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Patent # Description
2018/0312554 METHOD TO HARVEST INSECTS, EGGS, AND LARVAE
This process or components of this process may be used as a method of harvesting and processing for food consumption for many types of insects in various...
2018/0312553 ENHANCING ANTI-CANCER ACTIVITY OF IMMUNOMODULATORY FC FUSION PROTEINS
The present disclosure provides a method for enhancing the anti-tumor efficacy of an Fc fusion protein which binds specifically to a target, e.g., a...
2018/0312552 Pneumolysin Mutants and Methods of Use Thereof
The present disclosure provides, in various embodiments, immunogenic mutants of cholesterol-dependent cytolysins, such as pneumolysin, which have reduced...
2018/0312551 MODIFIED ALPHA HEMOLYSIN POLYPEPTIDES AND METHODS OF USE
Provided herein are alpha hemolysin polypeptides comprising modified amino acid sequences that can reduce the rate of translocation of a polymer. Also provided...
2018/0312550 METHOD TO ENHANCE IMMUNOGENICITY OF LIVE TYPHOID VACCINES AND CARRIERS
In certain embodiments, the present invention provides a recombinant Salmonella enterica serovar Typhi cell, vaccines and compositions, and methods of use...
2018/0312549 HIGH POTENCY IMMUNOGENIC COMPOSITIONS
Provided herein, in some embodiments, are immunogenic compositions that include a cationic lipid nanoparticle (LNP) encapsulating messenger ribonucleic acid...
2018/0312548 COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising...
2018/0312547 B-CELL RECEPTOR COMPLEX BINDING PROTEINS CONTAINING T-CELL EPITOPES
The present invention relates to a polypeptide comprising a) a binding peptide binding to at least one protein selected from the group consisting of CD22,...
2018/0312546 TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES
The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit...
2018/0312545 OPTIMIZED NUCLEIC ACID MOLECULES
The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid...
2018/0312544 RECOMBINANT HUMAN/BOVINE PARAINFLUENZA VIRUS 3 (B/HPIV3) EXPRESSING A CHIMERIC RSV/BPIV3 F PROTEIN AND USES THEREOF
Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a...
2018/0312543 CYCLOSPORIN A FORM 2 AND METHOD OF MAKING SAME
Disclosed herein are methods of making cyclosporin A Form 2.
2018/0312542 ENDOSOMAL ESCAPE PEPTIDES
The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. Previously, it has...
2018/0312541 PEPTIDES
The present invention relates to dual-site BACE1 inhibitors, their manufacture, pharmaceutical compositions containing them and their use as therapeutically...
2018/0312540 COMPOSITION FOR THE PREVENTION, IMPROVEMENT, OR TREATMENT OF NEUROLOGICAL DISORDER INCLUDING ADIPONECTIN...
A method for preventing, improving or treating a neurological disorder includes administering to a subject a composition including an adiponectin...
2018/0312539 METHODS FOR PREPARING HIGH THROUGHPUT PEPTIDOMIMETICS, ORALLY BIOAVAILABLE DRUGS AND COMPOSITIONS CONTAINING SAME
Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance,...
2018/0312538 AN IMPROVED PROCESS FOR THE PREPARATION OF (1S, 4S, 7Z, 10S, 16E, ...
The present invention is relates to an improved process for the preparation (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-d- ...
2018/0312537 METHOD OF MODIFYING A PEPTIDE
Described herein are methods of modifying a peptide with a chemical agent. The peptide may be an amphipathic peptide, such as a melittin-like peptide. The...
2018/0312536 IMMUNOMODULATING POLYNUCLEOTIDES, ANTIBODY CONJUGATES THEREOF, AND METHODS OF THEIR USE
Immunomodulating polynucleotides are disclosed. The immunomodulating polynucleotides may contain 5-modified uridine, 5-modified cytidine, a total of from 6 to...
2018/0312535 PHOSPHATE REPLACEMENT MRNA CAP ANALOGS
The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies....
2018/0312534 FLUORESCENT ANTICANCER PLATINUM DRUGS
The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent...
2018/0312532 SILICONE-COMPATIBLE COMPOUNDS
Compounds represented by the following Formula I: ##STR00001## wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are the same or different and are...
2018/0312531 SILICON-CONTAINING ORGANIC COMPOUND AND APPLICATIONS THEREOF
The present invention relates to a silicon-containing organic compound and an application thereof. The silicon-containing organic compound comprises one or...
2018/0312530 PROCESSES FOR MAKING ALKYLATED ARYLPIPERAZINE AND ALKYLATED ARYLPIPERIDINE COMPOUNDS INCLUDING NOVEL INTERMEDIATES
Novel processes, and intermediates, for making alkylated arylpiperazine and alkylated arylpiperidine compounds of the general formulas (I) and (VII),...
2018/0312529 Antitumoral Compounds
A compound of general formula I, wherein X, R.sub.1-R.sub.4 take various meanings, for use in the treatment of cancer. ##STR00001##
2018/0312528 PYRIDYL-TRIAZABICYCLES
The present invention provides a compound of formula I ##STR00001## having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing...
2018/0312527 ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND...
The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further...
2018/0312526 ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND...
The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further...
2018/0312525 NAMPT Inhibitors for Cancer Therapy
The invention features compounds of Formula (I), Formula (I)-A and Formula (I)-B as disclosed herein, as well as methods of synthesis, therapy, diagnostics,...
2018/0312524 BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases,...
2018/0312523 Propionic Acid Derivatives and Methods of Use Thereof
Provided herein are compounds and pharmaceutical compositions of formula I ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as ...
2018/0312522 SULFONE-CONTAINING FUSED HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
A sulfone-containing fused heterocyclic compound and application thereof. The sulfone-containing fused heterocyclic compound is represented by formula (1) ...
2018/0312521 METHOD FOR PREPARING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATES USED THEREIN
A method for preparing a thienopyrimidine compound of Formula 1, which is a selective inhibitor of tyrosine kinase activity, in particular, of mutant epidermal...
2018/0312520 NOVEL PROCESS FOR PREPARING THIENOPYRIMIDINE COMPOUND AND INTERMEDIATES USED THEREIN
The present invention relates to a novel method for preparing thienopyrimidine compound having an activity of selectively inhibiting tyrosine kinase,...
2018/0312519 SYNTHESIS OF SUBSTITUTED SALICYLALDEHYDE DERIVATIVES
Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde...
2018/0312518 Fusicoccane Derivatives and Methods
Provided are fusicoccane derivatives and methods of making fusicoccane derivatives. The methods may include contacting a tethered chromophore with light to...
2018/0312517 Pseudopolymorphic Forms of a HIV Protease Inhibitor
New pseudopolymorphic forms of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] isobutyl) ...
2018/0312516 Protein Kinase B Inhibitors
The invention relates to a novel group of compounds of Formula (I) or salts thereof: ##STR00001## wherein Y, Z.sup.1, Z.sup.2, R.sup.1, R.sup.4, R.sup.5 and n...
2018/0312515 NEW BICYCLIC COMPOUNDS AS ATX INHIBITORS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, Y, W, m, n, p and q are as defined herein, ...
2018/0312514 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
A compound containing indolocarbazole having a formula: ##STR00001## Formula I is disclosed.
2018/0312513 2-PHENYL-3,4-DIHYDROPYRROLO[2,1 -F] [1,2,4]TRIAZINONE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
The present invention relates to compounds of formula I ##STR00001## or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein R.sub.1 is...
2018/0312512 CRYSTAL FORM, PREPARATION METHOD AND INTERMEDIATE OF DIHYDROPYRIDO RING COMPOUND
Disclosed in the present disclosure are a crystal form of a dihydropyrido ring compound, and preparation method and intermediate thereof. ##STR00001##
2018/0312511 SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF
The present invention relates to a benzodiazepine derivative of Formula I as a short-acting anesthetic, a pharmaceutical composition comprising the same, a kit...
2018/0312510 PHARMACEUTICAL SALTS, PHYSICAL FORMS, AND COMPOSITIONS OF PYRROLOPYRIMIDINE KINASE INHIBITORS, AND METHODS OF...
Provided are methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related...
2018/0312509 AZEPINE DERIVATIVES AS 5-HT7 RECEPTOR MODULATORS
Azepine derivatives acting on 5-HT.sub.7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the ...
2018/0312508 PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND...
The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically...
2018/0312507 FUSED INDAZOLE PYRIDONE COMPOUNDS AS ANTIVIRALS
The invention provides compounds of Formula (I) ##STR00001## as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions...
2018/0312506 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS
The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3,...
2018/0312505 FUSED PYRIMIDINE COMPOUND OR SALT THEREOF
To provide a compound having an inhibitory activity for an androgen receptor. A fused pyrimidine compound represented by the following formula (I) or a...
2018/0312504 SUBSTITUTED IMIDAZOPYRIDINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
This application relates to substituted imidazopyridines, compositions comprising them and their uses in the treatment of diseases and conditions in which...
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