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Patent # Description
2018/0263968 METHODS USING 3-(4-AMINO-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE FOR TREATMENT OF MANTLE...
Methods of treating, preventing or managing mantle cell lymphomas are disclosed. The methods encompass the administration of an immunomodulatory compound of...
2018/0263967 HETEROCYCLIC COMPOUND
The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of inflammatory disease and the like, and...
2018/0263966 Inhibitors Of The Interaction Between MDM2 And P53
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising...
2018/0263965 PHARMACEUTICAL COMPOSITION COMPRISING PYRIDONE DERIVATIVES
A pyridone derivative compound and a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof, and a preventive or therapeutic pharmaceutical...
2018/0263964 METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS
The present application discloses a method for identifying an agent for the treatment or prevention of cancer or metastatic cancer comprising the steps of...
2018/0263963 MODULATORS OF THE ADENOSINE A3 RECEPTORS
Modulators of adenosin A.sub.3 receptors of formula (I): ##STR00001## And procedure for preparing these compounds. Other objectives of the present invention are...
2018/0263962 STABILIZED OXYMETAZOLINE FORMULATIONS AND THEIR USES
The present invention provides stabilized cream formulations of oxymetazoline and uses thereof. The present invention also provides a method of treating facial...
2018/0263961 SELENIUM CONTAINING KGA/GDH DUAL INHIBITORS AND THE APPLICATIONS THEREOF
The present invention relates to the field of biomedicine, and discloses a class of selenium-containing inhibitors that bind to the allosteric site of...
2018/0263960 Modulators of CA2+ Release-Activated CA2+ (CRAC) Channels and Pharmaceutical Uses Thereof
Described herein are compounds that modulate the activity of CRAC channels, methods of making such compounds, pharmaceutical compositions, and medicaments...
2018/0263959 METHODS OF TREATING MUSCULAR DYSTROPHY
Disclosed herein are .alpha.7.beta.1 integrin modulatory agents and methods of using such to treat conditions associated with decreased .alpha.7.beta.1...
2018/0263958 METHODS OF TREATING CONDITIONS RELATED TO THE S1P1 RECEPTOR
Provided are methods of treatment of a sphingosine 1-phosphate subtype 1 (S1P.sub.1) receptor-associated disorder comprising prescribing and/or administering...
2018/0263957 DULOXETINE SPRINKLES
The present invention relates in part to a multiparticulate sprinkle dosage form comprising duloxetine or a pharmaceutically acceptable salt thereof, having...
2018/0263956 STABILIZED ASCORBIC ACID SOLUTIONS; COMPOSITIONS COMPRISING THE SAME; AND METHOD OF USE THEREOF
This invention relates to improved solutions comprising ascorbic acid (vitamin C). These solutions may comprise as much as 15% ascorbic acid; they are stable,...
2018/0263955 C-MYC As A Biomarker For Tumor Sensitivity To Treatment With RNA Polymerase II Inhibition
Systems and methods for determining whether a cancer patient may respond to inhibition of RNA polymerase II as a treatment for the patient are provided....
2018/0263954 Sustained Release Cannabinoid Formulations
The present invention provides modified release pharmaceutical composition comprising one or more natural or synthetic cannabinoids and one or more...
2018/0263953 Sustained Release Cannabinoid Formulations
The present invention provides modified release pharmaceutical composition comprising one or more natural or synthetic cannabinoids and one or more...
2018/0263952 USE OF CANNABINOIDS IN THE TREATMENT OF INFLAMMATORY SKIN DISEASES
The present invention relates to the use of one or more cannabinoids in the treatment of an inflammatory skin disease. Preferably the one or more cannabinoids...
2018/0263951 METHOD OF QUENCHING SINGLET AND TRIPLET EXCITED STATES OF PHOTODEGRADABLE PIGMENTS, SUCH AS PORPHYRIN...
A method of quenching excited state energy from a photodegradable pigment that has been excited by absorption of light having a wavelength in the wavelength...
2018/0263950 METHODS FOR TREATING OR PREVENTING FATIGUE
The present invention relates to the use of compounds of the invention for treatment and/or prevention of fatigue, including fatigue associated with diseases...
2018/0263949 METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS
The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods...
2018/0263948 METHODS OF THERAPEUTIC MONITORING OF NITROGEN SCAVENGING DRUGS
The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods...
2018/0263947 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER
The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are...
2018/0263946 PHARMACEUTICAL COMPOSITIONS CONTAINING DIMETHYL FUMARATE
Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain...
2018/0263945 PYRUVATE COMPOUNDS FOR TREATMENT OF PERIPHERAL NEUROPATHY
A method of treating a subject having peripheral neuropathy is described that includes administering a therapeutically effective amount of a pyruvate compound...
2018/0263944 COMPOSITIONS AND METHODS FOR ACUTLEY RAISING NITRIC OXIDE LEVELS
Disclosed herein are compositions and methods for acutely raising nitric oxide levels in a subject. In one example, the composition can include, an effective...
2018/0263943 COMPOUND FOR TREATMENT OF MYOTONIC DYSTROPHY TYPE 1
Compound for treatment of myotonic dystrophy type The present invention relates to a compound, or a salt thereof, and a pharmaceutical composition comprising...
2018/0263942 MEDICAMENT FOR THERAPEUTIC TREATMENT OF NEUROPATHIC DISEASE
A medicament to be applied as an external preparation for therapeutic treatment of a local symptom of a neuropathic disease, which contains gabapentin or...
2018/0263941 Methods of Modulating miRNA Levels and Compositions for Use in the Same
Methods of modulating a miRNA level, such as a miR-29c and/or miR-200c level, in a cell are provided. Aspects of the methods include contacting the cell with...
2018/0263940 TREATMENT OF SKIN CONDITIONS
The present invention relates to compositions, methods and kits for the treatment of dermopathies. In particular, the compositions, methods and kits are...
2018/0263939 AUTOIMMUNE DISORDER TREATMENT USING RXR AGONISTS
The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat...
2018/0263937 USE OF AN OLEOGEL CONTAINING TRITERPENE FOR HEALING WOUNDS
An oleogel comprising a non-polar liquid and a powder containing triterpene is provided as an oleogel that may be used for healing wounds.
2018/0263936 GAMMA-HYDROXYBUTYRATE COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF DISORDERS
Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB). Also provided herein are methods of...
2018/0263935 TREATMENT FOR MITOCHONDRIAL DISEASES
The present application relates to methods of treating a subject with a disease or disorder associated with a mitochondrial deficit, comprising: determining at...
2018/0263934 Necrosis Inhibitors
The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides,...
2018/0263933 METHODS AND COMPOSITIONS FOR INTERFERING WITH EXTRACTION OR CONVERSION OF A DRUG SUSCEPTIBLE TO ABUSE
Effective methods and compositions to deter abuse of pharmaceutical products (e.g., orally administered pharmaceutical products) including but not limited to...
2018/0263932 Method For Relieving Sinus Congestion
A method for temporarily relieving sinus congestion and pressure comprising administering to a human a dose of a multi-particle pulsatile oral dosage form with...
2018/0263931 TOPICAL DAPSONE AND DAPSONE/ADAPLENE COMPOSITIONS AND METHODS FOR USE THEREOF
Dapsone and dapsone/adapalene compositions can be useful for treating a variety of dermatological conditions. The compositions of this disclosure include...
2018/0263930 DOSAGE REGIMEN OF AN S1P RECEPTOR MODULATOR
S1P receptor modulators are administered following a dosage regimen providing a positive benefit-risk profile.
2018/0263929 DOSAGE REGIMEN OF AN S1P RECEPTOR MODULATOR
S1P receptor modulators are administered following a dosage regimen providing a positive benefit-risk profile.
2018/0263928 AMANTADINE COMPOSITIONS AND METHODS OF USE
Methods of nighttime administration of amantadine to reduce sleep disturbances in patient undergoing treatment with amantadine are described, as well as...
2018/0263927 AFFINITY MEDICANT CONJUGATE
In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a...
2018/0263926 Restoring Physiology in Iron-Deficient Organisms Using Small Molecules
Provided are methods of treating a disease or condition characterized by a deficiency of or a defect in an iron transporter using a small molecule. For...
2018/0263925 METHODS FOR THE TREATMENT OF ALOPECIA AREATA UTILIZING GENE MODULATION APPROACHES
The present invention relates to methods and compositions for the treatment of alopecia areata. In some aspects, the present invention relates to haptens for...
2018/0263924 METHODS OF TREATING METABOLIC SYNDROME RELATED CCONDITIONS USING RETINOIC ACID RECEPTOR AGONISTS
This invention relates to pharmaceutical compositions and methods for treating (including managing) or preventing metabolic syndrome related conditions using...
2018/0263923 TRANSDERMAL DELIVERY SYSTEM CONTAINING METHYLPHENIDATE OR ITS SALTS AND METHODS THEREOF
Disclosed herein is a transdermal delivery system comprising methylphenidate or its salt as an active ingredient. Also provided are methods of delivering a...
2018/0263922 TRANSDERMAL DELIVERY SYSTEM CONTAINING METHYLPHENIDATE OR ITS SALTS AND METHODS THEREOF
Disclosed herein is a transdermal delivery system comprising methylphenidate or its salt as an active ingredient. Also provided are methods of delivering a...
2018/0263921 Polyvinylpyrrolidone For The Stabilization Of A Solid Dispersion Of The Non-Crystalline Form Of Rotigotine
The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a...
2018/0263920 TRANSDERMAL DRUG DELIVERY DEVICE INCLUDING FENTANYL
A transdermal drug delivery device includes a backing and an adhesive composition disposed on the backing. The adhesive composition includes a copolymer having...
2018/0263919 THERAPEUTIC ELECTROSPUN FIBER COMPOSITIONS
The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific...
2018/0263918 ENCAPSULATION OF MESSENGER RNA
The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention...
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