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Patent # Description
2018/0327442 CRYSTALLIZATION OF 25-HYDROXY-7-DEHYDROCHOLESTEROL
The present invention relates to a method of purification of compound of formula (I) which comprises the step of crystallization of compound of formula (I)...
2018/0327440 NOVEL GALACTOSIDE INHIBITORS OF GALECTINS
The present invention relates to a compound of the general formula. The compound of formula is suitable for use in a method for treating a disorder relating to...
2018/0327439 TOTAL SYNTHESIS OF SHISHIJIMICIN A AND ANALOGS THEREOF
In one aspect, the present disclosure provides shishijimicin analogs of the formula: wherein the variables are as defined herein. In another aspect, the...
2018/0327438 CARBOHYDRATE LIGANDS THAT BIND TO IGM ANTIBODIES AGAINST MYELIN-ASSOCIATED GLYCOPROTEIN
The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated...
2018/0327437 PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS
Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of...
2018/0327436 TRITERPENE SAPONIN ANALOGUES
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides...
2018/0327435 MANUFACTURE OF TRANS-[TETRACHLOROBIS(1H-INDAZOLE)RUTHENATE (III)] AND COMPOSITIONS THEREOF
The present invention relates to the preparation of compositions comprising sodium trans-[tetrachlorobis(1H-indazole)ruthenate (III)]. Synthesis and...
2018/0327434 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
The present invention includes novel phosphorescent metal complexes comprising fused imidazole-imidazole moieties. The invented compounds may be useful for...
2018/0327433 ETHER PHOSPHOLIPIDS AND METHOD FOR PRODUCING THE SAME
[PROBLEM TO BE SOLVED] It enables any superior ether phospholipids to the conventional ones and a method for producing the same in an easy manner on a massive...
2018/0327432 Monoallophanates based on alkoxysilane alkyl isocyanates
A monoallophanate can be used in paint or adhesive compositions. The monoallophanate has the formula 1: ##STR00001## where R, R.sup.1-R.sup.6 are each...
2018/0327431 METHOD FOR THE SELECTIVE SYNTHESIS OF TRIALKOXYSILANES
The invention provides a direct solvent free method for the selective synthesis of trialkoxysilanes having the formula SiH(OR).sub.3, the method comprises...
2018/0327430 Method for Preparing Methoxyboranes and for Producing Methanol
The present disclosure relates to a method for preparing methoxyboranes by dismutation of formic acid or at least one of the derivatives thereof or a mixture...
2018/0327429 Use for Boron Formates for Reducing Unsaturated Organic Functions
The present invention relates to a method for reducing unsaturated organic compounds chosen from the group formed by the aldehydes, the ketones, the imines,...
2018/0327428 PROCESS OF MAKING CENICRIVIROC AND RELATED ANALOGS
The disclosure includes high purity compounds having CCR5 and/or CCR2 antagonism, or a salt thereof, and processes for synthesizing the same.
2018/0327427 Method And Dyes For Detecting And Destroying Cancer Cells
This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared...
2018/0327426 MUSCARINIC RECEPTOR AGONISTS
This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor and which are useful in the treatment of muscarinic M.sub.1 receptor...
2018/0327425 Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
The present invention relates to novel compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as described...
2018/0327424 COMPOSITIONS TO DETECT REMNANT CANCER CELLS
Disclosed are compounds, compositions and methods for detecting remnant cancer cells in a tissue sample.
2018/0327423 HISTONE DEACETYLASE INHIBITORS
This invention relates to generally inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).
2018/0327422 OXADIAZASPIRO COMPOUNDS FOR THE TREATMENT OF DRUG ABUSE AND ADDICTION
The present invention relates to compounds having pharmacological activity towards the sigma (.sigma.) receptor, and more particularly to oxadiazaspiro...
2018/0327421 5-HT3 RECEPTOR ANTAGONISTS
The present invention provides 5-HT3 receptor antagonists of Formula (I): ##STR00001## which are useful for the treatment of diseases treatable by inhibition of ...
2018/0327420 TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
Described herein are tricyclic compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: ##STR00001## or...
2018/0327419 TARGETED PROTEIN DEGRADATION USING A MUTANT E3 UBIQUITIN LIGASE
The present application provides bifunctional compounds of Formula I or II: ##STR00001## or an enantiomer, diastereomer, or stereoisomer, or a pharmaceutically ...
2018/0327418 PYRIDINE DERIVATIVE
The problem to be solved by the present invention is to provide a compound suitable for a pharmaceutical composition, specifically a pharmaceutically...
2018/0327417 PROCESS FOR IMPROVED OXYMORPHONE SYNTHESIS
Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of...
2018/0327416 PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as...
2018/0327415 CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
2018/0327414 METHODS AND COMPOSITIONS FOR INHIBITING THE INTERACTION OF MENIN WITH MLL PROTEINS
The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The...
2018/0327413 SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINES AS KINASE INHIBITORS
The present disclosure provides compounds of Formula (IA) and/or pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular...
2018/0327412 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS
This application relates to compounds of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are...
2018/0327411 INDOLE AHR INHIBITORS AND USES THEREOF
The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
2018/0327410 PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as...
2018/0327409 CXCR4 RECEPTOR ANTAGONISTS
The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts,...
2018/0327408 [1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-7-YL COMPOUND
The present invention relates to a novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivative as inhibitor of phosphodiesterase 2 (PDE2). The invention is also...
2018/0327407 COMPOUNDS AND METHODS FOR TREATING SYNOVIAL SARCOMAS
The present invention includes compound and methods that are useful in treating certain cancers, such as synovial sarcomas.
2018/0327406 THERAPEUTIC COMPOUNDS FOR PAIN AND SYNTHESIS THEREOF
The invention provides compounds of Formula 1: ##STR00001## and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making...
2018/0327405 THERAPEUTIC COMPOUNDS FOR PAIN AND SYNTHESIS THEREOF
The invention provides compounds of Formula 1: ##STR00001## and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making...
2018/0327404 ERGOLINE COMPOUNDS AND USES THEREOF
Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or...
2018/0327403 HETEROCYCLIC COMPOUNDS AND USES THEREOF
Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their...
2018/0327402 TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating...
2018/0327401 IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of...
2018/0327400 DISUBSTITUTED DIARYLOXYBENZOHETERODIAZOLE COMPOUNDS
Disubstituted diaryloxybenzoheterodiazole compound having general formula (I) or (II) wherein --Z represents a sulfur atom, an oxygen atom, a selenium atom; or...
2018/0327399 HYDROXYALKYL THIADIAZOLE DERIVATIVES
Problem to be Solved There is a need for a new antibiotic having a novel mechanism of action which exhibit strong antibacterial activity not only against...
2018/0327398 PESTICIDALLY ACTIVE AMIDE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and...
2018/0327397 LACTAM COMPOUND DERIVATIVE AND APPLICATION THEREOF
The present invention relates to a lactam compound derivative, a medicine composition comprising the lactam compound derivative, and uses of the composition...
2018/0327396 NOVEL PYRIDINE DERIVATIVES
The invention relates to a compound of formula (I) ##STR00001## wherein A and R.sup.1 to R.sup.4 are defined as in the description and in the claims. The...
2018/0327395 CRYSTALLINE FORM OF CANAGLIFLOZIN AND A METHOD OF ITS PREPARATION
The invention relates to a new crystalline form of Canagliflozin of formula I, with its systematic name ...
2018/0327394 BENZOFURAN DERIVATIVE, PREPARATION METHOD THEREOF AND USE THEREOF IN MEDICINE
The present invention relates to a benzofuran derivative, a preparation method thereof and a use thereof in medicine. In particular, the present invention...
2018/0327393 AZIRIDINATED TRIGLYCERIDES AND POLYMERS FORMED THEREFROM
Various embodiments disclosed relate to aziridinated triglycerides and polymers formed therefrom. In various embodiments, the present invention provides an...
2018/0327392 3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES
The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine,...
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