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Patent # Description
2018/0298414 Production of Nucleic Acid
A method for the production of nucleic acid encoding a target protein. The method comprises (a) providing an array of RNA or DNA molecules including one or...
2018/0298413 Biosynthesis of Oligosaccharides
The present invention relates to methods for production of 2'Fucosyllactose by a microbial system comprising a .alpha.-1,2 fucosyltransferase (FucT2)...
2018/0298412 SACCHARIFICATION REACTION MIXTURE, SACCHARIFICATION ENZYME COMPOSITION, SUGAR PRODUCTION METHOD, AND ETHANOL...
A saccharification reaction mixture wherein the reaction mixture can saccharify at least one of cellulose and hemicellulose and contains at least one of...
2018/0298411 Method of Producing Heparan Sulfate Having Anticoagulant Activity
The present invention provides a method of producing a heparan sulfate having an anticoagulant activity. Specifically, the present invention provides the...
2018/0298410 ENZYMATIC METHOD FOR PRODUCING 2-HYDROXY-4-METHYLMERCAPTOBUTANOIC ACID (MHA)
The invention relates to an enzymatic method for producing 2-hydroxy-4-methylmercaptobutanoic acid from 3-methylthio-propanal (3-methylmercaptopropanal (MMP)...
2018/0298409 Biological and Chemical Process Utilizing Chemoautotrophic Microorganisms for the Chemosynthetic Fixation of...
The invention described herein presents compositions and methods for a multistep biological and chemical process for the capture and conversion of carbon...
2018/0298408 GAS PHASE BIOCATALYSIS METHOD AND PROCESS
A method of enzyme conversion comprises the steps of: immobilising an enzyme composition on a support material; drying the support material and enzyme...
2018/0298407 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2018/0298406 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2018/0298405 METHODS AND COMPOSITIONS TO INCREASE HUMAN SOMATIC CELL NUCLEAR TRANSFER (SCNT) EFFICIENCY BY REMOVING HISTONE...
The present invention provides methods and compositions to improve the efficiency of somatic cell nuclear transfer (SCNT) of human cells and the consequent...
2018/0298404 METHODS AND COMPOSITIONS USEFUL IN GENERATING NON CANONICAL CD8+ T CELL RESPONSES
Methods of inducing a CD8+ T cell response to a heterologous antigen in which at least 10% of the CD8+ T cells are MHC-E restricted are disclosed. The method...
2018/0298403 Podosphaera Leucotricha Resistance Providing Genes in Malus Domestica
Provided herein are Podosphaera leucotricha resistance conferring genes, plants, plant parts and seeds comprising the present resistance providing genes and...
2018/0298402 NUCLEOTIDE SEQUENCES AND POLYPEPTIDES ENCODED THEREBY USEFUL FOR MODIFYING PLANT CHARACTERISTICS
Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased...
2018/0298401 ENGINEERING PHOTOSYNTHESIS
Disclosed are plants including a cyanobacterial ribulose-1,5,-bisphosphate carboxylase/oxygenase (Rubisco) which can assemble and fix carbon without an...
2018/0298400 BRASSICA EVENTS LBFLFK AND LBFDAU AND METHODS FOR DETECTION THEREOF
The present invention provides transgenic Brassica events LBFLFK and LBFDAU and progeny thereof, and cells, seeds, plants comprising DNA diagnostic for these...
2018/0298399 IDENTIFICATION AND USE OF GRAPE GENES CONTROLLING SALT/DROUGHT TOLERANCE AND FRUIT SWEETNESS
The present invention provides the identification and use of EGTom1 and/or EGTom2, homologs of EGTom1 and/or EGTom2, orthologs of EGTom1 and/or EGTom2,...
2018/0298398 METHODS AND COMPOSITIONS FOR THE CONTROL OF RUST FUNGI BY INHIBITING EXPRESSION OF THE HXT1 GENE
The present invention relates to methods and compositions for the control of plant fungal pathogens, particularly rusts, by inhibiting one or more biological...
2018/0298397 METHODS AND COMPOSITIONS FOR TARGETED INTEGRATION IN A PLANT
Compositions and methods are provided for the targeted integration of a polynucleotide sequence of interest into the genome of a plant or plant cell. The...
2018/0298396 METHODS AND COMPOSITIONS FOR TARGETED INTEGRATION IN A PLANT
Compositions and methods are provided for the targeted integration of a polynucleotide sequence of interest into the genome of a plant or plant cell. The...
2018/0298395 TOMATO PLANT PRODUCING FRUITS WITH BENEFICIAL COMPOUNDS
The present invention relates to a tomato plant which carries at least one QTL in its genome that leads to its fruits comprising higher levels of anthocyanins...
2018/0298394 Selection in Fungi
The present invention relates to methods for constructing a recombinant fungal host cell comprising one or more copies of a polynucleotide construct integrated...
2018/0298393 Replicative Minicircle Vectors With Improved Expression
The present invention relates to the production and use of covalently closed circular (ccc) recombinant DNA molecules such as plasmids, cosmids, bacterial...
2018/0298392 METHODS FOR IMPROVING CRISPR/CAS-MEDIATED GENOME-EDITING
This application provides improved methods of editing the genome of a target cell. Cas9 molecules can be used to create a break in a genomic region of...
2018/0298391 Programmable Modification of DNA
A self-reconfiguring genome uses a cassette having operons or DNA sequences that code for guide RNA, reverse transcriptase, donor RNA, and a CRISPR cleavage...
2018/0298390 Novel Genetic Code and Translation System for Producing Polypeptide, and Method for Producing Polypeptide
The present invention provides a translation system for expressing a polypeptide having a predetermined amino acid sequence according to a code different from...
2018/0298389 METHOD OF PRODUCING 2'-FUCOSYLLACTOSE USING CORYNEBACTERIUM GLUTAMICUM
Disclosed are a recombinant Corynebacterium glutamicum (C. glutamicum) for producing fucosyllactose which is transformed to express ...
2018/0298388 CYTOTOXIC T CELL RESPONSE MODIFIERS
The present invention relates to a compound selectively binding to a sensory receptor or selectively altering the expression of a sensory receptor for use in a...
2018/0298387 GENETIC VARIATIONS ASSOCIATED WITH DRUG RESISTANCE
Methods and compositions are provided to determine if a cancer is resistant to treatment with anti-mitotic agents, including treatment with T-DM1. The methods...
2018/0298386 METHODS AND COMPOSITIONS INVOLVING TRANSMEMBRANE AND COILED-COIL DOMAINS 3 (TM-CO3) IN CANCER
Certain embodiments provide methods and compositions related to clinical management of cancer patients based on the expression level of TMCO3. Further...
2018/0298385 Methods for Treatment of Alport Syndrome
Provided herein are methods for the treatment of Alport Syndrome, using modified oligonucleotides targeted to miR-21. In certain embodiments, a modified...
2018/0298384 COMPOSITIONS AND METHODS FOR MODULATING SMN GENE FAMILY EXPRESSION
Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of SMN1 or SMN2. Further aspects provide compositions...
2018/0298382 Non-Coding RNAs Linked to Immortality and Associated Methods and Compositions
Aspects of the present disclosure include RNAs that confer a mortal phenotype and nucleic acids encoding same. Liposomes, recombinant cells, and pharmaceutical...
2018/0298381 CHIMERIC DECOY
Disclosed is a double-stranded oligonucleotide decoy including two transcription factor-binding sites, while keeping its size small. The double-stranded...
2018/0298380 MODIFIED AAV CONSTRUCTS AND USES THEREOF
The present disclosure relates to the field of rAAV delivery of transgenes. In some aspects, the disclosure relates to RNAi. Provided herein are recombinant...
2018/0298379 SMALL INTERFERING RNA MODIFICATION METHOD BY COMBINING WITH ISONUCLEOSIDE MODIFICATION, TERMINAL PEPTIDE...
Provided is a novel chemical modification method for small interfering RNA (siRNA). The method is combined with at least two of the three methods of...
2018/0298378 PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN RETINAL ENDOTHELIAL CELLS
The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid...
2018/0298377 GENOMIC COMBINATORIAL SCREENING PLATFORM
The present disclosure provides methods and compositions that enable the rapid insertion of two or more combinations of genetic elements into a target cell...
2018/0298376 ISOLATING TRAFFIC-ENHANCING MUTANTS OF DRUG DELIVERY PROTEIN
The invention relates to methods for isolating traffic-enhancing mutants of drug delivery proteins. In one embodiment, the invention provides a carrier for...
2018/0298375 SECRETED PROTEINS
The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host...
2018/0298374 METHODS FOR NON-COVALENT FC-DOMAIN-CONTAINING PROTEIN DISPLAY ON THE SURFACE OF CELLS AND METHODS OF SCREENING...
The present invention provides methods for the non-covalent surface display of proteins of interest (POI), in particular for Fc-domain containing proteins such...
2018/0298373 DIAGNOSIS OF PROSTATE CANCER
The invention provides methods for isolating RNA from whole urine and urine fractions for the diagnosis of prostate cancer and/or benign prostate hyperplasia....
2018/0298372 A METHOD FOR PRODUCING AND PURIFYING RNA, COMPRISING AT LEAST ONE STEP OF TANGENTIAL FLOW FILTRATION
The present invention relates to method for producing and purifying RNA comprising the steps of providing DNA encoding the RNA; transcription of the DNA into...
2018/0298371 Separation Using Angled Acoustic Waves
Methods and systems for separating material from a host fluid use an acoustophoresis device. These methods and systems can deflect material (e.g., a second...
2018/0298370 MODIFIED BACTERIAL NANOCELLULOSE AND ITS USES IN CHIP CARDS AND MEDICINE
The present invention relates to bacterial nanocellulose composite which comprises nanocellulose, sensor or signal processing molecule(s), actuator/effector...
2018/0298369 PROTEIN HAVING XYLOSE ISOMERASE ACTIVITY AND USE OF SAME
A eukaryotic cell having xylose utilization ability. Provided is a protein that has xylose isomerase activity and has an amino acid sequence including, when...
2018/0298368 METHODS AND COMPOSITIONS FOR STABILIZING TRANS-SPLICING INTEIN MODIFIED PROTEASES
Methods for producing a trans-splicing intein-modified protease with enhanced solubility and regulating its activity are described. Intein-modified proteases...
2018/0298367 SUPPRESSION OF ITCH
The invention provides a polypeptide, for use in suppressing or treating itch, wherein the polypeptide comprises: a non-cytotoxic protease, which protease is...
2018/0298366 CATIONIC NEUROTOXINS
The present invention provides an engineered clostridial toxin comprising at least one amino acid modification, wherein said at least one amino acid...
2018/0298365 Polypeptides Having Lysozyme Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having lysozyme activity and polynucleotides encoding the polypeptides. The invention also relates to...
2018/0298364 PULLULANASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to pullulanase variants comprising substitutions of the parent pullulanase at one or more positions corresponding to positions...
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