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Patent # Description
2018/0280525 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between...
2018/0280524 POLYMER CONJUGATE VACCINES
Monomers and copolymers are provided that both target antigen presenting cells (APCs) and activate toll-like receptor (TLR) on the APCs. In some embodiments,...
2018/0280523 Small Molecule Drug Conjugates
A binding moiety (B) for Carbonic Anhydrase IX (CAIX), the binding moiety comprising: ##STR00001## The binding moiety is univalent, bivalent, or multivalent. A...
2018/0280522 FOLATE-CONJUGATED MOLECULES FOR DELIVERY OF TOXIC SMALL MOLECULE INHIBITORS TO CANCER CELLS AND METHODS OF USE
The invention relates to novel derivatives of thapsigargin that are chemically modified with a group that targets a cell surface-expressed receptor, and...
2018/0280521 COMPOUNDS AND THERAPEUTIC USES THEREOF
The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating...
2018/0280520 COMPOSITIONS AND METHODS RELATED TO INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS ENTRY
Disclosed herein are compositions and methods for inhibiting respiratory syncytial virus (RSV) entry into a host cell. Also provided herein are methods of...
2018/0280519 METHODS FOR PREVENTING PLASTIC-INDUCED DEGRADATION OF BIOLOGICALS
The present invention provides methods for protecting a virus contained in a bioprocess bag from surface-induced degradation, thereby improving the...
2018/0280518 LINEAR POLYSACCHARIDE BASED FILM PRODUCTS
Film products, especially suitable for oral delivery, which can be formed during manufacture in the form of large and/or heavy film strips or sheets and...
2018/0280517 Nanocomposite, a Preparation Method Thereof and Method for Treating Cancer Using the Same
A nanocomposite, a preparation method thereof and a method for treating cancer using the same are provided. The preparation method includes: mixing a first...
2018/0280516 ANIONIC-CORE COMPOSITION FOR DELIVERY OF THERAPEUTIC AGENTS, AND METHODS OF MAKING AND USING THE SAME
The present invention is directed to compositions comprising a polymer backbone with protective chain and anionic groups, and a cationic therapeutic agent. The...
2018/0280515 STIMULUS-RESPONSIVE MICELLAR CARRIER
A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated...
2018/0280514 ANTIBODY FORMULATIONS
The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a...
2018/0280513 PATCH PREPARATION CONTAINING AN ACID SCAVENGER
An object of the present invention is to provide a patch preparation having an excellent skin permeability of medicament using an acid additional salt of basic...
2018/0280512 PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM
Disclosed herein are compositions comprising an NSAID such as meloxicam in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These...
2018/0280511 Continudihydroxyphenyl Neurotransmitter Compounds, Compositions And Methods
The present invention relates to new dihydoxyphenyl modulators of neurotransmitter levels, pharmaceutical compositions thereof, and methods of use thereof. ...
2018/0280510 Activatable Two-Component Photosensitizers
Provided herein is a two-component photosensitizer, which demonstrated robust and selective killing effects for transfected HEK cells and affibody targeted...
2018/0280509 TREATMENT OF BLOOD
Activation of senescent stem cells in humans to promote wound healing and other therapies, and to promote general enhancement of health by application of...
2018/0280508 ANTI-CANCER VACCINE COMBINATION
The invention relates to an anti-cancer vaccine combination. Particularly, the invention relates to a pharmaceutical combination comprising a PD-L1/PD-1...
2018/0280507 HUMANIZED ANTI-CD40 ANTIBODIES AND USES THEREOF
The present disclosure relates to anti-CD40 antibodies, such as humanized anti-CD40 antibodies, that may be used in various therapeutic, prophylactic and...
2018/0280506 ANTI-TIGIT ANTIBODIES, ANTI-PVRIG ANTIBODIES AND COMBINATIONS THEREOF
Anti-PVRIG and anti-TIGIT antibodies are provided.
2018/0280505 METHODS AND COMPOSITIONS FOR TREATING CANCER USING PD-1 AXIS ANTAGONISTS AND HPK1 ANTAGONISTS
Compositions and methods for enhancing an immune response and treating cancer are provided. Compositions comprise PD-1 axis antagonists and HPK1 antagonists....
2018/0280504 GLYCAN-INTERACTING COMPOUNDS AND METHODS OF USE
The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of...
2018/0280503 ANTI-PAD2 ANTIBODY FOR TREATING AND EVALUATING RHEUMATOID ARTHRITIS
A method for obtaining a prognosis for a subject having rheumatoid arthritis by measuring the levels of anti-PAD2 antibodies is described. Methods of using...
2018/0280502 Combination of immune effector cells specific for a target antigen and hematopoietic cells that express the...
The invention provides a system that comprises pharmaceutical agents for use in immunotherapy for reducing the side-effects of an antigen-recognizing receptor...
2018/0280500 TREATMENT OF LUPUS USING HUMANIZED ANTI-CXCR5 ANTIBODIES
This disclosure provides anti-CXCR5 antibodies and their use in the amelioration, treatment, or prevention of lupus. The disclosure also provides prophylactic,...
2018/0280499 PYRIMIDINE COMPOUND
The present invention provides a compound of the formula (1): ##STR00001## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, Y.sup.1, Y.sup.2, L,...
2018/0280498 ALUMINUM BASED ADJUVANTS FOR TOLEROGENIC VACCINATION
The present invention provides methods of modulating an immunological disorder or an immune response. The methods include administering to a subject or a cell...
2018/0280497 EXPRESSION VECTOR DELIVERY SYSTEM AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE
Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of...
2018/0280496 ZIKA RNA VACCINES
Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or...
2018/0280495 Gene Optimized Hantaan Virus M Segment DNA Vaccine For Hemorrhagic Fever With Renal Syndrome
A synthetic, codon-optimized Hantaan virus (HTNV) full-length M gene open reading frame that consists of a unique nucleotide sequence encoding HTNV proteins....
2018/0280494 METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES AND DIAGNOSTICS
The present invention provides compositions directed to recombinant flavivirus E glycoprotein ectodomain dimers for use in diagnostic and immunotherapeutic...
2018/0280493 Methods and Compositions Using Highly Conserved Pneumococcal Surface Proteins
Cold spot genes of S. pneumoniae are disclosed that encode surface proteins that are universally conserved among known strains and have exceptionally low...
2018/0280492 CHOLERA TOXIN CHIMERA AND ITS USE AS A STAPH VACCINE
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present...
2018/0280491 IMMUNOGENIC COMPOSITIONS AGAINST S. AUREUS
The invention relates to a conjugate of a saccharide covalently bound to a carrier protein, wherein the saccharide comprises repetitive units of 1,5 ribitol...
2018/0280490 METHODS AND COMPOSITIONS FOR PREVENTING A CONDITION
Provided herein are methods, compositions, and kits for preventing, inhibiting, reducing the severity of, or treating a disease or condition. A pharmaceutical...
2018/0280489 ENGINEERED LISTERIA AND METHODS OF USE THEREOF
The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners....
2018/0280488 Methods and Compositions for Binding Complement C3 for Targeting of Immune Cells
Disclosed are methods of treating a disease or condition in a subject comprising administering to a subject a nanoparticle, wherein the nanoparticle comprises...
2018/0280487 RECOMBINANT LISTERIA VACCINE STRAINS AND METHODS OF USING THE SAME IN CANCER IMMUNOTHERAPY
The present invention provides methods of treating, protecting against, and inducing an immune response against a human papillomavirus-associated tumor or...
2018/0280486 Modulation of Proprotein Convertase Subtilisin/Kexin 9 Expression (PCSK9) with HSP 27 and/or HSP25
The patent application pertains to compositions and methods for reducing Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) expression and for reducing serum...
2018/0280485 THIORETINAMIDE COMPOSITIONS FOR THE APOPTOSIS OF MALIGNANT CELLS WHILE PREVENTING THE APOPTOSIS OF NORMAL CELLS...
The invention pertains to novel compositions and related method for stimulating the immune system to promote the apoptosis of malignant cells while inhibiting...
2018/0280484 TREATMENT OF RAYNAUD'S PHENOMENON USING BOTULINUM TOXIN TYPE B
An effective amount of botulinum toxin type B is administered to a subject in need thereof for treating Raynaud's phenomenon. Botulinum toxin type B may be in...
2018/0280483 AGENT FOR PROTECTING UPPER RESPIRATORY TRACT AND FOOD OR DRINK COMPOSITION FOR PROTECTING UPPER RESPIRATORY TRACT
An agent for protecting upper respiratory tracts or a food or drink composition for protecting upper respiratory tracts which is effective in ameliorating...
2018/0280482 COMPOSITIONS AND METHODS FOR MODULATING TOLL-LIKE RECEPTOR 2 ACTIVATION
A method of promoting hair growth of a subject includes administering to follicle cells of the subject a therapeutically effective amount of a TLR2 agonist...
2018/0280481 PHARMACEUTICAL FORMULATIONS FOR THE ORAL DELIVERY OF PEPTIDE DRUGS
The present invention relates to improved pharmaceutical formulations, uses and methods for the oral delivery of peptide drugs with advantageously high...
2018/0280480 COMPOSITIONS AND PEPTIDES HAVING DUAL GLP-1R AND GLP-2R AGONIST ACTIVITY
The present invention relates to compositions and peptides having agonist activity towards both the human GLP-1 receptor and the human GLP-2 receptor, wherein...
2018/0280479 STABILIZED EXTERNAL PREPARATION COMPRISING THYMOSIN BETA 4 AS AN ACTIVE INGREDIENT
The present invention relates to a stabilized external preparation comprising thymosin beta 4 (T.beta.4) as an active ingredient. More specifically, the...
2018/0280478 ACTIVATORS OF CXCR3 FOR THE TREATMENT OF ANGIOPATHIES OF THE EYE
The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or...
2018/0280477 Therapeutic Dosing of a Neuregulin or a Subsequence Thereof for Treatment or Prophylaxis of Heart Failure
The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the...
2018/0280476 DIAGNOSTIC BIOMARKERS FOR FIBROTIC DISORDERS
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10...
2018/0280475 FIBROBLAST GROWTH FACTOR-9 PROMOTES HAIR FOLLICLE REGENERATION AFTER WOUNDING
The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic...
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