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Patent # Description
2018/0298363 HOST CELL CAPABLE OF PRODUCING ENZYMES USEFUL FOR DEGRADATION OF LIGNOCELLULOSIC MATERIAL
The invention relates to a host cell comprising at least four different heterologous polynucleotides chose from the group of polynucleotides encoding...
2018/0298362 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also...
2018/0298361 ENDOGLYCOSIDASE MUTANTS FOR GLYCOPROTEIN REMODELING AND METHODS OF USING IT
A mutant of Endos2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO:1), wherein the one or more mutations are in a peptide...
2018/0298360 CAS9 VARIANTS AND METHODS OF USE THEREOF
The present disclosure provides variant Cas9 proteins, nucleic acids encoding the variant Cas9 proteins, and host cells comprising the nucleic acids. The...
2018/0298359 INTRACELLULAR PROTEIN DELIVERY
A secretion signal peptide sequence (SP) in combination with a cleavage inhibition sequence (CIS) fused to a structural gene sequence in a recombinant...
2018/0298358 MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3' position of...
2018/0298357 DNA Polymerase Possessing Continuous Catalytic Capacity and Salt Tolerance
A DNA polymerase, having an amino acid sequence represented by SEQ ID NO:2, or a derivative of the amino acid sequence by substitution, deletion, or addition...
2018/0298356 MODIFIED TRANSPOSASES FOR IMPROVED INSERTION SEQUENCE BIAS AND INCREASED DNA INPUT TOLERANCE
Presented herein are transposase enzymes and reaction conditions for improved fragmentation and tagging of nucleic acid samples, in particular altered...
2018/0298355 TRANSAMINASE POLYPEPTIDES
The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme....
2018/0298354 TRANSAMINASES
The invention relates to transaminases that are particularly useful for catalyzing the conversion of amine substrates to ketone products and/or vice versa.
2018/0298353 P-COUMAROYL-COA:MONOLIGNOL TRANSFERASES
The invention is directed to p-coumaroyl-CoA:monolignol transferase enzymes, nucleic acids encoding p-coumaroyl-CoA:monolignol transferase enzymes, and...
2018/0298352 POLYPEPTIDE FOR THE ENZYMATIC DETOXIFICATION OF ZEARALENONE, ISOLATED POLYNUCLEOTIDE, AND ASSOCIATED ADDITIVE,...
The invention relates to a polypeptide for the enzymatic detoxification of zearalenone, said polypeptide being a monooxygenase which converts the keto group in...
2018/0298351 DEGRADATION OF SPOROPOLLENIN
A composition comprised of a perodixase, a catalase and a peroxide that, in combination, is suitable for degradation of pollen wall sporopollenin, and coatings...
2018/0298350 METHODS AND COMPOSITIONS FOR PRODUCING VITAMIN K DEPENDENT PROTEINS
The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells.
2018/0298349 SELECTION METHODS FOR GENETICALLY-MODIFIED T CELLS
In some aspects, isolated transgenic cells (e.g., transgenic T cells) are provided that comprise or express a transgene and DHFR.sup.FS and/or TYMS.sup.SS....
2018/0298348 Method to Produce Virus in Cultured Cells Supplemented With Alpha-Ketoglutarate
The present disclosure provides a method to enhance the production of virus in cultured fibroblasts by supplementing the cells with a TCA cycle intermediate,...
2018/0298347 COMPOSITIONS AND KITS FOR PURIFICATION OF VIRAL PARTICLES FROM HOST CELLS
The present disclosure provides methods for extracting viral particles from a sample comprising cells enclosing the viral particles. Also provided are kits...
2018/0298346 METHOD FOR PRODUCING HIGH-QUALITY iPS CELLS
An object of the present invention is to provide an agent for improving quality of an iPS cell, a method for producing an iPS cell, an iPS cell produced by...
2018/0298345 ADHESIVE SIGNATURE-BASED METHODS FOR THE ISOLATION OF CANCER-ASSOCIATED CELLS AND CELLS DERIVED THEREFROM
The present invention provides methods of isolating a cancer-associated cell, such as a cancer stem cell or tumor initiating cell or a cell derived therefrom,...
2018/0298344 Realistic Humanized Model of Disease Matrix Environment for Evaluation of Therapeutic Reversal or Cell Fate
The present invention relates to tunable hydrogels generated by selecting an amount of polymer and cross-linker such that the resulting hydrogel when...
2018/0298343 COMPOSITIONS AND METHODS FOR A THREE DIMENSIONAL EX-VIVO GLOMERULAR CELL CO-CULTURE BIOLOGICAL ENGINEERING MODEL
The invention provides compositions, methods and systems for the ex vivo co-culture of renal cells, more specifically, for the co-culture of glomerulus-derived...
2018/0298342 COMPOSITION FOR RAPIDLY SEPARATING ADIPOSE TISSUE-DERIVED STROMAL CELLS
The present invention provides a composition for isolating adipose-derived stromal cells, which comprises a Type I collagenase of 0.5-8% (v/v); a Trypsin of...
2018/0298341 STROMAL STEM CELLS
Stromal stem cells are prospectively isolated from human bone marrow then expanded into clonal populations and cultured and used, the isolation being on the...
2018/0298340 SYSTEMS FOR DETECTING, MONITORING OR TREATING DISEASES OR CONDITIONS USING ENGINEERED CELLS AND METHODS FOR...
Provided are methods for detecting and treating disease states, including cancer, diabetes, fibrosis, and autoimmune diseases, by detecting increased...
2018/0298339 APICIDIN-CONTAINING COMPOSITION FOR INDUCING DIFFERENTIATION OF MESENCHYMAL STEM CELLS INTO CARDIAC-COMMITTED CELLS
The present invention relates to an apicidin composition for inducing differentiation of mesenchymal stem cells into cardiac-committed cells, and a method for...
2018/0298338 T Cells With Increased Immunosuppression Resistance
This invention relates to the treatment of cancer in an individual by administration of a population of modified T cells that express a recombinant cAMP...
2018/0298337 METHOD FOR PRODUCING CD4-POSITIVE T CELLS FROM PRURIPOTENT STEM CELLS
An object of the present invention is induction of CD4-positive T cells from pluripotent stem cells. This object is achieved by production of CD4-positive T...
2018/0298336 T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to...
2018/0298335 SINGLE B-CELL CULTIVATION METHOD
Herein is reported a method for obtaining a B-cell comprising the following steps a) labeling B-cells, b) depositing the labeled B-cells as single cells, c)...
2018/0298334 Use of a Warmer For Promoting a Biological Reaction
The present invention relates to the use of warmers, or autonomous heat packs, for heating and maintaining a solution at a suitable temperature, for the period...
2018/0298333 PERSONALIZED 3D NEURAL CULTURE SYSTEM FOR GENERATING HUMAN OLIGODENDROCYTES AND STUDYING MYELINATION IN VITRO
Human pluripotent stem cells are differentiated in vitro into oligodendro-spheroids comprising oligodendrocytes for use in analysis, screening programs, and...
2018/0298332 Microfluidic Model of the Blood Brain Barrier
The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic...
2018/0298331 Microfluidic Model Of The Blood Brain Barrier
The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic...
2018/0298330 MEANS AND METHODS FOR GENERATING MIDBRAIN ORGANOIDS
The present invention provides means and methods for the generation of midbrain organoids which are useful for studying neurodevelopmental and ...
2018/0298329 SELF-ORGANIZED VASCULAR NETWORKS FROM HUMAN PLURIPOTENT STEM CELLS IN A SYNTHETIC MATRIX
The present invention is in the area of pluripotent stem cells and more particularly deals with a method to differentiate a vascular network from stem cells.
2018/0298328 ANGIOGENESIS USING STIMULATED PLACENTAL STEM CELLS
Provided herein are stimulated placental stem cells and methods of treating individuals having diseases or disorders of the circulatory system using stimulated...
2018/0298327 METHOD FOR PRODUCING CONTINUOUS CELL LINES
The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said...
2018/0298326 METHOD OF NOCICEPTOR DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS AND USES THEREOF
The present invention relates to the field of stem cell biology, in particular the lineage specific differentiation of pluripotent or multipotent stem cells,...
2018/0298325 SYSTEM AND METHOD FOR PRODUCTION OF ON-DEMAND PROTEINS IN A PORTABLE UNIT FOR POINT OF CARE DELIVERY
A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of...
2018/0298324 SINGLE-PARTICLE ANALYSIS METHOD, AND SYSTEM FOR PERFORMING SAID ANALYSIS
An object of the present invention is to purify and concentrate differentiating cells derived from ES cells, iPS cells, or the like without damaging them. The...
2018/0298323 ACOUSTIC PERFUSION DEVICES
Acoustic perfusion devices and processes for separating biomolecules from other material in a fluid mixture are disclosed. The devices include an inlet port,...
2018/0298322 THIN FILM CULTURE DEVICE WITH CARBON DIOXIDE GENERANT
The present disclosure provides a culture device for enumerating colonies of microorganisms. The device can comprise a base, a coversheet, and a nonporous...
2018/0298321 CELL CULTURE DEVICE
A cell culture apparatus in which on an abutting surface (2a) around an opening part of a thermostatic chamber (3) and a cold storage chamber (4) that abuts...
2018/0298320 Culture Insert Assembly and System for Culture, Transfer, and Analysis
Provided is a culture system comprising a base comprising a multiwell plate; a transwell-like type insert plate comprising a plurality of culture insert...
2018/0298319 INTERCONNECTIONS OF MULTIPLE PERFUSED ENGINEERED TISSUE CONSTRUCTS AND MICROBIOREACTORS, MULTI-MICROFORMULATORS...
The invention relates to a system of fluidic valves and pumps and associated fluidic channels integratable into a bio-object microfluidics module. The module...
2018/0298318 Microfluidic Devices for Optically-Driven Convection and Displacement, Kits and Methods Thereof
Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic...
2018/0298317 DEVICES FOR SIMULATING A FUNCTION OF A TISSUE AND METHODS OF USE AND MANUFACTURING THEREOF
Systems and methods for producing and using a body having a first structure defining a first chamber, a second structure defining a second chamber, a membrane...
2018/0298316 CONTAINERS FOR CLOSED SYSTEM SINGLE-USE BIOREACTORS AND CULTURE VESSELS
A multiport container system for use in cell culture processes in the field of regenerative medicine is disclosed. Specifically, the container system can have...
2018/0298315 METHOD FOR PRODUCING LIVING TISSUE AND ORGAN
A method for producing a living tissue and organ includes: collecting medical image information of a target tissue and organ, and converting the medical image...
2018/0298314 Photobioreactor, System and Method of Use
Photobioreactors having a vertically-oriented enclosure with a thin panel shape, systems providing mixing in an array of photobioreactors, and methods for...
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