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Patent # Description
2018/0200279 INHIBITION OF HSV-1-ASSOCIATED CORNEAL NEOVASCULARIZATION USING INHIBITORS OF CYCLIN-DEPENDENT KINASE 9
Provided are methods of preventing and/or treating herpes simplex virus-1 (HSV-1)-associated ocular neovascularization comprising administering a ...
2018/0200278 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF
The present invention relates to certain SGLT-2 inhibitors for treating and/or preventing metabolic disorders, such as type 1 or type 2 diabetes mellitus or...
2018/0200277 THERAPEUTIC AGENT FOR MYOTONIC DYSTROPHY
The present invention provides a therapeutic agent for myotonic dystrophy which inhibits aberrant splicing responsible for myotonic dystrophy, resulting in an...
2018/0200276 AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS
A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5'' position, exhibiting efficient stop codon mutation readthrough activity,...
2018/0200275 METHOD AND THE USE TO IMPROVE ORAL ABSORPTION OF NICOTINAMIDE AND NICOTINAMIDE RIBOSIDE
The present invention provides methods to improve oral absorption of nicotinamide or nicotinamide riboside or both nicotinamide and nicotinamide riboside via...
2018/0200274 INHIBITORY COMPOSITIONS
The present invention related to a composition comprising a pentose and one or more polyphenolic compounds, and to the use of said compositions for managing or...
2018/0200273 Silanol Based Therapeutic Payloads
Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting...
2018/0200272 MODIFIED RELEASE DOXYCYCLINE COMPOSITION
Doxycycline formulations with a reduced food effect are disclosed. Particularly disclosed are modified release formulations which can be administered once a...
2018/0200271 ORAL COMPOSITION OF CELECOXIB FOR TREATMENT OF PAIN
The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib...
2018/0200270 ORAL COMPOSITION OF CELECOXIB FOR TREATMENT OF PAIN
The present invention relates to a stable oral liquid pharmaceutical composition of celecoxib or its pharmaceutically acceptable salts thereof. The celecoxib...
2018/0200269 CHOLECALCIFEROL SULFATE SALTS AND THEIR USE FOR THE TREATMENT OF VITAMIN D DEFICIENCY
Pharmaceutically acceptable cholecalciferol sulfate salts are used for combating vitamin D.sub.3 deficiency. New cholecalciferol sulfate salts as well as...
2018/0200268 PHARMACEUTICAL FORMULATION FOR THE TREATMENT OF INFLAMMATORY CHANGES TO THE RECTUM
Disclosed is a storage-stable pharmaceutical formulation for rectal administration, containing budesonide or a pharmaceutically compatible salt or derivative...
2018/0200267 OXYSTEROLS AND METHODS OF USE THEREOF
Compounds are provided according to Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein...
2018/0200266 ESTROGEN RECEPTOR Beta PARTIAL AGONIST HAVING ESTROGEN RECEPTOR Alpha INHIBITORY EFFECT, AND GYNECOLOGICAL...
[Problem] To provide a therapeutic agent for estrogen-dependent gynecological diseases such as endometriosis, uterine fibroids, and uterus adenomyosis....
2018/0200265 OPTIMIZING MIFEPRISTONE LEVELS FOR CUSHING'S PATIENTS
The present invention provides a method for optimizing levels of mifepristone in a patient suffering from Cushing's syndrome. The method comprises the steps of...
2018/0200264 Compositions and Methods for Muscle Regeneration Using Prostaglandin E2
Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or...
2018/0200263 TOPICAL TREATMENT REGIMENS CONTAINING A PROSTAGLANDIN F2a ANALOG AND A TOPICAL STEROID
Disclosed herein is a topical treatment regimen including a prostaglandin F2.alpha. analog and a topical steroid for treating skin conditions, including skin...
2018/0200262 TARGETED NOTCH PATHWAY INHIBITORS
The instant invention relates to novel conjugates of the compound of formula (I): S-L-A (I) or salts thereof, wherein A is a .gamma.-secretase inhibitor, L is...
2018/0200261 METHODS AND MATERIALS FOR TREATING CANCER
This document provides methods and materials for treating cancer. For example, methods and materials for using an inhibitor of a BET polypeptide to increase...
2018/0200260 High Dosage Strength Tablets of Rucaparib
A tablet including high dosage of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[- 5,4,3-cd]indol-6-one camsylate salt has been...
2018/0200259 GALANTAMINE CLEARANCE OF AMYLOID
Galantamine and its pharmaceutically acceptable salts are of use in treating persons meeting criteria for having a risk of developing Alzheimer's type...
2018/0200258 METHODS FOR TREATING GI TRACT DISORDERS
Provided herein are methods, compositions, and kits for the treatment of an enteric nervous system disorder. Such methods may comprise administering to a...
2018/0200257 METHODS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
The present invention discloses compounds according to Formula I; or a pharmaceutically acceptable salt thereof, or a solvate or the salt of a solvate thereof,...
2018/0200256 NOVEL METHODS
The disclosure provides the use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of residual symptoms...
2018/0200255 SALTS AND SOLID FORMS OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDIN- ...
Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,- 6-dione, or a stereoisomer thereof, are disclosed....
2018/0200254 ANTIVIRAL THERAPY
The present invention relates to combinations of compounds comprising HIV integrase inhibitors and other therapeutic agents. Such combinations are useful in...
2018/0200253 Heteroaromatic Compounds and their Use as Dopamine D1 Ligands
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof and N-oxides thereof; processes for...
2018/0200252 PHARMACEUTICAL COMPOSITIONS OF 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-- ...
Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one,...
2018/0200251 METHODS FOR TREATING COGNITIVE DEFICITS ASSOCIATED WITH FRAGILE X SYNDROME
Provided herein are methods of treating a cognitive deficit, including cognitive deficits associated with a Fmr1 genetic defect. More particularly, provided...
2018/0200250 PROTEIN ACYL TRANSFERASE INHIBITORS AND METHODS OF TREATMENT
Embodiments of the present disclosure include compositions and pharmaceutical compositions that include protein acyl transferases (PAT) inhibitors, methods of...
2018/0200249 TEMOZOLOMIDE POWDER FORMULATION
The present invention relates to a solid pharmaceutical composition of temozolomide that has good and consistent flowability as a powder and taste masking and...
2018/0200248 TREATMENT OF HEARING AND BALANCE IMPAIRMENTS WITH REDOX-ACTIVE THERAPEUTICS
Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing or balance impairments involving neuronal damage, loss,...
2018/0200247 Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators
The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of...
2018/0200246 CRYSTALLINE FORMS OF AN 8-AZABICYCLO[3.2.1]OCTANE COMPOUND
The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-- ...
2018/0200245 SOLID FORMS COMPRISING 4-AMINO-2-(2,6-DIOXOPIPERIDINE-3-YL)ISOINDOLINE-1,3-DIONE AND A COFORMER, ...
Provided herein are solid forms comprising (a) 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and (b) a coformer. Pharmaceutical compositions...
2018/0200244 METHODS OF IMPROVING CELL-BASED THERAPY
Provided are methods for improving cell-based therapies by co-administration with an agent that increases the production and or levels of epoxygenated fatty...
2018/0200243 Novel FXR (NR1H4) binding and activity modulating compounds
The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the...
2018/0200242 Pirfenidone Treatment for Patients with Atypical Liver Function
Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone...
2018/0200241 METHODS OF USING SUSTAINED RELEASE AMINOPYRIDINE COMPOSITIONS
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a...
2018/0200240 PHARMACEUTICAL COMPOSITIONS COMPRISING AN INTEGRIN ALPHA4 ANTAGONIST FOR USE IN TREATING OCULAR INFLAMMATORY...
The invention relates to antagonists of integrin .alpha.4 and their use in pharmaceutical compositions, primarily topically administered ophthalmic...
2018/0200239 PROPHYLACTIC AND/OR THERAPEUTIC AGENT CONTAINING PYRIDYLAMINOACETIC ACID COMPOUND
The object of the present invention is to find a new application of isopropyl (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}p- ...
2018/0200238 THERAPEUTIC AND/OR PROPHYLACTIC AGENT FOR ADULT T CELL LEUKEMIA/LYMPHOMA
The present invention provides an agent for treating and/or preventing adult T cell leukemia/lymphoma containing a compound having a specific chemical...
2018/0200237 Accelerating Thrombus Resolution Through Augmentation of p53 Activity
A novel function for the p53 gene related to resolution of deep venous thrombosis is disclosed herein. Lack of the p53 gene results in impaired thrombus...
2018/0200236 Treatment for Chemotherapy-induced Peripheral Neuropathy
The present invention provides methods and compositions for treating chemotherapy induced peripheral neuropathy. One embodiment of the present invention is...
2018/0200235 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING IMMUNOINFLAMMATORY DERMAL DISORDERS
A method for preventing or treating immunoinflammatory dermal disorders is provided. Also provided is a pharmaceutical composition for preventing or treating...
2018/0200234 COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND BETA-ADRENERGIC AGONISTS
Combinations comprising (a) a .beta.2 agonist and (b) an antagonist of M3 muscarinic receptors which is ...
2018/0200233 COMPOSITIONS FOR PREVENTING CANCERS ASSOCIATED WITH HUMAN PAPILLOMA VIRUSES
Compositions and methods of treatment are provided for preventing cancers caused by high-risk human papilloma viruses (HPV). Cancers amenable to prevention...
2018/0200232 PHARMACEUTICAL COMPOSITIONS USEFUL FOR THE TREATEMENT OF TISSUE INJURY
The present invention relates to the field of tissue injury. More specifically, the present invention provides pharmaceutical compositions useful for the...
2018/0200231 IL-8 INIHIBITORS FOR USE IN THE TREATMENT OF SOME UROLOGICAL DISORDERS
The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1/CXCR2 receptor inhibitors, useful in the treatment and/or prevention of...
2018/0200230 METHODS OF TREATING NEURODEGENERATIVE DISEASES USING INDANE ACETIC ACID DERIVATIVES WHICH PENETRATE THE BLOOD...
This invention describes the use of indane acetic acid derivatives which are dual PPAR delta/gamma agonists, and which penetrate the Blood Brain Barrier and...
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