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Patent # Description
2018/0273509 PET Imaging Agents
Preparation of novel 2-benzyl-5-methyl-2H-tetrazole derivatives of the formula (I) for use as PET imaging agents. The present invention relates to novel...
2018/0273508 THERAPEUTIC COMPOUNDS
Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for...
2018/0273507 CRYSTAL FORMS OF A M1 RECEPTOR POSITIVE ALLOSTERIC MODULATOR
The invention is directed to novel anhydrous crystalline butenedioate salt form 1 of Compound I, which is a modulator of muscarinic M1 receptors. The novel...
2018/0273506 Preparation Method of Cobimetinib
The present invention discloses a preparation method of cobimetinib (XL518, GDC-0973) (I). The preparation steps include: taking (2S)-2-piperidinecarboxylic...
2018/0273505 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2018/0273504 Sulfonamide-Substituted Indole Modulators of RORC2 and Methods of Use Thereof
The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrro-lopyridines, pharmaceutical compositions thereof...
2018/0273503 NOVEL ANGIOTENSIN CONVERTING ENZYME INHIBITOR
This invention provides a novel compound having an activity for inhibiting an angiotensin converting enzyme (ACE). This invention relates to a compound...
2018/0273502 POLYCYCLOCARBONATE COMPOUNDS AND POLYMERS FORMED THEREFROM
Polycyclocarbonate compounds and upgraded molecular weight polymers made from such compounds are provided. The polymers have particular utility in coating...
2018/0273501 Methods for Purification of Non-Psychoactive Isoprenoid Compounds from Biological Extracts
A method for the extraction and isolation of the terpene and isoprenoid compounds from plant material, followed by a centrifugal force induced selective...
2018/0273500 TREATMENT OF MULTIPLE SCLEROSIS AND PSORIASIS USING PRODRUGS OF METHYL HYDROGEN FUMARATE
Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering...
2018/0273499 SALTS AND SOLID STATE FORMS OF VORTIOXETINE
The present disclosure relates to new salts of Vortioxetine, including butyrate, iso-butyrate, benzoate and propionate, solid state forms of the Vortioxetine...
2018/0273498 METHOD FOR PURIFYING PURE THIOFLAVIN T, METHOD FOR PRODUCING PURE THIOFLAVIN T, COMPOSITION INCLUDING...
The present invention relates to a method for purifying pure thioflavin T in having a step of preparing a thioflavin T solution in which crude thioflavin T is...
2018/0273497 METHOD FOR REFINING PURE THIOFLAVIN T, METHOD FOR PRODUCING PURE THIOFLAVIN T, COMPOSITION CONTAINING...
The present invention relates to a method for purifying pure thioflavin T having a step of preparing a thioflavin T solution in which crude thioflavin T is...
2018/0273496 Method for preparing N-(1,3,4-oxadiazol-2-yl)arylcarboxamides
A method for preparing N-(1,3,4-oxadiazol-2-yl)arylcarboxamides of formula (I) is described. ##STR00001## The substituents therein are radicals such as hydrogen,...
2018/0273495 OXADIAZOLE AMINE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION...
The present disclosure relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically...
2018/0273494 MICROBIOCIDAL OXADIAZOLE DERIVATIVES
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides. ##STR00001##
2018/0273493 AMORPHOUS TRISODIUM SACUBITRIL VALSARTAN AND A PROCESS FOR THE PREPARATION THEREOF
The amorphous form of trisodium sacubitril valsartan and methods for the preparation thereof are disclosed herein.
2018/0273492 METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES
Methods of selectively forming substituted pyrazines are provided. Methods of the present invention can include receiving a reaction solution including at...
2018/0273491 3-(CARBOXYETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES
The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in...
2018/0273490 Process for the Preparation of Eltrombopag Olamine
Salts of eltrombopag are provided. Eltrombopag olamine is prepared from salts of eltrombopag, which are used as intermediates.
2018/0273489 PYRAZOLE COMPOUND
The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT.sub.2C antagonistic action (antidepressive and anxiolytic...
2018/0273488 SMALL MOLECULE INHIBITORS OF LACTATE DEHYDROGENASE AND METHODS OF USE THEREOF
Provided is a compound of formula (I) [Formula (I) should be inserted here], in which Ar.sup.1, R.sup.1, U, V, W, X, and p are as described herein. Also...
2018/0273487 SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF
This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including...
2018/0273486 METHOD FOR THE PREPARATION OF 3-FLUOROALKYL-1-METHYLPYRAZOL-4-CARBOXYLIC ACID
The present invention relates to method for the preparation of 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid, wherein it comprises the following steps: step...
2018/0273485 CANNABINOID RECEPTOR MEDIATING COMPOUNDS
A compound, or a pharmaceutically acceptable salt or ester thereof, comprising (i) a CB.sub.1 receptor mediating scaffold conjugated to (ii) a second...
2018/0273484 DIAZIRINES AS PHOTOCAGES WHICH RELEASE MOLECULES CONTAINING DOUBLE BONDS
The present invention relates to the field of fragrance storage means as used, for example, in the field of washing or cleaning compositions, cosmetic...
2018/0273483 DIBENZO AZEPINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF OTIC DISEASES AND DISORDERS
The present disclosure provides crystalline Compound I and crystalline Compound II, pharmaceutical compositions comprising one of said crystalline compounds...
2018/0273482 COMPOSITIONS AND METHODS FOR INCREASING, OR PREVENTING OR REVERSING LOSS OF, SKIN PIGMENTATION IN A MAMMALIAN...
The present invention includes compounds, compositions comprising the same, and methods using the compounds and/or compositions therein, for modulating skin...
2018/0273481 POLYMORPHIC FORMS OF PITAVASTATIN SODIUM
The present invention is directed to polymorphic forms of Pitavastatin sodium and processes for preparation of the same.
2018/0273480 INOSITOL NICOTINATE CRYSTALLINE FORM A AND PREPARATION METHOD THEREFOR
Provided are an inositol nicotinate crystalline form A and a preparation method therefor. The X-ray powder diffraction analysis, obtained by using Cu-K.alpha....
2018/0273479 HETEROCYCLIC COMPOUNDS AND THEIR USES
Provided are certain pharmaceutical formulations of omecamtiv mecarbil and methods for their preparation and use.
2018/0273478 ANTI-CANCER COMPOUNDS
The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain...
2018/0273477 Synthetic Path To Pharmaceutically Acceptable Vismodegib
The present invention relates to a new route of synthesis to obtain pharmaceutically acceptable Vismodegib. In addition, besides the synthesis also suitable...
2018/0273476 AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found...
2018/0273475 HYDROPHILIC FENTANYL DERIVATIVES
Various fentanyl derivatives are described. The derivatives exhibit high binding affinity to opioid receptors, but also have decreased blood brain permeability...
2018/0273474 Novel Compositions For Preventing And/Or Treating Degenerative Disorders Of The Central Nervous System
The present invention provides novel compounds as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the...
2018/0273473 IMINOSUGARS USEFUL FOR THE TREATMENT OF VIRAL DISEASES
Formula IA, and their use for treating viral infections. ##STR00001##
2018/0273472 THALIDOMIDE ANALOGS AND METHODS OF USE
Thalidomide analogs and methods of using the thalidomide analogs are disclosed. Some embodiments of the disclosed compounds exhibit anti-angiogenic and/or...
2018/0273471 ISOTOPE-ENRICHED 3-AMINO-1-PROPANESULFONIC ACID DERIVATIVES AND USES THEREOF
There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions...
2018/0273470 SELECTIVE ANDROGEN RECEPTOR MODULATOR AND METHODS OF USE THEREOF
This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject including, inter alia,...
2018/0273469 MARMELIN ANALOGS AND METHODS OF USE IN CANCER TREATMENT
A pharmaceutical composition can include: a marmelin analog compound, and a pharmaceutically acceptable carrier having the compound. The compound can be...
2018/0273468 PROCESS FOR THE PREPARATION OF (1S,2R)-MILNACIPRAN
The invention relates to a process for the preparation of Levomilnacipran or salts thereof, compounds useful in the treatment of depression, with high yield.
2018/0273467 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as...
2018/0273466 BIFUNCTIONAL COMPOUND HAVING NORBORNANE SKELETON AND METHOD FOR PRODUCING SAME
The present invention is able to provide a bifunctional compound represented by formula (1). ##STR00001## (In the formula, R.sub.1 represents COOCH.sub.3,...
2018/0273465 HIGH-PURITY CARBOXYLIC ACID ESTER AND METHOD FOR PRODUCING SAME
The present invention makes it possible to provide a high-purity carboxylic acid ester in which the Ag, Al, Au, Ca, Cr, Cu, Fe, K, Mg, Na, Sn, and Zn contents...
2018/0273464 SYNTHESIS AND IN VITRO ACTIVITY OF D-LACTIC ACID OLIGOMERS
This invention describes the synthesis and pharmacologic activity of n=2, n=3, n=4, n=5, and n=6 D-lactic acid oligomers. D-lactic acid dimer has pharmacologic...
2018/0273463 CATALYST HAVING A MODIFIED SILICON CARBIDE SUPPORT AND ITS USE AS A HYDROGENATION CATALYST
Impure aromatic carboxylic acids such as are obtained by liquid phase oxidation of feed materials comprising aromatic compounds with substituent groups...
2018/0273462 Process for the Purification of Monochloroacetic Acid
The present invention pertains to a process for the purification of a feed comprising monochloroacetic acid and dichloroacetic acid wherein the feed is...
2018/0273461 High-Purity Dibasic Acid Compositions and Methods of Making the Same
High-purity dibasic acid compositions are generally disclosed. In some embodiments, the dibasic acid compositions are solutions or suspensions. In some other...
2018/0273460 METHOD FOR PREPARING ACRYLIC ACID FROM GLYCERIN
The present invention relates to a method for preparing acrylic acid from glycerin. More specifically, the present invention provides a method which can...
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