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Patent # Description
2018/0177901 EVALUATION OF PRESENCE OF AND VULNERABILITY TO ATRIAL FIBRILLATION AND OTHER INDICATIONS USING MATRIX...
The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (AF), and/or the likelihood of...
2018/0177900 Radiolabelling Process
The present invention relates to a novel composition comprising 1-amino-3-[.sup.18F]-fluorocyclobutanecarboxylic acid ([.sup.18F]-FACBC) wherein said...
2018/0177899 HYDROPHILIC PARTICLES, METHOD FOR PRODUCING THE SAME, AND CONTRAST AGENT UTILIZING SAME
Provided are a hydrophilic particle, a method for manufacturing the same, and a contrasting agent using the same. More specifically, the hydrophilic particle...
2018/0177898 GLUCOSE ANALOGS FOR DIAGNOSIS OF DISEASE STATES
Provided are methods and formulations for imaging at least one body region of a subject, employing a glucose analog resistant or inactive to phosphrylation, or...
2018/0177897 NOVEL RHODOL FLUOROPHORES FOR NEAR-INFRARED IMAGING
The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous...
2018/0177896 CHARGE-BALANCED IMAGING AGENTS
The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties...
2018/0177895 ORAL FOOD CHALLENGE MEAL FORMULATIONS
This invention relates to kits including novel oral food challenge meal formulations. In particular, the invention also relates to kits including novel oral...
2018/0177894 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL...
The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a...
2018/0177893 NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF
The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods...
2018/0177892 COMPOSITIONS OF NUCLEIC ACID-CONTAINING NANOPARTICLES FOR IN VIVO DELIVERY
Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at...
2018/0177891 Nanoparticle-Based Antigen Specific Immunotherapy
The present invention provides a nano particle comprising: a core comprising metal atoms; a corona comprising a plurality of ligands covalently linked to the...
2018/0177890 LIGAND-CYTOTOXIC DRUG CONJUGATE, PREPARATION METHOD THEREOF, AND USE THEREOF
Provide are ligand-cytotoxic drug conjugates with a general formula of PC-L-Dr, a preparation method thereof, and uses of the ligand-cytotoxic drug conjugate...
2018/0177889 TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES
The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or...
2018/0177888 COMPOUNDS FOR TARGETED IMMUNOTHERAPY
Compounds for targeted immunotherapy, compositions comprising the compounds and use of the compounds in the treatment of diseases such as cancer are disclosed....
2018/0177887 COMPOUNDS FOR TARGETED IMMUNOTHERAPY
Compounds for targeted immunotherapy, compositions comprising the compounds and use of the compounds in the treatment of diseases such as cancer are disclosed....
2018/0177886 Methods Of Treating Cancer Using Compounds Containing A Vascular Disrupting Agent
The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a MMP proteolytic cleavage...
2018/0177885 Recombinant Vaccines and Use Thereof
The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In...
2018/0177884 LOW MOLECULAR WEIGHT POLYETHYLENE GLYCOL DRUG CONJUGATES HAVING IMPROVED DRUG BIOLOGICAL ACTIVITY
Provided are polyethylene glycol drug conjugates of general formula (I), (II) or (III) and pharmaceutical compositions and a use thereof. The conjugates are...
2018/0177883 Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs,...
The presently described technology provides methods of treating a patient having moderate to severe pain, narcotic or opioid abuse or narcotic or opioid...
2018/0177882 SULFATED ALGINATE HYDROGELS FOR CELL CULTURE AND THERAPY
The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution;...
2018/0177881 Multicomponent Degradable Cationic Polymers
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis...
2018/0177880 ANTI-CD3 ANTIBODY FORMULATIONS
This invention relates to therapeutic, diagnostic and/or prophylactic formulations and dosages and dosing regimens of anti-CD3 antibodies, as well as to...
2018/0177879 EXTERNAL PREPARATION FOR TRANSDERMAL ADMINISTRATION
The present invention is intended to provide a cyclosporine external preparation that improves transdermal absorption of cyclosporine. The present invention...
2018/0177878 PHARMACOKINETICALLY EXTENDED ACTION TOPICAL HAIR GROWTH FORMULATION, AND ADMINISTRATION METHOD
A method of inducing hair growth by topical administration of minoxidil is described, including topically applying minoxidil to a skin region susceptible to...
2018/0177877 CHIMERIC CYTOKINE FORMULATIONS FOR OCULAR DELIVERY
Featured herein are vehicle formulations and formulations containing a chimeric cytokine designed for e.g., ocular delivery.
2018/0177876 Liquid Protein Formulations Containing Thiamine
Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently...
2018/0177875 Liquid Protein Formulations Containing Cimetidine
Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently...
2018/0177874 Methods of Treating Metabolic Syndrome Using Dopamine Receptor Agonists
The present invention is directed to a method of simultaneously treating hypertension, hypertriglyceridemia, a pro-inflammatory state, a pro-coagulative state,...
2018/0177873 MULTISPECIFIC ANTIGEN-BINDING PROTEINS
Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains...
2018/0177872 Combination of PD-1 antagonist with an EGFR inhibitor
The present invention relates to a pharmaceutical composition comprising PD-1 antagonist and an EGFR Inhibitor. The present combination can be administered...
2018/0177871 ADJUVANTED FORMULATIONS OF BOOSTER VACCINES
The invention improves TdaP vaccines by including a TLR agonist in them. This agonist can provide stronger protection, longer-lasting protection, and/or can...
2018/0177870 IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE
Compositions and methods for inducing PD-L1 internalization are disclosed. The methods include reducing the amount of cell surface PD-L1 by contacting a cell...
2018/0177869 MICROFLUIDIZED MYCOBACTERIUM AVIUM FRAGMENTS AS AN ADJUVANT AND CARRIER FOR MUCOSAL VACCINE DELIVERY
A vaccine adjuvant and immunogenic composition may be described herein. The vaccine adjuvant may comprise cell wall fragments of the genus Mycobacterium, and...
2018/0177868 COMPOSITIONS FOR MODULATING AN XBP1 PATHWAY IN A KERATINOCYTE AND METHODS OF USE
Provided herein are compositions and methods for increasing an immune response in a subject, immunizing a subject and/or treating a disease in a subject that...
2018/0177867 Adjuvant for Vaccines, Vaccine, and Immunity Induction Method
The present invention provides an adjuvant for vaccine including a Dectin-1 ligand and a TLR agonist, a vaccine including the adjuvant for vaccine and at least...
2018/0177866 HIV PRE-IMMUNIZATION AND IMMUNOTHERAPY
The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods relate to in vivo...
2018/0177864 RSV F Protein Mutants
The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein...
2018/0177863 METHODS OF MAKING AND USING LIVE ATTENUATED VIRUSES
This disclosure provides live, attenuated viruses, and methods of making and using the live, attenuated viruses.
2018/0177862 ANTIGENICALLY MATCHED INFLUENZA VACCINES
Disclosed herein are influenza vaccine compositions, related preparations and intermediates, formulations, production methods, immunization methods, and use...
2018/0177861 METHODS OF USE OF INFLUENZA VACCINE FOR PREVENTION OF PNEUMONIA
This application relates to the field of prevention of pneumonia by administration of a high-dose influenza vaccine.
2018/0177860 VACCINE CONTAINING VIRUS INACTIVATED BY GREEN TEA EXTRACT, AND PREPARATION METHOD THEREFOR
The present invention relates to a vaccine composition containing a virus inactivated by a green tea extract, and a preparation method therefor. According to...
2018/0177859 FLAVIVIRUS AND ALPHAVIRUS VIRUS-LIKE PARTICLES (VLPS)
Described herein are flavivirus virus-like particles (VLPs) that display on their surfaces antigenic flavivirus proteins. Also described are methods of making...
2018/0177858 INVOLUCRIN-DRIVEN RETROVIRAL EXPRESSION CASSETTES ENCODING HUMAN IMMUNODEFICIENCY VIRUS ENVELOPE GLYCOPROTEINS
The present invention provides for novel compositions and methods for delivering genes of interest to stem cells using vectors that contain ...
2018/0177857 Synthetic Antigen Constructs Against Campylobacter Jejuni
The invention relates to immunogenic synthetic constructs capable of inducing an immune response against Campylobacter jejuni (C. jejuni) in a subject...
2018/0177856 IMMUNOGENIC COMPOSITIONS AGAINST TUBERCULOSIS
Methods of preparing mutants of Mycobacterium tuberculosis with one or more disrupted genes are presented, where the disrupted genes include ctpV, rv0990c,...
2018/0177855 SOFT GEL DELIVERY METHOD FOR TREATING POULTRY
The present invention is directed to a method of treating poultry hatchlings in a hatchling tray. The method comprises of providing a soft gel form capable of...
2018/0177854 MICRO-RNA-155 ENHANCES THE EFFICACY OF DENDRITIC CELL VACCINE FOR CANCER
Engineered dendritic cell vaccines, and methods of forming and applying same, that may be used as effective immunotherapies for cancers.
2018/0177853 Compositions and Methods for Treating Cancer with Arginine Depletion and Immuno Oncology Agents
Methods of treating tumors or cancer include administration of an arginine depleting enzyme and an immune-oncology agent.
2018/0177852 TREATMENT OF HUMAN METAPNEUMOVIRUS
The present disclosure provides compositions and methods for treating an infection by human metapneumovirus (hMPV). In particular, the present disclosure...
2018/0177851 FUSION PROTEINS
The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and...
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