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Patent # Description
2018/0296591 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF COMPROMISED SKIN BARRIER FUNCTION
Compositions and methods useful in treating dermatological disorders are described. The methods include applying to the skin a composition comprising a...
2018/0296590 TREATMENT OF MYELOSUPPRESSION
Methods are presented for attenuating myelosuppressive side effects of treatment regimens, promoting thrombopoiesis and neutrophil production, and increasing...
2018/0296589 Therapeutic Use of a Sterile Aqueous Ophthalmic Solution
The present invention relates to a sterile aqueous ophthalmic solution comprising N-(N-acetylcysteinyl-)chitosan or a pharmaceutically acceptable salt thereof...
2018/0296588 COMBINATION THERAPY FOR TREATING VIRAL INFECTIONS
The present application relates to a method of treating and/or preventing a HBV disease or HIV disease or modulating HBV or HIV replication, comprising...
2018/0296587 COMPOSITIONS OF AND METHODS OF TREATMENT WITH ZWITTERIONIC POLYSACCHARIDE
The present disclosure includes compositions of a zwitterionic polysaccharide (e.g., B. fragilis capsular polysaccharide A (PSA)) (including active fragments...
2018/0296586 USE OF NADPH FOR PREPARATION OF A DRUG FOR ANTIPLATELET AGGREGATION
Use of NADPH for preparation of a drug for antiplatelet aggregation, according to the research, it is found that in-vitro administration of exogenous NADPH...
2018/0296585 SUBSTITUTED-6,8-DIOXABICYCLO[3.2.1]OCTANE-2,3-DIOL COMPOUNDS AS TARGETING AGENTS OF ASGPR
Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical...
2018/0296584 METHODS OF TREATING FELINE CORONAVIRUS INFECTIONS
Provided are methods of treating feline Coronavirus infections comprising administering a therapeutically effective amount of a compound of Compound 1 to...
2018/0296583 COMBINATION THERAPY FOR TREATING MALIGNANCIES
Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using a combination of an inhibitor of a mutant IDH1 enzyme...
2018/0296582 MICROBIOME REGULATORS AND RELATED USES THEREOF
Compositions comprising microbiome regulators are provided, as well as methods of using the same for the modulation of the human microbiota and to treat or...
2018/0296581 SOLUBLE DIETARY FIBER AND PREPARATION METHOD THEREOF
A soluble dietary fiber having a xylooligosaccharide purity of 70% or greater. The xylooligosaccharide has a total xylobiose and xylotriose content of 45% or...
2018/0296580 METHOD FOR TREATING CANCER USING DUAL ANTAGONISTS OF CXCR1 AND CXCR2
What is described is a method for treating cancer in a patient in need of such treatment through the use of a dual CXCR1/2 antagonist by administering a...
2018/0296579 METHODS OF TREATING IBRUTINIB-RESISTANT DISEASE
Disclosed are methods of treating an ibrutinib-resistant disease in a mammal with a compound of Formula (I): wherein R is described herein. In certain...
2018/0296578 MODULATING PHOSPHATASE ACTIVITY IN CARDIAC CELLS
Expression of a phosphatase inhibitor in heart cells can be used to treat cardiac disorders, e.g., heart failure. Decreasing phosphatase activity can improve...
2018/0296577 PRODUCTION OF ASPIRIN-TRIGGERED RESOLVINS WITHOUT THE USE OF ASPIRIN IN A DIETARY OMEGA-3 SUPPLEMENT
The present invention includes a composition and method of producing aspirin in situ, the method comprising: identifying a subject in need of aspirin or...
2018/0296576 Method of Treating and Preventing Secondary Hyperparathyroidism
The method of treating elevated blood levels of iPTH by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D...
2018/0296575 METHODS OF DIAGNOSING AND TREATING HEPATOCELLULAR CARCINOMA
Disclosed herein is a novel use of HSD3B1 in disease diagnosis. According to embodiments of the present disclosure, the mRNA or protein level of HSD3B1 may...
2018/0296574 Combination Therapy for Prostate Cancer
Provided are methods and compositions, for treating prostate cancer by administering to a patient in need thereof a therapeutically effective amount of a PARP...
2018/0296573 DRY POWDER FORMULATION COMPRISING A CORTICOSTEROID AND A BETA-ADRENERGIC FOR ADMINISTRATION BY INHALATION
Compositions comprising a corticosteroid and a beta-adrenergic are useful for treating inflammatory or obstructive airways diseases.
2018/0296572 REPLACEMENT OF CYTOTOXIC PRECONDITIONING BEFORE CELLULAR IMMUNOTHERAPY
Provided herein are novel therapeutic compositions and methods that keep cellular immunotherapies in the circulation or at the site of injection for extended...
2018/0296571 OPHTHALMIC SOLUTION OF DIFLUPREDNATE
The present invention provides an ophthalmic solution comprising a. therapeutically effective concentration of difluprednate, a crystal growth inhibitor and...
2018/0296570 TOPICAL COMPOSITIONS COMPRISING BIMATOPROST AND METHODS FOR STIMULATING HAIR GROWTH THEREWITH
Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or...
2018/0296569 COBALT PORPHYRINS FOR THE TREATMENT OF BLOOD-RELATED DISORDERS
The use of cobalt porphyrins for the manufacture of an agent for mobilizing bone marrow cells to peripheral blood, preferably used to treat congenital...
2018/0296568 Substrates for Drug Delivery Device and Methods of Preparing and Use
An assembly and method for producing a condensation aerosol are disclosed. The assembly includes a heat-conductive metal substrate with an oxidation resistant...
2018/0296567 METHODS FOR TREATING INTRAPULMONARY INFECTIONS
This disclosure relates to the treatment of intrapulmonary bacterial infections, including treatment of nosocomial pneumonia lung infections with...
2018/0296566 BROMODOMAIN INHIBITORS
The present invention provides for compounds of formula (I) ##STR00001## wherein A.sup.1, A.sup.2, A.sup.3, A.sup.4, X.sup.1, X.sup.2, Y.sup.1, L.sup.1, G.sup.1,...
2018/0296565 COMPOSITION COMPRISING A THERAPEUTIC AGENT AND A RESPIRATORY STIMULANT AND METHODS FOR THE USE THEREOF
The present disclosure provides a safe method for anesthesia or the treatment of pain by safely administering an amount of active agent to a patient while...
2018/0296564 METHOD FOR PREVENTING AND/OR TREATING CHRONIC TRAUMATIC ENCEPHALOPATHY - III
The present invention relates to a method for the prevention and/or treatment of chronic traumatic encephalopathy comprising administration of an effective...
2018/0296563 METHOD OF TREATING MALIGNANT RHABDOID TUMOR OF THE OVARY (MRTO)/SMALL CELL CANCER OF THE OVARY OF THE...
The disclosure provides a method of treating a malignant rhabdoid tumor in a subject in need thereof including administering to the subject a ...
2018/0296562 USE OF A PPAR-DELTA AGONIST FOR REDUCING LOSS OF MUSCLE STRENGTH, MUSCLE MASS, OR TYPE I MUSCLE FIBERS IN AN...
The present invention provides methods for reducing loss of muscle strength, muscle mass, or Type I muscle fibers in an immobilized limb by administering ...
2018/0296561 The Methods For Treatment Of Tumors
This invention is in the area of improved therapeutic combinations for and methods of treating selected cancers using specific Mer tyrosine kinase (MerTK)...
2018/0296560 AMINO PYRIMIDINE COMPOUNDS USEFUL AS SSAO INHIBITORS
The present invention provides compounds of the formula below ##STR00001## pharmaceutically acceptable salts of the compounds, methods of treating patients for...
2018/0296559 TREATMENT OF AIRWAY SMOOTH MUSCLE DYSFUNCTION
The present disclosure is directed to compositions and methods for treating airway smooth muscle dysfunction in a subject. The compounds target the tyrosine...
2018/0296558 COMBINATIONS
The invention relates to a combination of a first compound selected from N-(3,5-dimethoxyphenyl)-N'-(1-methylethyl)-N-[3-(1-methyl-1H-pyrazol-4-yl- ...
2018/0296557 SURVIVIN-TARGETING ANTI-TUMOR AGENTS AND USES THEREOF
Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions...
2018/0296556 PARENTERAL FORMULATIONS OF LIPOPHILIC PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME
There may be provided compositions of lipophilic pharmaceutical agents with improved solubility and stability. For example, there may be provided a non-aqueous...
2018/0296555 2-PYRIDONE ANTIMICROBIAL COMPOSITIONS
Disclosed herein are compounds of Formula I ##STR00001## wherein R.sup.1, R.sup.2, X, and Y are defined herein. These compounds are type II topoisomerase...
2018/0296554 INHIBITORS OF THE FKBP51 PROTEIN FROM A HIGH-THROUGHPUT DRUG SCREEN AND METHODS OF USE
The subject invention concerns materials and methods for treating depression, stress disorders, such as PTSD, anxiety disorders, and/or a neurodegenerative...
2018/0296553 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PAIN
The present invention relates to a pharmaceutical composition comprising a combination of trazodone or a salt thereof, and gabapentin or a salt or prodrug...
2018/0296552 Composition for inhibiting alpha-glucosidase
A composition for inhibiting .alpha.-glucosidase has lower side effects to a user, other than the inhibition of .alpha.-glucosidase. The composition comprises...
2018/0296551 METHODS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES
A method of treating a neurodegenerative disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a CXCR4...
2018/0296550 Compositions, Dosage Forms, and Co-Administration of an Opioid Agonist Compound and an Analgesic Compound
The present invention relates generally to the co-administration of an opioid agonist compound and an analgesic compound. In addition, the invention relates...
2018/0296549 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER
The present invention relates to methods and pharmaceutical compositions for the treatment of cancer. More particularly, the present invention relates to a...
2018/0296548 AMINOTHIOLESTER COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, FOR USE IN THE TREATMENT OF CANCER
The present invention relates to the treatment of cancer in a subject, wherein cancer cells of said subject overproduce H.sub.2O.sub.2 and have a level of GSH...
2018/0296547 DOSAGE REGIMEN OF MDM2 INHIBITOR FOR TREATING CANCERS
The present invention provides a method for treating a cancer in a subject in need thereof, comprising administering a specific MDM2 inhibitor to the subject...
2018/0296546 P38 MAP Kinase Inhibitors for Wound Healing
Methods of the invention treat, reduce, or reverse fibrosis of a bodily tissue by administering to the local affected tissue a composition comprising an...
2018/0296545 COMPOSITIONS AND METHODS FOR PROVIDING CARDIOPROTECTIVE EFFECTS
The invention provides compositions and methods for providing a cardioprotective effect in a subject. Specifically, the invention provides compositions and...
2018/0296544 Compositions And Methods For Increasing Athletic Performance
Compositions, methods, and uses are contemplated in which a betalain-containing preparation is administered to a mammal to enhance athletic performance. Most...
2018/0296543 THERAPEUTIC COMPOUNDS
The present embodiments relate to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said...
2018/0296542 IMINOSUGARS FOR IMPROVING BONE MINERAL DENSITY IN BONE DISEASE
Disclosed are methods for treating bone diseases. More particularly, the present disclosure relates to methods of treating osteopenia, osteoporosis,...
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