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Patent # Description
2018/0223007 Processes For Preparing Functionalized Polymers, Related Functionalizing Compound And Preparation Thereof
Disclosed herein are processes for preparing functionalized polymers, functionalizing compounds useful in the processes and processes for preparing the...
2018/0223006 MODIFIER AND MODIFIED AND CONJUGATED DIENE-BASED POLYMER PREPARED USING THE SAME
The present invention provides a modifier including a silane-based compound of Formula 1, which may prevent the agglomeration of a filler in a rubber...
2018/0223005 CATALYST COMPOSITIONS AND THEIR USE FOR HYDROGENATION OF NITRILE RUBBER
Catalyst compositions based on Ruthenium- or Osmium-based complex catalysts and specific co-catalysts are provided for selectively hydrogenating nitrile...
2018/0223004 POLYISOPRENE PRODUCTION METHOD
The present invention provides a method for producing polyisoprene including the steps of: (A) combining a plant tissue containing polyisoprene with an organic...
2018/0223003 Novel Chelator and Use Thereof
The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification...
2018/0223002 CATIONIC POLY ALPHA-1,3-GLUCAN ETHERS
Poly alpha-1,3-glucan ether compounds are disclosed herein comprising positively charged organic groups. The degree of substitution of the ether compounds is...
2018/0223000 HETERODIMERIC ANTIBODIES THAT BIND CD3 AND TUMOR ANTIGENS
The present invention is directed to novel heterodimeric antibodies.
2018/0222999 HUMANIZED ANTIBODIES
The present disclosure provides humanized antibodies, including antibodies comprising an ultralong CDR3 and uses thereof.
2018/0222998 MUC1* ANTIBODIES
The present describes monoclonal antibody to MUC1*.
2018/0222997 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CANCER
An isolated antibody that specifically binds to an extracellular domain of two or more human FZD receptors and inhibits growth of tumor cells is described....
2018/0222996 BISPECIFIC SCFV IMMUNOFUSION (BIF)
Certain embodiments are directed to a bispecific immunoglobulin that is capable of binding cell surface molecules on a target cell, such as cancer cells, and...
2018/0222995 USE OF CHIMERIC ANTIGEN RECEPTOR MODIFIED CELLS TO TREAT CANCER
The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using chimeric antigen receptor (CAR)...
2018/0222994 ANTIBODY WHICH SPECIFICALLY BINDS TO HUMAN CRTH2
There is provided an anti-human CRTH2 antibody which has desired activity by recognizing and binding to a specific human CRTH2; the antibody fragment; DNA...
2018/0222993 BISPECIFIC ANTI-HUMAN CD20/HUMAN TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE
Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
2018/0222992 BISPECIFIC ANTI-HUMAN A-BETA/HUMAN TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE
Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.
2018/0222991 METHOD FOR THE SELECTION OF ANTIBODIES AGAINST BCMA
An antibody specifically binding to human BCMA, characterized in that the binding of said antibody is not reduced by APRIL and not reduced by BAFF, said...
2018/0222990 Combination Treatments and Uses and Methods Thereof
Disclosed herein are combinations of an OX40 modulator and a CTLA-4 modulator, pharmaceutical compositions thereof, uses thereof, and methods of treatment...
2018/0222989 COMBINATION TREATMENTS AND USES AND METHODS THEREOF
Disclosed herein are combinations of an OX40 modulator and a PD-1 modulator, pharmaceutical compositions thereof, uses thereof, and methods of treatment...
2018/0222988 THERAPEUTIC AGENT FOR CHRONIC ARTHRITIDES DISEASES OF CHILDHOOD-RELATED DISEASES
A therapeutic agent for chronic arthritides diseases of childhood-related diseases, for example chronic arthritides diseases of childhood, Still's disease and...
2018/0222987 ANTI-CD3 ANTIBODIES, ANTI-CD123 ANTIBODIES AND BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO CD3 AND/OR CD123
The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example...
2018/0222986 CANCER METASTASIS INHIBITOR
The present inventors used a model of intrasplenically induced liver metastasis to determine whether or not NF-.kappa.B activation in the liver is involved in...
2018/0222985 ANTIBODIES AGAINST HUMAN CSF-1R FOR USE IN INDUCING LYMPHOCYTOSIS IN LYMPHOMAS OR LEUKEMIAS
The present invention relates to anti-CSF-1R induced lymphocytosis in lymphomas and leukemias and a combination therapy of antibodies which bind human CSF-1R...
2018/0222984 METHODS AND COMPOSITIONS FOR MODULATION OF BLOOD-NEURAL BARRIER
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy...
2018/0222983 METHODS, COMPOSITIONS, AND KITS FOR TREATMENT OF CANCER
Provided herein are the use of FGFR3 inhibitors and taxanes to treat solid and hematologic cancers, as well as compositions and kits comprising an FGFR3...
2018/0222982 COMBINATION THERAPIES COMPRISING ANTIBODY MOLECULES TO PD-1
Combination therapies comprising antibody molecules that specifically bind to PD-1 disclosed. The combination therapies can be used to treat or prevent...
2018/0222981 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In...
2018/0222980 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In...
2018/0222979 ANTI-CS1 ANTIBODIES AND ANTIBODY DRUG CONJUGATES
The present disclosure provides antibodies and antibody drug conjugates that bind human CS1 and their uses to treat subjects diagnosed with a plasma cell...
2018/0222978 MUSCARINIC ACETYLCHOLINE RECEPTOR BINDING AGENTS AND USES THEREOF
Agents that specifically bind to a muscarinic acetylcholine receptor in a conformationally specific way can be used to induce a conformational change in the...
2018/0222977 ANTI-PD-1 ANTIBODIES FOR CNS DISEASES
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
2018/0222976 Anti-ASIC1 Antibodies and Uses Thereof
The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1)....
2018/0222975 IL-6 ANTAGONISTS AND USES THEREOF
IL-6 antagonists are provided that are specific for binding to site II of IL-6. Methods of using such inhibitors to treat IL-6 related diseases, e.g., disease...
2018/0222974 COMPOSITIONS AND METHODS FOR USING ANTI-IL-34 ANTIBODIES TO TREAT NEUROLOGICAL DISEASES
The invention provides methods for treating neurological diseases and reducing microglia density using anti-IL-34 antibodies.
2018/0222973 COMBINED USE OF ANTI PD-1 AND ANTI M-CSF ANTIBODIES IN THE TREATMENT OF CANCER
The present application n relates to a pharmaceutical composition comprising a PD-1 antibody and an M-CSF antibody. The combination can be administered...
2018/0222972 ANTI-TNF ANTIBODIES, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF ACTIVE ANKYLOSING SPONDYLITIS
The present invention relates to compositions and methods utilizing anti-TNF antibodies having a heavy chain (HC) comprising SEQ ID NO:36 and a light chain...
2018/0222971 COMPOUNDS AND METHODS FOR TREATING PAIN
This disclosure provides compositions and methods for controlling pain. In particular the disclosure provides a method for controlling pain comprising...
2018/0222970 SCFV-FC DIMERS THAT BIND TRANSFORMING GROWTH FACTOR-BETA1 WITH HIGH AFFINITY, AVIDITY AND SPECIFICITY
An scFv-Fc dimer binds and neutralizes TGF.beta.1 selectively and with high affinity and avidity. The scFv region may comprise the same VH and VL domains or...
2018/0222969 COMPLEMENT COMPONENT C5 ANTIBODIES
The present disclosure relates to antibodies and polynucleotides encoding the same, that may be used to prevent, control, or reduce the activity of the...
2018/0222968 ANTIBODY THAT BINDS MURINE WISE PROTEIN
The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal...
2018/0222967 METHODS FOR TREATING PAIN USING ANTIBODIES TO KALLIDIN AND DES-ARG10-KALLIDIN
The invention provides antibodies that specifically bind to Kallidin or des-Arg10-Kallidin. The invention also provides pharmaceutical compositions, as well as...
2018/0222966 TRANSGENIC PLANT COMPRISING A POLYNUCLEOTIDE ENCODING A VARIABLE DOMAIN OF HEAVY-CHAIN ANTIBODY
This disclosure relates to a transgenic plant or plant tissue. In particular, this disclosure relates to a transgenic plant or plant tissue or plant cell...
2018/0222965 Fc VARIANTS THAT IMPROVE FcRn BINDING AND/OR INCREASE ANTIBODY HALF-LIFE
The present invention discloses the generation of novel variants of Fc domains, including those found in antibodies, Fc fusions, and immuno-adhesions, which...
2018/0222964 ANTIBODY VARIANTS
The present invention relates to methods of selecting, screening, engineering, making and modifying antibodies that have improved bioavailability upon...
2018/0222963 ALBUMIN VARIANTS
The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also...
2018/0222962 Single-Chain Trail-Receptor Agonist Proteins
Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated...
2018/0222961 Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0222960 MODIFIED RELAXIN POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCER AND USES THEREOF
The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded...
2018/0222959 EXPOSED COLLAGEN-TARGETED FUSION CYTOKINE FOR IMMUNE MODULATION IN INVASIVE CANCERS AND LESIONS OF INFECTIONS
Provided herein are new compositions and methods to target pharmaceutical agents to pathological areas by utilizing fusion polypeptides. These fusion...
2018/0222958 LYMPHOTOXIN-BETA RECEPTOR-BINDING AGENTS, TARGETING ANTIBODIES, AND USES THEREOF
Polypeptides, agents, and molecules that bind lymphotoxin-beta receptor (LT.beta.R) and/or tumor-associated antigens are disclosed. The polypeptides, agents,...
2018/0222957 MODIFIED CXCL12 POLYPEPTIDES AND USES THEREOF
The present invention relates to modified CXCL12 polypeptides, modified CXCL12 locked monomers, and CXCL12 locked dimers. The invention further relates to...
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