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Patent # Description
2018/0282447 METHOD OF PREPARING VINYL CHLORIDE-BASED POLYMER
The present invention relates to a method of preparing a vinyl chloride-based polymer, and more specifically, to a method comprising the steps of, (S1)...
2018/0282446 DIENE POLYMER, METHOD FOR PRODUCING DIENE POLYMER, AND RUBBER COMPOSITION
The present invention is to provide a diene polymer that exhibits excellent low rolling resistance when used in a tire, a method for producing the diene...
2018/0282445 CURABLE COMPOSITION, ADHESIVE LAYER, TRANSPARENT SURFACE MATERIAL, LAMINATE AND IMAGE DISPLAY DEVICE
To provide a curable composition to be used to form an adhesive layer having deterioration by light suppressed, an adhesive layer obtained by curing the...
2018/0282444 MODIFIED RESINS AND USES THEREOF
Modified thermoplastic hydrocarbon thermoplastic resins are provided, as well as methods of their manufacture and uses thereof in rubber compositions. The...
2018/0282443 Metallocene-Catalyzed Polyalpha-Olefins
Unsaturated and hydrogenated polyalpha-olefin products can be made with a high selectivity toward vinylidenes and tri-substituted vinylenes combined, a high...
2018/0282442 METALLOCENE SUPPORTED CATALYST AND METHOD FOR PREPARING POLYOLEFIN USING THE SAME
The present invention provides a metallocene supported catalyst that can prepare a polyolefin having excellent transparency even when processed into a film, as...
2018/0282441 WATER-ABSORBENT RESIN PARTICLES AND METHOD FOR PRODUCING SAME
Provided is a method for producing water-absorbent resin particles, which is capable of improving the gel strength for the purpose of achieving a good balance...
2018/0282440 PROCESS FOR PREPARING VINYL ACETATE-ETHYLENE COPOLYMERS BY EMULSION POLYMERIZATION
Subjects of the invention are processes for preparing vinyl acetate-ethylene copolymers in the form of their aqueous dispersions or water-redispersible powders...
2018/0282439 PROCESS FOR DEPLETING EPOXIDE SPECIES IN CROSSLINKED POLYSACCHARIDE GEL COMPOSITIONS AND COMPOSITIONS OBTAINED...
The present invention relates to a process for depleting epoxide species in epoxy-crosslinked polysaccharide gel compositions. In addition, the present...
2018/0282438 POLYMER MATERIAL, FILM, CIRCULAR POLARIZING PLATE, IMAGE DISPLAY APPARATUS, AND MANUFACTURING METHOD FOR FILM
Provided is a polymer material containing at least one kind of a cellulose derivative having (a) an organosilyl group (the organosilyl group having a first...
2018/0282437 METHOD FOR PREPARATION OF NOVEL MODIFIED BIO BASED MATERIALS
A process is disclosed for converting cellulose to nanocellulose. The process comprises dissolving a cellulose feedstock in an inorganic molten salt solvent...
2018/0282436 METHOD FOR PRODUCING HYDROXYALKYL ALKYL CELLULOSE
Provided is a method for producing a hydroxyalkyl alkyl cellulose having high thermal gel strength while suppressing a reduction in thermal gelation...
2018/0282435 METHOD FOR PRODUCING CELLULOSE ETHER
A method for producing a cellulose ether having a high viscosity while keeping the same degree of polymerization as that in the production of a shaped pulp...
2018/0282434 CELLULOSE ACETATE, AND METHOD AND DEVICE FOR PRODUCING CELLULOSE ACETATE
An object is to provide a cellulose acetate remarkably good in hue even when a low-quality pulp is used. A method for producing the cellulose acetate includes a...
2018/0282433 USE OF IL-17A AND IL-17F CROSS-REACTIVE MONOCLONAL ANTIBODIES FOR TREATING INFLAMMATORY DISEASES
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are...
2018/0282432 HETERODIMERIC ANTIBODIES THAT BIND CD3 AND TUMOR ANTIGENS
The present invention is directed to novel heterodimeric antibodies.
2018/0282431 PRODUCTION OF HETEROMULTIMERIC PROTEINS
Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as...
2018/0282430 ANTI-TFPI ANTIBODY VARIANTS WITH DIFFERENTIAL BINDING ACROSS PH RANGE FOR IMPROVED PHARMACOKINETICS
Antibodies are disclosed that bind to and inhibit the anti-coagulant function of TFPI and have a lower affinity for TFPi at pH 6.0 than at pH 7.4. The lower...
2018/0282429 Bispecific Antigen-Binding Constructs Targeting HER2
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding...
2018/0282428 ANTI-ErbB2 ANTIBODIES
Anti-ErbB2 antibodies are described which bind to an epitope in Domain 1 of ErbB2 and induce cell death via apoptosis. Various uses for these antibodies are...
2018/0282427 CAR-EXPRESSING NK-92 CELLS AS CELL THERAPEUTIC AGENTS
The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably...
2018/0282426 NEUTRALIZING ANTIBODIES AND METHODS OF USE THEREOF
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the...
2018/0282425 TREATMENT OF INFLAMMATORY DISEASES WITH INHIBITORS OF C5A ACTIVITY
The present invention relates to inhibitors of C5a activity and their use in the treatment of cutaneous, neutrophilic, inflammatory diseases in a subject.
2018/0282424 MOLECULES WITH BIMODAL ACTIVITY DEPLETING TARGET AT LOW DOSE AND INCREASING IMMUNOSUPPRESSION AT HIGHER DOSE
The present disclosure involves biologically active proteins termed stradobodies and having bimodal activity. Thus, the present disclosure provides...
2018/0282423 METHODS AND COMPOSITIONS FOR ACTIVATION OF T CELLS USING NANOPARTICLES CONJUGATED WITH MULTIPLE LIGANDS FOR...
The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different...
2018/0282422 Fully Human Antibody Against Human CD137 And Use Thereof
Disclosed are a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable...
2018/0282421 ANTIGEN-BINDING PROTEINS THAT ACTIVATE THE LEPTIN RECEPTOR
The present invention provides antibodies and antigen-binding fragments of antibodies that bind to leptin receptor (LEPR), and methods of using the same....
2018/0282420 ANTIGEN-BINDING PROTEINS THAT ACTIVATE THE LEPTIN RECEPTOR
The present invention provides antibodies and antigen-binding fragments of antibodies that bind to leptin receptor (LEPR), and methods of using the same....
2018/0282419 Bispecific Constructs and Their Use in the Treatment of Various Diseases
The present invention relates to bispecific constructs that specifically bind to immune effector cells and, simultaneously, to IL23R-carrying target cells, as...
2018/0282418 INHIBITORS OF THE INTERACTION BETWEEN CLEC14A AND MULTIMERIN-2 FOR INHIBITION OF ANGIOGENESIS
The invention provides a method of inhibiting angiogenes--is in an individual, the method comprising administering to the individual an agent that inhibits the...
2018/0282417 TUMOR BURDEN AS MEASURED BY CELL FREE DNA
Disclosed are methods for treating cancer (e.g., solid tumor cancers, lung cancer, bladder head and neck cancer) with an anti-PD-L1 antibody in a patient...
2018/0282416 Methods To Protect Transplanted Tissue From Rejection
The present invention includes compositions and methods for an HLA-A2 specific chimeric antigen receptor (CAR). In certain embodiments the HLA-A2 specific CAR...
2018/0282415 Combination of a PD-1 Axis Binding Antagonist and an ALK Inhibitor for Treating ALK-Negative Cancer
The present disclosure describes combination therapies useful for the treatment of cancer. In particular, the invention relates to a combination therapy which...
2018/0282414 CANCER IMMUNOTHERAPY BY DISRUPTING PD-1/PD-L1 SIGNALING
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a...
2018/0282413 CANCER IMMUNOTHERAPY BY DISRUPTING PD-1/PD-L1 SIGNALING
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a...
2018/0282412 PD-1 ANTIBODIES AND USES THEREOF
The present invention provides monoclonal antibodies that specifically bind to human PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of...
2018/0282411 Heavy Chain Constant Regions with Reduced Binding to Fc Gamma Receptors
The invention provides antibody heavy chain constant regions with a hinge region modified to reduce binding to Fc.gamma. receptors. The modification occurs...
2018/0282410 ANTI-CD3XROB04 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
The present invention generally relates to bispecific antigen binding molecules for activating T cells, more particularly bispecific antigen binding molecules...
2018/0282409 HUMANIZED ANTI-HUMAN CD19 ANTIBODIES AND METHODS OF USE
Herein is reported an antibody that specifically binds to human CD 19, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID...
2018/0282408 ANTI-TRANSFERRIN RECEPTOR ANTIBODIES WITH TAILORED AFFINITY
Herein is reported an anti-transferrin receptor antibody that specifically binds to human transferrin receptor and cynomolgus transferrin receptor, which...
2018/0282407 INHIBITOR OF HEPATITIS C VIRUS INFECTION
An inhibitor of HCV infection having a high inhibitory effect on HCV infection wherein the effect is unaffected by genotypes or gene mutations of HCV is...
2018/0282406 ANTIBODIES THAT BIND HUMAN CANNABINOID 1 (CB1) RECEPTOR
The present invention relates to novel antibodies and fragments thereof that binds cannabinoid 1 (CB1) receptor. The antibodies and fragments thereof as...
2018/0282405 CYTOPLASMIC EXPRESSION SYSTEM
The present invention provides host cells having an oxidizing cytoplasm, which are capable of growing to high cell densities and producing recombinant proteins...
2018/0282404 ANTIBODIES AGAINST HUMAN ANGIOPOIETIN 2
The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions...
2018/0282403 AGENTS FOR REDUCING THE ACTIVITY OF GDF15
The present invention relates to agents for reducing the activity of GDF15 and in particular the use of such agents to treat or prevent conditions associated...
2018/0282402 ANTI-HRS ANTIBODIES AND COMBINATON THERAPIES FOR TREATING CANCERS
Provided are antibodies that specifically bind to human histidyl-tRNA synthetase and related therapeutic compositions and methods for treating cancer,...
2018/0282401 PROTEIN-BASED THERAPY AND DIAGNOSIS OF TAU-MEDIATED PATHOLOGY IN ALZHEIMER'S DISEASE
The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions...
2018/0282400 Broadly-Neutralizing ANTI-HIV Antibodies
The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome...
2018/0282399 TRIVALENT, BISPECIFIC ANTIBODIES
The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and...
2018/0282398 EXPRESSION OF FC-CONTAINING PROTEINS
The present invention provides compositions comprising a Fc-containing protein wherein substantially all the Fc domains have a C-terminal lysine. Further...
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