in methods of antimicrobial...
2018/0179254 NOVEL PEPTIDE
Provided are a novel peptide, a polynucleotide encoding the peptide, an expression vector including the polynucleotide, and a pharmaceutical composition...
2018/0179253 CELL PENETRATING PEPTIDES FOR INTRACELLULAR DELIVERY OF MOLECULES
A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of XWXRLXXXXXX (SEQ ID No: 5), wherein X in position 1 is...
2018/0179252 BACE1 INHIBITOR PEPTIDES
The present invention relates to dual-site BACE1 inhibitors, their manufacture, pharmaceutical compositions containing them and their use as therapeutically...
2018/0179251 NOVEL ANTIBACTERIAL AND FUNGICIDAL PEPTIDE IN WHICH LYSINE AND TRYPTOPHAN RESIDUES ARE REPEATED, AND USE THEREOF
The present invention relates to an antibacterial and fungicidal peptide in which a lysine and tryptophan dipeptide is repeated. More specifically, the...
2018/0179250 LIGAND IMMOBILIZATION METHOD
A method for immobilizing a ligand on a formyl group-containing insoluble base material includes producing an imine by mixing the ligand and the formyl...
2018/0179249 METHOD OF MAKING A HYDROLYZED COLLAGEN GEL
The method of making a hydrolyzed collagen gel is a manufacturing method for producing a hydrolyzed collagen gel to be used as a topical wound treatment. A...
2018/0179248 DECARBOXYLATIVE CONJUGATE ADDITIONS AND APPLICATIONS THEREOF
Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative...
2018/0179247 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R.sup.1, R.sup.2, R.sup.3, and...
2018/0179246 SILYL ETHERIFIED DERIVATIVES OF 5-AZACYTIDINES IN CARBOHYDRATE MOIETY
The present invention relates to a prodrug of 5-azacytidine or 2'-deoxy-5-azacytidine having remarkable stability against cytidine deaminase, a metabolic...
2018/0179245 PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING CRYSTALLINE ALPHA, ALPHA-TREHALOSE DI-HYDRATE
A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an...
2018/0179244 FIDAXOMICIN PURIFICATION METHOD
A fidaxomicin purification method, comprising: fermenting Actinoplanes sp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the...
2018/0179243 MAGNESIUM SULFONATE SYNTHESIS
An overbased magnesium sulfonate detergent is made by (A) preparing a mixture of a sulfonic acid or salt with a magnesium oxide, water, a C.sub.1-C.sub.5...
2018/0179242 CATALYSTS AND METHODS FOR POLYMER SYNTHESIS
The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are...
2018/0179241 BISTABLE COMPLEXES AND DEVICES AND METHODS OF MAKING AND USING THE SAME
Disclosed herein are embodiments of complexes exhibiting reversible light-induced magnetization, and/or heat, and/or electrically-induced switching with...
2018/0179240 PHARMACEUTICAL COMPOSITION OF CARBOPLATIN BASED CO-CRYSTALS AND USE THEREOF
The current invention relates to series of co-crystals of carboplatin with cyclic amides as co-formers and their pharmaceutical use. The co-crystals of the...
2018/0179239 Novel Platinum (IV) Complex
According to the present invention, there is a demand for novel platinum(IV) complex which has sufficient water-solubility, stability, antitumor activity, and...
2018/0179238 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC...
An organometallic compound represented by Formula 1: ##STR00001## wherein, in Formula 1, groups and variables are the same as described in the specification.
2018/0179237 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
A phosphorescent emitter compound having a first ligand L.sub.A having a Formula I, ##STR00001## is disclosed. An OLED having the compound incorporated therein...
2018/0179236 DISUBSTITUTED COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, or a pharmaceutically acceptable salt...
2018/0179235 STAT3 DIMERIZATION INHIBITORS
The subject matter disclosed herein relates to compositions and methods of making and using the compositions. In a further aspect, the subject matter disclosed...
2018/0179234 COMPOUNDS BASED ON ADDUCTS WITH ISOCYANATES FOR COATING COMPOSITIONS
The present invention relates to compounds based on adducts with isocyanates. The present invention further relates to a method for preparation thereof,...
2018/0179233 NEAR-IR GLUCOSE SENSORS
Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and...
2018/0179232 BORONIC ACID DERIVATIVES
Compounds of formula (I) are inhibitors of LMP7 and can be employed, inter alia, for the treatment of an autoimmune disorder or hematological malignancies. ...
2018/0179231 BORONIC ACID DERIVATIVES
Compounds of formula (I) are inhibitors of LMP7 and can be employed, inter alia, for the treatment of an autoimmune disorder or hematological malignancies. ...
2018/0179230 COMPLEX AND PROCESS FOR PREPARING COMPLEX
An object of the present invention is to provide a novel complex having at least one carbon-carbon double bond and/or carbon-carbon triple bond. The present...
2018/0179229 PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE
Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for...
2018/0179228 NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVE
There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and...
2018/0179227 SYNTHETIC METHOD OF FUSED HETEROAROMATIC COMPOUND AND FUSED HETEROAROMATIC COMPOUND AND INTERMEDIATE THEREFOR
A synthetic method of a fused heteroaromatic compound includes preparing a first intermediate represented by Chemical Formula 1, obtaining a second...
2018/0179226 Processes for the Preparation of Edoxaban and Intermediates Thereof
The present invention provides processes for the preparation of Edoxaban (1) and salts thereof, as well as intermediates thereof. In particular, intermediate...
2018/0179225 ANTIMICROBIAL AGENTS
The invention provides compounds of formula (I): ##STR00001## wherein R.sup.1-R.sup.3, n, and W have any of the values defined in the specification, and salts...
2018/0179224 Tetrahydro[1,8]naphthyridine Sulfonamide And Related Compounds for Use as Agonists of RORy and the Treatment of...
The invention provides tetrahydro[1,8]naphthyridine and related compounds, pharmaceutical compositions, methods of promoting RORy activity, increasing the...
2018/0179223 PROCESS FOR PREPARING SUBSTITUTED TETRACYCLIC HETEROCYCLE COMPOUNDS
The present invention is directed to processes for preparing Substituted Tetracyclic Heterocycle Compounds of formula (I): (I) which may be useful as HCV NS5A...
2018/0179222 DEUTERATED THIENOPIPERIDINE DERIVATIVES, MANUFACTURING METHOD, AND APPLICATION THEREOF
The present invention discloses deuterated thienopiperidine derivatives, a manufacturing method and an application thereof. The deuterated thienopiperidine...
2018/0179221 HPK1 INHIBITORS AND METHODS OF USING SAME
Thienopyridinone compounds of Formula (I) and pharmaceutically acceptable salts thereof are described. In these compounds, one of X.sub.1; X.sub.2, and X.sub.3...
2018/0179220 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS
The invention provides novel nicotinic acetylcholine receptor agonists, for example, phantasmidine and derivatives thereof, for example a compound of formula...
2018/0179219 METHOD FOR PURIFYING MITOMYCIN C
Provided are a method for purifying mitomycin C, comprising a step of recrystallizing crude mitomycin C crystals using a high-purity methanol; mitomycin C...
2018/0179218 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2018/0179217 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2018/0179216 SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS
The invention provides a chemical entity of Formula (I): ##STR00001## wherein R.sup.1, R.sup.2, X, Y and Z have any of the values described herein, and...
2018/0179215 CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
2018/0179214 CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
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