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Patent # Description
2018/0265537 Nucleoside Triphosphates with Stable Aminoxy Groups
This invention claims aqueous compositions that comprise triphosphates of 2'-deoxynucleoside derivatives that have, instead of a 3'-OH moiety, a 3'-ONH.sub.2...
2018/0265536 Use Of Avermectin Derivative For Increasing Bioavailability And Efficacy Of Macrocyclic Lactones
The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented...
2018/0265535 AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS
Novel pseudo-disaccharide and pseudo-trisaccharide aminoglycosides, represented by Formulae I or Ia, as defined in the instant specification, designed to...
2018/0265534 MULTI-FUNCTIONALIZED POLYSACCHARIDE COMPOUNDS AND USE THEREOF FOR TARGETING THE CATION-INDEPENDENT MANNOSE...
The subject matter of the present invention is a compound characterized in that it has the general formula (I): in which P.sup.1, X, n, A, L and L.sub.1 are as...
2018/0265533 SYNTHESIS OF MONOETHERS OF SUGAR COMPRISING A LONG ALKYL CHAIN AND USES THEREOF AS A SURFACTANT
A process for obtaining a mixture of C4-C8 and C9-C18 alkyl monoether of saccharide, comprising: a) a first step of acetalization or trans-acetalization of a...
2018/0265532 METAL CARBENE OLEFIN METATHESIS CATALYSTS
This invention relates generally to metal carbene olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such...
2018/0265531 TC-PTP INHIBITORS AS APC ACTIVATORS FOR IMMUNOTHERAPY
The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also...
2018/0265530 CRYSTALLINE FORMS OF TENOFOVIR ALAFENAMIDE
The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the...
2018/0265529 PROCESS FOR PRODUCING PHOSPHINATES
The present invention relates primarily to a process for producing particular phosphinates (phosphonous acid monoesters) and use thereof for producing...
2018/0265528 NOVEL BRANCHED AMPHIPHILIC LIPIDS
Disclosed are novel branched amphiphilic lipids, in particular novel branched amphiphilic lipids of general formula (II). Also disclosed is a method of...
2018/0265527 Acyl Germanium Photoinitiators And Process For The Preparation Thereof
Acyl germanium compound according to general formula [R.sub.mAr--(C.dbd.O)--].sub.4--Ge and process for the preparation thereof. The compound is suitable as...
2018/0265526 ORGANIC METAL COMPOUND-CONTAINING COMPOSITION
An organic metal compound-containing composition, comprising: at least one organic metal compound (A) selected from the group consisting of metal alkoxides and...
2018/0265525 POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY
The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory...
2018/0265524 SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL...
This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions...
2018/0265523 ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS
The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more...
2018/0265522 MARINOPYRROLE DERIVATIVES AND METHODS OF MAKING AND USING SAME
Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents...
2018/0265521 LIBRARIES OF HETEROARYL-CONTAINING MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
The present disclosure relates to novel macrocyclic compounds and libraries thereof containing heteroaryl moieties that are useful as research tools for drug...
2018/0265520 MONOCYCLIC THIENO, PYRIDO, AND PYRROLO PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE OF SAME
The present invention provides a compound of Formula I: ##STR00001## wherein R is H, a methyl group, an ethyl group, a n-propyl group, an iso-propyl group, or a...
2018/0265519 TRICYCLIC PROTEASOME ACTIVITY ENHANCING COMPOUNDS
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates....
2018/0265518 APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
2018/0265517 EZH2 Inhibitors
The present invention relates to compounds that inhibit EZH2 activity. In particular, the present invention relates to compounds, pharmaceutical compositions...
2018/0265516 Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof
The present invention relates to a class of substituted triazolopiperazine compounds, tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic...
2018/0265515 THERAPEUTIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF USE THEREOF
Compounds of Formula (00A) and salts thereof, wherein R.sup.1, R.sup.2 R.sup.3, R.sup.4 and n are defined herein, are useful as inhibitors of one or more Janus...
2018/0265514 SALT OF CD80 ANTAGONIST
Choline salt of the CD80 antagonist compound 4-(6-fluoro-3-oxo-1,3-dihydro-pyrazolo[4,3-c]cinnolin-2-yl)-N-(2,2-difluo- ro-ethyl)-benzamide.
2018/0265513 NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR
The present invention relates to a novel and improved process for the preparation of Sitagliptin of Formula (I) and its pharmaceutically acceptable salts. The...
2018/0265511 COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES
Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
2018/0265510 6,7-CYCLICMORPHINAN DERIVATIVES AND USE THEREOF
The application provides compounds of Formula I and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2018/0265509 Tetrahydro-Pyrido-Pyrimidine Derivatives
The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), ##STR00001## wherein Y, R1, R2 and m are as defined in the...
2018/0265508 CRYSTALLINE FORMS OF A COMPOUND THAT INHIBITS BROMODOMAIN
Forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1- H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid were prepared and characterized in the...
2018/0265507 HOST TARGETED INHIBITORS OF DENGUE VIRUS AND OTHER VIRUSES
Novel antiviral compounds of Formulae (I)-(III) are provided: ##STR00001## The inventive compounds, pharmaceutical compositions thereof, and kits including the...
2018/0265506 BENZYL AMINE-CONTAINING HETEROCYCLIC COMPOUNDS AND COMPOSITIONS USEFUL AGAINST MYCOBACTERIAL INFECTION
Described herein are compounds and compositions, and methods of making and their use as effective agents against mycobacterial infections.
2018/0265505 PROCESS FOR THE PREPARATION OF N-[(3-AMINOOXETAN-3-YL) ...
The present invention relates to a novel process for the preparation of a compound of the formula (I): ##STR00001## and pharmaceutically acceptable acid addition...
2018/0265504 AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
Compounds having the following formula I: ##STR00001## or a stereoisomer or pharmaceutically-acceptable salt thereof, where R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2018/0265503 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in...
2018/0265502 TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE
The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions,...
2018/0265501 CYCLOPROPANECARBOXAMIDE MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
The present invention relates to new cyclopropanecarboxamide modulators of cystic fibrosis transmembrane conductance regulator proteins, pharmaceutical...
2018/0265500 TETRAHYDROQUINOLINE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR...
Tetrahydroquinoline sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and...
2018/0265499 BIARYL PIPERIDINE AMIDE COMPOUNDS AND METHODS OF USE THEREOF
The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of...
2018/0265498 1,4-DI-(4-METHYLTHIOPHENYL)-3-PHTALOYLAZETIDINE-2-ONE AND THE DERIVATIVES THEREOF
The present invention relates to a compound with formula (I) or a salt and/or a pharmaceutically acceptable solvate thereof, the method for preparing same as...
2018/0265497 PYRIMIDINYL-PYRIDYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF TREATING IRE1-RELATED DISEASES AND DISORDERS
Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or...
2018/0265496 SUBSTITUTED QUINOLONE DERIVATIVES, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR STEREOISOMERS THEREOF, AND...
Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a...
2018/0265495 NEW CRYSTAL FORM OF NERATINIB MALEATE AND PREPARATION METHOD THEREFOR
The present invention relates to novel crystalline forms of Neratinib maleate and the preparation method thereof. The maleate novel crystalline forms of...
2018/0265494 SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables...
2018/0265493 PROCESS FOR MAKING M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]b- ...
2018/0265492 ANTIFUNGAL COMPOUNDS AND PROCESSES FOR MAKING
Provided are polymorphic forms of compound 5 or 5*, or mixtures thereof, and polymorph forms of compound 14 or 14*, or mixtures thereof. Also provided are...
2018/0265491 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2018/0265490 METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES
The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.
2018/0265489 NOVEL ANTICANCER AGENT
The problem of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention relates to a compound...
2018/0265488 OXIDATION CHEMISTRY ON FURAN ALDEHYDES
Provided herein are methods of producing halomethylfuroic and acyloxymethylfuroic acid and ester compounds from furfural starting compounds. For example,...
2018/0265487 SWEET TASTE MODULATORS
Sweet taste modulators for enhancing sweetness of an oral consumer product having a sweetener are described. The sweet taste modulators include...
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