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Patent # Description
2018/0187215 DNA EDITING USING SINGLE-STRANDED DNA
Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In...
2018/0187214 SUBGROUP B RECOMBINANT HUMAN ADENOVIRUS VECTOR, AND METHODS FOR CONSTRUCTING AND FOR USING THE SAME
A subgroup B recombinant human adenovirus vector Ad11-5EP (SEQ ID NO: 1), which is constructed by a method including: substituting a 365 bp fragment containing...
2018/0187213 Variant AAV and Compositions, Methods and Uses for Gene Transfer to Cells, Organs and Tissues
The invention relates to adeno-associated virus (AAV) serotype AAV-Rh74 and related AAV vectors, and AAV-Rh74 and related AAV vector mediated gene transfer...
2018/0187212 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE PERIPHERAL NERVOUS...
The present invention relates to methods and pharmaceutical compositions for expressing a polynucleotide of interest in the peripheral nervous system of a...
2018/0187211 METHODS AND COMPOSITIONS FOR COMBINATION IMMUNOTHERAPY
Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in...
2018/0187210 NON-HLA MATCHED HUMANIZED NSG MOUSE MODEL WITH PATIENT-DERIVED XENOGRAFT
The invention described herein provides non-HLA matched humanized mouse model (e.g., NSG mouse model) with patient-derived xenograft (PDX), as well as methods...
2018/0187209 Fertility Gene and Use Thereof
The present disclosure relates to a fertility gene and the use thereof, and relates to the biotechnology field, particularly to a method of plant hybrid...
2018/0187208 FERTILITY GENE AND USE THEREOF
The present disclosure relates to a fertility gene and the use thereof, and relates to the biotechnology field, particularly to a method of plant hybrid...
2018/0187207 COMPOSITIONS AND METHODS FOR THE MODULATION OF ROOT HAIR PRODUCTION AND STRESS RESPONSES IN PLANTS
Compositions and methods for modulating root hair production and stress responses in plants are provided.
2018/0187206 NOVEL PROTEIN, NOVEL GENE, EXPRESSION VECTOR, TRANSFORMANT, METHOD FOR PRODUCING TRANSFORMANT, AND METHOD FOR...
The present invention provides a novel fluorescent protein. A novel protein includes the following protein (F1): (F1) a protein consisting of an amino acid...
2018/0187205 CLONING VECTOR
The object is to provide an expression vector capable of expressing with a higher expression efficiency a protein derived from a foreign structural gene by...
2018/0187204 COMBINATION OF BACTERIAL CHAPERONES POSITIVELY AFFECTING THE PHYSIOLOGY OF A NATIVE OR ENGINEERED EUKARYOTIC CELL
The invention relates to the expression of a specific combination of three bacterial chaperones in a eukaryotic cell, which significantly improves the growth...
2018/0187203 POLYCISTRONIC EXPRESSION SYSTEM FOR BACTERIA
The invention relates to polycistronic expression in gram-positive bacterium and in particular concerns polycistronic expression units comprising one or more...
2018/0187202 METHODS FOR WOUND HEALING
The invention relates to plasmids capable of expressing a protein targeting immune cells when transformed into a lactic acid bacterial cell, wherein the...
2018/0187201 COMPOSITIONS AND METHODS FOR CLOSTRIDIAL TRANSFORMATION
The invention provides compositions and methods for clostridial bacteria that have been engineered to produce and/or to improve efficiency of production of...
2018/0187200 Recombinant Cells and Organisms Having Persistent Nonstandard Amino Acid Dependence and Methods of Making Them
Novel recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making novel recombinant...
2018/0187199 MULTI-TARGET MODULATION FOR TREATING FIBROSIS AND INFLAMMATORY CONDITIONS
The present invention relates to compositions comprising one or more active agents that selectively modulate the expression of two or more genes, for example...
2018/0187198 METHODS AND COMPOSITIONS FOR TREATING A PROPROTEIN CONVERTASE SUBTILISIN KEXIN (PCSK9) GENE-ASSOCIATED DISORDER
The invention relates to methods of inhibiting the expression of a PCSK9 gene in a subject, as well as therapeutic and prophylactic methods for treating...
2018/0187197 Multiaptamer Target Detection
Described herein are compositions comprising a first aptamer, second aptamer and a target that are capable of forming a ternary complex, and wherein the first...
2018/0187196 INHIBITORS OF DEK PROTEIN AND RELATED METHODS
The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of...
2018/0187195 RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
Isolation or in vitro assembly of the Cas9-crRNA complex of the Streptococcus thermophilus CRISPR3/Cas system and use for cleavage of DNA bearing a nucleotide...
2018/0187194 METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA
The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides...
2018/0187193 MICRORNA INHIBITION FOR THE TREATMENT OF INFLAMMATION AND MYELOPROLIFERATIVE DISORDERS
The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of...
2018/0187192 SYNTHETIC HAMMERHEAD RIBOZYMES WITH LIGAND-RESPONSIVE TERTIARY INTERACTIONS
A ligand-responsive hammerhead ribozyme is provided. In some embodiments, the ribozyme comprises: i. a first loop that has been replaced by an RNA aptamer that...
2018/0187191 Targeted-Delivery of Small Interference RNA Against Anthrax
The present invention includes a composition for the targeted-delivery of small interference RNA against bacteria comprising: a detoxified bacterial protein...
2018/0187190 NEW CRISPR ASSAYS
The present invention relates to expression vectors harboring eukaryotic CRISPR sequences and their use in assays to study the intervention of eukaryotic...
2018/0187189 Nucleic Acid Functionalized Nanoparticles for Therapeutic Applications
Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.
2018/0187188 CANCER SPECIFIC-SPLICING RIBOZYME AND USE THEREOF
The present invention relates to a recombination vector, a transformation cell into which the recombinant vector is introduced, a ribozyme expressed from the...
2018/0187187 SELF-ASSEMBLING MOLECULAR NANOSYSTEM FOR TARGETED DNA AND GENE DELIVERY
Devices and methods of use for delivering genetic material to specific targets in living systems. The delivery methods involve employing a DNA-based nanosystem...
2018/0187186 COMPOSITIONS COMPRISING NUCLEIC ACIDS AND METHODS OF USING THE SAME
The disclosure relates to compositions comprising and methods for chemical modification of single guide RNA (sgRNA), tracrRNA and/or crRNA used individually or...
2018/0187185 COMPOSITIONS AND METHODS FOR DIRECTING PROTEINS TO SPECIFIC LOCI IN THE GENOME
Disclosed are compositions and methods for directing proteins to specific loci in the genome and uses thereof. In one aspect, the disclosed methods allow for...
2018/0187184 NOVEL CONSTRUCTS AND SCREENING METHODS
The invention relates to the field of functional genomics. The invention provides novel polynucleotides and vectors as well as libraries and kits comprising...
2018/0187183 DNA MICROSCOPY
The present invention relates to DNA microscopy methods to record the cellular co-localization and/or spatial distributions of arbitrary nucleic acid...
2018/0187182 DIRECTED EVOLUTION THROUGH MUTATION RATE MODULATION
The present invention relates to methods and systems for the directed evolution of macromolecules. The methods involve increasing the mutation rate of an...
2018/0187181 Combined Lysis Protocol for Comprehensive Cell Lysis
Disclosed are methods for lysis of cells, such as bacteria present in microbiomes, that combine three lysis steps--(1) heat, (2) detergent and (3) base--into a...
2018/0187180 PENICILLIN-G ACYLASES
The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and...
2018/0187179 VARIANTS OF CHYMOSIN WITH IMPROVED PROPERTIES
Variants of chymosin with improved properties.
2018/0187178 Methods of increasing the cellulolytic enhancing activity of a polypeptide
The present invention relates to methods of increasing the activity of a polypeptide having cellulolytic enhancing activity, comprising: adding a soluble...
2018/0187177 CELLS PRODUCING GLYCOPROTEINS HAVING ALTERED N- AND O-GLYCOSYLATIONPATTERNS AND METHODS AND USE THEREOF
The present application relates to the field of glyco-engineering and, more specifically, to eukaryotic cells wherein both an endoglucosaminidase is present...
2018/0187176 CRISPR/CPF1 SYSTEMS AND METHODS
This invention pertains to recombinant AsCpf1 and LbCpf1 nucleic acids and polypeptides for use in CRISPR/Cpf1 endonuclease systems and mammalian cell lines...
2018/0187175 Polypeptides
The present invention relates to polypeptides, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides. The present invention...
2018/0187174 Therapeutic Nuclease Compositions and Methods
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an...
2018/0187173 METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING AND CORRECTION IN HEMATOPOIETIC STEM CELLS
The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic stem cell.
2018/0187172 REGULATED GENE EXPRESSION FROM VIRAL VECTORS
The present disclosure relates to vectors for the controlled expression transgenes and methods of use therefor.
2018/0187171 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
2018/0187170 Productivity and Bioproduct Formation in Phototropin Knock/Out Mutants in Microalgae
Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these...
2018/0187169 THIOLASE VARIANTS AND METHODS OF USE THEREOF
Described herein are thiolase variants, cells expressing the thiolase variants, and methods of their use for the biosynthesis of desired products.
2018/0187168 TAL-Tet1 Fusion Proteins and Methods of Use Thereof
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes...
2018/0187167 CELLULOLYTIC COMPOSITIONS COMPRISING MONOOXYGENASE POLYSACCHARIDE ENZYMES WITH IMPROVED ACTIVITY
The invention refers to methods and compositions for stabilizing and increasing the activity of enzymatic mixtures comprising GH61 (PMO or polysaccharide...
2018/0187166 METHOD FOR LARGE SCALE PRODUCTION AND PURIFICATION OF PARVOVIRUS
Described is a reproducible, effective and scalable process for parvovirus production including characterization strategies, preferably production of H-1PV.
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