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Patent # Description
2018/0265587 METHODS OF MEDIATING CYTOKINE EXPRESSION
The present disclosure provides methods of modulating regulatory T-cell activity and function.
2018/0265586 ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,...
2018/0265585 CHIMERIC ANTIGEN RECEPTORS, AND T CELLS IN WHICH CHIMERIC ANTIGEN RECEPTOR IS EXPRESSED
Disclosed is a chimeric antigen receptor comprising an antigen binding domain; a hinge region; a transmembrane domain; a costimulatory domain; and a...
2018/0265584 Targeted Immunotolerance
Methods and compounds for conferring site-specific or local immune privilege.
2018/0265583 HUMANIZED MONOCLONAL ANTIBODIES AND METHODS OF USE FOR THE DIAGNOSIS AND TREATMENT OF COLON AND PANCREAS CANCER
This invention relates to humanized antibodies that selectively bind the 31.1 epitope on the A33 protein differentially expressed in cancers including, lung...
2018/0265582 Immunological Reagents
This disclosure relates to binding agents with specificity for programmed cell death 1 (PD-1) and to methods for using the same to treat, prevent and/or...
2018/0265581 JAML Specific Binding Agents, Antibodies, and Uses Related Thereto
Certain embodiments of the disclosure relate to targeted binding agents that specifically bind to JAM-like protein and therein inhibit epithelial damage....
2018/0265580 NOVEL P2X7 EPITOPES
The invention relates to purinergic (P2X) receptors, more specifically to P2X7 receptors, the generation of antibodies and the use of antibodies and immunogens...
2018/0265579 TREATMENT OF FIBROSIS
Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment,...
2018/0265578 ANTIBODY TO GDF8 AND USES THEREOF
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific...
2018/0265577 ANTIBODIES TO TAU AND USES THEREOF
Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of...
2018/0265576 ANTIBODIES TO OXIDIZED PHOSPHOLIPIDS
The disclosure provides for single chain variable fragments to oxidized phospholipid epitopes and methods of use thereof, including the production of...
2018/0265575 ANTI-PHF-TAU ANTIBODIES AND USES THEREOF
Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions...
2018/0265574 Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
The present invention relates to compositions and methods for the treatment of infection caused by Streptococcus pneumonia. In particular, the invention...
2018/0265573 ANTIBODIES AGAINST INFLUENZA VIRUS HEMAGGLUTININ AND USES THEREOF
Provided herein are antibodies that cross-react with hemagglutinin from strains of influenza virus of the same subtype or different subtypes, host cells for...
2018/0265572 MULTIVALENT FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS
The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The...
2018/0265571 HETEROLOGOUS TARGETING PEPTIDE GRAFTED AAVS
The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure...
2018/0265570 ALBUMIN VARIANTS
The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also...
2018/0265569 ALBUMIN VARIANTS
The present invention relates to variants of a parent albumin, the variants having altered plasma half-life compared with the parent albumin. The present...
2018/0265568 ALBUMIN VARIANTS AND CONJUGATES
The present invention relates to conjugation-competent albumins and albumin-related polypeptides, and their conjugates with at least one moiety, and to...
2018/0265567 IL-33 Antagonists and Uses Thereof
The present invention provides interleukin-33 (IL-33) antagonists comprising one or more IL-33-binding domains and one or more multimerizing domains and...
2018/0265566 METHODS FOR CONTROLLING T CELL PROLIFERATION
The technology relates generally to the field of immunology and relates in part to compositions and methods for controlling the proliferation of T cells, for...
2018/0265565 Method of Redirecting T Cells to Treat HIV Infection
The present invention relates to compositions and methods for treating of a HIV infected mammal using a CD4 membrane-bound chimeric receptor or a HIV specific...
2018/0265564 METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF
Herein is a fusion polypeptide with the formula R1-FC-R2, wherein R1 denotes a first Fc-receptor, R2 denotes a second Fc-receptor, and FC denotes a heavy chain...
2018/0265563 Consumable Cryopreserved Cells Transiently Overexpressing Gene(s) Encoding Drug Transporter Protein(s) and/or...
The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter...
2018/0265562 Consumable Cryopreserved Cells Transiently Overexpressing Gene(s) Encoding Drug Transporter Protein(s) and/or...
The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter...
2018/0265561 FREEZE-DRIED PREPARATION CONTAINING HIGH-PURITY PTH AND METHOD FOR PRODUCING SAME
Provided herein are freeze-dried preparations comprising a high-purity parathyroid hormone (PTH) peptide and one or more PTH analogs, and methods for the...
2018/0265560 BIPHASIC SINGLE-CHAIN INSULIN ANALOGUES
A single-chain insulin comprises a C-domain of 6 to 11 amino acid residues comprising at least two acidic residues at the N-terminal side of the C-domain and...
2018/0265559 POLYPEPTIDES, NUCLEIC ACIDS AND USES THEREOF
We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence...
2018/0265558 MODIFIED FIBROBLAST GROWTH FACTOR 1 (FGF-1) POLYPEPTIDES WITH INCREASED BINDING AFFINITY FOR HEPARIN AND...
A modified FGF-1 polypeptide that has an increased binding affinity for heparin relative the wild-type human FGF-1's binding affinity for heparin is described....
2018/0265557 Complement split product C4d for the treatment of inflammatory conditions
The present invention relates to a pharmaceutical composition comprising complement split product C4d for use in treating an inflammatory condition, such as...
2018/0265556 NOVEL DERMATOPHAGOIDES FARINAE PROTEIN
Provided are a novel Dermatophagoides farinae protein, and a diagnostic drug, a prophylactic drug and a therapeutic drug for an allergic disease caused by...
2018/0265555 Method for Producing Fibroin-Like Protein
A method for producing a fibroin-like protein is provided. A fibroin-like protein is produced by a method of culturing Escherichia coli having a gene encoding...
2018/0265554 USE OF A POLYPEPTIDE FOR EFFECTING IMMUNE SIGNALLING AND/OR AFFECTING INTESTINAL BARRIER FUNCTION AND/OR...
It has been found that an extracellular polypeptide derived from Akkermansia municiphila is capable of modulating and/or promoting gut mucosal immune system...
2018/0265553 VACCINE ANTIGEN WITH INCREASED IMMUNOGENICITY
According to the invention, immunogenicity of an antigenic peptide is increased by administering a fusion protein, which comprises an antigenic peptide and an...
2018/0265552 NEPOVIRUS COAT PROTEIN FUSION POLYPEPTIDES AND THEIR USE
The present invention relates to novel fusion polypeptides and the uses thereof. The invention particularly relates to conjugated coat proteins derived from...
2018/0265551 CYTOMEGALOVIRUS ANTIGENS
The invention generally relates to recombinant human cytomegalovirus (CMV) gB proteins and immunogenic fragments thereof, which do not comprise a transmembrane...
2018/0265550 THERAPIES, VACCINES, AND PREDICTIVE METHODS FOR FLAVIVIRUSES
The present invention provides therapies, vaccines, and predictive methods for Flaviviruses, including Zika virus, Dengue virus, and Japanese encephalitis...
2018/0265549 CYCLIC POLYPEPTIDES, METHOD FOR OBTAINING THEM AND THE THERAPEUTIC USE THEREOF
The invention relates to a polypeptide #including the following amino acid sequence: W-S-X1-W-X2-X3-C-S-X4-C-G (SEQ ID NO: 59), wherein X1, X2 and X3 are,...
2018/0265548 LIGANDS FOR INTEGRIN AV 6, SYNTHESIS AND USES THEREOF
Disclosed are compound exhibiting highly active and selective binding to .alpha..nu..beta.6 integrin, which are represented by the following general formula...
2018/0265547 Z-SELECTIVE OLEFIN METATHESIS OF PEPTIDES
The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has...
2018/0265546 SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS
The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the...
2018/0265545 Genetic system for producing a proteases inhibitor of a small peptide aldehyde type
The present invention describes a new peptide aldehyde produced naturally by Streptomyces lividans 66, which we have called livipeptin. Using genome mining of...
2018/0265544 SEPARATION METHOD FOR FUCOSYLATED ANTIBODIES
The present invention relates to a method for the separation of antibodies, specifically antibodies having different degrees of fucosylation. The method is...
2018/0265543 METHOD OF PURIFYING AN ANTIBODY
The present disclosure relates generally to methods of producing, processing, or purifying antibodies. The present disclosure also relates to methods of...
2018/0265542 LIGAND FUNCTIONALIZED POLYMERS
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
2018/0265541 PRODRUGS OF 17.BETA.-HSD1-INHIBITORS
The present invention accordingly provides novel compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the claims. The invention further relates...
2018/0265540 SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS
A process is provided for the making of estetrol starting from a 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is an C.sub.1-C.sub.5 alkyl group,...
2018/0265539 TRANSITION METAL MOLYBDOTUNGSTEN OXY-HYDROXIDE
A hydroprocessing catalyst has been developed. The catalyst is formed from a unique transition metal molybdotungsten oxy-hydroxide material. The...
2018/0265538 THIOL COMPOUNDS AND THE USE THEREOF FOR THE SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES
The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also...
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