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Patent # Description
2018/0271889 COMBINATION THERAPY FOR CANCER
Disclosed is a combination of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate (chemical name: 2'-Deoxy-2',2'-difluoro-D-cytidine-5'-O-[phenyl ...
2018/0271888 COMPOSITIONS AND METHODS FOR PARKINSON'S DISEASE THERAPY
This disclosure provides methods for the treatment of one or more of: Parkinson's disease (PD); PD symptoms; movement disorders; neurodegenerative diseases...
2018/0271887 DOSAGE FORMS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING DISEASE
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form, can be used to treat or alleviate pain or related conditions,...
2018/0271886 TREATMENT OF LYMPHANGIOLEIOMYOMATOSIS
Embodiments disclosed herein provide compositions and methods for treating lymphangioleiomyomatosis (LAM) comprising inhibiting COX overexpression and...
2018/0271885 Stabilized Modified Release Vitamin D Formulation and Method of Administering Same
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D.sub.2 and...
2018/0271884 Stabilized Modified Release Vitamin D Formulation and Method of Administering Same
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D.sub.2 and...
2018/0271883 Cancer Drug and Uses
A pharmaceutical composition comprising a cancer therapeutic that is capable of inhibiting and/or reducing the ability of a cancer cell to take up and utilize...
2018/0271882 METHODS FOR THE SEPARATION AND DETECTION OF AN OXYSTEROL
Assay methods for determining purity of a sample of a sterol are provided. These methods include providing an HPLC eluent including a sterol, other compounds...
2018/0271881 NO-RINSE CHEMICAL FOAM CONTAINING CLOBETASOL PROPIONATE, AND USE THEREOF IN THE TREATMENT OF PSORIASIS
A self-foaming composition is described that includes clobetasol propionate, for a no-rinse topical application and for application to the skin. The...
2018/0271880 SEX STEROID PRECURSORS ALONE OR IN COMBINATION WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE PREVENTION...
Novel methods for treating or reducing the likelihood of acquiring vaginal dysfunctions, more particularly vaginal dryness and dyspareunia, leading to sexual...
2018/0271879 SCALARANE SESTERTERPENOID, PHARMACEUTICAL COMPOSITION AND TOPOISOMERASE II AND Hsp90 INHIBITOR FOR TREATING...
The present invention discloses scalarane sesterterpenoids represented by formula (I) and meroditerpenoid represented by formula (II), which are extracted from...
2018/0271878 PROSTAMIDE-CONTAINING INTRAOCULAR IMPLANTS AND METHODS OF USE THEREOF
Prostamide-containing intraocular implants that biodegrade in the eye and that are effective for reducing intraocular pressure in an eye for a sustained...
2018/0271877 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR ANESTHESIOLOGICAL APPLICATIONS
Pharmaceutical compositions and methods for inducing conscious sedation using such compositions are described, the compositions comprising a ...
2018/0271876 TRICYCLIC DIBENZOTHIAZEPINE TYPE COMPOUNDS FOR USE IN THE THERAPY OF CDKL5 DISORDER
Tricyclic dibenzothiazepine compounds for use in the treatment of CDKL5 disorder. Specifically, a compound of Formula I, or a pharmaceutically or veterinarily...
2018/0271875 Alkaloid Compounds For Treating Depression, Substance Addictions, And Indications Associated With Chronic...
Alkaloid compounds described herein are useful for treating disorders associated with monoamine oxidase (MAO) activity, such as depression, pain, smoking...
2018/0271874 BRAIN-PENETRANT CHROMONE OXIME DERIVATIVE FOR THE THERAPY OF LEVODOPA-INDUCED DYSKINESIA
The present invention provides a chromone oxime derivative of formula (I), which is a modulator of nervous system receptors sensitive to the neuroexcitatory...
2018/0271873 METHODS FOR TREATING VIRAL INFECTIONS
Described herein are methods for treating a viral infection comprising administering to an individual in need thereof a therapeutically effective amount of a...
2018/0271872 LIQUID PHARMACEUTICAL COMPOSITION COMPRISING PEMETREXED
The present invention relates to a liquid pharmaceutical composition suitable for parenteral administration comprising: a) pemetrexed diacid; b) at least one...
2018/0271871 BUMPED KINASE INHIBITOR COMPOSITIONS AND METHODS FOR TREATING CANCER
The present disclosure is generally directed to bumped kinase inhibitor (BKI) compositions and methods for treating cancer.
2018/0271870 Compositions and Methods for Immune Therapy
Inhibiting Akt1 and Akt2 but not Akt3 in a subject has been found to be an effective immune therapy that delays the exhaustion of CD8 T cells, prolongs CD8 T...
2018/0271869 TREATMENT OF ANXIETY DISORDERS AND AUTISM SPECTRUM DISORDERS
Disclosed are methods for treating autism spectrum disorders and/or anxiety disorders by administering certain NR2B subunit-selective NMDA (N methyl-D...
2018/0271868 PHARMACEUTICAL PREPARATION COMPRISING PHENYLALANINE DERIVATIVE
The disclosed pharmaceutical preparation comprises a compound represented by the chemical formula (A) or a pharmaceutically acceptable salt thereof, which is...
2018/0271867 COMPOSITIONS AND METHODS FOR WHITE TO BEIGE ADIPOGENESIS
Disclosed herein are compositions and methods for transitioning or converting a white adipocyte to a beige adipocyte. The compositions and methods may be used...
2018/0271866 3-(SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING...
The invention provides 3-deuterium-enriched 3-(6-, 7-, or 8-substituted-4-oxoquinazolin-3(4H)-yl)-piperidine-2,6-diones, deuterated derivatives thereof,...
2018/0271865 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF
The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of...
2018/0271864 COMPOSITIONS AND METHODS OF USING TYROSINE KINASE INHIBITORS
The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine...
2018/0271863 TARGETING P2 PURINERGIC RECEPTORS TO TREAT HEPATOCELLULAR CARCINOMA (HCC)
Embodiments of the present disclosure pertain to methods of inhibiting cancer cells by exposing the cancer cells to a purinergic receptor antagonist that...
2018/0271862 NOVEL COMPOSITIONS AND METHODS
The disclosure provides new transmucosal and subcutaneous pharmaceutical compositions comprising ...
2018/0271861 THERAPEUTIC AGENT FOR A TUMOR COMPRISING AN IDO INHIBITOR ADMINISTERED IN COMBINATION WITH AN ANTIBODY
The present invention provides a method for treating a tumor comprising administering an effective amount of an antibody which specifically binds to human CC...
2018/0271860 PHARMACEUTICAL COMPOUNDS
This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the...
2018/0271859 TREATMENT FOR DIABETES IN PATIENTS INAPPROPRIATE FOR METFORMIN THERAPY
The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases,...
2018/0271858 SOLUTION FOR ORAL ADMINISTRATION
Provided is a solution suitable for oral administration of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one (compound (I)) or a salt...
2018/0271857 TREATMENT OF CANCER BY INHIBITING EZH2 ACTIVITY
The invention relates to inhibitors of EZH2 for use in the treatment of cancers characterised by expression of mutated histone H3 having a mutation of amino...
2018/0271856 METAP2 INHIBITORS AND METHODS OF TREATING OBESITY
The present invention relates to modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of preventing, inducing,...
2018/0271855 METHODS FOR TREATING ANTIPSYCHOTIC-INDUCED WEIGHT GAIN
The present invention relates to the discovery of a novel opioid modulator effective in reducing pharmacologically induced weight gain associated with atypical...
2018/0271854 LOWER DOSAGE STRENGTH IMIQUIMOD FORMULATIONS AND SHORT DOSING REGIMENS FOR TREATING GENITAL AND PERIANAL WARTS
Pharmaceutical formulations and methods for the topical or transdermal delivery of 1isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine or ...
2018/0271853 Method of Use for Inhibitors of Epidermal Growth Factor Receptor Variant III
The invention comprises methods and compositions useful for treatment and detection of cancers expressing variant forms of epidermal growth factor receptor EGFR.
2018/0271852 Histone Deacetylase (hdac) Inhibitors For The Treatment Of Cancer
The present invention relates generally to methods for treating cancer. In one respect, the present invention relates to a method of treating a hematological...
2018/0271851 ASSAYS, METHODS AND MEANS
A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF...
2018/0271850 ASSAYS, METHODS AND MEANS
A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF...
2018/0271849 PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Disclosed are a pharmaceutical composition and an application thereof. The pharmaceutical composition includes one or more of a benzoheterocyclic compound as...
2018/0271848 INDOLINYL-SULFONAMIDE INHIBITORS OF TANKYRASE AND METHODS OF USE THEREOF
The present disclosure provides compounds that may be useful for inhibiting the Tankyrase enzyme. In some aspects, these compounds are useful in the treatment...
2018/0271847 TREATMENT OF ACUTE TRAUMATIC INJURY
Compositions and methods of treating a subject with an acute traumatic injury are disclosed. The methods include administering to the subject a therapeutically...
2018/0271846 FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR
The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt...
2018/0271845 NOVEL COMPOUNDS ALPHA v BETA 6 INTEGRIN ANTAGONISTS
A compound of formula (I): ##STR00001## being 4-(3-Fluoro-3-(2-(5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-2-yl) ethyl) pyrrolidin-1-yl)-3-(3-(2-methoxyethoxy)...
2018/0271844 Treatment of Cognitive Disorders with (R)-7-Chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-Carboxamide and ...
(R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide has been found to have procognitive effects in humans at unexpectedly low doses. Thus,...
2018/0271843 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine...
2018/0271842 METHODS OF TREATING HEPATIC ENCEPHALOPATHY
The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific...
2018/0271841 FUNGAL KERATITIS PROPHYLACTIC OR THERAPEUTIC AGENT
For preventing or treating keratomycosis, a medicament containing rapamycin or a salt thereof as an active ingredient is used.
2018/0271840 COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS IN RESPONDERS
A method for treating amyotrophic lateral sclerosis (ALS) in a subject in need thereof comprising administering to said subject an effective amount of...
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