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Patent # Description
2018/0273966 SYNTAXIN 7 NUCLEIC ACID MOLECULES TO CONTROL COLEOPTERAN AND HEMIPTERAN PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through RNA interference-mediated inhibition of target...
2018/0273965 HSF-LIKE TRANSCRIPTION FACTOR, TBF1, IS A MAJOR MOLECULAR SWITCH FOR GROWTH-TO-DEFENSE TRANSITION IN PLANTS
The present invention relates to new methods to study and control the expression of plant genes, particularly nucleotide sequences located downstream from...
2018/0273964 BREEDING METHODS TO DEVELOP IMPROVED XENIA POLLINATORS
This invention describes a new, high-efficiency method of selecting and advancing pollen donator strains in a breeding or product advancement program, wherein...
2018/0273963 SIMULTANEOUS GENE EDITING AND HAPLOID INDUCTION
The presently disclosed subject matter relates to using a haploid inducing line (whether existing or created) and transforming the haploid line so that it...
2018/0273962 RECOMBINANT MAIZE B CHROMOSOME SEQUENCE AND USES THEREOF
The present disclosure provides maize B chromosome genomic loci and methods of using for agronomic practices.
2018/0273961 A CRISPR/Cas9 SYSTEM FOR HIGH EFFICIENT SITE-DIRECTED ALTERING OF PLANT GENOMES
Cassettes comprising a YAO promoter operably linked to at least one nucleotide sequence encoding a nuclease, vectors comprising the same are provided. A system...
2018/0273960 METHODS AND COMPOSITIONS FOR MARKER-FREE GENOME MODIFICATION
Compositions and methods are provided for modifying a nucleotide sequence in the genome of a plant cell, without the use of a selectable marker. The methods...
2018/0273959 METHODS FOR PRODUCING TRANSGENIC PLANTS
A method of producing a stably transformed corn plant in a single container is demonstrated. This method allows for the automation of the transformation...
2018/0273958 BIOLOGICAL INDICATOR
This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene...
2018/0273957 BIOLOGICAL INDICATOR
This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene...
2018/0273956 Bacteria Engineered to Treat Diseases that Benefit from Reduced Gut Inflammation and/or Tighten Gut Mucosal Barrier
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory...
2018/0273955 STEROL REGULATORY ELEMENT BINDING PROTEIN (SREBP) CHAPERONE (SCAP) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
The invention relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting the SCAP gene, as well as methods of inhibiting expression...
2018/0273954 INDUCED EXON INCLUSION IN SPINAL MUSCLE ATROPHY
The invention relates to the use of an antisense compound for inducing exon inclusion as a treatment for Spinal Muscle Atrophy (SMA). More particularly it...
2018/0273953 COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION
Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric...
2018/0273951 METHODS FOR MODULATING KLHL1 LEVELS, METHODS FOR MODULATING CURRENT ACTIVITY IN T-TYPE CALCIUM CHANNELS,...
Methods for modulating T-type calcium channel activity without directly targeting the T-type calcium channels are provided that include modulating kelch-like...
2018/0273950 METHODS AND COMPOSITIONS FOR THE PRODUCTION OF SIRNAS
The technology described herein relates to siRNAs, e.g., methods and compositions relating to the production of siRNAs in bacterial cells.
2018/0273949 MODULATION OF TRANSTHYRETIN EXPRESSION
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to...
2018/0273948 RNAi CONJUGATES, PARTICLES AND FORMULATIONS THEREOF
Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, comprising conjugates of an RNAi agent attached to a targeting...
2018/0273947 PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the programmed cell death 1 ligand 1 (PD-L1) gene, and methods of...
2018/0273946 MODULATION OF TRANSTHYRETIN EXPRESSION
Provided herein are methods, compounds, and compositions for reducing expression of transthyretin mRNA and protein in an animal. Such methods, compounds, and...
2018/0273945 COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN
Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods...
2018/0273944 OLIGONUCLEOTIDE-BASED INHIBITORS COMPRISING LOCKED NUCLEIC ACID MOTIF
The present invention relates to chemical modification motifs for oligonucleotides. The oligonucleotides of the present invention, such as chemically modified...
2018/0273943 MODULATION OF SMN EXPRESSION
Certain embodiments are directed to methods and compounds for inhibiting SMN-NAT, the natural antisense transcript of SMN. Such methods and compounds are...
2018/0273942 COMPOUNDS AND METHODS FOR MODULATION OF DUX4
The present disclosure pertains generally to double-stranded small interfering RNAs that modulate gene expression for use in research, diagnostics, and/or...
2018/0273941 Short Non-Coding Protein Regulatory RNAs (sprRNAs) and Methods of Use
The present invention provides isolated nucleic acid molecules comprising short non-coding protein regulatory RNAs (sprRNA), variants, fragments and inhibitors...
2018/0273940 TREATING AND PREVENTING MICROBIAL INFECTIONS
The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment...
2018/0273939 sgRNA and method for specifically activating human RSPO2 gene with CRISPR-Cas9 and application thereof
A method of constructing a specific CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats associated) to activate a RSPO2 (R-spondin 2) gene...
2018/0273938 GENOME EDITING ENHANCEMENT
This invention pertains to single-stranded carrier nucleic acids and their methods of use for enhancing genome editing ribonucleoprotein complex transfection...
2018/0273937 METHODS AND COMPOSITIONS FOR SEQUENCE SPECIFIC ANTIMICROBIALS
The invention relates to antimicrobial compositions comprising cell-penetrating peptides linked to CRISPR RNAs and methods for their use.
2018/0273936 VARIANT LIBRARIES OF THE IMMUNOLOGICAL SYNAPSE AND SYNTHESIS THEREOF
Disclosed herein are methods for the generation of highly accurate nucleic acid libraries encoding for predetermined variants of a nucleic acid sequence. The...
2018/0273935 METHODS AND COMPOSITIONS FOR GENERATING CRISPR/CAS GUIDE RNAS
The present disclosure provides methods, kits, and compositions for generating DNA molecules encoding CRISPR/Cas guide RNAs (e.g., Cas9 single guide RNAs or...
2018/0273934 SELECTIVE OPTIMIZATION OF A RIBOSOME BINDING SITE FOR PROTEIN PRODUCTION
A method for optimising a nucleotide sequence for protein expression in a host cell, comprising the steps of: (a) constructing an expression library comprising...
2018/0273933 METHODS AND COMPOSITIONS FOR ANALYZING CELLULAR COMPONENTS
Embodiments of the present invention relate to analyzing components of a cell. In some embodiments, the present invention relate to analyzing components of a...
2018/0273932 USE OF EXONUCLEASES TO IMPROVE CRISPR/CAS-MEDIATED GENOME EDITING
The present disclosure is directed to methods of producing a modified nucleic acid comprising a precise deletion in a target nucleic acid in a cell comprising...
2018/0273931 CRYSTALLINE MATERIALS ON BIOLOGICAL TISSUE AND METHODS FOR MAKING THE SAME
Provided are compositions including a direct interface between a biological tissue and a crystalline material, wherein the crystalline material has a...
2018/0273930 Producing Adipic Acid and Related Compounds Using Hybrid Polyketide Synthases
The present invention provides for a polyketide synthase (PKS) capable of synthesizing a carboxylic acid, said PKS comprising a synthetic or hybrid module. The...
2018/0273929 ASPARAGINASE
The present invention relates to a polypeptide having asparaginase activity selected from the group consisting of: (i) a polypeptide having an amino acid...
2018/0273928 RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins....
2018/0273927 Polypeptides Having Protease Activity
The present invention relates to isolated polypeptides having protease activity and isolated nucleic acid sequences encoding the proteases. The invention also...
2018/0273926 MULTIFUNCTIONAL MICROBIAL CELLULASES
Disclosed herein are methods of making multifunctional microbial cellulases. The engineered multifunctional microbial cellulases disclosed herein exhibit...
2018/0273925 ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
2018/0273924 POLYPEPTIDES HAVING ALPHA-AMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to isolated polypeptides having alpha-amylase activity, catalytic domains, carbohydrate binding domains and polynucleotides...
2018/0273923 TAL EFFECTOR MEANS USEFUL FOR PARTIAL OR FULL DELETION OF DNA TANDEM REPEATS
The application relates to means, which derive from TAL effectors and TALENs. The structure of the means of the application is especially adapted for partial...
2018/0273922 Methods and Compositions for Modifying a Single Stranded Target Nucleic Acid
The present disclosure provides compositions and methods for binding and/or cleaving a single stranded target nucleic acid. Subject compositions include a Cas9...
2018/0273921 Polypeptide Containing DNA-Binding Domain
The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting...
2018/0273920 DEIMMUNIZED THERAPEUTIC COMPOSITIONS AND METHODS
This disclosure provides a bispecific ligand directed toxin (BLT) that includes a diphtheria toxin (DT) molecule that has been mutated to create a DT molecule...
2018/0273919 GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS
Compositions are disclosed herein comprising poly alpha-1,3-1,6-glucan with a weight average degree of polymerization (DP.sub.w) of at least 1000. This glucan...
2018/0273918 GENES AND USES THEREOF, METHODS FOR SYNTHESIZING ODD NUMBERED MEDIUM CHAIN ALIPHATIC ALDEHYDES AND METHODS FOR...
Provided are genes, coding proteins and uses thereof, gene elements, genes and uses, gene elements, methods for synthesizing odd numbered medium chain...
2018/0273917 HEME PROTEIN CATALYSTS FOR CARBON-BORON BOND FORMATION IN VITRO AND IN VIVO
Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the...
2018/0273916 NOVEL 7BETA-HYDROXYSTEROID DEHYDROGENASES AND THEIR USE
The invention relates to novel 7 -hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus Collinsella, especially of the strain...
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