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Patent # Description
2018/0186862 IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS
IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are...
2018/0186861 REGENERATION AND REPAIR OF MESENCHYMAL TISSUE USING AMELOGENIN
A method of treating an injury to hyaline cartilage in a subject in need thereof. The method comprises administering to the subject a therapeutically effective...
2018/0186860 SYNTHETIC APOLIPOPROTEINS, AND RELATED COMPOSITIONS METHODS AND SYSTEMS FOR NANOLIPOPROTEIN PARTICLES FORMATION
Synthetic apolipoproteins based on native/naturally occurring homolog proteins can be prepared using solid-phase peptide synthesis approaches combined with...
2018/0186859 ALBUMIN-SUGAR CHAIN COMPLEX
An object of the present invention is to provide an albumin-sugar chain complex bound with a number of sugar chains sufficient for obtaining a sugar chain...
2018/0186858 PROCESS FOR ENHANCED PRODUCTION OF RECOMBINANT HUMAN SERUM ALBUMIN IN E. COLI THROUGH CHAPERONE ASSISTANCE
The present disclosure provides a process for improved production and extraction of recombinant human serum albumin (rHSA) using E. coli as a host system. The...
2018/0186857 FACTOR VIII PROTEIN COMPOSITIONS AND METHODS OF TREATING OF HEMOPHILIA A
Compositions of recombinant FVIII protein comprising point mutations. Methods for using recombinant FVIII to activate FX and FIXa in cells and treat diseases...
2018/0186856 SHORTENED CD95-FC VARIANTS
The present invention relates to an isolated fusion protein comprising an extracellular CD95 domain or a functional fragment thereof and an Fc domain or...
2018/0186855 CHIMERIC RECEPTORS AND METHODS OF USE THEREOF
The present disclosure is related to compositions that include polynucleotides encoding chimeric receptors, methods of delivering polynucleotides encoding...
2018/0186854 TREATING TYPE I AND TYPE II DIABETES
This document provides methods and materials for treating diabetes. For example, methods and materials for using nucleic acid encoding human preproinsulin to...
2018/0186853 GLUCAGON DERIVATIVE AND A COMPOSITION COMPRISING A LONG ACTING CONJUGATE OF THE SAME
The present invention relates to a glucagon derivative, a long-acting conjugate of the glucagon derivative, and a use thereof.
2018/0186852 LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING SAME
A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a...
2018/0186851 METHODS AND COMPOSITIONS FOR INCREASING RED BLOOD CELLS
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including...
2018/0186850 CHIMERIC FIBROBLAST GROWTH FACTOR 19 PROTEINS AND METHODS OF USE
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine...
2018/0186849 CHIMERIC FIBROBLAST GROWTH FACTOR 21 PROTEINS AND METHODS OF USE
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine...
2018/0186848 THERMOSTABLE HUMAN EPIDERMAL GROWTH FACTOR-SPIDER VENOM FUSION PROTEIN WITH INCREASED SKIN CELL PROLIFERATION...
A thermostable human epidermal growth factor-spider venom fusion protein with increased skin cell proliferation effect has the amino acid sequence of SEQ ID...
2018/0186847 CHEMOENZYMATIC GLYCOENGINEERING OF ANTIBODIES AND FC FRAGMENTS THEREOF
The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the...
2018/0186846 TOXIC PEPTIDE PRODUCTION, PEPTIDE EXPRESSION IN PLANTS AND COMBINATIONS OF CYSTEINE RICH PEPTIDES
New insecticidal proteins, nucleotides, peptides, their expression in plants, methods of producing the peptides, new processes, production techniques, new...
2018/0186845 PEPTIDES AND COMPOSITIONS FOR PREVENTION OF CELL ADHESION AND METHODS OF USING SAME
Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2),...
2018/0186844 New antimicrobial peptides, their variants and uses
The present invention relates to novel antimicrobial peptide and variants thereof. The invention further relates to method of killing or inhibiting growth of...
2018/0186843 New antimicrobial peptides, their variants and uses
The present invention relates to novel antimicrobial peptide and variants thereof. The invention further relates to method of killing or inhibiting growth of...
2018/0186842 HIGH PRODUCTIVITY ALGAL MUTANTS HAVING REDUCED PHOTOSYNTHETIC ANTENNA
Disclosed herein are mutant photosynthetic microorgnaisms having an attenuated SGI1 gene. The mutants have reduced chlorophyll and increased productivity with...
2018/0186841 MALTOSE DEPENDENT DEGRONS, MALTOSE-RESPONSIVE PROMOTERS, STABILIZATION CONSTRUCTS, AND THEIR USE IN PRODUCTION...
The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational...
2018/0186840 GENETIC REPROGRAMMING OF BACTERIAL BIOFILMS
Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions...
2018/0186839 STABILIZED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) TRIMER VACCINES AND METHODS OF USING SAME
The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors...
2018/0186838 CONOTOXIN PEPTIDE k-CPTX-BTL01, PREPARATION METHOD THEREFOR, AND USES THEREOF
Provided is a new conotoxin peptide .kappa.-CPTx-btl01. The conotoxin peptide .kappa.-CPTx-btl01 has derivative polypeptide that has an amino acid sequence...
2018/0186837 BROAD-SPECTRUM ANTI-INFECTIVE PEPTIDES
Provided herein are anti-infective peptides and uses thereof. Such anti-infective peptides are useful against bacteria and viruses. Also provided herein are...
2018/0186836 NOVEL MACROCYCLES
The invention relates to cyclic compounds of general formula (I): wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, and their use as...
2018/0186835 Treatments for Gastrointestinal Disorders
The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited...
2018/0186834 NOVEL PEPTIDE AND USE THEREOF
This invention relates to a peptide consisting of an amino acid sequence of SEQ ID NO:1 or a pharmaceutically acceptable salt thereof, and to the use thereof....
2018/0186833 SELECTIVE CYSTEINE PROTEASE INHIBITORS AND USES THEREOF
The present invention relates to compounds of Formula I, II, IA-VA, IVA1-IVA5, IIIA1-IIIA5 and their pharmaceutical uses. Particular aspects of the invention...
2018/0186832 Method for the reduction of host cell proteins in affinity chromatography
The current invention reports a method for purifying an antibody by reducing the content of a host cell protein. The method employs a wash step with a low...
2018/0186831 ENHANCED PURIFICATION OF ANTIBODIES AND ANTIBODY FRAGMENTS BY APATITE CHROMATOGRAPHY
Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one...
2018/0186830 COUPLED PEPTIDE CHAIN FOR DISSOLVING POORLY SOLUBLE POLYPEPTIDES AND APPLICATION THEREOF FOR SEPARATION AND...
The invention discloses a coupled peptide chain for dissolving poorly soluble polypeptides and an application thereof for separation and purification in liquid...
2018/0186829 NOVEL PROCESS FOR THE PREPARATION OF PASIREOTIDE
The present invention relates to a novel process for the preparation of Pasireotide of formula 11 [Cyclo [Phe-{4-(OCO--NH--CH.sub.2--CH.sub.2--NH.sub.2)) ...
2018/0186828 CYCLIC DI-NUCLEOTIDES AS MODULATORS OF STING
A compound of formula (1) ##STR00001## Or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said...
2018/0186827 Ectonucleotidase Inhibitors and Methods of Use Thereof
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or...
2018/0186826 PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS
A method of deprotecting a solid support bound polynucleotide comprising at least one 2'-protected ribonucleotide in which a step of contacting the...
2018/0186825 METHODS OF PREPARING SUBSTITUTED NUCLEOSIDE ANALOGS
Disclosed herein are methods of preparing a nucleoside analog, which are useful in treating diseases and/or conditions such as viral infections, and...
2018/0186824 Methods of Preparing Nicotinamide Riboside and Derivatives Thereof
The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a...
2018/0186823 PLATINUM COMPOUNDS, COMPOSITIONS, AND USES THEREOF
The present teachings relate to compounds and compositions comprising a platinum (IV) complex having at least one reacting group for reacting with a functional...
2018/0186822 PHARMACEUTICAL CO-CRYSTAL COMPOSITION AND USE THEREOF
The current invention relates to series of co-crystals of platinum analogues and their pharmaceutical use. The co-crystals of the subject invention may be used...
2018/0186821 PROTEIN PROXIMITY ASSAY IN FORMALIN FIXED PAFFAFIN EMBEDDED TISSUE USING CAGED HAPTENS
Disclosed herein are caged haptens and caged hapten-antibody conjugates useful for enabling the detection of targets located proximally to each other in a sample.
2018/0186820 SURFACE TREATING AGENT INCLUDING PERFLUORO(POLY)ETHER-GROUP-CONTAINING SILANE COMPOUND
A surface-treating agent including at least one perfluoro(poly)ether group containing silane compound of the formula (1): ##STR00001## wherein each of symbols is...
2018/0186819 ORGANIC COMPOUND, AND ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DISPLAY DEVICE INCLUDING THE SAME
Embodiments relate to an organic compound of Formula 1: ##STR00001## The excitons in the triplet state are engaged in emission such that the emitting efficiency...
2018/0186818 SUBSTITUTED DIHYDROPYRROLOPYRAZOLE DERIVATIVE
The present invention provides a compound represented by the general formula (Ia) or a pharmacologically acceptable salt thereof. In the general formula (Ia),...
2018/0186817 COMPOUND AND COLOR CONVERSION FILM COMPRISING SAME
The present specification relates to a novel compound, and a color conversion film, a backlight unit and a display apparatus including the same.
2018/0186816 COMPLEX AND PROCESS FOR PREPARING COMPLEX
An object of the present invention is to provide a novel complex having at least two carbon-carbon double bonds and/or carbon-carbon triple bonds. The present...
2018/0186815 PHARMACEUTICAL COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CANCER
The present application is directed to pharmaceutical compositions comprising derivatives of 6-(4-substitutedphenyl)-2-(substituted ...
2018/0186814 TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL
The present invention provides a compound exhibiting a strong antimicrobial spectrum against various bacteria, including gram-negative bacteria, or a...
2018/0186813 CHIRAL DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES
The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to...
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