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Patent # Description
2018/0282397 POLYPEPTIDES THAT BIND ACTIVATED RAS PROTEINS
The invention provides for polypeptides that bind to Ras proteins and methods of using the same, as described herein. For example, the disclosure provides an...
2018/0282396 SELECTIVE IL-6-TRANS-SIGNALLING INHIBITOR COMPOSITIONS
A selective IL-6-trans-signalling inhibitor can be used to treat a variety of IL-6-mediated conditions, including inflammatory diseases and cancer. The...
2018/0282395 MUTANT PROTEINS AND METHODS FOR THEIR PRODUCTION
The present invention relates to mutant transmembrane proteins which have increased conformational stability when compared to their parent protein, methods of...
2018/0282394 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0282393 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0282392 SYNTAC POLYPEPTIDES AND USES THEREOF
Methods and compositions for clonally inhibiting or clonally stimulating T-cells are provided.
2018/0282391 CD8a AND T CELL RECEPTOR VARIANTS AND METHODS OF USING SAME IN MODULATING IMMUNE CELL RESPONSES
Novel costimulatory fusion proteins and DNA sequences that enhance T cell responses to weakly immunogenic and/or lowly expressed antigens and that confer T...
2018/0282390 ANTIGEN RECEPTORS AND USES THEREOF
The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention...
2018/0282389 CLAUDIN-18.2-SPECIFIC IMMUNORECEPTORS AND T CELL EPITOPES
The present invention provides Claudin-18.2-specific immunoreceptors (T cell receptors and artificial T cell receptors (chimeric antigen receptors; CARs)) and...
2018/0282388 INSULIN ANALOGS AND USE THEREOF
An insulin analog with an improved in vitro effect compared with native insulin, a nucleic acid encoding the same, an expression vector including the nucleic...
2018/0282387 Protein Conjugates
The invention relates to protein conjugates and in particular conjugates of more than two protein or polypeptides. The compounds include a trivalent linker...
2018/0282386 THERAPEUTIC COMPOUNDS AND METHODS
This disclosure describes engineered compounds that engage NK cells and methods of using the compounds. Generally, the compound includes an NK engaging domain,...
2018/0282385 POLYPEPTIDES CAPABLE OF PRODUCING GLUCANS HAVING ALPHA-1,2 BRANCHES AND USE OF THE SAME
Disclosed herein are proteins capable of forming glucans having alpha-1,2 linkages/branches, reactions and methods for producing such glucan, compositions...
2018/0282384 PEPTIDES
The present invention relates to novel peptides, which impair PBX-dependent regulation of gene transcription and thus have utility in the treatment or...
2018/0282383 SMALL MOLECULES BLOCKING HISTONE READER DOMAINS
The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small...
2018/0282382 COMPOUNDS AND METHODS OF TREATING USHER SYNDROME III
An isolated polynucleotide includes a nucleic acid sequence that includes a cDNA coding sequence of a clarin-1 gene and a 3'UTR nucleic acid that is derived...
2018/0282381 COMPOSITIONS AND METHODS FOR PRODUCING HIGH SECRETED YIELDS OF RECOMBINANT PROTEINS
The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the...
2018/0282380 COMPOSITIONS AND METHODS FOR PRODUCING HIGH SECRETED YIELDS OF RECOMBINANT PROTEINS
The present disclosure relates to methods for producing recombinant proteins, as well as compositions used in and produced by such methods. Specifically, the...
2018/0282379 GLYCOSYLATED YGHJ POLYPEPTIDES FROM ENTEROTOXIGENIC ESCHERICHIA COLI (ETEC)
The present invention relates to glycosylated YghJ poly-peptides from or derived from enterotoxigenic Escherichia coli (ETEC) that are immunogenic. In...
2018/0282377 HEPATITIS C VIRUS E1/E2 HETERODIMERS AND METHODS OF PRODUCING SAME
The present disclosure provides affinity tagged heterodimeric polypeptides comprising a hepatitis C virus (HCV) E1 polypeptide and an HCV E2 polypeptide, where...
2018/0282376 SYNTHESIZING VACCINES, IMMUNOGENS, AND ANTIBODIES
Systems and methods have been developed to design and engineer glycan dynamics to improve immunogen antigenicity. These include systems for identify...
2018/0282375 PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY
This application pertains to orthogonally protected esters of peptide nucleic acid (PNA) monomers, which ester groups can be removed under conditions that...
2018/0282374 ANTIMICROBIAL POLYMYXIN DERIVATIVE COMPOUNDS
The present invention relates to antimicrobial polymyxin derivative compounds and their uses, and in particular to peptide polymyxin antibiotics which may be...
2018/0282373 PEPTIDE-BASED INHIBITORS OF MLL/SET1 FAMILY CORE COMPLEXES
Provided are peptides, compositions comprising the peptides, and methods of using the peptide compositions for inhibition of growth of cancer cells. The...
2018/0282372 KINASE SUBSTRATES AND METHODS OF USE THEREOF
The invention provides kinase substrates and methods comprising their use.
2018/0282371 PROTEIN BASED ADHESIVE COMPOSITION AND METHOD
A protein adhesive of a novel sequence is disclosed. The protein adhesive according to the present disclosures enables adhesion between two non-biological...
2018/0282370 NOVEL THERAPEUTIC USES OF MU-OPIATE RECEPTOR PEPTIDES
The present invention pertains to novel uses of endomorphine-1 peptide, analogs, and salts thereof for therapy of children, patients currently suffering from...
2018/0282369 NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST
The present invention relates to novel short-chain peptides of the general formula (I), which are selective and peripherally acting KOR agonist, their...
2018/0282368 METHOD FOR SEPARATING AND PURIFYING ALPHA2-MACROGLOBULIN FROM COHN FRACTION IV PRECIPITATION
The present invention discloses a method for separating and purifying .alpha.2-macroglobulin from Cohn Fraction IV precipitation, in which Cohn Fraction IV...
2018/0282367 NEW METHODS FOR MAKING BARUSIBAN AND ITS INTERMEDIATES
The present invention relates to new solid phase peptide methods for synthesizing analogues that exhibit oxytocin antagonist activity, specifically Barusiban...
2018/0282366 CRYSTALLINE AND AMORPHOUS FORMS OF 17-ALPHA-HYDROXYPROGESTERONE CAPROATE
The disclosure is in part directed to crystalline forms of 17-.alpha.-hydroxyprogesterone caproate and variants thereof.
2018/0282365 OLIGONUCLEOTIDE PRODUCTION METHOD, AND NUCLEOSIDE, NUCLEOTIDE, OR OLIGONUCLEOTIDE
Oligonucleotides may be produced by a process, including (1) condensing a nucleoside, nucleotide or oligonucleotide (a) or the like wherein a 5'-hydroxy group...
2018/0282364 BETA-D-2'-DEOXY-2'-ALPHA-FLUORO-2'-BETA-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTI- TUTED PURINE NUCLEOTIDES FOR HCV...
A compound of the structure: ##STR00001## or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to an...
2018/0282363 GLUCOPYRANOSIDE COMPOUND
A compound of the formula: ##STR00001## wherein Ring A and Ring B are: (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring...
2018/0282362 CRYSTAL FORMS OF b-NICOTINAMIDE MONONUCLEOTIDE
The invention relates to crystalline forms of a .beta.-nicotinamide mononucleotide, methods of their preparation, and related pharmaceutical preparations...
2018/0282361 AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS
Novel aminoglycosides, represented by Formulae Ia and Ib, as defined in the instant specification, designed to exhibit stop codon mutation readthrough...
2018/0282360 SWEETENER AND METHOD OF PRODUCTION THEREOF
A sweetener and to a method of production thereof is provided. The task of the present invention consists of providing a sucrose-based sweetener, in the...
2018/0282359 Metallocene Compounds
Unsaturated and hydrogenated polyalpha-olefin products can be made with a high selectivity toward vinylidenes and tri-substituted vinylenes combined, a high...
2018/0282358 ALKOXIDE COMPOUND, THIN FILM-FORMING STARTING MATERIAL, THIN FILM FORMATION METHOD, AND ALCOHOL COMPOUND
The alkoxide compound of the present invention is characteristically represented by the following general formula (I): ##STR00001##
2018/0282357 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
Tetradentate ligand based on strapped phenenthradine-imidazole (SIP) based Pt or Pd complexes useful as emitters in PHOLEDs is disclosed.
2018/0282356 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
A compound having the formula [L.sub.A].sub.3-nIr[L.sub.B].sub.n is disclosed. In the formula, L.sub.A is ##STR00001## and L.sub.B is ##STR00002## Formula I.
2018/0282355 BIARYL LIGANDS, METHODS OF MAKING BIARYL LIGANDS, AND METHODS OF USE THEREOF
Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as "biaryl compound"), biaryl complexes, methods of making biaryl...
2018/0282354 SUPPORTED MOLYBDENUM PEROXO COMPLEXES FOR TRANSFORMING ORGANO PHOSPHATE NEUROTOXINS TO A VALUE-ADDED, COMMODITY...
The invention relates to degradation of organophosphate neurotoxins with molybdenum complexes. In particular, the degradation of phosphate ester neurotoxins...
2018/0282353 NOVEL METHOD FOR PREPARING AMINOSILANE-BASED COMPOUND
The present invention provides a novel method for preparing an aminosilane-based compound, by which an aminosilane-based compound used for preparing a modified...
2018/0282352 PROTEASOME ACTIVITY ENHANCING COMPOUNDS
The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a...
2018/0282351 Amorphous Ixazomib Citrate
The present disclosure provides amorphous ixazomib citrate and processes for the preparation thereof. Crystalline form M1, form M2, form M3, and form M4 of...
2018/0282350 RARE EARTH-BASED METAL-ORGANIC FRAMEWORK FOR MOISTURE REMOVAL AND CONTROL IN CONFINED SPACES
A method for preparing a metal-organic framework (MOF) comprising contacting one or more of a rare earth metal ion component with one or more of a tetratopic...
2018/0282349 BIARYL PYRAZOLES AS NRF2 REGULATORS
The present invention relates to biaryl pyrazole compounds of Formula (I) ##STR00001## methods of making them, pharmaceutical compositions containing them and ...
2018/0282348 IMIDAZO[2,1-B]THIAZOLE AND 5,6-DIHYDROIMIDAZO[2,1-B]THIAZOLE DERIVATIVES USEFUL AS S100-INHIBITORS
A compound of formula (I) or a pharmaceutically acceptable salt thereof. The compound is useful for use in the treatment of cancer, an inflammatory disorder,...
2018/0282347 BICYCLIC COMPOUNDS AS PEST CONTROL AGENTS
The present application relates to novel bicyclic compounds, to compositions comprising these compounds, to their use for controlling animal pests and to...
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