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Patent # Description
2018/0179213 HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS
Disclosed are compounds of Formula (I) or salts thereof, wherein: HET is a heteroaryl selected from imidazo[1,2-b]pyridazinyl and pyrazolo[1,5-a]pyrimidinyl,...
2018/0179212 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS
The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) ##STR00001## or a pharmaceutically acceptable salt thereof...
2018/0179211 HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS
Disclosed herein is a compound of formula I and/or a pharmaceutically acceptable salt thereof that can serve as Erk inhibitors: ##STR00001## They are potentially...
2018/0179210 Inhibitors of the TEC Kinase Enzyme Family
The present invention relates to a novel family of kinases inhibitors. Compounds of this class have been found to have inhibitory activity against members of...
2018/0179209 JAK INHIBITORS
Disclosed is a series of JAK inhibitors, which specifically relates to a compound shown in formula (I) or pharmaceutically acceptable salts thereof.
2018/0179208 ANTIVIRAL ALIPHATIC ESTER PRODRUGS OF TENOFOVIR
Compounds of Formula I: ##STR00001## and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may...
2018/0179207 PROCESS FOR THE PREPARATION OF A XANTHINE-BASED COMPOUND
This invention relates to a method for preparation of a xanthine-based compound, as well as to intermediates useful in such preparation.
2018/0179206 ORGANIC ELECTROLUMINESCENCE DEVICE AND ELECTRONIC DEVICE
A compound represented by formula (1): ##STR00001## wherein R.sup.1 to R.sup.8, R.sup.12 to R.sup.18, R.sup.21 to R.sup.25, R.sup.31 to R.sup.48, L.sup.1 to...
2018/0179205 SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE...
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds,...
2018/0179204 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2018/0179203 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
Provided herein are compounds of the General Formula I: ##STR00001## and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B,...
2018/0179202 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2018/0179201 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2018/0179200 PYRAZOLO[3,4-b]PYRIDINES AND IMIDAZO[1,5-b]PYRIDAZINES AS PDE1 INHIBITORS
The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of...
2018/0179199 DERIVATIVES OF QUINOLINE AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES
The present invention relates to the compound of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof. The present invention is further...
2018/0179198 TRICYCLIC MODULATORS OF TNF SIGNALING
The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and...
2018/0179197 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2018/0179196 CRYSTALLINE FORMS OF CADAZOLID
The present invention relates to crystalline forms of cadazolid.
2018/0179195 DIAZASPIROALKANEONE-SUBSTITUTED OXAZOLE DERIVATIVES AS SPLEEN TYROSINE KINASE INHIBITORS
The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by...
2018/0179194 NADPH OXIDASE 4 INHIBITORS
The invention relates to 2,5-disubstituted benzoxazole and benzothiazole derivatives of Formula (I) ##STR00001## wherein L, X, Y, and ring (A) are as described...
2018/0179193 N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof
The invention relates to a homoserine lactone derivative of Formula I, preparation method and use thereof. The compound has an effect of regulatory of...
2018/0179192 NOVEL COMPLEXES FOR THE SEPARATION OF CATIONS
Complexes including a solid support and a material with a matrix structure containing domains complexing rare earth or strategic metals, preparation process...
2018/0179191 SYNTHESIS OF A COMPOUND THAT MODULATES THE ACTIVITY OF BROMODOMAIN-CONTAINING PROTEINS
The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## or a salt or co-crystal thereof, that modulates the...
2018/0179190 METALLO-BETA-LACTAMASE INHIBITORS
The present invention relates to metallo-.beta.-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z,...
2018/0179189 ADIPATE FORMS AND COMPOSITIONS OF BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable...
2018/0179188 SUBSTITUTED PIPERAZINE COMPOUNDS AND METHODS OF USE AND USE THEREOF
The invention relates to substituted piperazine compounds and methods of use and uses thereof, and further to the pharmaceutical compositions comprising the...
2018/0179187 Nrf2 REGULATORS
Provided are aryl analogs, pharmaceutical compositions containing them and their use as NRF2 regulators.
2018/0179186 ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I'' and I''' or a pharmaceutically...
2018/0179185 AMINO COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I'' and I''' or a pharmaceutically...
2018/0179184 BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AND/OR M4 RECEPTOR AGONISTS
This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic...
2018/0179183 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES
The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF...
2018/0179182 METHODS OF TREATMENT USING PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS
Compounds useful for the treatment of pain or cancer in a mammal.
2018/0179181 PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE
PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved...
2018/0179180 Factor XIa Inhibitors
The present invention provides a compound of Formula (I) ##STR00001## and pharmaceutical compositions comprising one or more said compounds, and methods for...
2018/0179179 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2018/0179178 SELECTIVE ANTI-CANCER COMPOUNDS
A compound of formula I, wherein the compound of formula I has the structure: wherein R.sup.1 to R.sup.5, Y, L, Z and X.sub.1 to X.sub.7 have meanings given in...
2018/0179177 N-ACYLIMINO HETEROCYCLIC COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS
The present invention relates to N-acylimino compound of formula (I): ##STR00001## wherein X is O or S, in particular O; m is an integer selected from 0, 1, 2,...
2018/0179176 BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR
The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage...
2018/0179175 PROCESSES FOR PREPARING ANTIVIRAL COMPOUNDS
The present disclosure provides processes for the preparation of a compound of formula: ##STR00001## which is useful as an antiviral agent. The disclosure also...
2018/0179174 12H-BENZO[b]XANTHEN-12-ONES, COMPOSITIONS CONTAINING, AND USES OF, SAME
The present invention provides compounds of the following structure, ##STR00001## methods of using such compounds, and pharmaceutical compositions containing...
2018/0179173 MULTI-STAGE ESTERIFICATION PROCESS
A process for efficiently esterifying furan dicarboxylic acid, especially 2,5-furan dicarboxylic acid in the presence of an alcohol and, optionally, a catalyst...
2018/0179172 NOVEL GLUCAGON-LIKE PEPTIDE 1 MODULATOR AND USES THEREOF
Disclosed herein are novel glucagon-like peptide-1 (GLP-1) modulators and their uses in manufacturing medicaments for the treatment and/or prophylaxis of...
2018/0179171 N-(1,3,4-OXADIAZOL-2-YL)ARYL CARBOXAMIDE DERIVATIVES WITH HERBICIDAL ACTION
N-(1,3,4-Oxadiazol-2-yl)arylcarboxamide derivatives of the general formula (I) are described as herbicides. ##STR00001## In this formula (I), V, X and Z...
2018/0179170 PHARMACEUTICAL COMPOSITIONS AND SALTS OF A 1,2,4-OXADIAZOLE BENZOIC ACID
Provided herein are pharmaceutical compositions, which comprise a 1,2,4-oxadiazole benzoic acid or a pharmaceutically acceptable salt thereof. Further provided...
2018/0179169 PHENYL AMINO PYRIMIDINE COMPOUND OR POLYMORPH OF SALT THEREOF
The present invention relates to a phenyl amino pyrimidine compound or a polymorph of a salt thereof, specifically, to ...
2018/0179168 SUBSTITUTED PHENYLOXAZOLIDINONES FOR ANTIMICROBIAL THERAPY
The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing...
2018/0179167 Nrf2 REGULATORS
The present invention relates to aryl analogs Formula (I), pharmaceutical compositions containing them and their use as Nrf2 regulators. ##STR00001##
2018/0179166 SMALL MOLECULE INHIBITORS OF GP120-MEDIATED HIV INFECTION AND METHODS OF USE
Small molecule inhibitors GP120-mediated HIV infections, methods for identifying the same, and methods and uses employing of these compounds in treatment,...
2018/0179165 AMIDINE CATALYST FOR CURABLE COMPOSITIONS
The present invention relates to an amidine of the formula (I) and its use as a catalyst for crosslinking a curable composition. The amidine of the formula (I)...
2018/0179164 SUBSTITUTED 2-THIOXO-IMIDAZOLIDIN-4-ONES AND SPIRO ANALOGUES THEREOF, ACTIVE ANTICANCER INGREDIENT,...
Novel (R)-stereoisomers of substituted 2-thioxo-imidazolidin-4-ones of formula 1, or spiro analogues thereof, which exhibit androgen receptor antagonist...
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