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Patent # Description
2018/0312604 BINDING MOLECULES THAT INHIBIT CANCER GROWTH
The invention provides means and methods for inhibiting growth of a cancer. The means in some embodiments comprise proteins and antibodies that binds an...
2018/0312603 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF CANCERS
The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody...
2018/0312602 ANTI-GPC3 ANTIBODIES AND IMMUNOCONJUGATES
The invention provides anti-GPC3 antibodies and immunoconjugates and methods of using the same.
2018/0312601 ANTI-ENDOGLIN ANTIBODIES AND USES THEREOF
The present application relates to compositions of humanized and deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One aspect relates...
2018/0312600 METHODS AND COMPOSITIONS FOR MODIFYING MACROPHAGE POLARIZATION INTO PRO-INFLAMMATORY CELLS TO TREAT CANCER
The present disclosure concerns the use of an anti-SIRPa compound able to inhibit the polarization of anti-inflammatory M2-type macrophages and/or favors...
2018/0312599 ANTI-TNFRSF25 ANTIBODIES
Anti-TNFRSF25 antibodies and variants thereof, including those that bind to an epitope in the region of amino acids 48-71, are disclosed. Also contemplated are...
2018/0312598 HUMAN TNFRSF25 ANTIBODY
Antibodies and antigen binding fragments that bind specifically to TNFRSF25 are provided herein. Methods for using the antibodies and antigen binding fragments...
2018/0312597 Biologically active molecule conjugates, reagents and methods of manufacture, and therapeutic uses
The present disclosure relates to conjugates comprising biologically active molecules linked to a multimeric antigen-binding compound or a multimeric...
2018/0312596 IL3Ralpha ANTIBODY CONJUGATES AND USES THEREOF
The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3R.alpha.) chain, and compositions comprising such antibodies....
2018/0312595 TREATMENT OF CANCER USING A CD123 CHIMERIC ANTIGEN RECEPTOR
The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen...
2018/0312594 ANTI-EGFRvIII ANTIBODIES AND USES THEREOF
The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain...
2018/0312593 Anti-FLT-1 Antibodies in Treating Duchenne Muscular Dystrophy
The present invention provides, among other things, methods and compositions for treating muscular dystrophy, in particular, Duchenne muscular dystrophy (DMD)....
2018/0312592 CYSTEINE-SUBSTITUTED IMMUNOGLOBULINS
The disclosure provides cysteine substituted immunoglobulins, including polypeptides, antibodies, nucleic acids encoding such polypeptides and antibodies, host...
2018/0312591 ANTI-INTEGRIN BETA-1 ANTIBODY COMPOSITIONS AND METHODS OF USE THEREOF
The current invention provides human variable chain framework regions and humanized antibodies comprising the framework regions, the antibodies being specific...
2018/0312590 CANCER IMMUNOTHERAPY BY DISRUPTING PD-1/PD-L1 SIGNALING
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a...
2018/0312589 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In...
2018/0312588 HUMANIZED ANTIGEN-BINDING DOMAINS AND METHODS OF USE
The invention provides a humanized anti-CD19 antibody or antigen binding fragment thereof comprising a light chain variable (VL) region and a heavy chain...
2018/0312587 ANTI-SIRP ALPHA ANTIBODIES
The present invention relates to anti-SIRP antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
2018/0312586 ANTI-CD33 ANTIBODIES AND IMMUNOCONJUGATES
The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.
2018/0312585 METHODS AND COMPOSITIONS COMPRISING PURIFIED RECOMBINANT POLYPEPTIDES
Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making...
2018/0312584 ANTI-IL-17A AND IL-17F CROSS REACTIVE ANTIBODY VARIANTS AND COMPOSITIONS COMPRISING AND METHODS OF MAKING AND...
The present application relates to variants of an anti-IL-17A/F antibody, in particular, an glycosylation variant, a charge variant, an acidic variant, a HMWS...
2018/0312583 POLYPEPTIDES AGAINST IL-23
The present invention relates to amino acid sequences that are directed against IL-23. The amino acid sequences of the present invention comprise two...
2018/0312582 Protecting Group Comprising a Purification Tag
The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from...
2018/0312581 Method For Making Heteromultimeric Molecules
Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include...
2018/0312580 TRANSFORMING GROWTH FACTOR-BETA-RESPONSIVE POLYPEPTIDES AND THEIR METHODS FOR USE
Aspects of the disclosure relate to polypeptides comprising a signal peptide, an antigen-binding domain that specifically binds TGF-.beta., a peptide spacer, a...
2018/0312579 ANTI RSPO ANTIBODIES AND METHODS OF USE
Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.
2018/0312578 IMPROVED SERUM ALBUMIN-BINDING IMMUNOGLOBULIN VARIABLE DOMAINS
The present invention relates to amino acid sequences binding to serum albumin. In particular, the present invention relates to improved immunoglobulin single...
2018/0312577 ANTI-AGE ANTIBODIES AND METHODS OF USE THEREOF
An anti-AGE antibody comprises a protein or peptide that comprises at least one amino acid sequence having at least 90% sequence identity, preferably at least...
2018/0312576 ANTIBODIES TARGETING A MANNAN-BASED O-ANTIGEN OF K. PNEUMONIAE
The invention provides for an isolated antibody that specifically recognizes an epitope of the lipopolysaccharide (LPS) O3b-antigen structure of Klebsiella...
2018/0312575 ANTIBODIES AGAINST INFLUENZA VIRUS AND METHODS OF USE THEREOF
The invention provides human scFv antibodies and monoclonal antibodies that neutralize influenza virus. Also provided are methods of treating and/or preventing...
2018/0312574 ANTIBODY-MEDIATED NEUTRALIZATION OF MARBURG VIRUS
The present disclosure is directed to antibodies binding to Marburg virus (MARV) glycoprotein (GP) and methods of use therefore.
2018/0312573 ANTIGEN BINDING PROTEINS
The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said...
2018/0312572 CD40L-Specific TN3-Derived Scaffolds and Methods Of Use Thereof
The present invention provides Tenascin-3 Fnlll domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with...
2018/0312571 CpG REDUCED FACTOR VIII VARIANTS, COMPOSITIONS AND METHODS AND USES FOR TREATMENT OF HEMOSTASIS DISORDERS
CpG reduced nucleic acid variants encoding FVIII protein and methods of use thereof are disclosed. In particular embodiments, CpG reduced nucleic acid variants...
2018/0312570 Receptor
The present invention provides a chimeric receptor which comprises: a ligand-binding exodomain; and an endodomain which comprises: (i) a cytokine receptor...
2018/0312569 Oligomers for TNF Superfamily Inhibition, Methods of Making and Using
Methods for constructing efficient inhibitors of target TNF superfamily receptors, single chain target TNF superfamily ligands that inhibit of target TNF...
2018/0312568 MONOCYTE MODULATION AND CONTROL OF TUMOR METASTASIS
Disclosed herein are methods of increasing numbers of monocytes to a tumor or cancer metastasis site in a subject. Non-limiting embodiments include...
2018/0312567 INTEGRIN BINDING PEPTIDES AND USES THEREOF
The invention relates to integrin binding peptides, pharmaceutical compositions comprising the peptides and to uses thereof as therapeutic, diagnostic, imaging...
2018/0312566 Fc FUSION HIGH AFFINITY IgE RECEPTOR ALPHA-CHAIN
Provided is an Fc fusion high affinity IgE receptor .alpha.-chain having excellent stability at low pH. An Fc fusion protein comprising: (i) a high affinity...
2018/0312565 NEW POLYPEPTIDE
The present disclosure relates to a class of engineered polypeptides having a binding affinity for programmed death-ligand 1 (PD-L1), and provides a PD-L1...
2018/0312564 Antibodies Against Novel PD1 Isoforms and Uses Thereof
The present invention pertains to antibodies against a novel isoform of human PD1 protein (.DELTA.42PD1) that contains a 42-nucleotide in-frame deletion in...
2018/0312563 Treatment of CD47+ Disease Cells with SIRP Alpha-FC Fusions
CD47+ disease cells, such as CD47+ cancer cells, are treated with an agent that blocks signalling via the SIRP.alpha./CD47 axis. The agent is a human...
2018/0312562 WATER SOLUBLE MEMBRANE PROTEINS AND METHODS FOR THE PREPARATION AND USE THEREOF
The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.
2018/0312561 FOCUSED INTERFERON IMMUNOTHERAPY FOR TREATMENT OF CANCER
The present invention relates to methods of treating a proliferative disease (such as cancer) in an individual, comprising administering to the individual a...
2018/0312560 IL-15 AND IL-15R\ALPHA SUSHI DOMAIN BASED IMMUNOCYTOKINES
The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an antibody or a fragment thereof directly or indirectly linked by...
2018/0312559 METHODS FOR TREATING REFRACTORY ANEMIA WITH RINGED SIDEROBLASTS
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including...
2018/0312558 OXIDIZED A BETA PEPTIDE
The invention provides an A.beta. peptide aggregation inhibitor, an A.beta. peptide toxicity reducing agent, and a preventive and/or therapeutic agent for...
2018/0312557 Leg1 Protein, Leg1 Gene, and Uses and Drugs thereof
Provided are an Leg1 protein, an Leg1 gene, uses and drugs thereof, which relate to the technical field of the functions and uses of genes. Very comprehensive...
2018/0312556 Compositions and Methods for Ceramide-Elevating Therapeutic Strategies
The present invention is directed towards the use of Growth Differentiation Factor 1 (Gdf1) and variants thereof to modulate and regulate ceramide...
2018/0312555 CHIMERIC MOLECULE USEFUL IN IMMUNOTHERAPY FOR LEISHMANIASIS, WHICH INCLUDES A FRAGMENT OF THE PFR1 PROTEIN OF...
The present invention claims an isolated nucleotide sequence characterized by encoding the PFR1 protein of Leishmania infantum or a fragment thereof. This PFR1...
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