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Patent # Description
2018/0312858 TRANSGENIC PLANTS WITH ALTERED NITRATE LEVELS IN LEAVES
The present invention relates to genetic constructs, which can be used in the preparation of transgenic plants. The constructs can have the ability of reducing...
2018/0312857 NOVEL PLANT TERMINATOR SEQUENCES
This invention relates to gene expression regulatory sequences, specifically transcription terminator sequences. Plant transcription terminator sequences are...
2018/0312856 SYNTHETIC PROMOTOR INDUCED BY ABIOTIC STRESS, GENETIC CONSTRUCT CONTAINING SAME AND PLANT CELLS TRANSFORMED...
The present invention relates with the technical field of biotechnology, and particularly provides a promoter inducible under abiotic stress conditions, which...
2018/0312855 ALGAL PROMOTERS
The present invention provides a nucleic acid molecule comprising: DGAT1 promoter or an active fragment thereof, the ammonium transporter promoter or an active...
2018/0312854 USE OF NON-AGROBACTERIUM BACTERIAL SPECIES FOR PLANT TRANSFORMATION
The invention relates to methods for Rhizobia-mediated genetic transformation of plant cells, including soybean, canola, corn, and cotton cells. These include...
2018/0312853 TRANSFORMANT, AND METHOD FOR PRODUCING TRANSFERRIN
To provide a method for producing transferrin by secretion with high productivity using a transformant of Schizosaccharomyces pombe, and a transformant...
2018/0312852 PROMOTER SYSTEM INDUCING EXPRESSION BY 3-HYDROXYPROPIONIC ACID AND METHOD FOR BIOLOGICAL PRODUCTION OF...
The present invention relates to a promoter system inducing expression of 3-hydroxypropionic acid (3-HP) and a method of biologically producing 3-HP using the...
2018/0312851 Bacteria Engineered to Treat Diseases that Benefit from Reduced Gut Inflammation and/or Tightened Gut Mucosal...
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory...
2018/0312850 TNT CLONING SYSTEM
Disclosed herein are vectors and components for a nucleic acid cloning system, and methods of use of the vectors and components in cloning nucleic acid...
2018/0312849 Methods For Producing Heterologous Polypeptides In Mutants Of Trichoderma
The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more genes selected from...
2018/0312848 Altering Gene Expression in Modified T Cells and Uses Thereof
The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene...
2018/0312847 Methods of Treatment Using Antisense Oligomers and Conjugates Targeting PCSK9
The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a...
2018/0312845 MODULATORS OF DIACYGLYCEROL ACYLTRANSFERASE 2 (DGAT2)
The present embodiments provide methods, compounds, and compositions useful for inhibiting DGAT2 expression, which may be useful for treating, preventing, or...
2018/0312844 TREATMENT FOR CANCER METASTASIS
The present disclosure relates to combination therapies for melanoma using anti-folates and/or inhibitors of ALDH1L1, ALDH1L2, or MTHFD1, and in particular,...
2018/0312843 STAT3 INHIBITORS AND USES THEREOF
Described herein, inter alia, are STAT-binding nucleic acids-including compositions and methods of using the same.
2018/0312842 Immunostimulatory Plasmids
The present invention relates to immunomodulator compositions and methods of use as well as methods of making. The immunomodulator compositions comprise...
2018/0312841 NOVEL RIG-I LIGANDS AND METHODS FOR PRODUCING THEM
The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and...
2018/0312840 COMPOUNDS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION FOR IMPROVING A DIABETIC PROFILE
Provided herein are improved compounds, compositions and associated methods for reducing expression of ApoCIII mRNA and protein in a subject having, or at risk...
2018/0312839 METHODS AND COMPOSITIONS FOR INCREASING SMN EXPRESSION
Aspects of the disclosure provide compositions or compounds for activating or enhancing expression of SMN. Further aspects provide compositions and kits, e.g.,...
2018/0312838 MODULATION OF MICRORNA 184 TO TREAT PATHOLOGICAL LYMPHANGIOGENESIS
The present invention provides in certain embodiments a method of suppressing pathological lymphatic formation in a tissue or organ in a mammal in need thereof...
2018/0312837 COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGODEOXYNUCLEOTIDE, AND METHODS OF USE THEREOF
The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a...
2018/0312836 PROMOTER, PROMOTER CONTROL ELEMENTS, AND COMBINATIONS, AND USES THEREOF
The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements,...
2018/0312835 crRNA for detecting RSPO2 gene in body fluid with CRISPR-Cas13a specificity and applications thereof
Plural crRNA for detecting RSPO2 gene in body fluid with CRISPR-Cas13a specificity and applications thereof are disclosed. The crRNA is able to construct the...
2018/0312834 DE NOVO SYNTHESIZED NUCLEIC ACID LIBRARIES
Disclosed herein are methods for the generation of nucleic acid libraries encoding for gRNA sequences. The gRNAs encoded by methods described herein may be...
2018/0312833 SAMPLE PREPARATION ON A SOLID SUPPORT
Presented are methods and compositions for using immobilized transposase and a transposon end for generating an immobilized library of 5'-tagged ...
2018/0312832 METHOD OF MEASURING ADAPTIVE IMMUNITY
A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the...
2018/0312831 ENDONUCLEASE-BARCODING
The instant invention relates to a method for labeling endonuclease-treated cells, comprising the steps of: a) providing cells or a composition comprising...
2018/0312830 CAPTURE OF NUCLEIC ACIDS USING A NUCLEIC ACID-GUIDED NUCLEASE-BASED SYSTEM
Provided herein are methods and compositions for the capture of nucleic acids, for example by using a nucleic acid-guided nuclease-based system.
2018/0312829 Directed modification of glucosamine synthase mutant and application thereof
The present invention discloses a directionally modified glucosamine synthase mutant and its application. The amino acid sequence of the glucosamine synthase...
2018/0312828 NUCLEOBASE EDITORS COMPRISING NUCLEIC ACID PROGRAMMABLE DNA BINDING PROTEINS
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including...
2018/0312827 Engineered Nucleic-Acid Targeting Nucleic Acids
The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the...
2018/0312826 METHODS AND COMPOSITIONS FOR GENE INACTIVATION
Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage...
2018/0312825 NUCLEOBASE EDITORS AND USES THEREOF
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including...
2018/0312824 ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS, ENZYMES AND GUIDE SCAFFOLDS OF CAS9 ORTHOLOGS AND VARIANTS...
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are...
2018/0312823 CALB Variants
The invention relates to amino acid sequence variants of a lipase with improved activity for catalyzing synthesis reactions and methods of preparing the...
2018/0312822 MMLV REVERSE TRANSCRIPTASE VARIANTS
Disclosed herein, are compositions, methods, and kits comprising engineered reverse transcription enzymes that exhibit several desired properties such as...
2018/0312821 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
2018/0312820 Modification of 3' Terminal Ends of Nucleic Acids by DNA Polymerase Theta
The invention provides compositions and methods for modifying the 3'-terminal ends of nucleic acids using DNA polymerase .theta. terminal transferase activity.
2018/0312819 PROTEIN INHIBITORS TO COMPLEMENT AND VEGF PATHWAYS AND METHODS OF USE THEREOF
The invention provides bispecific fusion proteins that inhibit activation of complement pathway and vascular endothelial growth factor (VEGF) pathway and...
2018/0312818 BIOCATALYSTS FOR EZETIMIBE SYNTHESIS
The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods...
2018/0312817 KETOREDUCTASE POLYPEPTIDES
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme...
2018/0312816 Host Cells and Systems for Membrane Protein Expression
Provided herein are host cells or host cellular expression systems that express a membrane protein. Also, methods are provided that use such host cells or host...
2018/0312815 ENONE REDUCTASES
The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related...
2018/0312814 METHOD FOR THE PREVENTION AND/OR THE BIOLOGICAL CONTROL OF BACTERIAL WILT CAUSED BY RALSTONIA SOLANACEARUM, VIA...
A method is for prevention and/or biological control of wilt caused by Ralstonia solanacearum, by use of suitable bacteriophages. In addition a method uses the...
2018/0312813 METHOD FOR REJUVENATING CELLS
The invention relates to a method for reprogramming cells from aged donors or senescent cells to pluripotent cells that have lost marks of senescence. In...
2018/0312812 Method for Producing Pancreatic Endocrine Cells, and Transdifferentiation Agent
A method for producing pancreatic endocrine cells, including introducing (A), (B), (C), or (D) into somatic cells: (A) mutated GLIS1 gene having ...
2018/0312811 METHODS TO MANIPULATE QUALITY ATTRIBUTES OF POLYPEPTIDES PRODUCED IN CHO CELLS
In accordance with the present invention, CHO cells expressing a recombinant polypeptide of interest are grown in media where the amino acids, vitamins,...
2018/0312810 SYSTEMS AND METHODS FOR PRODUCING MICRO-ENGINEERED MODELS OF THE HUMAN CERVIX
The presently disclosed subject matter provides systems and methods for producing a three-dimensional model of a human cervix. A microdevice is provided for...
2018/0312809 AGENTS AND METHODS TO ELICIT ANTI-TUMOR IMMUNE RESPONSE
The invention provides an isolated, purified population of human cells comprising CD8.sup.+ T cells with reduced Cbl-b activity. The invention provides uses of...
2018/0312808 EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT GAMMA DELTA T CELLS AND USES OF THESE CELLS
This invention relates to the expansion of non-haematopoietic tissue-resident .gamma..delta. T cells in vitro by culturing lymphocytes obtained from...
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