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Patent # Description
2018/0296541 ARYL UREAS WITH ANGIOGENISIS INHIBITING ACTIVITY
This invention relates to methods of using aryl ureas to treat diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal...
2018/0296540 METHOD AND COMPOSITION FOR TREATING ALZHEIMER-TYPE DEMENTIA
There is described a method for increasing the maximal tolerated dose and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient...
2018/0296539 TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANTI-PROLIFERATE AND ANTI-INFLAMMATORY DRUGS
Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic...
2018/0296538 CRYSTALLINE FORMS OF 3-[5-(2-FLUOROPHENYL)-[1,2,4]OXADIAZOL-3-YL]-BENZOIC ACID FOR THE TREATMENT OF DISEASE
The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms...
2018/0296537 METHODS AND COMPOSITIONS FOR DIAGNOSING, TREATING, AND MONITORING TREATMENT OF SHANK3 DEFICIENCY ASSOCIATED...
The invention provides novel methods and compositions for diagnosing, treating, and monitoring treatment of Shank3 (SH3 and multiple ankyrin repeat domains 3)...
2018/0296536 FORMULATIONS OF BENDAMUSTINE
Long term storage stable bendamustine-containing compositions are disclosed. The compositions can include bendamustine or a pharmaceutically acceptable salt...
2018/0296535 FORMULATIONS OF BENDAMUSTINE
Long term storage stable bendamustine-containing compositions are disclosed. The compositions can include bendamustine or a pharmaceutically acceptable salt...
2018/0296534 BENDAMUSTINE PHARMACEUTICAL COMPOSITIONS
The present invention provides pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use. The present invention further provides...
2018/0296533 PREPARATION OF AND FORMULATION COMPRISING A MEK INHIBITOR
The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-car- boxylic acid...
2018/0296532 RNA-Focused Small Molecules for Inhibiting RNA Toxicity in Myotonic Dystrophy
The invention provides compounds and their pharmaceutical compositions according to Formula (I) that are useful for inhibiting RNA toxicity, such as in the...
2018/0296531 STIMULATION OF 11B-HSD2 EXPRESSION TO IMPROVE HORMONAL THERAPY OF STEROID-DEPENDENT DISEASE
A method of treating a steroid-dependent disease in a subject is described. The method includes providing steroid hormonal therapy to the subject while...
2018/0296530 METHOD FOR TREATING ATOPIC DERMATITIS
A method for treating atopic dermatitis in a subject in need thereof is provided. The method includes administering to the subject a composition containing a...
2018/0296529 LIPOSOME COMPOSITION CO-ENCAPSULATING DOXORUBICIN AND A PRODRUG OF MITOMYCIN C
A composition comprising liposomes comprising a lipid layer defining an internal aqueous compartment, an anthracycline drug entrapped in the internal aqueous...
2018/0296528 PTGDR-1 AND/OR PTGDR-2 ANTAGONISTS FOR PREVENTING AND/OR TREATING SYSTEMIC LUPUS ERYTHEMATOSUS
The present invention concerns a PTGDR-1 antagonist, a PTGDR-2 antagonist, a dual PTGDR-1/PTGDR-1 antagonist, or a combination of PTGDR-1 antagonist and...
2018/0296527 USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE TO TREAT ADDICTIVE AND ALCOHOL-RELATED DISORDERS
The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising ...
2018/0296526 A PHARMACEUTICAL COMPOSITION CONTAINING AN ARYLALKYLAMINE COMPOUND
The present invention provides a pharmaceutical composition and the like comprising (4-{(3S)-3-[(1R)-1-(naphthalen-1-yl)ethylamino]pyrrolidin-1-yl}phenyl)ace- ...
2018/0296525 TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND OTHER EYE DISEASES WITH ONE OR MORE THERAPEUTIC AGENTS
The present disclosure provides therapeutic agents for the treatment of age-related macular degeneration (AMD) and other eye disorders. One or more therapeutic...
2018/0296524 METHODS FOR DETECTION AND ERADICATION OF MYELOID LEUKEMIA STEM CELLS
There are provided, inter alia, methods and compositions for diagnosis and treatment of acute myeloid leukemia (AML), secondary acute myeloid leukemia (sAML),...
2018/0296523 USE OF POLYMETHOXYLATED FLAVONES TO AMELIORATE CIRCADIAN RHYTHM DISORDERS
Disclosed are methods comprising administering to a mammal suffering from, or at risk of suffering from, a clock-controlled disorder, such as metabolic...
2018/0296522 ENHANCED EXPRESSION OF mTOR AND INHIBITED EXPRESSION OF MYOSTATIN IN SKELETAL MUSCLE CELLS
Processes for increasing expression of a MTOR gene or a mTOR protein or decreasing expression of a MSTN gene or a myostatin protein in a subject in need of...
2018/0296521 METHODS AND COMPOSITIONS FOR TREATING GASTROINTESTINAL INFLAMMATION
Methods and compositions for treating gastrointestinal inflammation in a subject are provided.
2018/0296520 METHOD FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
The present invention provides methods for treating, controlling or mitigating paroxysmal nocturnal hemoglobinuria (PNH), comprising administering a...
2018/0296519 SACUBITRIL CALCIUM SALTS
The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methy- l butanoic acid...
2018/0296518 Compositions and Methods for Diagnosis and Treatment of Metabolic Syndrome
Compositions including an odd chain fatty acid, and salts and derivatives thereof, and methods for metabolic syndrome treatment and prophylaxis are provided,...
2018/0296517 INHIBITORS OF METALLO- -LACTAMASE-ENZYMES
The present application relates to combination treatments for bacterial infections. For example, the application relates to the use of one or more...
2018/0296516 AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating...
2018/0296514 NOVEL FORMULATION OF DICLOFENAC
The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac,...
2018/0296513 FORMULATIONS WITH ENHANCED STABILITY AND BIOAVAILABILITY FOR ADMINISTANTION OF (E)-2,6-DIALKOXYSTYRYL...
Pharmaceutical compositions of (E)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulpho- ne and pharmaceutically acceptable salts thereof are...
2018/0296512 LIQUID DOSAGE FORMS OF SODIUM NAPROXEN
Described herein are oral pharmaceutical compositions comprising liquid dosage forms of sodium naproxen in soft gel capsules. In one embodiment, the...
2018/0296511 Compositions and Methods for Treating Chronic Inflammation and Inflammatory Diseases
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a...
2018/0296510 THERAPEUTIC NEUROPATHIC PAIN LOTION
Technologies are described for a formulation and production of a formulation. The methods may comprise depositing a non-steroidal anti-inflammatory drug...
2018/0296509 BACTERICIDAL AND VIRUCIDAL PHARMACEUTICAL COMPOSITION
A bactericidal and virucidal pharmaceutical composition for use on epithelial tissues such as pulmonary, nasal and oral tissues, which comprises a...
2018/0296508 USE OF AN OLEOGEL CONTAINING TRITERPENE FOR HEALING WOUNDS
An oleogel comprising a non-polar liquid and a powder containing triterpene is provided as an oleogel that may be used for healing wounds.
2018/0296507 REDOX-ACTIVATED GLYCOCONJUGATED PROCHELATORS
Compositions of iron prochelator compounds conjugated to a carbohydrate moiety are described herein. The glycoconjugates are prochelators that are activated in...
2018/0296506 HIGH CONCENTRATION LOCAL ANESTHETIC FORMULATIONS
A transdermal topical anesthetic formulation, which can be used to ameliorate or inhibit pain, has been developed. In the preferred embodiment, the topical...
2018/0296505 BOOSTER DRUG THERAPY FOR MYCOBACTERIUM INFECTIONS
In one embodiment, the invention provides a method of treating a subject who suffers from, or who is suspected of suffering from, a Mycobacterium infection,...
2018/0296504 Novel Antioxidizing Intraocular Perfusion Solution
The present invention addresses the problem of providing an intraocular irrigating solution that allows the intraocular tissue to be sufficiently protected...
2018/0296503 TREATMENT OF RETINITIS PIGMENTOSA WITH N-ACETYLCYSTEINE AMIDE
The present invention includes a method for the treatment of retinitis pigmentosa in a human that comprises administering to the human a therapeutically...
2018/0296502 Method for Enhancing Folding and Transport of Misfolded Glucocerebrosidase
Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as...
2018/0296501 METHODS OF TREATING DEVELOPMENTAL ENCEPHALOPATHIES
Methods of treating developmental encephalopathies by administering compositions including ketamine, norketamine, or other derivatives of ketamine, or a...
2018/0296500 NOVEL TREATMENT OF PROSTATE CARCINOMA
Disclosed herein are naphthoquinone analogs, such as plumbagin, pharmaceutical compositions that include naphthoquinone analogs, such as plumbagin, and methods...
2018/0296499 HALOGENATED ETHER COMPOUNDS AND METHODS OF INDUCING ANESTHESIA
A method of inducing anesthesia in a subject is provided. In some embodiments, the method provides administering to the subject via the respiratory system or...
2018/0296498 MODULAR TRANSDERMAL DELIVERY SYSTEM AND ASSOCIATED METHODS OF MANUFACTURE AND USE
A modular transdermal drug delivery system is provided, the system including: an upper module in which an outer backing layer is laminated to a...
2018/0296497 Method and Articles for Inhibiting Bladder Contractions
A method and article for alleviating a subject's urge to urinate is described. The article includes a support and a composition with a stimulation agent such...
2018/0296496 UNIFORM FILMS FOR RAPID-DISSOLVE DOSAGE FORM INCORPORATING ANTI-TACKING COMPOSITIONS
The present invention relates to water-soluble films incorporating anti-tacking agents and methods of their preparation. Anti-tacking agents may improve the...
2018/0296495 A FAST ACTING ORALLY DISINTEGRATING FILM FOR ADMINISTRATION OF LOCAL ANESTHESIA
A fast acting orally disintegrating film (ODF) for administration of local anesthetic for alleviating physical and psychological discomfort in the oral cavity...
2018/0296494 METHODS TO ENHANCE BIOAVAVAILABILITY OF ORGANIC SMALL MOLECULES AND DEPOSITED FILMS MADE THEREFROM
Solid films and articles having a surface with discrete regions patterned with a deposited low molecular weight organic compound, such as pharmaceutical...
2018/0296493 LIPID NANOPARTICLE COMPOSITIONS AND METHODS AS CARRIERS OF CANNABINOIDS IN STANDARDIZED PRECISION-METERED...
This disclosure teaches phospholipid nanoparticle compositions of cannabinoids formed from phospholipids and simpler lipids in an unfired sequential process...
2018/0296492 GM3 FUNCTIONALIZED NANOPARTICLES
Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and...
2018/0296491 NANOPARTICLE THERAPEUTICS FOR TREATING SKIN INFLAMMATORY DISORDERS
The present invention provides nanoparticles and methods for treating and preventing skin inflammatory conditions or disorders. The conditions or disorders...
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