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Patent # Description
2018/0312503 NOVEL NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND
A compound represented by general formula [I] wherein X represents N or the like, Y represents CH or the like; R.sup.A represents a cycloalkyl group which may...
2018/0312502 N1-And N7-Substituted Sibiriline Derivatives And Their Use As Inhibitor Of Cellular Necroptosis
The present invention relates to new N1- and N7-substituted sibiriline derivatives of the following general formula (I): (I) or a pharmaceutically acceptable...
2018/0312501 PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS
Polycyclic derivatives of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers,...
2018/0312500 ANTI-ALPHAVBETA1 INTEGRIN COMPOUNDS AND METHODS
Provided herein, inter alia, are methods and compositions for inhibiting .alpha.v.beta.1 integrin and for treating fibrosis.
2018/0312499 ARYL SULFONAMIDES AS BLT1 ANTAGONISTS
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are antagonists of leukotriene B.sub.4 receptor 1 (BLT1) and...
2018/0312498 Propionic Acid Derivatives and Methods of Use Thereof
Provided herein are compounds and pharmaceutical compositions of formula I ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and R.sup.6 are as ...
2018/0312497 SUBSTITUTED TETRAHYDROPYRIDINE DERIVATIVES AS IDO-1 INHIBITORS AND USES THEREOF
Compounds of formula I that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase, pharmaceutical compositions including such compounds and...
2018/0312496 BICYCLIC HETEROCYCLE DERIVATIVES AS BROMODOMAIN INHIBITORS
The invention relates to novel bicyclic heterocycle derivatives of formula (I) ##STR00001## wherein Cy.sub.1, Cy.sub.2, R.sub.1, R.sub.2, and L.sub.1 have the ...
2018/0312495 SELECTIVE NR2B ANTAGONISTS
The present disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) compounds are ligands for NR2B...
2018/0312494 POLYMORPHIC FORMS OF AFATINIB FREE BASE AND AFATINIB DIMALEATE
The present invention relates to crystalline forms of Afatinib and its dimaleate salt. The present invention also relates to processes for the preparation of...
2018/0312493 Antibiotic Compounds, Pharmaceutical Formulations Thereof And Methods And Uses Therefor
The present invention relates to compounds of formula (I) wherein G.sup.1 to G.sup.8 are as defined herein. The compounds are PK inhibitors and as such...
2018/0312492 BIPYRAZOLE DERIVATIVES AS JAK INHIBITORS
The present invention provides compounds of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, as well as their compositions and methods of...
2018/0312491 SELECTIVE NR2B ANTAGONISTS
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds...
2018/0312490 C5-ANILINOQUINAZOLINE COMPOUNDS AND THEIR USE IN TREATING CANCER
The invention concerns compounds of Formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have...
2018/0312489 SUBSTITUTED INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
The present invention relates to compounds according to Formula (I) and pharmaceutically acceptable salts thereof. Such compounds can be used in the treatment...
2018/0312488 HETEROBICYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF TUBERCULOSIS
It is an object of the present invention to provide a compound having an excellent antibacterial activity against tuberculosis bacteria, multidrug-resistant...
2018/0312487 PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation...
2018/0312486 PIPERDINYL NOCICEPTIN RECEPTOR COMPOUNDS
The present invention provides novel piperidinyl-containing nociceptin receptor ligand compounds and pharmaceutical compositions useful in the treatment of...
2018/0312485 SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The...
2018/0312484 Process for the Preparation of Sofosbuvir
A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein. ...
2018/0312483 Method for Industrial Production of Optically Active Fluoroalkyl Ethylene Oxide
It is possible to produce an optically active fluoroalkyl chloromethyl alcohol with a high optical purity and a good yield by treating a fluoroalkyl...
2018/0312482 HETEROCYCLICALKYL DERIVATIVE COMPOUNDS AS SELECTIVE HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL...
The present invention relates to novel heterocyclicalkyl derivatives having histone deacetylase (HDAC) inhibitory activity, optical isomers thereof or...
2018/0312481 POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
The present invention provides a compound represented by the general formula (I), and a polymerizable composition containing the compound. When the...
2018/0312480 HETEROCYCLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS
The present application relates to novel heterocycle derivatives of Formula (I), to processes for preparing them, pharmaceutical compositions containing them,...
2018/0312479 OXA-AZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN
The present invention relates to oxa-azaspiro compounds having pharmacological activity towards the sigma (.sigma.) receptor, to processes of preparation of...
2018/0312478 ALLYLIC TERMINALLY UNSATURATED HYDROFLUOROAMINE AND ALLYLIC TERMINALLY UNSATURATED HYDROFLUOROETHER COMPOUNDS...
Described herein is an unsaturated fluorinated compound of formula (I) where X is O or N; Y is F or H; Z is F or CF.sub.3; and A is F or CF.sub.3 wherein when...
2018/0312477 COMPOSITIONS FOR TREATING AND/OR PREVENTING CELL OR TISSUE NECROSIS SPECIFICALLY TARGETING CATHEPSIN C AND/OR...
Inhibitor compounds and agents of Cathepsin C, CELA1, CELA3A and/or structurally related molecules thereto, compositions comprising same and uses thereof in...
2018/0312476 METHOD FOR PREPARING OXAZOLIDINONE INTERMEDIATE
The invention relates to a method for preparing an oxazolidinone intermediate. Specifically, a synthesis procedure for the intermediate comprises: directly...
2018/0312475 ALDOSTERONE SYNTHASE INHIBITORS
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein X, R.sup.1, R.sup.2 and R.sup.3 are as defined...
2018/0312474 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A,...
2018/0312473 PHENAZINE DERIVATIVES AS ANTIMICROBIAL AGENTS
The present invention provides novel phenazine derivatives, such as compounds of Formula (I') (e.g., Formula (I)), (II), and (III), and pharmaceutically...
2018/0312472 QUINAZOLIN CROTYL COMPOUND DIMALEATE CRYSTALS AND PREPARATION METHODS AND USES THEREOF
Disclosed are crystal forms K, E, F and G of the dimaleate of the compound as shown in formula I, and preparation methods and uses thereof. The crystal forms...
2018/0312471 Ion Channel Inhibitory Compounds, Pharmaceutical Formulations, and Uses
The present invention is directed towards new chemical entities which primarily inhibit the human T-type calcium channels and differentially modulate other key...
2018/0312470 DERIVATIVES OF HALO QUINABACTIN
The present invention relates to novel sulfonamide derivatives of formula (I), to processes and intermediates for preparing them, to plant growth regulator...
2018/0312469 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT
Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
2018/0312468 ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS
Described herein is a chemical class of odorless thiols which can serve as reducing agents. This chemical class involves thiols which can be used as reducing...
2018/0312467 INTERMEDIATES TO PREPARE PYRIDAZINONE HERBICIDES, AND A PROCESS TO PREPARE THEM
Disclosed is a process for preparing a compound of Formula 1, ##STR00001## from a compound of Formula 2 wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5,...
2018/0312466 BRANCHED HETERO POLYETHYLENE GLYCOL AND INTERMEDIATE
A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: ##STR00001## wherein X and Y represent each an atomic...
2018/0312465 Heat-Sensitive Recording Material And Diphenylsulfone
The content of compound(s) having a molecular weight of 650-670, typically a molecular weight of 660, as measured by mass spectrometry, is reduced to 0.5 mass...
2018/0312464 PROCESS FOR PRODUCING ALKALI TAURINATE
There is disclosed a process for producing alkali taurinate by the ammonolysis of alkali ditaurinate, alkali tritaurinate, or a solution of alkali ditaurinate...
2018/0312463 Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired...
2018/0312462 BENZAMIDE DERIVATIVE
The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the...
2018/0312461 METHOD FOR SOLVENT-FREE DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION
The present application provides solvent-free methods for decarboxylation of amino acids via imine formation with a ketone, enone, enal, aldehyde co-reagent or...
2018/0312460 USING PRESSURIZED WET GAS LINES TO AVOID FOULING IN PURIFIED TEREPHTHALIC ACID (PTA) FILTERS AND LINES
Processes for recovering a purified aromatic carboxylic acid include contacting a crude aromatic carboxylic acid with hydrogen in the presence of a catalyst in...
2018/0312459 SEPARATING CARBOXYLIC ACIDS
Provided is a process of separating carboxylic acids comprising (a) providing an aqueous solution comprising (i) one or more mono-carboxylic acids, (ii) one...
2018/0312458 METHOD F0R THE PURIFICATION OF CYCLOHEXADEC-8-EN-1-ONE
The present invention relates to a novel method for purifying cyclohexadec-8-en-1-one, a method for preparing cyclohexadec-8-en-1-one and cyclopentadecenones,...
2018/0312457 SYSTEMS AND METHODS FOR SYNTHESIS OF PHENOLICS AND KETONES
Embodiments herein relate to apparatus and systems for phenolic and ketone synthesis and methods regarding the same. In an embodiment, a method of producing...
2018/0312455 Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from...
Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function...
2018/0312454 PROCESS FOR THE PREPARATION OF DEUTERATED ETHANOL FROM D2
The invention relates to a process for the preparation of a deuterated ethanol from an acetic acid, an acetate, or an amide by reaction with D.sub.2 in the...
2018/0312453 COMPOSITION COMPRISING HF AND 1,3,3,3-TETRAFLUOROPROPENE
An azeotropic or quasi-azeotropic composition including hydrogen fluoride, 1,3,3,3-tetrafluoropropene and one or more (hydro)halogen-carbon compounds including...
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