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Patent # Description
2018/0200379 VITAMIN D RECEPTOR AGONISTS TO TREAT DISEASES INVOLVING CXCL12 ACTIVITY
Provided herein are methods of treating pancreatic ductal adenocarcinoma in a mammalian subject. In some examples, such methods include administering a...
2018/0200378 COMPOUNDS FOR TREATING CANCER
The present invention provides compounds, compositions thereof, and methods of using the same.
2018/0200377 MULTI-LIGAND DRUG CONJUGATES AND USES THEREOF
A conjugate compounds or pharmaceutically acceptable salt thereof, comprises a payload and two or more kinds of cell-interacting molecules. The...
2018/0200376 NANOASSEMBLED COMPLEXES OF NUCLEIC ACIDS, AVIDIN AND BIOTINYLATED COMPOUNDS FOR USE AS DRUG CARRIERS
Nanoassembled complexes of nucleic acids, avidin and biotinylated compounds functionalized to make them suitable for delivering and releasing drugs are...
2018/0200375 COMPOSITIONS AND METHODS RELATING TO SALTS OF SPECIALIZED PRO-RESOLVING MEDIATORS
The present invention relates to compounds of Formulas I-IV, which are salts of special lipid mediators of inflammation, compositions containing same, and...
2018/0200374 AMINE-CONTAINING TRANSFECTION REAGENTS AND METHODS FOR MAKING AND USING SAME
There are provided for herein novel amine-containing transfection compounds and methods for making and using same. The compounds are generally obtained by...
2018/0200373 ILEUM-TARGETING, MUCOADHESIVE THIOLATED HPMCP VACCINE PROTEIN DELIVERY AGENT
The present disclosure relates to a thiolated hydroxypropyl methylcellulose phthalate (T-HPMCP) drug delivery vehicle which is pH responsive and is loaded with...
2018/0200372 COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF PROSTAGLANDINS TO SUBCUTANEOUS FAT
Described herein are compositions comprising a prostaglandin FP receptor agonist (PFPRA) compound and a fatty acid ester (e.g., isopropyl myristate),...
2018/0200371 HYALURONIC ACID STABILIZER
An embodiment of the present disclosure provides a composition that comprises hyaluronic acid, or its salt or derivative thereof, and an antimicrobial agent,...
2018/0200370 Pharmaceutical Composition Comprising a GLP-1 Agonist, an Insulin and Methionine
A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof, an insulin or/and a pharmacologically tolerable salt...
2018/0200369 Vitamin E tocotrienols inhibition of intracellularly obligate pathogen Chlamydia and methods of use
This invention reveals the beneficial use of vitamin E tocotrienols for inhibition of chlamydial infections. Chlamydial infection levels in mouse macrophages...
2018/0200368 DISRUPTION OR ALTERATION OF MICROBIOLOGICAL FILMS
A method for altering and/or disrupting a microbiological film is described. The method comprises introducing a composition into a microbiological film, the...
2018/0200367 Marrow Infiltrating Lymphocytes (MILS) as a Source of T-Cells for Chimeric Antigen Receptor (CAR) Thereapy
In some embodiments, marrow-infiltrating lymphocytes ("MILs") comprising a chimeric antigen receptor ("CAR") are provided. In some aspects, the embodiments...
2018/0200366 MULTIMERIC IL-15-BASED MOLECULES
The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease...
2018/0200365 Methods and Compositions for Inhibiting Akt3
Compounds and compositions for selectively inhibiting Akt3 are provided. Methods of using the compounds are also provided. Because Akt3 modulates the...
2018/0200364 LIPIDATED IMMUNE RESPONSE MODIFIER COMPOUND COMPOSITIONS, FORMULATIONS, AND METHODS
The compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c] quinolin-1-yl]oxy}butyl)octadecanamide is a useful drug compound for enhancing immune response and can be...
2018/0200363 Process for Producing an Allergen Extract
The present invention discloses processes for producing native, depigmented and polymerised allergen extracts. The invention further discloses extracts...
2018/0200362 Process for Producing an Allergen Extract
The present invention discloses processes for producing native, depigmented and polymerised allergen extracts. The invention further discloses extracts...
2018/0200361 METHODS OF MANUFACTURE OF NUT FLOURS AND FORMULATIONS FOR ORAL IMMUNOTHERAPY
The present technology relates generally to methods of manufacture of nut flours and/or formulations, ultra-low fat nut flours and uses for nut flour...
2018/0200360 VACCINE AGAINST RSV
Compositions including a recombinant respiratory syncitial virus (RSV) Fusion (F) polypeptide that is stabilized in the pre-fusion conformation are described....
2018/0200359 PROCESSING OF A MODIFIED FOOT-AND-MOUTH DISEASE VIRUS P1 POLYPEPTIDE BY AN ALTERNATIVE PROTEASE
Polynucleotide constructs that express an engineered foot-and-mouth disease (FMDV) P1 precursor protein and a non-FMDV TEV protease and methods for safe and...
2018/0200358 REDUCING THE RISK OF DEVELOPING OF ATOPIC DERMATITIS BY USE OF SUPERANTIGEN
A superantigen selected from the group consisting of the staphylococcal enterotoxins G and I (SEG and SEI) and staphylococcal enterotoxin-like toxins M, N and...
2018/0200357 Recombinant Mycobacterium as an Immunotherapeutic Agent for the Treatment of Cancer
The invention relates to a recombinant Mycobacterium cell for use as an immunotherapeutic agent in the treatment of cancer, particularly in the treatment of...
2018/0200356 IMMUNE INDUCER
An object of the present invention is to discover a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide...
2018/0200355 Immunogenic Preprocalcitonin Peptides
The invention relates to combinations of peptides carrying T-cell epitopes of the antigen preprocalcitonin, presented by the MHC. These peptides can be used in...
2018/0200354 Dickkopf2 (Dkk2) Inhibition Suppresses Tumor Formation
The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8.sup.+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor...
2018/0200353 Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of...
The invention relates to cell stimulatory fusion proteins and DNA sequences, vectors comprising at least two agonists of TNF/TNFR super family, immunoglobulin...
2018/0200352 Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of...
The invention relates to cell stimulatory fusion proteins and DNA sequences, vectors comprising at least two agonists of TNF/TNFR super family, immunoglobulin...
2018/0200351 Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of...
The invention relates to cell stimulatory fusion proteins and DNA sequences, vectors comprising at least two agonists of TNF/TNFR super family, immunoglobulin...
2018/0200350 Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of...
The invention relates to cell stimulatory fusion proteins and DNA sequences, vectors comprising at least two agonists of TNF/TNFR super family, immunoglobulin...
2018/0200349 Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of...
The invention relates to cell stimulatory fusion proteins and DNA sequences, vectors comprising at least two agonists of TNF/TNFR super family, immunoglobulin...
2018/0200348 Treatment of human immunodeficiency virus/acquired immunodeficiency syndrome
Methods of treating a patient with human immunodeficiency virus are disclosed. The method includes a providing intradermal and intravenous doses of a aTh1...
2018/0200347 METHODS OF TREATMENT USING ALPHA-1-ANTITRYPSIN COMPOSITIONS
A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as Coh fraction IV precipitate, is provided. In the...
2018/0200346 ALBUMIN FUSION PROTEINS
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by...
2018/0200345 PROCESS AND COMPOSITION FOR LOW DOSE INSEMINATION
The present invention relates to a composition for use in low dose artificial insemination and to a process for artificial insemination of a female mammal...
2018/0200344 COMPOSITIONS COMPRISING SULFORAPHANE OR A SULFORAPHANE PRECURSOR AND A MUSHROOM EXTRACT OR POWDER
The present disclosure relates to the synergistic combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to...
2018/0200343 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
A method of treating a subject having or at risk for having a virus infection, by administering a therapeutically effective amount of a composition comprising...
2018/0200342 IMPROVING SEQUENCE-SPECIFIC ANTIMICROBIALS BY BLOCKING DNA REPAIR
The invention relates to the improvement of endonuclease-based antimicrobials by blocking DNA repair of double-strand break(s) (DSB(s)) in prokaryotic cells....
2018/0200341 HYALURONIC ACID CONTAINING COMPOSITIONS FOR PREVENTION OF THE FORMATION OF POST-SURGICAL SCARS AND...
The present invention relates to pharmaceutical compositions enhancing the therapeutic effect of biologically active peptides, especially peptides derived from...
2018/0200340 Wound Treatment
The application discloses hydrogel wound treatment formulation containing collagen and decorin, and optionally fibrin. This is especially useful for the...
2018/0200339 METHODS OF REDUCING CORNEAL ENDOTHELIAL CELL LOSS
Provided herein are methods of reducing corneal endothelial cell loss (e.g., nerve loss-related corneal endothelial cell loss) that include selecting a subject...
2018/0200338 COMBINATION THERAPY OF TUMOR-TARGETED IL-2 VARIANT IMMUNOCYTOKINES AND ANTIBODIES AGAINST HUMAN PD-L1
The present invention relates to the combination therapy of specific tumor-targeted IL-2 variant immunocytokines with specific antibodies which bind human PD-L1.
2018/0200337 MOLECULAR DESIGN OF RECOMBINANT PROTEIN DRUG
Provided is amutant of an endostatin. The mutant has improved ATPase activity and improved activity of inhibiting angiogenesis and inhibiting tumors. Further...
2018/0200336 Vehicles For Controlled Delivery of Different Pharmaceutical Agents
A "nanolipogel" is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or...
2018/0200335 B Cell Activation Inhibitor, and Therapeutic Agent For Autoimmune Diseases
The inventors found that B cell activation is suppressed by TGF-.beta.3 produced by LAG3.sup.+ Treg. They also discovered a B cell activation suppressor which...
2018/0200334 METHODS FOR TREATING METABOLIC DISORDERS USING FGF
The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance,...
2018/0200333 FUSION POLYPEPTIDES AND METHODS OF USE
Provided are fusion polypeptides comprising fragments from a first and a second FGF family member, nucleic acids encoding the fusion polypeptides, vectors and...
2018/0200332 METHODS AND COMPOSITIONS FOR TREATING TRINUCLEOTIDE REPEAT DISORDERS
Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.
2018/0200331 BST-2 AS A THERAPEUTIC TARGET AND DIAGNOSTIC MARKER FOR BREAST CANCER GROWTH AND METASTASIS
Disclosed are compositions, kits, and methods for treating and/or diagnosing cancer in a subject in need thereof. The compositions, kits, and methods may be...
2018/0200330 Compositions and Methods for the Treatment of Diseases Related to the Renin-Angiotensin-System
The present invention relates to pharmaceutical compositions, kits and methods for the treatment of diseases related to the renin-angiotensin system (RAS),...
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