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Patent # Description
2018/0327745 METHODS OF CONTROLLING CELL FATE AND CONSEQUENCES FOR DISEASE
Provided herein are methods for performing cellular reprogramming that include treatment of somatic cells with an inhibitor of CAF-1, Sumo2, Nutd21, or...
2018/0327744 iRNA AGENTS WITH BIOCLEAVABLE TETHERS
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose that...
2018/0327743 Antisense Polynucleotides to Induce Exon Skipping and Method of Treating Dystrophies
Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided,...
2018/0327742 Targeted Self-Assembly of Functionalized Carbon Nanotubes on Tumors
Provided herein is the two component self-assembly single wall nanotube system and the single wall nanotube construct that is the second component. The two...
2018/0327741 NUCLEIC ACID NANOSTRUCTURES WITH CORE MOTIFS
Optimized inhibitory nucleic acids are provided. The nucleic acids have sequences which include an optimal inhibitory motif, such as a GGG. Related methods are...
2018/0327740 HIGH-THROUGHPUT CRISPR-BASED LIBRARY SCREENING
Provided herein is an improved method for performing CRISPR/Cas based screening that is not dependent on viral cloning methods.
2018/0327739 De Novo Design of Allosteric Proteins
Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change...
2018/0327738 STABILIZED REAGENTS FOR GENOME MODIFICATION
The present disclosure generally relates to compositions and methods for genetic modification of cells. In particular, the disclosure relates to stabilized...
2018/0327737 APPARATUS AND METHOD FOR DEHYDRATING BIOLOGICAL MATERIALS WITH FREEZING AND MICROWAVING
An apparatus and method for dehydrating biological materials, such as vaccines and microorganism cultures, in which the materials are dehydrated in an...
2018/0327736 PEPTIDES DERIVED FROM LENGSIN (LGSN), COMPLEXES COMPRISING SUCH PEPTIDES BOUND TO MHC MOLECULES
The present invention relates to novel peptides derived from Lengsin (LGSN), complexes comprising such peptides bound to recombinant MHC molecules, and cells...
2018/0327735 Production of high purity chondroitinase ABC
The present invention provides a method for purifying Chondroitinase ABC (ChABC). The present method includes using a heparin-immobilized affinity ...
2018/0327734 ENGINEERED PRIMATE CYSTINE/CYSTEINE DEGRADING ENZYMES FOR THERAPEUTIC USES
Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, disclosed are modified...
2018/0327733 MONOTERPENE-PRODUCING GENETICALLY MODIFIED HOST CELLS AND METHODS OF USE OF SAME
The present disclosure provides a genetically modified host cell capable of producing linalool (or 3,7-dimethylocta-1,6-dien-3-ol).
2018/0327732 POLYPEPTIDES HAVING PROTEASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention also relates to...
2018/0327731 METHOD OF PRODUCING COLLAGENASE
The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and...
2018/0327730 NOVEL RECOMBINANT CLOSTRIDIAL NEUROTOXINS WITH INCREASED DURATION OF EFFECT
This invention relates to novel recombinant clostridial neurotoxins exhibiting increased duration of effect and to methods for the manufacture of such...
2018/0327729 NOVEL CELLULASE GENE
An object is to identify endoglucanase and .beta.-glucosidase genes by isolating genomic DNA containing cellulase genes, which are classified into...
2018/0327728 ENZYME VARIANTS WITH IMPROVED ESTER SYNTHASE PROPERTIES
The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant...
2018/0327727 ENGINEERED ENZYME HAVING ACETOACETYL-COA HYDROLASE ACTIVITY, MICROORGANISMS COMPRISING SAME, AND METHODS OF...
The disclosure provides engineered enzymes that are capable of mediating the conversion of acetoacetyl-CoA to acetoacetate that do not react with the same...
2018/0327726 ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
2018/0327725 TATk-CDKL5 Fusion Proteins, Compositions, Formulations, And Use Thereof
Disclosed herein are compositions and formulations containing a TATk-CDKL5 fusion protein. Also disclosed are methods of producing a TATk-CDKL5 fusion protein...
2018/0327724 METHOD FOR PRODUCING HEAVY CHAIN AMINOCARBOXYLIC ACID
The present invention relates to a method for producing a medium chain aminocarboxylic acid and, more particularly, to a recombinant microorganism in which a...
2018/0327723 Production of Glycosylated Nootkatol in Recombinant Hosts
The invention relates to methods for producing glycosylated nootkatol. In particular, a recombinant host comprising a gene encoding a UDP-glycosyltransferase...
2018/0327721 Host Cells with Artificial Endosymbionts
The present invention is directed generally to eukaryotic host cells comprising artificial endosymbionts and methods of introducing artificial endosymbionts...
2018/0327720 METHODS AND PRODUCTS FOR TRANSFECTION
The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these...
2018/0327719 METHOD FOR PRODUCING PANCREATIC BUD CELLS
Provided is a method for generating pancreatic bud cells, comprising the step of culturing PDX1.sup.+/NKX6.1.sup.- cells in a medium comprising KGF, EGY, a DMP...
2018/0327718 ENHANCED DIFFERENTIATION OF MESENCHYMAL STEM CELLS
Isolated populations of mesenchymal stem cells (MSCs) are provided, including mammalian mesenchymal stem cells (MSCs) characterized by the lack of CD54...
2018/0327717 Methods for Cardiac Differentiation of Human Induced Pluripotent Stem Cells
The present invention relates to monolayer cardiac differentiation techniques utilizing defined conditions providing feeder-free monolayer culture systems,...
2018/0327716 MODIFIED CELLS FOR PRODUCTION OF BLOOD CELLS
The present disclosure relates to a genetically modified cell (e.g., stem cells) containing a complete or partial gene deletion of one or more genes of a blood...
2018/0327715 Engineered 3D-Printed Artificial Axons
Materials and methods for cell-mimetics having mechanical properties of biological neural axons are provided. A cell-mimetic device includes an array of fibers...
2018/0327714 NEURAL CELL EXTRACELLULAR VESSICLES
Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain...
2018/0327713 TREATMENT OF RETINAL DEGENERATION USING PROGENITOR CELLS
Methods and compositions for treating and reducing retinal degeneration using progenitor cells and conditioned media from progenitor cells, such as...
2018/0327712 METHODS OF MAKING SPHEROIDS INCLUDING BIOLOGICALLY-RELEVANT MATERIALS
Methods of making a spheroid are provided whereby a suspension is first produced including one or more biologically-relevant materials dispersed within a...
2018/0327711 Fermentation Processes With Reduced Foaming
The present invention relates to processes of producing a fermentation product from readily fermentable sugar-material in a fermentation vat comprising a...
2018/0327710 Process for improved fermentation of a microorganism
A method for improving biomass production and/or growth rate of a microorganism in a fermentation process is shown, and includes: (i) providing one or more...
2018/0327709 A Method Of Producing High Amount Of Ethanol At High Temperature By Modified Yeast Strain Saccharomyces Cerevisiae
The present invention relates to a modified yeast strain of Saccharomyces cerevisiae having MCC accession number 0069 with osmo-tolerant, thermo-tolerant,...
2018/0327708 Instrument resource scheduling
Aspects of the present invention relate to an automated cell culture instrument and to methods for operating such an instrument. In one aspect, the cell...
2018/0327707 MIXING DEVICE FOR MIXING THE CONTENT OF A BIOREACTOR, COMPRISING A SYNCHRONIZATION MECHANISM
The present invention relates to a system comprising a mixing device for mixing the content of a bioreactor. The system comprises at least one movement device...
2018/0327706 CRISPR-CAS9 DELIVERY TO HARD-TO-TRANSFECT CELLS VIA MEMBRANE DEFORMATION
The CRISPR-Cas nuclease system represents an efficient tool for genome editing and gene function analysis. It consists of two components: single-guide RNA...
2018/0327705 Gas Stirring Fermentation Device
A gas stirring fermentation device has excellent mixing performance of a culture liquid and is applicable to aerobic culture requiring a high demanded oxygen...
2018/0327704 DISPERSING FEEDSTOCKS AND PROCESSING MATERIALS
Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example,...
2018/0327703 LARGE SCALE CELL MANUFACTURE SYSTEM
Methods of culturing and manufacturing of cells on a large-scale level are disclosed. Particularly, a manufacturing system and device, and methods of using the...
2018/0327702 CARTRIDGE-BASED SYSTEM FOR LONG TERM CULTURE OF CELL CLUSTERS
Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological...
2018/0327701 DEVICE AND MICROFLUIDIC SYSTEM FOR STUDYING CELL CULTURES
The present invention relates to a novel microfluidic device and a microfluidic system for culturing cell samples based on: one or more culture wells (2)...
2018/0327700 MICROFLUIDIC PLATFORM FOR INVESTIGATING CELL-BASED INTERACTIONS
A microfluidic platform for investigating cell-based interactions with a chip base is made of a suitable plastics material with the appropriate optical...
2018/0327699 ANALYSIS DEVICE
An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed...
2018/0327698 ALCOHOLIC FOAM
The present invention concerns an alcoholic foam, a use and a method for preparing said foam, the foam comprising:--An aqueous ethanolic solution;--An aqueous...
2018/0327697 CLEANING COMPOSITION, METHOD OF MAKING AND USE THEREOF
A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent...
2018/0327696 FABRIC TREATMENT METHOD FOR STAIN RELEASE
A fabric treatment composition is provided that includes at least one zeta potential modifier, a fluoropolymer and a hydrophobic agent with a melting point or...
2018/0327695 PHOTOLABILE PRO-FRAGRANCES
Photolabile pro-fragrances may include the ketones of Formula (I) ##STR00001## Such compounds may be used in detergents, cleaning agents, cosmetic agents,...
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