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Patent # Description
2018/0298110 PLASMA KALLIKREIN INHIBITORS AND USES THEREOF FOR PREVENTING HEREDITARY ANGIOEDEMA ATTACK
Provided herein are plasma kallikrein antibodies binding to active plasma kallikrein and methods of using such antibodies in preventing hereditary angioedema...
2018/0298109 POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention...
2018/0298108 THERAPEUTIC ANTIBODIES AND THEIR USES
The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell...
2018/0298107 HUMAN MONOCLONAL ANTIBODY HUMAN CD134 (OX40) AND METHODS OF MAKING AND USING SAME
The invention provides antibodies that specifically bind to OX40 (CD134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention...
2018/0298106 ANTIBODIES AGAINST HUMAN CD38
Isolated monoclonal antibodies which bind to human CD38 and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical...
2018/0298105 Human CD30 Ligand Antigen Binding Proteins
Provided are compositions and methods relating to human CD30L antigen binding proteins. Compositions described herein include: human CD30L antigen binding...
2018/0298104 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TH17 MEDIATED DISEASES
The present invention relates to methods and pharmaceutical compositions for the treatment of Th17-mediated diseases. In particular, the present invention...
2018/0298103 MONOCLONAL ANTIBODIES DIRECTED TO PEPTIDE IN THE CONTEXT OF MHC AND METHODS OF MAKING AND USING MONOCLONAL...
Phycoerythrin (PE) and peptide:MHCII (p:MHCII) reactive monoclonal antibodies; methods to generate monoclonal antibodies including, for example, peptide:MHC...
2018/0298102 METHODS AND COMPOSITIONS FOR TREATING AGING-ASSOCIATED IMPAIRMENTS
Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the 2-microglobulin (B2M) level in...
2018/0298101 Inhibition of Cytokine-Induced SH2 Protein in NK Cells
The present invention relates to therapeutic and prophylactic methods based on inhibition of CIS in NK cells. In particular, the present invention relates to...
2018/0298100 Combination Therapy for the Treatment of Cancer
This invention relates to a pharmaceutical composition that comprises a first molecule that specifically binds HER2/neu and a second molecule that specifically...
2018/0298099 T-Cell Recepter (TCR) Targeting Therapies for Immune-Mediated Adverse Drug Reactions (ADRs) and Other Conditions
The present invention provides methods and compositions for treating immune mediated adverse drug reactions using anti-.alpha..beta. TCR antibodies and...
2018/0298098 IMMUNOTHERAPEUTIC TARGETING OF PLACENTAL-LIKE CHONDROITIN SULFATE USING CHIMERIC ANTIGEN RECEPTORS (CARS) AND...
The present invention relates to polypeptides comprising conditionally active chimeric antigen receptor (CAR) and a split-protein binding system, a VAR2CSA...
2018/0298097 ANTIBODIES AGAINST TIM3 AND USES THEREOF
Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also...
2018/0298096 Anti-ILT4 Antibodies and Antigen-Binding Fragments
The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof,...
2018/0298095 INTERACTIONS BETWEEN CEACAM AND TIM FAMILY MEMBERS
Described herein are compositions and methods for modulating immune response, which can be upregulated or down regulated by enhancement or inhibition of...
2018/0298094 MONOCLONAL ANTIBODIES TARGETED TO HUMAN TAXILIN ALPHA AND METHODS FOR USE OF SAME
A method for diagnosis or aiding in the diagnosis of Sjogren's Syndrome (SS). The diagnosis method requires testing a sample obtained or derived from a subject...
2018/0298093 GLYCOENGINEERED BINDING PROTEIN COMPOSITIONS
Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of...
2018/0298092 METHODS FOR TREATING OCULAR DISEASES
A method is provided for reducing the treatment burden for patients who have an intraocular neovascular disorder, the method comprising administering a...
2018/0298091 MONOCLONAL ANTIBODIES TO GROWTH AND DIFFERENTIATION FACTOR 15 (GDF-15), AND USES THEREOF FOR TREATING CANCER...
The present invention relates to monoclonal anti-human-GDF-15 antibodies. The antibodies include chimeric antibodies and humanized antibodies. The invention...
2018/0298090 NOVEL ANTI-NODAL ANTIBODIES AND METHODS OF USING SAME
The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder...
2018/0298089 Chimeric and Humanized Anti-Histone Antibodies
The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein....
2018/0298088 COMPOSITIONS AND METHODS FOR STEM CELL DELIVERY
This invention provides compositions of matter, articles of manufacture and methods for delivering and/or affixing a stem cell to a target tissue. This...
2018/0298087 HUMANIZED MONOCLONAL ADVANCED GLYCATION END-PRODUCT ANTIBODY
A humanized monoclonal antibody that binds to an advanced glycation end-product-modified protein or peptide on a cell comprises a heavy chain and a light...
2018/0298086 ANTIBODY BASED REAGENTS THAT SPECIFICALLY RECOGNIZE TOXIC OLIGOMERIC FORMS OF TAU
The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau,...
2018/0298085 ACTIVATABLE ANTIBODIES HAVING NON-BINDING STERIC MOIETIES AND METHODS OF USING THE SAME
The invention relates generally to activatable antibodies and methods of making and using these activatable antibodies in a variety of therapeutic, diagnostic...
2018/0298084 BACTERICIDAL MONOCLONAL ANTIBODY TARGETING KLEBSIELLA PNEUMONIAE
A human or humanized monoclonal IgG antibody (mAb) specifically recognizing the D-galactan-II antigen of Klebsiella pneumoniae O1 which is characterized by a...
2018/0298083 NEUTRALIZING ANTIBODIES TO GP120 AND THEIR USE
Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors...
2018/0298081 Antibodies Against F Glycoprotein of Hendra and Nipah Viruses
The present invention relates to antibodies or antibody fragments that bind, neutralize, and/or inhibit Hendra or Nipah virus. The invention provides...
2018/0298080 PROCESS FOR PREPARING APOLIPOPROTEIN A-I (APO A-I)
The present invention relates to processes of obtaining Apo A-I from an Apo A-I containing protein fraction (A), comprising suspending the Apo A-I containing...
2018/0298079 Compositions and Methods for Immunomodulation in an Organism
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need...
2018/0298078 METHOD FOR PRODUCING FUSION PROTEIN HAVING IGG FC DOMAIN
The present invention relates to a method for preparing a fusion protein having an IgG Fc domain and, specifically, to a method for preparing a fusion protein...
2018/0298077 GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) ANALOGUES
GLP-2 analogues are disclosed which comprise one of more substitutions as compared to h[Gly2]GLP-2 and which may have the property of an altered GLP-1...
2018/0298076 MODIFIED GLUCAGON MOLECULES
The invention generally relates to modified glucagon molecules. In certain embodiments, the invention provides a glucagon molecule that includes one or more...
2018/0298075 Interferon Analogs
The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted...
2018/0298074 TARGETED MODIFIED TNF FAMILY MEMBERS
The present invention relates to a modified cytokine of the TNF superfamily, with reduced activity to its receptor, wherein said modified cytokine is...
2018/0298073 MODIFIED FGF-21 POLYPEPTIDES AND THEIR USES
Modified FGF-21 polypeptides and uses thereof are provided.
2018/0298072 DIAGNOSIS OF A NOVEL AUTOIMMUNE DISEASE
Polypeptides including Neurochondrin and autoantibodies binding to polypeptides including Neurochondrin are provided. Methods for diagnosing or treating...
2018/0298071 Chimeric Protein in the Treatment of Amyloidosis
The present invention relates to a chimeric protein comprising at least one human amyloid P component and at least one fragment of an Fc region of a human...
2018/0298070 PEPTIDE COMPOUND
The present invention provides a novel peptide compound having an activating action on GIP receptors and use of the peptide compound as a medicament. ...
2018/0298069 CELL LINES FOR SCREENING ODORANT AND AROMA RECEPTORS
Provided herein is a cell line with improved odorant receptor function comprising an activated endogenous RTP1 gene, which further expresses an RTP1 protein....
2018/0298068 TREATMENT OF CANCER USING CHIMERIC ANTIGEN RECEPTOR AND PROTEIN KINASE A BLOCKER
The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The...
2018/0298067 METHODS FOR THE PRODUCTION OF A COSMETIC COMPOSITION COMPRISING LEUKOLECTIN AND USES THEREOF
The present invention relates to cosmetic compositions comprising polypeptides obtained or obtainable from Salmonidae hatching fluid, methods of producing said...
2018/0298066 PEPTIDES HAVING REDUCED TOXICITY THAT STIMULATE CHOLESTEROL EFFLUX
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length...
2018/0298065 PROTEASE-RESISTANT STREPTAVIDIN
The present invention relates to modified streptavidin molecules that are resistant to cleavage by Lys-C or other proteases. These modified streptavidin...
2018/0298064 PROTEINS AND NUCLEIC ACIDS FROM MENINGITIS/SEPSIS-ASSOCIATED ESCHERICHIA COLI
Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of...
2018/0298063 ENGINEERED INFLUENZA ANTIGENIC POLYPEPTIDES AND IMMUNOGENIC COMPOSITIONS THEREOF
The present invention provides, among other things, a novel and improved method for generating "mosaic" influenza antigenic polypeptides including ...
2018/0298062 SELF-ASSEMBLED STRUCTURES COMPOSED OF MONOMERS OF PEPTIDE NUCLEIC ACID AND TUNABLE PHOTONIC CRYSTALS MADE THEREFROM
Ordered structures composed of a plurality of self-assembled peptide nucleic acid (PNA) monomers, and processes of generating same are provided. The plurality...
2018/0298061 SYNTHETIC N-ACETYL-MURAMIC ACID DERIVATIVES AND USES THEREOF
The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is...
2018/0298060 Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same
A cyclopeptide is disclosed, which is represented by the following formula (I) or (I'): ##STR00001## wherein R.sub.1 is defined in the specification. In...
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