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Patent # Description
2018/0273611 A method for development of monoclonal antibodies
This invention provides a method and a kit for rapid and robust development monoclonal antibodies. The method does not require hybrid technologies nor does it...
2018/0273610 MODIFIED SERPINS FOR THE TREATMENT OF BLEEDING DISORDERS
This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to...
2018/0273609 MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES
The present application provides materials and methods for treating hemoglobinopathies. More specifically, the application provides methods for producing...
2018/0273608 MULTI-EPITOPIC CONSTRUCT
The invention relates to multiple epitope constructs, immunogenic and vaccine compositions comprising recombinant molecules presenting inserted multiple and...
2018/0273607 MODIFIED BLOOD CLOTTING FACTORS AND METHODS OF USE
The invention provides compositions including modified blood clotting factors that have a non-native proteolytic cleavage site engineered into them allowing...
2018/0273606 POWDERED G-PROTEIN COUPLED RECEPTORS (GPCR)
A method for generating detergent-solubilized G-protein coupled receptors (GPCRs) in powdered form. The powdered GPCRs is storable at temperatures of...
2018/0273605 METHODS OF MODULATING IMMUNE RESPONSES USING BCMA POLYPEPTIDE
A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
2018/0273604 THERAPEUTIC TNFR-1B TARGETS AND USES THEREOF
Disclosed are tumor necrosis factor receptor 1B (TNFR-1B) signaling targets and TNFR-1B mutants and their uses for treatment of diseases and disorders.
2018/0273603 FUSION PROTEIN
The present invention relates to a p75NTR neurotrophin binding protein (NBP)-Fc fusion protein comprising a p75NTR(NBP) portion and an immunoglobulin portion....
2018/0273602 T CELL RECEPTORS AND IMMUNE THERAPY USING THE SAME AGAINST PRAME POSITIVE CANCERS
The present invention pertains to antigen recognizing constructs against tumor associated antigens (TAA), in particular against Preferentially Expressed...
2018/0273601 IMMUNE CELL COMPOSITIONS AND METHODS OF USE
Disclosed herein are cells that are immune cells or precursor cells thereof, which cells recombinantly express a chimeric antigen receptor (CAR), and a...
2018/0273600 INSULIN SECRETING POLYPEPTIDES
This document provides methods and materials related to insulin secreting polypeptides. For example, polypeptides having the ability to induce insulin...
2018/0273598 ADHD MARKER, APPLICATION THEREOF AND KIT
The present invention provides a marker for ADHD and applications thereof. The marker is ghrelin, and the marker can screen for potential ADHD patients by...
2018/0273597 COMPOSITIONS AND METHODS RELATING TO THE TREATMENT OF DISEASES
A compressible adjunct is used with a surgical instrument. The compressible adjunct includes a hollow fibrous construct and a core fibrous construct housed...
2018/0273596 MODIFIED INTERLEUKIN-7 PROTEIN AND USES THEREOF
The present invention provides a modified interleukin-7 and a use thereof. The modified IL-7 or an IL-7 fusion protein of the present invention comprising the...
2018/0273595 ERG TARGETED THERAPY
The present disclosure relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In...
2018/0273594 TREATMENT OF RETINITIS PIGMENTOSA
A polynucleotide comprising a nucleotide sequence encoding the retinitis pigmentosa GTPase regulator ORF15 isoform (RPGR.sup.ORF15), wherein the ...
2018/0273593 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION
The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of...
2018/0273592 Highly Crystalline Spherical Silk Fibroin Micro-Particles and A Process For Preparation Thereof
The present invention provides silk fibroin micro-particles having a high crystallinity index (1.3-1.5) and low sphericity index (.ltoreq.0.01) and a process...
2018/0273591 TREATMENT OF ISCHEMIA
A system, including methods and compositions, for treatment of ischemia.
2018/0273590 CHARGE-REVERSED N-TERMINAL SPIDER SILK PROTEIN DOMAIN AND USES THEREOF
A protein comprising a moiety of 100-160 amino acid residues having at least 70% identity with the N-terminal (NT) fragment of a spider silk protein, wherein...
2018/0273589 Neurospora Crassa Strains with Amplified Expression of Cellulases and Production of Biofuel Therefrom
Transgenic strains of Neurospora crassa engineered to comprise a synthetic positive feedback loop for a transcriptional activator of cellulase expression such...
2018/0273588 FILOVIRUS VECTORS AND PARTICLES PRODUCED THEREFROM
Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles.
2018/0273587 WARHEAD-CONTAINING PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF BFL-1
The disclosed peptidomimetic macrocycles modulate the activity of BFL-1 or a BCL-2 family protein. BFL-1, an anti-apoptotic BCL-2 family member, blocks...
2018/0273586 AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND...
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders,...
2018/0273585 Medical Use
The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in...
2018/0273584 HER2 PEPTIDE REGENTS AND METHODS
The present disclosure is directed to HER2-specific peptide reagents, methods for detecting pre-cancer (dysplasia), early cancer and/or cancer using the...
2018/0273583 SAMPLE PLATES FOR BUFFER EXCHANGE AND METHODS OF MANUFACTURE
Sample plates and methods for exchanging buffer solutions are disclosed herein. The sample plates and methods may be used with automated buffer exchange...
2018/0273582 SMALL MOLECULE AFFINITY MEMBRANE PURIFICATION SYSTEMS AND USES THEREOF
Disclosed are purification systems and methods for providing purified preparations of antibodies from a fluid, particularly a biological fluid comprising or...
2018/0273581 PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A ONE-STEP PROCESS
The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a...
2018/0273580 NOVEL 7-DEHYDROCHOLESTEROL DERIVATIVES AND METHODS USING SAME
The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as...
2018/0273579 COMPOUNDS WITH HIV MATURATION INHIBITORY ACTIVITY
The present invention relates to compounds characterized by having a structure according to the following Formula I: ##STR00001## or a pharmaceutically...
2018/0273578 MODIFIED CYCLIC DINUCLEOTIDE COMPOUNDS
Compounds of formula (I) ##STR00001## wherein Base.sup.1 and Base.sup.2 are defined as in claim 1 are modulators of STING.
2018/0273577 MODULATORS OF KRAS EXPRESSION
The present embodiments provide methods, compounds, and compositions for inhibiting KRAS expression, which can be useful for treating, preventing, or...
2018/0273576 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS
Provided herein are methods and compositions for synthesizing 5'Capped RNAs wherein the initiating capped oligonucleotide primers have the general form...
2018/0273575 PROCESS FOR PREPARING NUCLEOSIDE PRODRUGS
A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral center of the phosphorus atom P, is...
2018/0273574 NUCLEOTIDE AND OLIGONUCLEOTIDE PRODRUGS
The present invention discloses compounds of formula (I): ##STR00001## which exhibit antiviral properties. The present invention further relates to...
2018/0273573 INHIBITORS OF MENAQUINONE BIOSYNTHESIS
Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and...
2018/0273572 DERIVATIVES OF AMPHOTERICIN B
Disclosed are derivatives of amphotericin B (AmB) characterized by improved therapeutic index compared to AmB. The AmB derivatives include C16 ureas,...
2018/0273571 CONCISE SYNTHESIS OF UREA DERIVATIVES OF AMPHOTERICIN B
Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are...
2018/0273570 NOVEL XYLENE-BASED AMPHIPHILIC COMPOUND AND USE THEREOF
The present invention relates to a xylene-based amphiphilic compound, a method for preparing the same, and a method for extracting, solubilizing, stabilizing...
2018/0273569 PROCESSING BIOMASS
Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example,...
2018/0273568 METHOD FOR PRODUCING METAL-ORGANIC FRAMEWORKS
The present invention relates to a method for the preparation of a metal-organic framework structure compound, the metal-organic framework structure compound...
2018/0273567 COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
2018/0273566 PLATINUM(II) COMPLEXES WITH SELONE LIGANDS AND METHOD OF USE
Platinum(II) complexes with various selones (L) having the general formula PtL.sub.2Cl.sub.2 are disclosed. The platinum(II) complexes of the invention inhibit...
2018/0273565 METHOD FOR PRODUCING RUTHENIUM COMPLEX
The present invention relates to a method for efficiently producing a ruthenium complex (1.sup.A) by reacting a dinuclear ruthenium complex (2.sup.A) with a...
2018/0273564 CARBON MONOXIDE RELEASING MOLECULES
Disclosed are carbon monoxide releasing complexes comprising a transition metal, at least one carbon monoxide ligand, and a pH responsive ligand that modulates...
2018/0273563 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC...
An organometallic compound represented by Formula 1: M(L.sub.1).sub.n1(L.sub.2).sub.n2 Formula 1 wherein M, L.sub.1, L.sub.2, n1, and n2 are the same as described in...
2018/0273562 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC...
An organometallic compound represented by Formula 1: M(L.sub.11).sub.n1(L.sub.12).sub.n2 Formula 1 wherein, in Formula 1, M is a third row transition metal,...
2018/0273561 BISMUTH PERFLUOROALKYLPHOSPHINATES AS LEWIS ACID CATALYSTS
The invention relates to bismuth perfluoroalkylphosphinates as Lewis acid catalysts, the compounds, and processes for the preparation thereof. ...
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