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Patent # Description
2018/0311339 Compositions and Methods for the Treatment or Prevention of Hepatitis B Virus Infection
Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV...
2018/0311338 MICRONEEDLE COMPOSITIONS AND METHODS OF USING SAME
Described herein, are microneedle devices comprising a recombinant alphavirus replicon encoding an exogenous polypeptide, wherein the recombinant alphavirus...
2018/0311337 MDCK SUSPENSION CELL LINES IN SERUM-FREE, CHEMICALLY-DEFINED MEDIA FOR VACCINE PRODUCTION
Disclosed is an adapted Madin-Darby canine kidney cell line capable of suspension culture in the absence of serum, and a chemically-defined medium for culture...
2018/0311336 BROAD SPECTRUM INFLUENZA VIRUS VACCINE
The disclosure relates to influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
2018/0311335 CELL SURFACE ANCHORING ANTIGEN CONJUGATES TO TREAT CANCER
This disclosure provides cell surface anchoring antigen conjugates, formulations comprising cell surface anchoring antigen conjugates, and methods of using the...
2018/0311334 Compositions and Methods for Inducing an Immune Response
The invention provides a modified cell having an immunomodulatory molecule bound to the cell surface. In some aspects, the invention provides compositions and...
2018/0311333 Injectable Botulinum Toxin Formulations And Methods Of Use Thereof Having Long Duration Of Therapeutic Or...
This invention provides novel injectable compositions comprising botulinum toxin that may be administered to a subject for various therapeutic, aesthetic...
2018/0311332 NEOSPORA VACCINE COMPOSITION
The present invention relates to new protein compositions, methods for producing said protein compositions, pharmaceutical compositions comprising said protein...
2018/0311331 PROGNOSIS AND TREATMENT OF SQUAMOUS CELL CARCINOMAS
DNA methylation profiles predictive of head and neck squamous cell carcinoma (HNSCC) patient prognosis, as well as therapeutic protein and adoptive cell...
2018/0311330 Novel immunotherapy against several tumors of the blood, such as acute myeloid leukemia (AML)
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2018/0311329 VACCINES AGAINST ANTIGENS INVOLVED IN THERAPY RESISTANCE AND METHODS OF USING SAME
Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods...
2018/0311328 Peptide Selection Method
There is provided a method for selecting a tolerogenic peptide by selecting a peptide which is capable of binding to an MHC class I or H molecule without...
2018/0311327 AQUAPORIN 2 PROTECTS CATTLE FROM TICKS AND TICK-BORNE PARASITES
A novel method of using an aquaporin protein from Rhipicephalus microplus (RmAQP2), fragments of RmAQP2, and/or the cDNA encoding RmAQP2 and/or the fragments...
2018/0311326 IMMUNOASSEMBLIN (IA) PROTEIN COMPLEXES
The technology provided herein relates to a novel type of recombinant protein complexes, in particular of antibody-like recombinant fusion protein complexes,...
2018/0311325 CHEMICALLY MODIFIED CYSTATHIONINE BETA-SYNTHASE ENZYME FOR TREATMENT OF HOMOCYSTINURIA
The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine .beta.-synthase (CBS) to...
2018/0311324 METHOD AND COMPOSITIONS FOR INHIBITING OR PREVENTING ADVERSE EFFECTS OF ORAL ANTIBIOTICS
This invention provides, in part, various compositions and methods for protecting the gastrointestinal microbiome from antibiotic disruption.
2018/0311323 METHODS AND COMPOSITIONS FOR TREATING METABOLIC IMBALANCE IN NEURODEGENERATIVE DISEASE
In some aspects, the disclosure relates to compositions and methods useful for the diagnosis and treatment of neurodegenerative diseases, such as...
2018/0311322 METHODS AND COMPOSITIONS FOR SAFE AND EFFECTIVE THROMBOLYSIS
Provided herein are methods, compositions, and kits for safe and effective thrombolysis, e.g., in therapy for a potential stroke or acute myocardial infarction...
2018/0311321 ASSISTED ENZYME REPLACEMENT THERAPY
Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the...
2018/0311320 USE OF RECOMBINANT HUMAN CALCINEURIN B SUBUNIT
Provided is a use of a recombinant human calcineurin B subunit (rhCNB) in the preparation of a medicine for killing and/or inhibiting the gastric cancer.
2018/0311319 TREATMENT OF OCULAR NEOVASCULARIZATION USING ANTI-VEGF PROTEINS
The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by...
2018/0311318 METHODS AND COMPOSITIONS FOR TREATMENT OF MITOCHONDRIAL DISORDERS
The present invention concerns in general novel fusion proteins comprising a membrane-transferring moiety and an enzymatic moiety. The present invention...
2018/0311317 Factor VIII Sequences
There is provided a nucleic acid molecule comprising a nucleotide sequence encoding for a functional factor VIII protein, wherein the portion of the nucleotide...
2018/0311316 INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN WHOSE PI IS BETWEEN 5.8 AND 8.5
A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, includes at least a basal insulin, the isoelectric point...
2018/0311315 LONG-ACTING CONJUGATE OF TRIPLE GLUCAGON/GLP-1/GIP RECEPTOR AGONIST
The present invention relates to a long-acting conjugate of a triple agonist having activities to all of glucagon, GLP-1, and GIP receptors and uses thereof.
2018/0311314 Glucokinase Activator Compositions for the Treatment of Diabetes
The present invention relates to the use of liver-selective glucokinase activators and a GLP1 analog in restoring insulin sensitivity and treating type II...
2018/0311313 COMPOSITION HAVING TISSUE-REPAIRING ACTIVITY, AND USE THEREFOR
A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the...
2018/0311312 Use of a Neuregulin to Treat Peripheral Nerve Injury
Embodiments of the invention are directed to use of neuregulins to prevent or treat peripheral nerve injury, to attenuate, ameliorate or avoid the loss of...
2018/0311311 METHODS FOR PREVENTING OR TREATING DISORDERS BY INCREASING BIOAVAILABILITY OF IRON AND RELATED PHARMACEUTICAL...
The present disclosure relates to methods of treating, ameliorating or preventing a disorder comprising administering a therapeutically effective amount of a...
2018/0311310 THERAPEUTIC & DIAGNOSTICS COMPOSITIONS TARGETING TOLL-LIKE RECEPTORS AND METHODS THEREOF
Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences...
2018/0311309 METHOD OF TREATING MELANOCORTIN-4 RECEPTOR PATHWAY-ASSOCIATED DISORDERS
The disclosure is related to a method of treating a disorder, such as Prader Willi Syndrome (PWS), obesity or hyperphagia, in a subject using a melanocortin-4...
2018/0311308 METHODS OF TREATING MYELOID LEUKEMIA
There is provided a method of treating a myeloid leukemia. The method includes the step of administering to a subject in need thereof a therapeutically...
2018/0311307 THERAPEUTIC VITAMIN D CONJUGATES
The invention provides non-hormonal vitamin D conjugated via the third carbon on the vitamin D backbone to parathyroid hormone (PTH) proteins that result in...
2018/0311306 METHODS FOR TREATING HYPOTENSION
The present disclosure relates to the use of angiotensin II in therapeutic methods for the treatment of hypotension, especially catecholamine-resistant...
2018/0311305 LOW-BURST POLYMERS AND METHODS TO PRODUCE POLYMER
A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein...
2018/0311304 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEPRESSION AND ANXIETY
Compositions and methods for treating a depressive disorder or an anxiety disorder in a subject in need of such treatment are described. A therapeutically...
2018/0311303 Materials and Methods for Treatment of Inflammation
The subject invention pertains to peptides and salts thereof that are useful as anti-inflammatory agents and to compositions containing such peptides and salts...
2018/0311302 CXCR ANTAGONISTIC PEPTIDES AND USES THEREOF
The present invention provides a novel class of medicament based on CXCR antagonistic peptides. Among other things, the present invention provides peptides,...
2018/0311301 MITOCHONDRIAL-TARGETED ANTIOXIDANTS PROTECT AGAINST MECHANICAL VENTILATION-INDUCED DIAPHRAGM DYSFUNCTION AND...
The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian...
2018/0311300 BICYCLIC PEPTIDE LIGANDS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
2018/0311299 EFFICACY OF AN ANTI-C5 ANTIBODY IN THE PREVENTION OF ANTIBODY MEDIATED REJECTION IN SENSITIZED RECIPIENTS OF A...
A method for preventing AMR in a human kidney transplant recipient is provided. The method comprises: selecting a deceased donor; selecting a kidney transplant...
2018/0311298 Composition, and Method of Using the Composition, Effective for Minimizing the Harmful Effects Associated With...
The present invention relates to a composition, and methods of using the composition, for minimizing the harmful effects associated with alcohol consumption....
2018/0311297 PHARMACEUTICAL COMPOSITION FOR INCREASING CONTENT AND AVAILABILITY OF CYCLIC ADENOSINE MONOPHOSPHATE IN A BODY...
The present invention discloses a pharmaceutical composition to rapidly increase a content and an availability of a cyclic adenosine monophosphate (cAMP) in a...
2018/0311296 METHOD FOR EXTRACTING STILBENE COMPOUNDS
A method for extracting stilbene compounds comprises the following steps: grinding a medicinal material rich in stilbene compounds such as rheum officinale;...
2018/0311295 METHOD FOR REDUCING WEIGHT
This invention relates to methods and compositions for reducing excessive body weight from a mammal subject suffering from excessive weight or overt obesity....
2018/0311294 COMPOSITION COMPRISING A MIXTURE OF MOLECULES EXTRACTED FROM CHRYSANTHELLUM INDICUM, CYNARA SCOLYMUS AND LYCIUM...
A composition comprising at least a mixture of molecules extracted from Chrysanthellum indicum, Cynara scolymus and Lycium barbarum. This composition is in...
2018/0311293 Thylakoid Extract Composition and Formulation for the Treatment of Inflammatory Bowel Disease
There is provided the use of a functional thylakoid extract, particularly in admixture with a physiologically acceptable carrier, in pharmaceutical ...
2018/0311292 PRODUCTS AND METHODS
The invention relates to fungal cells and spores, as well as extracts of either, for use, in particular, in prevention or treatment of Chlamydia, or...
2018/0311291 ONCOLYTIC ADENOVIRUSES ARMED WITH HETEROLOGOUS GENES
The present disclosure relates to a group B adenovirus comprising a sequence of formula (I): 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR wherein: B1 is bond or comprises:...
2018/0311290 MODULATION OF AAV VECTOR TRANSGENE EXPRESSION
Aspects of the invention relate to recombinant adeno-associated viruses (rAAVs). In some aspects, the rAAVs comprise artificial genetic regulatory elements...
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