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Patent # Description
2018/0296693 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS
Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in...
2018/0296692 METHOD OF TREATING LEUKEMIA
The present disclosure relates to methods of reducing the number of abnormal PBMC cells in a leukemia patient. The methods may include administering an...
2018/0296691 ANTI-EFNA4 ANTIBODY-DRUG CONJUGATES
The present invention provides for anti-EFNA4 antibody-drug conjugates and methods for preparing and using the same.
2018/0296690 PROTEIN CONJUGATES
Provided are conjugates of an arginine deiminase (ADI) and a Tumor Necrosis Factor (TNF) superfamily ligand, and related compositions and methods of use...
2018/0296689 NEOADJUVANT USE OF ANTIBODY-DRUG CONJUGATES
The present invention concerns improved methods and compositions for neoadjuvant use of antibody-drug conjugates (ADCs) in cancer therapy, preferably ADCs...
2018/0296688 ANTI-CANCER COMPOUNDS AND CONJUGATES THEREOF
Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical...
2018/0296687 VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE SEROTYPE 5
The present invention relates to well-defined synthetic saccharides of general formula (I) that are related to the repeating unit of Streptococcus pneumoniae...
2018/0296686 PEPTIDE AND PEPTIDE MIMETIC BINDING ANTAGONISTS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE
The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the...
2018/0296685 TARGETED CONSTRUCTS AND FORMULATIONS THEREOF
Targeted constructs and pharmaceutical formulations thereof, comprising at least one conjugate of an active agent such as a therapeutic, prophylactic, or...
2018/0296684 TARGETED THERAPEUTIC NUCLEOSIDES AND THEIR USE
Provided herein are compounds comprising one or more therapeutic nucleosides and one or more targeting groups. In certain embodiments, the compounds further...
2018/0296683 COMPOSITIONS AND METHODS FOR DISASSEMBLING AMYLOID FIBRILS
The present disclosure provides multivalent polymer-peptide conjugate compositions capable of breaking already formed amyloid fibrils. Also provided are...
2018/0296682 PEPTIDE-OLIGONUCLEOTIDE CHIMERAS (POCS) AS PROGRAMMABLE BIOMOLECULAR CONSTRUCTS FOR THE ASSEMBLY OF...
This disclosure related to modular and programmable peptide-oligonucleotide chimeras comprising of peptide and oligonucleotide segments interlinked by an...
2018/0296681 PEPTIDE PHARMACEUTICALS
Described herein are methods of syntheses and therapeutic uses of covalently modified peptides and/or proteins. The covalently modified peptides and/or...
2018/0296680 SUPRAMOLECULAR MODIFICATION OF PROTEINS
The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the...
2018/0296679 PHARMACEUTICAL COMPOSITIONS OF POLYANIONIC AND NON-IONIC CYCLODEXTRIN-BASED DENDRIMERS AND USES THEREOF
The present application provides pharmaceutical compositions comprising polyanionic and polynon-ionic cyclodextrin-based dendrimers. The compositions can be...
2018/0296678 Compositions and Methods Using Rebaudioside X to Provide Sweetness Enhancement
Sweetened compositions comprising at least one sweetener and rebaudioside X are provided herein. Rebaudioside X is present in the sweetened compositions in a...
2018/0296677 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
This invention provides for a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1-R.sup.4, L and X are defined...
2018/0296676 PHARMACEUTICAL FORMULATION FOR REDUCING BLADDER SPASMS AND METHOD OF USE THEREOF
Methods and compositions for reducing bladder spasms are disclosed. The methods comprise administering to a subject in need thereof a pharmaceutical...
2018/0296675 COMBINATION THERAPIES FOR TREATMENT OF CANCER
A method for treatment of prostate cancer or benign prostate hyperplasia by combination therapy comprising administering to a patient an androgen-deprivation...
2018/0296674 LIQUID PHARMACEUTICAL COMPOSITION
The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, and at least one...
2018/0296673 ANTI-PODOCALYXIN ANTIBODIES AND METHODS OF USING THE SAME
The present invention is directed to anti-podocalyxin antibodies, compositions comprising the same, and methods of using such antibodies and compositions for...
2018/0296672 Methods for Treating Patients with Hypercholesterolemia that is not Adequately Controlled by Moderate-Dose...
The present invention provides methods for treating hypercholesterolemia. The methods of the present invention comprise administering to a patient a...
2018/0296671 METHODS AND COMPOSITIONS FOR TREATMENT OF METABOLIC DISORDERS
The present invention relates to the discovery that increases in invariant NKT cell (iNKT) number and/or activity can reduce the incidence or severity of...
2018/0296670 COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND METHODS OF USING SAME
The present invention provides compositions and methods of treating and improving the symptoms of rheumatoid arthritis using an antibody or antigen-binding...
2018/0296668 LIBRARY OF ANTIGEN-BINDING MOLECULES INCLUDING MODIFIED ANTIBODY VARIABLE REGION
The present inventors have successfully prepared a library consisting essentially of a plurality of antigen-binding molecules differing in sequence from each...
2018/0296667 METHOD FOR PREPARING VIRAL PARTICLES WITH CYCLIC DINUCLEOTIDE AND USE OF SAID PARTICLES FOR INDUCING IMMUNE...
The present invention relates to methods for preparing virus-like particles comprising immunogenic cyclic dinucleotides.
2018/0296666 Sustained Production of High Affinity Antigen Specific Antibody by High Dose BAFF Receptor-Targeting mAb-siRNA...
The present invention includes a composition and a method of modulating an immune response with a composition that comprises an anti-BAFF receptor antibody or...
2018/0296665 CONSENSUS/ANCESTRAL IMMUNOGENS
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV...
2018/0296664 H3 INFLUENZA A VIRUS
The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
2018/0296663 VACCINE COMPOSITION
A composition or combination comprising at least a first immunogenic component and at least a second adjuvant component, wherein the first immunogenic...
2018/0296662 SEXUALLY TRANSMITTED DISEASE VACCINES
The disclosure relates to sexually transmitted disease ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and...
2018/0296661 Compositions and Treatments for Haemophilus Influenzae
Immunogenic peptides, fusion polypeptides, and carrier molecules which include the immunogenic peptides, and immunogenic compositions which include these...
2018/0296660 Immunogenic composition for preventing pneumococcal diseases and preparation method thereof
The invention provides an immunogenic composition for preventing pneumococcal diseases, comprising PspA-MRXI, PspA-EF5668, PspA-EF3296 and PlyL460D, wherein...
2018/0296659 Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus
Disclosed are novel immunogenic proteins derived from Staphylococcus aureus, as well as methods for their use in conferring protective immunity against S....
2018/0296658 METHODS OF TREATING AND DIAGNOSING DISEASE USING BIOMARKERS FOR BCG THERAPY
The invention provides methods of treating disease, such as hypercholesterolemia (e.g., by modulating serum lipids, such as cholesterol, low-density...
2018/0296657 VIRB10 FOR VACCINATION AGAINST GRAM NEGATIVE BACTERIA
The invention pertains to the use of VirB10 to immunize a host against an infection by a bacterium having T4SS. The invention provides a vaccine comprising...
2018/0296656 CHIMERIC OSPA GENES, PROTEINS AND METHODS OF USE THEREOF
The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the...
2018/0296655 NKT CELL-ACTIVATION PHARMACEUTICAL COMPOSITION, METHOD FOR PRODUCING THEREOF AND METHOD OF STORING ANTIGEN...
A pharmaceutical composition includes a physiological solution containing a dendritic cell as an active component and plasma. The dendritic cell expresses a...
2018/0296654 METHOD FOR PREPARING AN IMMUNOGENIC LYSATE, THE LYSATE OBTAINED, DENDRITIC CELLS LOADED WITH SUCH LYSATE AND A...
The present invention relates to a method for the preparation of an immunogenic lysate from mesothelioma tumor cells, to such a lysate and to dendritic cells...
2018/0296653 ANTI-TUMORAL COMPOSITION
A pharmaceutical composition characterised in that it comprises at least one poxvirus, a naked nucleic acid sequence encoding at least one specific neoantigen...
2018/0296652 FORMULATIONS OF PEGYLATED ARGININE DEIMINASE
Provided are lyophilized formulations comprising pegylated arginine deiminase (ADI-PEG) and related reconstituted liquid compositions and methods of using the...
2018/0296651 Novel Method of Treating Macular Degeneration Using Botulinum Toxin-Based Pharmaceuticals
Formulations and methods of treatment are disclosed for prevention and/or treatment of visual loss from age-related macular degeneration. The disclosed...
2018/0296650 Method for Treating Pervasive Development Disorders
A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme...
2018/0296649 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic...
2018/0296648 CONJUGATES OF SOMATOSTATIN ANALOGUES
Conjugates of carriers and hydrogels for controlling the biological half-life of somatostatin and its analogs are disclosed.
2018/0296647 PROPHYLACTIC AND THERAPEUTIC AGENT FOR RETT SYNDROME (RTT) COMPRISING GHRELIN AS ACTIVE INGREDIENT
A prophylactic and therapeutic agent for Rett Syndrome (RTT) is provided, a pharmaceutical composition comprising ghrelin and a pharmaceutically acceptable...
2018/0296646 TREATMENT OF EPITHELIAL LAYER LESIONS
Methods for the treatment of lesions originating in an epithelial layer, particularly diseases of the epithelium of the skin, bladder, oral mucosa, vagina and...
2018/0296645 COMBINATION OF AN IL-2RBETA-SELECTIVE AGONIST AND A LONG-ACTING IL-15 AGONIST
In one or more embodiments of the invention, a method is provided, the method comprising the steps of administering to a cancer patient: (a) an ...
2018/0296644 COMPOSITIONS COMPRISING IL-31 AND USES THEREOF
A method for treating cancer and/or preventing or reducing metastasis or treating angiogenesis related disorders comprising the step of administering IL-31 or...
2018/0296643 SDF-1 FOR ANAL AND SPHINCTER WOUND HEALING
A method for treating an anal or sphincter wound of a subject is described. The method includes administering a therapeutically effective amount of a stromal...
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