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Patent # Description
2018/0282346 NOVEL MODIFIED MACROCYCLIC COMPOUNDS
The present invention relates to novel modified macrocyclic compounds of general formula (I) as described and defined herein, and methods for their...
2018/0282345 TRICYCLIC FUSED DERIVATIVES OF 1-(CYCLO)ALKYL PYRIDIN-2-ONE USEFUL FOR THE TREATMENT OF CANCER
The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates,...
2018/0282344 LOW MOLECULAR WEIGHT DERIVATIVES OF CARBOXAMIDE HALOGENATED PORPHYRINS, NAMELY CHLORINS AND BACTERIOCHLORINS,...
The present invention relates to carboxamide halogenated porphyrin derivatives, in particular bacteriochlorin or chlorin, of formula (I) use of the same or a...
2018/0282343 CARM1 INHIBITORS AND USES THEREOF
Provided herein are compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X,...
2018/0282342 Salt of Pyrrolo[2,3-D]pyrimidine Compound and Novel Polymorph of Salt
The present invention relates to novel crystalline forms of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyr- imidine-6-carboxylic acid...
2018/0282341 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES
The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in...
2018/0282340 Imidazotriaines and Imidazopyrimidines as Kinase Inhibitors
The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are...
2018/0282339 PROCESS FOR THE PREPARATION OF THE AMORPHOUS FORM OF IBRUTINIB AND NOVEL CRYSTALLINE FORM
Subject-matter of the invention is a process for the preparation of the amorphous form of ibrutinib and a novel crystalline form.
2018/0282338 SUBSTITUTED 5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-AMINE COMPOUNDS AS PDE2 INHIBITORS
The invention provides a chemical entity of Formula (I): (I), wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4, have any of the values described herein, and...
2018/0282337 SYNTHESIS OF COPANLISIB AND ITS DIHYDROCHLORIDE SALT
The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel...
2018/0282336 Active Acrylamides
The present invention refers to the synthesis and intermediates of substituted bicyclic compounds, which are used as a masked form of acrylamides and in...
2018/0282335 RIPK2 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
The invention is a compound represented by Structural Formula (I): (I); or a pharmaceutically acceptable salt thereof. Values for the variables are provided...
2018/0282334 ADENINE CONJUGATE COMPOUNDS AND THEIR USE AS VACCINE ADJUVANTS
The present specification relates to adenine conjugate compounds represented by the formula (1), wherein A, L.sup.1, L.sup.2, X.sup.1, R.sup.1, R.sup.2,...
2018/0282333 NEW 2, 1 L -DIAZA-[3.3](2,6)PYRIDINOPHANE COMPOUNDS AND THEIR APPLICATION AS LIGANDS OF ESSENTIAL METAL ION...
The one subject of the invention is the compounds of general formula (I), their isomers, their physiologically acceptable salts and/or Mn(II), Fe(II), Fe(III),...
2018/0282332 SUBSTITUTED SPIROCYCLIC INHIBITORS OF AUTOTAXIN
The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of...
2018/0282331 7-Oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of...
Compounds of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, their preparation, and use in treating a bacterial infection are...
2018/0282330 METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: ##STR00001## comprises: (a) reacting Compound (X): ##STR00002## or a...
2018/0282329 PROCESS FOR PREPARING METHYL {4,6-DIAMINO-2-[1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL]PYRIMID- ...
The present invention relates to a process for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3 -yl]pyrimidin-5 -yl...
2018/0282328 NAPHTHYRIDINES AS INHIBITORS OF HPK1
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an...
2018/0282327 METHOD OF MAKING TETRAHYDRONAPHTHYRIDINYL NONANOIC ACID COMPOUNDS
The present application relates to methods of preparing a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt or solvate thereof.
2018/0282326 FUSED TRICYCLIC UREA COMPOUNDS AS RAF KINASE AND/OR RAF KINASE DIMER INHIBITORS
Provided are certain fused tricyclic urea compounds and salts thereof, compositions thereof, and methods of use therefor.
2018/0282325 CHEMICAL COMPOUNDS
The specification relates to compounds of Formula (I): ##STR00001## and to pharmaceutically acceptable salts thereof, to processes and intermediates used for...
2018/0282324 CRYSTALLINE FORMS OF A PYRROLOPYRIDINE COMPOUND
Disclosed are crystalline forms of (R)--N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)c- yclopropanecarboxamide, and salts, solvates, and...
2018/0282323 Mesoionic imidazole derivatives as insecticides
What are demonstrated are compounds of the formula (I) ##STR00001## which are suitable for controlling animal pests, including arthropods and especially insects,...
2018/0282322 AZETIDINE DERIVATIVES FOR TAU IMAGING
The present invention provides a novel compound of the formula: methods of making this compound, methods of using this compound for tau imaging, and...
2018/0282321 COMPOUND FOR TREATING OR PREVENTING HYPERURICEMIA OR GOUT
The invention discloses a class of compounds for treating or preventing hyperuricemia or gout, which is a compound shown in general formula (I) or a...
2018/0282320 TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE
The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds....
2018/0282319 BICYCLIC COMPOUNDS AS PEST CONTROL AGENTS
The present application relates to novel bicyclic compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.
2018/0282318 DOPAMINE D3 RECEPTOR ANTAGONISTS
The disclosure is directed to novel dopamine D3 receptor antagonists, processes for their preparation, intermediates used in these processes, pharmaceutical...
2018/0282317 PROTEASOME INHIBITORS AND USES THEREOF
The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R, R.sup.1-R.sup.5, k, m, n, and q...
2018/0282316 BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing...
2018/0282315 4-SUBSTITUTED COUMARIN DERIVATIVES AND PREPARATION METHODS AND USES THEREOF
The present invention pertains to the field of chemical medicine, particularly to 4-substituted coumarin derivatives and preparation methods and applications...
2018/0282314 COUMARIN-LINKED TAXANES FOR DETECTION AND CIRCUMVENTION OF CELLULAR EFFLUX
A compound can be a fluorescent taxane derivative having a structure of Formula 1, salt, stereoisomer, tautomer, polymorph, or solvate thereof. Formula 1 can...
2018/0282313 1,3-BENZODIOXOLE DERIVATIVE
The present invention provides a compound having a particular chemical structure or a pharmacologically acceptable salt thereof which has an excellent...
2018/0282312 HYDROCHLORIDE SALT FORM FOR EZH2 INHIBITION
Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl ...
2018/0282311 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters...
2018/0282310 FORMS AND COMPOSITIONS OF BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable...
2018/0282309 1,2-SUBSTITUTED CYCLOPENTANES AS OREXIN RECEPTOR ANTAGONISTS
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, ##STR00001## wherein L, X, R.sup.a, R.sup.b, R.sup.1,...
2018/0282308 INHIBITORS OF KRAS G12C MUTANT PROTEINS
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically...
2018/0282307 INHIBITORS OF KRAS G12C MUTANT PROTEINS
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically...
2018/0282306 KINASE INHIBITORS AND METHOD OF TREATING CANCER
The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: ##STR00001## Compounds...
2018/0282305 TRIAZOLES AS NR2B RECEPTOR INHIBITORS
Provided here in are compounds of Formula I having the structure: ##STR00001## Also provided herein are compositions comprising compounds of Formula I and...
2018/0282304 RORC2 INHIBITORS AND METHODS OF USE THEREOF
The present invention provides compounds, pharmaceutical compositions, methods of inhibiting ROR.gamma. activity and/or reducing the amount of IL-17 in a...
2018/0282303 SQUARYLIUM COMPOUNDS AND INFRARED CUT FILMS, INFRARED CUT FILTERS AND ELECTRONIC DEVICES INCLUDING THE SAME
A squarylium compound has high transmittance in a visible wavelength spectrum of light and is configured to selectively absorb light in an infrared/near...
2018/0282302 HETEROCYCLIC COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
The present application is concerned with heterocyclic compounds that inhibit the activity of Pim kinases and are useful in the treatment of diseases related...
2018/0282301 PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS
The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy ...
2018/0282300 CRYSTAL FORM OF A POTASSIUM-COMPETITIVE ACID BLOCKER AND PREPARATION METHOD THEREOF
The present invention relates to a crystal form of a potassium-competitive acid blocker, that is, ...
2018/0282299 BLUE LUMINESCENT COMPOUNDS
There is provided a compound having Formula I, Formula II, Formula III, Formula IV, Formula V, or Formula VI: ##STR00001## ##STR00002##
2018/0282298 PROCESS FOR THE PREPARATION OF THE 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE
3-(3-chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine.dihydrochloride with a dialkyl maleate to provide an alkyl...
2018/0282297 POLYMORPHS OF 3-(4-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE
The present application relates to polymorphs of Compound A: ##STR00001## or a stereoisomer thereof, and methods of preparation and use thereof.
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