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Patent # Description
2018/0298059 A NEW TYPE POLYPEPTIDE TARGETING TUMOURS
Provided is a nRGD polypeptide formed by connecting alanine-alanine-asparagine (AAN) and a polypeptide containing arginine-glycine-aspartic acid (RGD), wherein...
2018/0298058 A Multi-Functional Peptide Benefiting Expression, Purification, Stabilization and Catalytic efficiency of...
The present invention relates to a multi-functional peptide benefiting expression, purification, stabilization and catalytic efficiency of recombinant...
2018/0298057 Compositions and Methods for Managing Respiratory Conditions
This disclosure relates to compositions for use in managing respiratory distress and related disorders. In certain embodiments, the disclosure relates to...
2018/0298056 PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL ...
The present invention relates to process for the preparation of (2S)--N--((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-y- ...
2018/0298055 INHIBITORS OF NF KAPPA-B ACTIVITY FOR TREATMENT OF DISEASES AND DISORDERS
Peptides and methods of use thereof, are disclosed for use in treating various disease and disorders, including inflammation, pain, oral mucositis, oral...
2018/0298054 TARGETED NITROXIDE AGENTS
Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a...
2018/0298053 ANTIBIOTIC OLIGOPEPTIDES
Disclosed are methionine mimetics that possess antibiotic properties in prokaryotic cells. These mimetics are coupled to one or more optionally substituted...
2018/0298052 PROTEIN PURIFICATION METHOD
An object of the present invention is to obtain a protein monomer useful as a raw material for medicines industrially and economically in high yield and high...
2018/0298051 METHODS AND COMPOSITIONS RELATED TO FUNCTIONAL POLYPEPTIDES EMBEDDED IN HETEROLOGOUS PROTEIN SCAFFOLDS
The present invention provides methods for generating functional derivatives of effector polypeptides (e.g., hormones and receptor ligands) embedded in a...
2018/0298050 COMPOUND FOR TREATING CANCER
A compound and pharmaceutically acceptable salts thereof for treating cancer, having a structure represented by the following formula (I) or formula (II): ...
2018/0298049 UV-B ABSORBING COMPOUNDS ISOLATED FROM PLANTS
The present invention relates to compounds according to general formula (I) with enhanced absorption of UV-B irradiation. The present invention also relates to...
2018/0298048 MACROLIDES AND METHODS OF THEIR PREPARATION AND USE
Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides,...
2018/0298047 TRIGGER-ACTIVATABLE METABOLIC SUGAR PRECURSORS FOR CANCER-SELECTIVE LABELING AND TARGETING
Disclosed are compounds for the selective labeling of cell-surface sugars in cancer cells. The compounds are activatable by triggers specific to cancer cells,...
2018/0298046 PROCESS FOR PRODUCING RUTHENIUM COMPLEXES AND INTERMEDIATES THEREOF AND THEIR USE IN OLEFIN METATHESIS
The invention provides a new process for producing ruthenium complexes represented by the Formula 1. Invention provides also the use of ruthenium complexes...
2018/0298045 Synthesis of Phosphoramidates
A process for preparing a compound of formula (I) or a salt thereof, the process comprising providing a compound of formula (III) wherein PG is an inert...
2018/0298044 FURAN-CONTAINING FLAME RETARDANT MOLECULES
A furan-containing flame retardant molecule includes a furan moiety bonded to a phosphorus moiety via a phosphoryl linkage or via a phosphinyl linkage.
2018/0298043 Alkyne Compounds for Treatment of Complement Mediated Disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2018/0298042 GOLD(I) COMPLEXES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF TREATING CANCER
Gold(I) complexes and gold(I) dithiocarbamate polymers as anticancer therapeutics. The Au(I) ion within the gold(I) complexes is coordinated to two phosphine...
2018/0298041 PHOSPHATE COMPOSITION
A process for the preparation of a composition comprising amine-containing phosphate glycerides including: phosphorylating a solution which comprises mixed...
2018/0298040 MACROCYCLES
The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
2018/0298039 Anti-Fogging Agent
A transformed metal oxide sol, according to the present invention, has as main components: a hydrolysis product of a surface-active silane coupling agent, a...
2018/0298038 METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES
The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms...
2018/0298037 COMPOUND FOR SPECIFICALLY BINDING TO AMYLOID -PROTEIN
Provided is a compound for specifically binding to amyloid .beta.-protein. The compound has thereon a nuclide with a large thermal neutron capture cross...
2018/0298036 UREA PEPTOID BORIC ACID COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USES THEREOF
The present invention provides a urea peptidomimetic boronic compound and pharmaceutical compositions thereof, their preparative methods and uses. The...
2018/0298035 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE
Provided are compounds of formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and...
2018/0298034 Method for Preparing Four-Coordinated Organic Boron Compound
The present invention relates to a method for preparing a four-coordinated organic boron compound, and more specifically, to a method for preparing various and...
2018/0298033 TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
2018/0298032 NEW THIENOPYRIMIDINE DERIVATIVES AS NIK INHIBITORS
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of ...
2018/0298031 HETEROCYCLE AMINES AND USES THEREOF
Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of...
2018/0298030 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PLATELET AGGREGATION
The present invention provides compounds of Formula I: wherein Y, AA, W, R.sup.3' R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X.sup.1, X.sup.2, X.sup.3,...
2018/0298029 GLUCOSE UPTAKE INHIBITORS
Provided herein are compounds that modulate glucose uptake activity and are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases,...
2018/0298028 DEUTERATED OTX-015
This invention relates to novel thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines, and pharmaceutically acceptable salts thereof. This invention also provides...
2018/0298027 COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1.alpha., GSPT1, aiolos, and/or...
2018/0298026 Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators
Compounds of the formula I or II: ##STR00001## wherein X, m, Ar, R.sup.1 and R.sup.2 are as defined herein. The subject compounds are useful for treatment of...
2018/0298025 PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF
The present disclosure provides solid forms, including a salt or co-crystal, of Compound I: ##STR00001## which exhibits Acetyl-CoA carboxylase ("ACC") inhibitory...
2018/0298024 CORTISTATIN ANALOGS AND USES THEREOF
Specific Cortistatin derivatives with advantageous properties for in vivo administration to a host, including a human, in need thereof are provided. These...
2018/0298023 POLYISOCYANATES FROM FUSED BICYCLIC POLYOLS AND POLYURETHANES THEREFROM
The present invention is directed to polyisocyanates and polyurethanes derived therefrom. In various embodiments, the present invention provides ...
2018/0298022 TETRANDRINE FAMILY PHARMACEUTICAL FORMULATIONS AND METHOD
Drug formulations, methods and their use in treatment of diseases using formulations of pure di-acid salts of tetrandrine family members, especially...
2018/0298021 Substituted Thiohydantoin Derivatives As Androgen Receptor Antagonists
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such...
2018/0298020 Piperidine Derivative and Preparation Method and Pharmaceutical Use Thereof
The present invention relates to a piperidine derivative and the preparation method and a pharmaceutical use thereof. In particular, the present invention...
2018/0298019 A SALT OF EGFR INHIBITOR, CRYSTALLINE FORM AND USES THEREOF
The invention relates to a salt, a hydrate or a crystalline form of an EGFR inhibitor, and use thereof. Specifically it relates to ...
2018/0298018 FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR FARNESOID X RECEPTORS
The present invention relates to compounds of Formula I, ##STR00001## a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate...
2018/0298017 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer,...
2018/0298016 PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-alpha]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
2018/0298015 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
Compounds of Formula 0, Formula I, and Formula II and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.
2018/0298014 STABLE PEMETREXED ARGININE SALT AND COMPOSITIONS COMPRISING IT
The present invention relates to arginine salt of pemetrexed of formula (1), ##STR00001## particularly to a stable solid form thereof, and to ...
2018/0298013 ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND USES THEREOF
The disclosure relates to aryl hydrocarbon receptor antagonists, such as substituted imidazopyridines and imidazopyrazines, as well as methods of expanding...
2018/0298012 OCTAHYDROPYRROLOPYRROLES THEIR PREPARATION AND USE
The present invention provides compounds comprising variously substituted octahydropyrrolopyrroles, their synthesis, methods of making, methods of using,...
2018/0298011 PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT
The invention provides compounds of Formula I or Formula II: ##STR00001## or a pharmaceutically acceptable salt or ester, thereof, as described herein. The...
2018/0298010 PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
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