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Patent # Description
2018/0265891 EXPRESSION VECTOR SYSTEM COMPRISING TWO SELECTION MARKERS
The invention pertains to an expression vector or a combination of at least two expression vectors comprising at least (a) a polynucleotide encoding a...
2018/0265890 EFFICIENT AND SAFE TRANSPOSON INTEGRATION SYSTEM AND USE THEREOF
The invention belongs to the field of molecular biology, and relates to an efficient and safe transposon integration system and use thereof. The invention also...
2018/0265889 DIRIGENT GENE EG261 AND ITS ORTHOLOGS AND PARALOGS AND THEIR USES FOR PATHOGEN RESISTANCE IN PLANTS
The present invention provides the identification and use of EG261, homologs of EG261, orthologs of EG261, paralogs of EG261, and fragments and variations...
2018/0265888 P0 GENE SILENCING CONSTRUCTS AND USE
A recombinant BMYV P0 viral nucleotide sequence when transcribed in a cell is capable of forming a double stranded self-complementary RNA sequence.
2018/0265887 Basil Plants With High Tolerance to Downy Mildew
Ocimum basilicum plants or germplasm having tolerance or improved tolerance to Peronospora belbahrii infection, comprising in its genome the single nucleotide...
2018/0265886 HYPERSENSITIVE ABA RECEPTORS
Hypersensitive PYR/PYL polypeptides, compositions, and methods are provided.
2018/0265885 HIGHLY EXPRESSED PROTECTIVE PLANT-DERIVED BROADLY NEUTRALIZING HIV MONOCLONAL ANTIBODIES FOR USE IN PASSIVE...
Monoclonal antibodies produced in plants at high levels wherein elimination of L chain glycans improves plasma stability of certain plant derived bnAbs are...
2018/0265884 Wheat with Reduced Lipoxygenase Activity
A series of independent human-induced non-transgenic mutations found at one or more of the Lpx genes of wheat; wheat plants having these mutations in one or...
2018/0265883 WHEAT WITH INCREASED RESISTANT STARCH LEVELS
A series of independent human-induced non-transgenic mutations found at one or more of the SBEII genes of wheat; wheat plants having these mutations in one or...
2018/0265882 PLANTS WITH INCREASED SEED SIZE
The invention relates to genetically modified plants with an altered seed phenotype, in particular increased seed size. The invention relates to a plant that...
2018/0265881 MAIZE AND SORGHUM S-ADENOSYL-HOMOCYSTEINE HYDROLASE PROMOTERS
The disclosure describes promoter sequences, specifically S-Adenosyl-Homocysteine Hydrolase promoter sequences from maize and sorghum, which are useful for...
2018/0265880 Arogenate dehydrogenase polynucleotides, polypeptides and methods of using the same
The invention generally relates to arogenate dehydrogenase polynucleotides and methods of using the same. More specifically, the invention relates in part to...
2018/0265879 MANUFACTURING METHOD OF AN IMMUNOTHERAPEUTIC FORMULATION COMPRISING A RECOMBINANT LISTERIA STRAIN
The present invention discloses a process for manufacturing a formulation comprising a drug substance, said drug substance comprising a recombinant Listeria...
2018/0265878 METHOD OF REAL-TIME PROGNOSIS OF FLOODING PHENOMENON IN PACKED COLUMN
A method of real-time prognosis of a flooding phenomenon in a packed column includes steps as follows. An online data collection step is conducted, wherein a...
2018/0265877 METHODS AND COMPOSITIONS FOR AGROBACTERIUM COMPRISING NEGATIVE SELECTION MARKERS
The present disclosure comprises methods and compositions comprising a plant transforming bacterium of the Order Rhizobiales comprising conditional negative...
2018/0265876 Methods for Improving Expression Levels of Foreign Proteins by Means of Phospholipase Fusion Expression
The invention discloses a method for improving the extracellular expression level of a foreign protein by means of phospholipase fusion expression. Four...
2018/0265875 CANDIDA CARBONYL REDUCTASE AND METHOD FOR PREPARING (R)-LIPOIC ACID PRECURSOR
Disclosed herein is Candida parapsilosis CGMCC 9630, the carbonyl reductase expressed by said strain and the encoding gene and amino acid sequence thereof, the...
2018/0265874 METHODS FOR TREATING AND/OR PREVENTING A TUMOR GROWTH, INVASION AND/OR METASTASIS
The invention relates to a method for treating and/or preventing a tumor growth, invasion and/or metastasis by inhibiting an overexpression of PD-L1 in the...
2018/0265873 Genetic Or Pharmacological Reduction Of Perk Enhances Cortical- And Hippocampus-Dependent Cognitive Function
A method for improving a cognitive function in a subject comprising administering to said subject an active agent reducing PKR-like endoplasmic reticulum...
2018/0265872 AMPHIPHILIC DENDRIMERS COMPLEXED WITH SIRNA FOR TREATMENT OF CANCER
The invention pertains to amphiphilic dendrimers complexed with Bcl3 siRNA. The amphiphilic dendriplexes described herein are biodegradable and exhibit...
2018/0265871 RIBOSOMAL NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through RNA interference-mediated inhibition of target...
2018/0265870 AGENTS USEFUL IN TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY
The invention teaches antisense agents and RNA interference agents useful for treating diseases and conditions the treatment of which can benefit from reducing...
2018/0265869 SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE (3dT)
The present invention relates to RNAi molecules, and compositions thereof, comprising a 2' internucleoside linkage connecting the nucleotide at position 1 and...
2018/0265868 METHODS AND COMPOSITIONS COMPRISING APSE KNOTS
The invention describes recombinant DNA sequences transcribed into RNA constructs capable of forming pseudoknots and being encapsidated in Virus Like Particles...
2018/0265867 NUCLEIC ACID MOLECULES WITH ENHANCED ACTIVITY
Double-stranded nucleic acid molecules (100, 200, 300, 400, 500 and 600) are provided comprising a sense strand (110, 210, 310, 410, 510 and 610) and an...
2018/0265866 ANTISENSE NUCLEIC ACIDS
The present invention provides an oligomer which allows exon 45 skipping in the human dystrophin gene.
2018/0265865 RAAV-BASED COMPOSITIONS AND METHODS
The invention relates to isolated nucleic acids and rAAV-based compositions, methods and kits useful for treating genetic diseases (e.g., alpha-1 antitrypsin...
2018/0265864 Genome Engineering Methods Using a Cytosine-Specific CAS9
Described herein are methods and compositions for rapid and precise genome editing at any desired genomic position in almost all cells and organisms. The...
2018/0265863 NOVEL HIGH EFFICIENCY LIBRARY-IDENTIFIED AAV VECTORS
Aspects of the disclosure relate to barcoded chimeric adeno-associated virus (AAV) capsid libraries, chimeric capsids and related recombinant AAVs (rAAVs)...
2018/0265862 THE METHOD OF SYNTHESIS AND PURIFICATION OF A NUCLEOSIDE AND/OR A NUCLEOTIDE, A MODIFIED NUCLEOSIDE AND/OR...
The object of the invention is a method of synthesis and purification of a nucleoside and/or a nucleotide being a mono-, di- or triphosphate, wherein a...
2018/0265861 PHAGE MICROARRAY PROFILING OF THE HUMORAL RESPONSE TO DISEASE
The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present...
2018/0265860 Method and Apparatus for Isolating Nucleic Acids
A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution...
2018/0265858 SYSTEMS AND METHODS FOR MAGNETIC GUIDANCE AND PATTERNING OF MATERIALS
Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some...
2018/0265857 RECOMBINANT BATROXOBIN MIXED COMPOSITION AND A HEMOSTATIC POWDER OR HEMOSTATIC PAD COMPRISING SAME
The present invention relates to a novel recombinant batroxobin mixture, a hemostatic composition comprising the same, and a method for preparing the same....
2018/0265856 ENDOTOXIN-REDUCED THERMOLYSIN
It is necessary to establish a purification method effective for the removal of endotoxin, in order to obtain thermolysin containing a reduced amount of...
2018/0265855 SUBTILASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding...
2018/0265854 Cleavage of Fucose in N-Glycans
Provided herein is an .alpha.-fucosidase that can cleave a conjugate comprising an N-glycan and a label where the label is added by amine reactive chemistry....
2018/0265853 YEAST STRAINS FOR THE EXPRESSION AND SECRETION OF HETEROLOGOUS PROTEINS AT HIGH TEMPERATURES
The present disclosure relates to recombinant yeast strains capable of maintaining their robustness at high temperature as well as recombinant proteins...
2018/0265852 Compositions and Methods Comprising the Use of Exiguobacterium Acetylicum and Bacillus Coagluans...
An isolated and/or purified .alpha.-glucanotransferase from Exiguobacterium Acetylicum, recombinantly engineered variants thereof, active fragments thereof,...
2018/0265851 TRANSGLUTAMINASE VARIANTS FOR CONJUGATING ANTIBODIES
Transglutaminase variants capable of conjugating an antibody that is not conjugated by wild-type transglutaminase from Streptomyces mobaraensis.
2018/0265850 NOVEL ARTIFICIAL BIOLUMINESCENT ENZYMES
The present invention relates to provision of novel artificial bioluminescent enzymes. According to one embodiment of the present invention, there is provided...
2018/0265849 Stabilization of Dehydrogenases with Stable Coenzymes
The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further...
2018/0265848 RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS
The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding...
2018/0265847 SYNTHETIC MEMBRANE-RECEIVER COMPLEXES
Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or...
2018/0265846 CHIMERIC ANTIGEN RECEPTOR ANTI-INFLAMMATORY CELLS AND METHODS OF USE
A nucleic acid construct and an immune cell, which harbor nucleic acids encoding a CAR and nucleic acids encoding at least one anti-inflammatory or...
2018/0265845 GENETICALLY-MODIFIED CELLS COMPRISING A MODIFIED HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE
Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has...
2018/0265844 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13R-alpha-2
Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain that includes IL-13 or a variant thereof that binds interleukin-13R.alpha.2...
2018/0265843 METHOD AND MEDIUM FOR NEURAL DIFFERENTIATION OF PLURIPOTENT CELLS
The invention relates to a culture medium comprising an inhibitor of the BMP signaling pathway; and an inhibitor of the TGF/activin/nodal signaling pathway and...
2018/0265842 PLURIPOTENT STEM CELL CULTURE ON MICRO-CARRIERS
The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on micro-carriers.
2018/0265841 Method for Generating Human Multipotent Mammary Stem Cells From Normal Primary Breast Luminal Cells
The invention relates to methods for generating multipotent mammary stem cells from isolated and cultured human breast luminal cells. The method comprises the...
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